Claims
- 1. A compound of the formula ##SPC24##
- wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or alkyl having 1 to 7 carbon atoms, R.sub.4 is alkyl having 1 to 7 carbon atoms, aryl having 6 to 10 carbon atoms, aralkyl in which aryl and alkyl are as defined, or a 5 or 6-membered heterocyclic ring having one or two atoms selected from the group consisting of nitrogen, oxygen or sulfur and R.sub.5 is hydrogen, alkyl having 1 to 7 carbon atoms, alkoxy having 1 to 7 carbon atoms, and hydroxyl and the corresponding pharmaceutically acceptable acid addition salt.
- 2. A compound according to claim 1 which is 2[2-(dimethylamino) ethyl]-3-[(ethylthio)methyl]indole.
- 3. A compound according to claim 1 which is 2[2-(dimethylamino) ethyl]-3-[(phenylthio)methyl]indole.
- 4. A compound according to claim 1 which is 1-methyl-2-[2-(dimethylamino)ethyl]-3-[(phenylthio)methyl]indole.
- 5. A compound according to claim 1 which is 2-[2-(dimethylamino) ethyl]-3-[(p-chlorophenylthio)methyl]indole.
- 6. A compound according to claim 1 which is 2-[2-(dimethylamino) ethyl]-3-[2-(dimethylamino)ethylthiomethyl]-indole.
- 7. A compound according to claim 1 which is 2-[2-(dimethylamino) ethyl]-3-[(2-thiazolin-2-ylthio)methyl]indole.
- 8. A compound according to claim 1 which is 2-[2-(dimethylamino) ethyl]-3-[(o-tolylthio)methyl]indole.
- 9. A compound according to claim 1 which is 2-[2-(dimethylamino) ethyl]-3-[(2-furylmethylthio)methyl]indole.
- 10. A compound according to claim 1 which is 2-[2-(dimethylamino) ethyl]-3-[(1-methylimidazol-2-ylthio)methyl]indole.
- 11. A compound according to claim 1 which is 2-[2-(dimethylamino) ethyl]-3-[(benzylthio)methyl]indole.
- 12. A compound according to claim 1 which is 5-bromo-2-[2-(dimethylamino)ethyl]-3-[(phenylthio)methyl]indole.
- 13. A compound according to claim 1 which is 1-methyl-2-[2-(dimethylamino)ethyl]-3-[(ethylthio)methyl]indole.
- 14. A compound according to claim 1 which is 2-[2-(ethylmethylamino)ethyl]-3-[(phenylthio)methyl]indole.
- 15. A compound according to claim 1 which is 5-methoxy-2-[2-(dimethylamino)ethyl]-3-[(phenylthio)methyl]indole.
- 16. A compound according to claim 1 which is 1-ethyl-2-[2-(dimethylamino)ethyl]-3-[(phenylthio)methyl]indole.
- 17. A compound according to claim 1 which is 1-n-propyl-2-[2-(dimethylamino)ethyl]-3-[(phenylthio)methyl]indole.
- 18. A compound according to claim 1 which is 2-[2-(Dimethylamino) ethyl]-3-[p-tolylthiomethyl]indole.
- 19. A compound according to claim 1 which is 2-[2-(Dimethylamino) ethyl]-3-[(m-tolylthio)methyl]indole.
- 20. A compound according to claim 1 which is 2-[2-(Dimethylamino) ethyl]-1-methyl-3-[(p-tolylthio)methyl]indole.
- 21. A compound according to claim 1 which is 2-[2-(Dimethylamino) ethyl]-1-methyl-3-[m-tolylthio)methyl]indole.
- 22. A process for the production of a compound according to claim 1 which comprises refluxing a compound of the formula ##SPC25##
- with a compound of the formula
- R.sub.4 S.sup.-Na.sup.+
- in which R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined in claim 1.
Parent Case Info
This application is a continuation-in-part of our co-pending application Ser. No. 391,171 filed Aug. 23, 1973 now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3033875 |
Nutting et al. |
May 1962 |
|
3478051 |
Houlihan et al. |
Nov 1969 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
391171 |
Aug 1973 |
|