Claims
- 1. A compound of the formula ##STR52## including all enantiomeric and diasteromeric forms thereof wherein: R.sub.3 is hydrogen or ##STR53## X is ##STR54## n is zero, one, or two; R.sub.5 is lower alkyl, ##STR55## R.sub.4 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, halo, hydroxy, CF.sub.3, phenyl, ##STR56## q is zero or an integer from 1 to 7.
- 2. A compound of claim 1 wherein
- X is ##STR57## n is zero; and R.sub.3 is hydrogen or ##STR58##
- 3. The compound of claim 2, (S,S)-3,3,3-trifluoro-2-(mercaptomethyl)-N-[2-(1H-indol-3-yl)-1-(1H-tetrazol-5-yl)ethyl]propanamide or (S,R)-3,3,3-trifluoro-2-(mercaptomethyl)-N-[2-(1H-indol-3-yl)-1-(1H-tetrazol-5-yl)ethyl]propanamide.
- 4. A compound of claim 1 wherein
- X is ##STR59## n is zero; and R.sub.3 is hydrogen or ##STR60##
- 5. The compound of claim 3, (S,R)-3,3,3-trifluoro-2-(mercaptomethyl)-N-[2-(1H-indol-3-yl)-1-(1H-tetrazol-5-yl)ethyl]propanamide.
- 6. A compound of the formula; ##STR61## including all enantiomeric and disastereomeric forms thereof wherein R.sub.3 is hydrogen or ##STR62## and X is ##STR63##
- 7. A pharmaceutical composition useful for reducing blood pressure and producing diuresis and natriuresis as well as treating congestive heart failure, renal failure, or hepatic cirrhosis comprising a pharmaceutically acceptable carrier and an effective amount of an endopeptidase inhibiting compound of the formula ##STR64## wherein X and R.sub.3 are as defined in claim 6.
RELATED APPLICATION
This application is a continuation-in-part of Ser. No. 497,386 filed Mar. 22, 1990, now abandoned.
US Referenced Citations (14)
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Country |
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Oct 1981 |
BEX |
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EPX |
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Entry |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
497386 |
Mar 1990 |
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