Claims
- 1. A compound of formula 1, its pharmaceutically acceptable salts and its geometric isomers whereinR1 is selected from a methyl or amino group, R2 is selected from the group consisting of hydrogen, halogen C1-C3-alkyl substituted or not substituted by halogens, amino, hydroxy, hydroxycarbonyl, nitro or cyano group, and X is an oxime as a substituted or not substituted form.
- 2. The compound of formula 1 according to claim 1, in which R1 is methyl group, R2 is hydrogen and X is an oxime (═N—OH) as a substituted or not substituted form wherein a substituent for said oxime is selected from the group consisting of methyl, ethyl, benzyl, acetyl or benzyloxyacetyl group.
- 3. The compound according to claim 1, wherein said compound of formula 1 is selected from the group consisting of:(E)-1-(4-methanesulfonyl-benzylidene)-3,4-dihydro-1H-naphthalene-2-one oxime; (E)-1-(4-methanesulfonyl-benzylidene)-3,4-dihydro-1H-naphthalene-2-one O-ethyl-oxime; (E)-1-(4-methanesulfonyl-benzylidene)-3,4-dihydro-1H-naphthalene-2-one O-methyl-oxime; (E)-1-(4-methanesulfonyl-benzylidene)-3,4-dihydro-1H-naphthalene-2-one O-benzyl-oxime; (E)-1-(4-methanesulfonyl-benzylidene)-3,4-dihydro-1H-naphthalene-2-one O-acetyl-oxime; and (E)-1-(4-methanesulfonyl-benzylidene)-3,4-dihydro-1H-naphthalene-2-one O-(benzyloxyacetyl)-oxime.
- 4. The compound according to claim 1, wherein said halogen is selected from the group consisting of fluoride, chloride, bromide and iodide.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2001-62488 |
Oct 2001 |
KR |
|
RELATED APPLICATIONS
This application is a divisional application of U.S. patent application Ser. No. 10/264,073, filed Oct. 3, 2002, now U.S. Pat. No. 6,686,493 entitled 3,4-Dihydro-1H-naphthalene derivatives as a highly selective cyclooxygenase-2 inhibitor which claims priority to Korean patent application no. 2001-62488,filed Oct. 10, 2001 entitled 3,4-Dihydro-1H-naphthalene derivatives as a highly selective cyclooxygenase-2 inhibitor which is incorporated herein by reference in its entirety.
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO 9500501 |
Jan 1995 |
WO |