Claims
- 1. A compound of the formula ##STR131## in which R.sub.1, R.sub.1 ', R.sub.3 and R.sub.3 ' denote a hydrogen atom or a direct bond to X,
- R.sub.2 and R.sub.2 ' denote a hydrogen atom, a C.sub.1 to C.sub.4 alkyl group or a direct bond to X, with the proviso that one and only one of the radicals R.sub.1, R.sub.2 and R.sub.3 and one and only one of the radicals R.sub.1 ', R.sub.2 ' and R.sub.3 ' represent a direct bond to X, and
- in which
- X corresponds to the formula
- --(A).sub.m --(R.sub.4).sub.n --(Y).sub.P --(R.sub.5).sub.q --(B).sub.r --
- in which
- A and B independently denote, CH.sub.2, CH.sub.2 --NH, CH.sub.2 --NH--CO, CH.sub.2 --NHCONH, CH.sub.2 --NHSO.sub.2 NH, CH.sub.2 --NH--SO.sub.2, CH.sub.2 --NHCS--NH, CH.sub.2 --NH--COO, CH.sub.2 --NHCS, ##STR132## CH.sub.2 --O, CO or COO, R.sub.4 and R.sub.5 independently correspond to the formula
- --(R.sub.13).sub.s --(U).sub.t --(R.sub.14).sub.v --
- in which
- R.sub.13 and R.sub.14 independently denote C.sub.1 to C.sub.18 -alkylidene, C.sub.2 to C.sub.18 -alkenylidene with up to three double bonds, C.sub.2 to C.sub.10 alkenylidene, C.sub.3 -C.sub.10 -cycloalkylidene
- phenylene, phenylene with one or two substituents from phenoxy, C.sub.1 to C.sub.4 alkyl,
- F, Cl, or Br or piperazine,
- U denotes O, S, SO, SO.sub.2, NH, NR.sub.6, CO, COO, CS, OCOO, NHCOO, CONH, NHCONH, NHCSNH, CH.dbd.N, SO.sub.2 NH or NHSO.sub.2 NH,
- and
- s, t, v, independently are 0 or 1,
- Y has the meaning given for U, or has any of the meanings given for R.sub.13 and R.sub.14, and
- m, n, p, q and r are 0 or 1, with the proviso that the sum of m and r is 1 or 2 and that p is 0 when n and/or q are 0 and with the proviso that there are excluded the compounds of the formula ##STR133## wherein X is phenylene.
- 2. A compound according to claim 1, in which X is (CH.sub.2)--C.dbd.C--(CH.sub.2).sub.a wherein a is an integer from 1 to 6.
- 3. A compound according to claim 1, in which X is --(CH.sub.2).sub.b -- wherein b is an integer from 1 to 6.
- 4. A compound according to claim 1, having the formula ##STR134##
- 5. A compound according to claim 1, having the formula ##STR135##
- 6. A compound according to claim 1, having the formula ##STR136##
- 7. A compound according to claim 1, in which A denotes CH.sub.2 if X is linked via R.sub.2, or CH.sub.2 --NHCO, CH.sub.2 NHSO.sub.2, CH.sub.2 NHCOO, --CH.sub.2 NHCSNH-- or CH.sub.2 -- NHCONH if X is linked via R.sub.1 or R.sub.3, B denotes CH.sub.2 if X is linked via R.sub.2 ', or CH.sub.2 NHCO, CH.sub.2 NHSO.sub.2, CH.sub.2 NHCOO, --CH.sub.2 NHCSNH-- or CH.sub.2 NHCONH if X is linked via R.sub.1 ' or R.sub.3 ', R.sub.13 and R.sub.14 denote C.sub.1 to C.sub.18 -alkylidene, C.sub.2 to C.sub.18 -alkenylidene or phenylene, U denotes O, SO.sub.2, CO, CH.sub.2, S, SO, NH, CONH, NHCONH, NHCSNH, SO.sub.2 NH, Y is U or CH.dbd.CH, phenylene or phenylene with one or two substitutents from C.sub.1 to C.sub.4 alkyl, F, Cl, or Br, m and n denote 1, and r, p and q denote 0 or 1.
- 8. A compound according to claim 1, in which
- A denotes CH.sub.2 if X is linked via R.sub.2, or CH.sub.2 --NHCO, CH.sub.2 NHSO.sub.2, CH.sub.2 NHCOO or CH.sub.2 NHCONH if X is linked via R.sub.1 or R.sub.3 and
- B denotes CH.sub.2 if X is linked via R.sub.2 ' or CH.sub.2 NHCO, CH.sub.2 NHSO.sub.2, CH.sub.2 NHCOO or CH.sub.2 NHONH if X is linked via R.sub.1 ' or R.sub.3 '.
- 9. A pharmaceutical composition containing as an active ingredient an effective amount for combating diabetes, hyperlipamia or adiposity, of a compound according to claim 1 in admixture with a solid, liquid or liquefied gaseous diluent.
- 10. A pharmaceutical composition of claim 9 in the form of a sterile or physiologically isotonic aqueous solution.
- 11. A composition according to claim 9 or 10 containing from 0.5 to 99.5% by weight of the said active ingredient.
- 12. A medicament in dosage unit form comprising an effective amount for combating diabetes, hyperlipemia or adiposity, of a compound of claim 1 together with an inert pharmaceutical carrier.
- 13. A medicament of claim 12 in the form of tablets, pills, dragees, capsules, ampoules or suppositories.
- 14. A method of combating diabetes, hyperlipemia or adiposity which comprises administering to the animals an effective amount for combating diabetes, hyperlipemia or adiposity, of active compound according to claim 1 either alone or in admixture with a diluent or in the form of a medicament.
- 15. A method of combating adiposity, diabetes or hyperlipaemia in warm-blooded animals which comprises administering to the animals an effective amount for combating adiposity, diabetes or hyperlipaemia, of active compound according to claim 1 either alone or in admixture with a diluent or in the form of a medicament.
- 16. A method according to claim 14 or 15 in which the active compound is administered in an amount of 1 to 1.times.10.sup.4 saccharase inhibitor units per kg body weight per day.
- 17. A medicament feed comprising an effective amount of a compound according to claim 1 and a nutritious material.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2922760 |
Jun 1979 |
DEX |
|
Parent Case Info
This is a continuation of application Ser. No. 153,286 filed May 27, 1980 now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4336373 |
Matsumura et al. |
Jun 1982 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
2067989 |
Aug 1981 |
GBX |
Continuations (1)
|
Number |
Date |
Country |
Parent |
153286 |
May 1980 |
|