Claims
- 1. A compound of the formula ##STR14## and a pharmaceutically acceptable base or acid addition salt thereof; wherein
- Z is O, NOH, or NOCH.sub.3 ;
- Ar is ##STR15## wherein X is O
- R is hydrogen, lower alkyl, halogen, CO.sub.2 R.sub.2 or ##STR16## wherein R.sup.1 is hydrogen or lower alkyl; and
- R.sup.2 and R.sup.3 are independently hydrogen or lower alkyl; and
- n is an integer of one or two with the proviso that when n is two then R cannot be CO.sub.2 R.sub.2 or ##STR17##
- 2. A compound of claim 1 wherein Z is O and Ar is as defined above.
- 3. A compound of claim 1 wherein Z is NOH and Ar is as defined above.
- 4. A compound of claim 1 wherein Z is NOCH.sub.3 and Ar is as defined above.
- 5. A compound of claim 1 which is [3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl](5-methyl-3-isoxazolyl)methanone.
- 6. A compound of claim 1 which is [3,5-bis(1,1-dimethylethyl)-4 -hydroxyphenyl](5-methyl-3-isoxazolyl)methanone, O-methyl oxime.
- 7. A compound of claim 1 which is [3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-oxazolyl methanone.
- 8. A compound of claim 1 which is [3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-oxazolyl methanone oxime.
- 9. A compound of claim 1 which is [3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-oxazolyl methanone, O-methyloxime.
- 10. A pharmaceutical composition for use as an inhibitor of 5-lipoxygenase, cyclooxygenase, or both comprising a 5-lipoxygenase, cyclooxygenase or both inhibiting amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
- 11. A method for treating an inflammatory disease or condition in a human suffering therefrom which comprises administering a compound of claim 1 in unit dosage form.
- 12. A pharmaceutical composition which comprises a compound of claim 1 and a nonsteroidal antiinflammatory agent in a weight ratio of from 1000 to 1 to 1 to 1000.
Parent Case Info
This is a divisional application of U.S. application Ser. No. 07/646,411 filed Jan. 31, 1991, now U.S. Pat. No. 5,086,064, which is a continuation-in-part of U.S. Application Ser. No. 07/500,175, filed Mar. 27, 1990, now abandoned.
US Referenced Citations (4)
Foreign Referenced Citations (3)
Number |
Date |
Country |
0059090 |
Sep 1982 |
EPX |
0189771 |
Aug 1986 |
EPX |
0269981 |
Jun 1988 |
EPX |
Non-Patent Literature Citations (7)
Entry |
Milaev, Zh Obshck. Khim, 50, (2) 473 (1980). |
EPO 91 104 797 (corresponding) Search Report. |
Derwent Abstract No. 88-326016/46 (J63239-273-A). |
Derwent Abstract No. 87-285927/41 (EP 241-043-A). |
Derwent Abstract No. 83-786513/41 (J58148-858-A). |
Derwent Abstract No. 19743 D/12 (EP 24-829). |
Derwent Abstract No. 88-199352/29 (EP 274-867-A). |
Divisions (1)
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Number |
Date |
Country |
Parent |
646411 |
Jan 1991 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
500175 |
Mar 1990 |
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