Claims
- 1. A compound or pharmaceutically acceptable salt thereof selected from the group consisting of:
- 4-{3-[4-((N',N'-dimethylaminocarbonyl)-N-methylamino)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran,
- 4-{3-[2-((N',N'-dimethylaminocarbonyl)-N-methylamino)pyrid-5-ylthio]-5-fluorophenyl}-4-methoxytetrahydropyran,
- 4-{3-[4-((N'-methylaminocarbonyl)-N-methylamino)phenylthio]phenyl}-4-methoxytetrahydropyran,
- 4-{3-[4-((4-morpholinocarbonyl)-N-methylamino)phenylthio]phenyl}-4-methoxytetrahydropyran,
- 4-{3-[4-((4-morpholinocarbonyl)-N-methylamino)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran,
- 4-{3-[4-(((4-methylpiperazinyl)carbonyl)-N-methylamino)phenylthio]phenyl}-4-methoxytetrahydropyran,
- 4-{3-[4-(((4-methylpiperazinyl)carbonyl)-N-methylamino)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran,
- 4-{3-[4-(((4-methylpiperazinyl)carbonyl)-N-methylamino)phenylthio]phenyl}-4-methoxytetrahydropyran hydrochloride,
- 4-{3-[4-(((4-methylpiperazinyl)carbonyl)-N-methylamino)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran hydrochloride,
- 4-{3-[4-((N'-allyl-N'-methylamino)carbonyl)-N-methylamino)phenylthio]phenyl}-4-methoxytetrahydropyran,
- 4-{3-[4-(((4-methylpiperazinyl)carbonyl)-N-methylamino)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran,
- 4-{3-[4-(N",N"-dimethyl-N'-cyano-N-methylguanidinyl)phenylthio]phenyl}-4-methoxytetrahydropyran,
- 4-{-3-[4-((N',N'-dimethylaminocarbonyl)-N-methylamino)phenylsulfinyl]phenyl}-4-methoxytetrahydropyran,
- 4-{-3-[4-((N',N'-dimethylaminocarbonyl)-N-methylamino)phenylsulfonyl]phenyl}-4-methoxytetrahydropyran,
- 4-{-3-[4-((N',N'-dimethylaminocarbonyl)-N-methylamino)phenylsulfinyl]-5-fluorophenyl}-4-methoxytetrahydropyran, and
- 4-{-3-[4-((N',N'-dimethylaminocarbonyl)-N-methylamino)phenylsulfonyl]-5-fluorophenyl}-4-methoxytetrahydropyran.
- 2. A pharmaceutical composition comprising a therapeutically effective amount of a compound as defined by claim 1 in combination with a pharmaceutically acceptable carder.
- 3. A method of inhibiting 5-lipoxygenase enzyme activity in a mammal in need of such treatment comprising administering an effective amount of a compound as defined by claim 1.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of application Ser. No. 08/061,988 filed May 14, 1993 now U.S. Pat. No. 5,346,914.
US Referenced Citations (6)
Foreign Referenced Citations (2)
Number |
Date |
Country |
53-105478 |
Sep 1978 |
JPX |
0401664 |
Oct 1973 |
SUX |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
61988 |
May 1993 |
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