Claims
- 1. A method of inhibiting gastric acid secretion which comprises administering to a mammal in need thereof an effective amount of a compound of structure (I): ##STR8## in which R.sup.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxyl C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-6 alkyl, the phenyl groups being unsubstituted or substituted by 1 to 3 radicals selected from C.sub.1-6 alkyl, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylthio, or halogen;
- R.sup.2 is C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl-C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-6 alkyl or phenyl substituted by 1-3 radicals selected from C.sub.1-6 alkyl, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylthio, halogen, or hydroxy;
- R.sup.3 is C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, C.sub.1-6 alkanoyl, amino, C.sub.1-6 alkylamino, di-C.sub.1-6 alkylamino, or halogen; and
- n is 0, 1 or 2, provided that when n is 2 and R.sup.3 has 4 to 6 carbon atoms, the R.sup.3 groups are para or meta to each other;
- or a pharmaceutically acceptable salt thereof.
- 2. A method of treatment of gastrointestinal diseases and other conditions caused or exacerbated by gastric acidity which comprises administering to a mammal in need thereof an effective amount of a compound according to claim 1.
- 3. A method to claim 1 in which the compound is 3-butyryl-4-(2-methylphenylamino)-8-methoxyquinoline.
- 4. A method according to claim 2 in which the compound is 3-butyryl-4-(2-methylphenylamino)-8-methoxyquinoline.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8621425 |
Sep 1986 |
GBX |
|
Parent Case Info
This is a continuation of application Ser. No. 092,749 filed on Sept. 3, 1987.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4343804 |
Munson, Jr. et al. |
Aug 1982 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
184322 |
Jun 1986 |
EPX |
191603 |
Aug 1986 |
EPX |
193329 |
Sep 1986 |
EPX |
Non-Patent Literature Citations (2)
Entry |
Godard et al., J. Het Chem; 17, 465-473 (1980). |
Schafer et al., Monatshefte fur Chemie, 109 527-535 (1978). |
Continuations (1)
|
Number |
Date |
Country |
Parent |
92749 |
Sep 1987 |
|