Claims
- 1. A compound selected from those of formula (I): ##STR18## in which: R.sub.1 represents hydroxy, amino, lower alkylamino, lower alkoxy, or halogen,
- R.sub.2 represents hydrogen, lower alkyl, lower acyl, or lower alkoxycarbonyl,
- R represents:
- an aromatic radical selected from unsubstituted and substituted quinoline, isoquinoline, and quinazoline, which
- the term "substituted" meaning that the group so qualified is be substituted by one or more groups selected from halogen, lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, nitro, amino, and lower alkylamino,
- its optical isomers and its salts of addition with a pharmaceutically-acceptable base or acid,
- the terms "lower alkyl", "lower alkoxycarbonyl", "lower alkoxy", "lower alkylamino" and "lower acyl" indicating group containing 1 to 6 carbon atoms inclusive in a straight or branched chain.
- 2. A compound of claim 1 wherein R is a radical selected from the group consisting of unsubstituted quinoline, isoquinoline, and quinazoline radicals.
- 3. A compound of claim 1, wherein R is a quinoline radical.
- 4. A pharmaceutical composition useful in treating a disorder related to a dysfunction of GABA.sub.B receptors including spastic disorders and senescence disorders, containing as active principle an effective amount of a compound as claimed in claim 1 in combination with a pharmaceutically-acceptable excipient or vehicle.
- 5. A method for treating a living animal afflicted with a disorder related a dysfunction of GABA.sub.B receptors, including spastic disorders or senescence disorders, comprising the step of administering to the said living animal an amount of a compound of claim 1 which is effective for alleviation of the said condition.
Priority Claims (1)
Number |
Date |
Country |
Kind |
90 08093 |
Jun 1990 |
FRX |
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Parent Case Info
The present application is a division of our prior-filed copending application Ser. No. 07/713,760, filed Jun. 11, 1991, now U.S. Pat. No. 5,163,364 issued Nov. 10, 1992.
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Date |
Kind |
4581167 |
Carpino et al. |
Apr 1986 |
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4698333 |
Fauss et al. |
Oct 1987 |
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4889953 |
Inoue et al. |
Dec 1989 |
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4963530 |
Hemmi et al. |
Oct 1990 |
|
Non-Patent Literature Citations (3)
Entry |
Berthelot et al., J. Med Chem., vol. 30, No. 4, pp. 743-746 (1987) Chemical Abstracts, vol. 106, entry 176087e, 1987. |
Chemical Abstracts, vol. 111, entry 50294e, 1989. |
Chemical Abstracts, vol. 111, entry 50265w, 1989. |
Divisions (1)
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Number |
Date |
Country |
Parent |
713760 |
Jun 1991 |
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