Claims
- 1. A compound of the formula
- wherein each or R.sub.1 and R.sub.2 is independently hydrogen; C.sub.1-4 alkyl or benzyl; n is 2, 3, or 4; and R is C.sub.3-6 cycloalkyl, ##STR36## wherein m is 0, 1 or 2; and p is 0, 1 or 2, or a pharmaceutically acceptable salt thereof.
- 2. A compound of claim 1 wherein n is 3.
- 3. A compound of claim 2 wherein R.sub.1 is hydrogen or methyl; and R.sub.2 is methyl or benzyl.
- 4. A compound of claim 3 wherein R is tetrahydrofuryl, cyclopentyl, cyclopropyl, or dihydrobenzofuryl.
- 5. A compound of the formula ##STR37## wherein R.sub.1 and R.sub.2 are as defined in claim 1.
- 6. A compound of the formula ##STR38## wherein R.sub.1 and R.sub.2 are as defined in claim 1.
- 7. A compound of the formula ##STR39## wherein R.sub.1 and R.sub.2 are as defined in claim 1.
- 8. A compound of the formula ##STR40## wherein R.sub.1 and R.sub.2 are as defined in claim 1.
- 9. N.sub.1 -(4-amino-6,7-dimethoxyquinazol-2-yl)-N.sub.1 -methyl-N.sub.2 -(tetrahydrofuroyl-2)-propylenediamine or a pharmaceutically acceptable salt thereof.
- 10. A pharmaceutical composition comprising an antihypertensively effective amount of at least one compound according to claim 1, 2, 3, 4 or 9 together with a pharmaceutically acceptable carrier or diluent.
- 11. A method of treating a cardiovascular disorder comprising administering to a subject suffering therefrom a therapeutically effective dose of a compound according to claim 1, 2, 3, 4 or 9.
Priority Claims (2)
Number |
Date |
Country |
Kind |
78 03175 |
Feb 1978 |
FRX |
|
78 36819 |
Dec 1978 |
FRX |
|
Parent Case Info
The present invention is a continuation-in-part of copending application Ser. No. 8,931, filed Feb. 2, 1979 and now abandoned.
US Referenced Citations (3)
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
8931 |
Feb 1979 |
|