Claims
- 1. A method of treating diseases in a mama which respond to treatment by administration of a dopamine D.sub.2 agonist which comprises administration to a mammal in need thereof of a therapeutically effective amount of a compound according to the formula ##STR8## wherein: R.sup.1 is hydrogen or C.sub.1 -C.sub.6 alkyl;
- R.sup.2 is selected from hydrogen, straight-chain and branched C.sub.1 -C.sub.10 alkyl, cyclohexylmethyl or --(CH.sub.2).sub.m Ar where Ar is phenyl, naphthyl, thienyl, furanyl or pyridinyl, each optionally substituted by one or two substituents selected independently from C.sub.1 -C.sub.6 alkyl, halogen, C.sub.1 -C.sub.6 alkoxide and trifluoromethyl;
- or NR.sup.1 R.sup.2 is 1, 2, 3, 4-tetrahydroquinolin-1-yl or 1, 2, 3, 4-tetrahydroisoquinolin-2-yl;
- m is 1-5;
- n is 1 or 2;
- R.sup.3 is hydrogen or C.sub.1 -C.sub.6 alkyl;
- Y is halogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;
- or a pharmaceutically acceptable salt thereof.
- 2. The method of treatment according to claim 1 wherein the disease treated is schizophrenia.
- 3. The method of treatment according to claim 1 wherein the disease treated is Parkinson's disease.
- 4. The method of treatment according to claim 1 wherein the disease treated is Tourette's syndrome.
- 5. The method of treatment according to claim 1, wherein the disease treated is alcohol or drug addiction.
Parent Case Info
This application is a divisional application of U.S. Ser. No. 09/025,083, filed Feb. 17, 1998, U.S. Pat. No. 5,990,144 (not yet known) which claims the benefit of prior U.S. Provisional application No. 60/038,682 filed Feb. 18, 1997.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
5750556 |
Mewshaw et al. |
May 1998 |
|
5990144 |
Mewshaw et al. |
Nov 1999 |
|
Divisions (1)
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Number |
Date |
Country |
Parent |
025083 |
Feb 1998 |
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