Claims
- 1. A compound having the formula ##STR11## and the pharmaceutically acceptable acid addition salts thereof wherein R is selected from the group consisting of ##STR12## wherein R.sub.3 is selected from the group consisting of a first subgroup consisting of ##STR13## a second subgroup consisting of: heterocyclyl and a third subgroup consisting of: alkyl having from one to four carbon atoms;
- wherein each of X and Y is selected from the group consisting of hydrogen, chloro, bromo, fluoro, alkyl having from one to four carbon atoms and alkoxy having from one to four carbon atoms; and Z is selected from the group consisting of X, dimethylamino, nitro and amino;
- heterocyclyl is selected from the group consisting of thienyl, furyl and pyridyl;
- and each of R.sub.1 and R.sub.2 is selected from the group consisting of hydrogen and alkanoyl having from two to three carbon atoms.
- 2. A compound according to claim 1 wherein R is --C(.dbd.O)--C(.dbd.O)--R.sub.3.
- 3. A compound according to claim 2 wherein R.sub.1 is alkanoyl and R.sub.2 is hydrogen.
- 4. A compound according to claim 2 wherein R.sub.1 is acetyl and R.sub.3 is ##STR14##
- 5. A compound according to claim 4 wherein each of X and Y is hydrogen.
- 6. A compound according to claim 5 wherein Z is chloro.
- 7. The compound according to claim 5 wherein Z is hydrogen.
- 8. A compound according to claim 3 wherein R.sub.1 is acetyl and R.sub.3 is heterocyclyl.
- 9. A compound according to claim 2 wherein each of R.sub.1 and R.sub.2 is hydrogen.
- 10. A compound according to claim 9 wherein R.sub.3 is ##STR15##
- 11. A compound according to claim 10 wherein each of X and Y is hydrogen.
- 12. The compound according to claim 11 wherein Z is hydrogen.
- 13. A compound according to claim 9 wherein R.sub.3 is heterocyclyl.
- 14. The compound according to claim 13 wherein R.sub.3 is 2-thienyl.
- 15. The compound according to claim 13 wherein R.sub.3 is 2-furyl.
- 16. A compound according to claim 13 wherein R.sub.3 is pyridyl.
- 17. A compound according to claim 1 wherein R is --C(.dbd.S)--C(.dbd.O)--R.sub.3.
- 18. A compound according to claim 17 wherein R.sub.1 is alkanoyl and R.sub.2 is hydrogen.
- 19. A compound according to claim 18 wherein R.sub.3 is ##STR16##
- 20. A compound according to claim 19 wherein R.sub.1 is acetyl, and each of X and Y is hydrogen.
- 21. The compound according to claim 20 wherein Z is hydrogen.
- 22. A compound according to claim 18 wherein R.sub.1 is acetyl and R.sub.3 is heterocyclyl.
- 23. A compound according to claim 18 wherein R.sub.1 is acetyl and R.sub.3 is alkyl.
- 24. A compound according to claim 17 wherein each of R.sub.1 and R.sub.2 is hydrogen.
- 25. A compound according to claim 24 wherein R.sub.3 is ##STR17##
- 26. A compound according to claim 25 wherein each of X and Y is hydrogen.
- 27. The compound according to claim 26 wherein Z is hydrogen.
- 28. A compound according to claim 24 wherein R.sub.3 is heterocyclyl.
- 29. The compound according to claim 28 wherein R.sub.3 is 2-furyl.
- 30. The compound according to claim 28 wherein R.sub.3 is 2-thienyl.
- 31. A compound according to claim 28 wherein R.sub.3 is pyridyl.
- 32. A compound according to claim 24 wherein R.sub.3 is alkyl.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of copending application Ser. No. 866,890 filed Jan. 3, 1978 now abandoned.
US Referenced Citations (3)
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
866890 |
Jan 1978 |
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