Claims
- 1. Compounds of the formula ##STR23## wherein R.sub.1 represents fluorine, chlorine or dimethylamino, X represents (CH.sub.2)n where n is 2 or 3, R.sub.2 and R.sub.3 are hydrogen or methyl.
- 2. Compounds as claimed in claim 1 in which the group represented by the formula: ##STR24## is selected from the group consisting of: 3-(4-fluorophenyl)-1-methylpropyl,
- 3-(4-chlorophenyl)-1-methylpropyl,
- 3-(4-dimethylaminophenyl)-1-methylpropyl,
- 3-(2-fluorophenyl)-1-methylpropyl,
- 3-(3-fluorophenyl)-1-methylpropyl,
- 3-(4-fluorophenyl)propyl,
- 3-(4-fluorophenyl)-1,1-dimethylpropyl, and
- 4-(4-fluorophenyl)-1-methylbutyl.
- 3. Compounds as claimed in claim 1 in which R.sub.1 represents a fluorine or chlorine atom.
- 4. Compounds as claimed in claim 1 in which at least one of R.sub.2 and R.sub.3 represents a methyl group.
- 5. A compound of claim 1 which is .alpha..sup.1 -[[[3-(4-fluorophenyl)-1-methylpropyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol.
- 6. A compound of claim 1 which is .alpha..sup.1 -[[[3-(3-fluorophenyl)-1-methylpropyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol.
- 7. A compound of claim 1 which is erythro-.alpha..sup.1 -[1-[[3-(4-fluorophenyl)propyl]amino]ethyl]-4-hydroxy-1,3-benzenedimethanol.
- 8. A compound of claim 1 which is .alpha..sup.1 -[[[3-(4-fluorophenyl)propyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol
- 9. A compound of claim 1 which is .alpha..sup.1 -[[[3-(4-chlorophenyl)-1-methylpropyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol.
- 10. A compound of claim 1 which is .alpha..sup.1 -[[[3-(3-chlorophenyl)-1-methylpropyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol.
- 11. A compound of claim 1 which is 4-hydroxy-.alpha..sup.1 -[[[3-(4-(dimethylamino)phenyl]-1-methylpropyl]amino]methyl]-1,3-benzenedimethanol.
- 12. A compound of claim 1 which is .alpha..sup.1 -[[[3-(4-fluorophenyl)-1-ethylpropyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol.
- 13. A compound of claim 1 which is .alpha..sup.1 -[[[3-(4-fluorophenyl)1,3,3-trimethylpropyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol.
- 14. A compound of claim 1 which is .alpha..sup.1 [[[4-(4-fluorophenyl)-1-methylbutyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol.
- 15. A compound of claim 1 which is .alpha..sup.1 -[[[5-(4-fluorophenyl)-1-methylpentyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol.
- 16. A compound of claim 1 which is .alpha..sup.1 -[[[3-(4-fluorophenyl)-2,2-dimethylpropyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol.
- 17. A compound of claim 1 which is .alpha..sup.1 -[[[3-(4-fluorophenyl)-1,1-dimethylpropyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol.
- 18. A pharmaceutical composition comprising a compound as claimed in claim 1 in association with an inert pharmaceutically acceptable carrier or diluent.
- 19. Compositions as claimed in claim 18 adapted for oral use and in the form of tablets.
- 20. Compositions as claimed in claim 19 in dosage unit form each dosage unit containing up to 100 mg of active ingredient.
- 21. A composition as claimed in claim 18 adapted for administration by inhalation and in the form of a metered dose inhalation aerosol, a solution or suspension suitable for nebulisation by mechanical means, or as a cartridge from which the powdered composition may be inhaled with the aid of a suitable device.
- 22. A composition as claimed in claim 21 in which the metered dose is from 50-1000 .mu.g.
- 23. A method for the treatment of a patient to relieve bronchospasm which comprises administering an effective amount of a compound as claimed in claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
31678/75 |
Jul 1975 |
GBX |
|
Parent Case Info
This is a continuation of application Ser. No. 709,926, filed July 29, 1976, now abandoned.
US Referenced Citations (4)
Continuations (1)
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Number |
Date |
Country |
Parent |
709926 |
Jul 1976 |
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