Claims
- metal, akaline earth and amine salts..]. .[.2. A compound according to claim 1 which is 4-Hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-Dioxide..]. .[.3. A compound according to claim 1 which is 4-Hydroxy-3-(3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-Dioxide..]. .[.4. A compound according to claim 1 which is 4-Hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2H-1,2-benzothiazine 1,1-Dioxide..]. pg,5 .[.5. A process for production of the compound of claim 1 which comprises refluxing together a compound of Structure II: ##STR11## in which R.sub.4 is lower alkyl with a compound of Structure III: ##STR12## in an inert solvent in the presence of a molecular sieve adapted to remove
- the by-product alcohol formed..]. .[.6. A process for the production of the compound of claim 2 which comprises treating a compound of the formula: ##STR13## with sodium hydride in dimethylformamide, treating the resulting anion with methyl iodide; adding water to the reaction mixture; and recovering
- compound I as a precipitate..]. .Iadd. 7. A process for the production of a compound of the formula I: ##STR14## wherein R.sub.1 is hydrogen or methyl and R.sub.2 and R.sub.3 are hydrogen or alkyl having 1 to 7 carbon atoms or its corresponding alkali metal, alkaline earth and amine salts; which comprises refluxing together a compound of the formula II: ##STR15## in which R.sub.4 is lower alkyl with a compound of the formula III: ##STR16## in an inert solvent in the presence of a molecular sieve adapted to remove
- the by-product alcohol formed. .Iaddend..Iadd. 8. A process for the production of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide which comprises treating a compound of the formula IV: ##STR17## with sodium hydride in dimethylformamide, treating the resulting anion with methyl iodide; adding water to the reaction mixture; and recovering 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide as a precipitate. .Iaddend.
Parent Case Info
.[.This application is a continuation-in-part of our copending application U.S. Ser. No. 33,821, filed Feb. 20, 1973, which in turn is a divisional of U.S. Ser. No. 119,967 filed Mar. 1, 1971, now abandoned..].
.Iadd.This application is a reissue of U.S. Pat. No. 3,822,858, filed as U.S. Ser. No. 356,026 on Apr. 30, 1973, which is a continuation-in-part of U.S. Ser. No. 333,821, filed Feb. 20, 1973, now U.S. Pat. No. 3,816,828, which in turn is a divisional of U.S. Ser. No. 119,967, filed Mar. 1, 1971, now U.S. Pat. No. 3,787,324. .Iaddend.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3646021 |
Zinnes et al. |
Feb 1972 |
|
3704298 |
Zinnes et al. |
Nov 1972 |
|
3714155 |
Zinnes et al. |
Jan 1973 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
119967 |
Mar 1971 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
333821 |
Feb 1973 |
|
Reissues (1)
|
Number |
Date |
Country |
Parent |
356026 |
Apr 1973 |
|