Claims
- 1. A compound of the formula: ##STR6## wherein R.sup.o is alkyl of 1 to 6 carbon atoms or allyl,
- M is hydrogen or a pharmaceutically acceptable cation, and
- R' is hydrogen or methyl.
- 2. A compound of claim 1 in which M is hydrogen.
- 3. A compound of claim 1 in which R' is hydrogen.
- 4. The compound of claim 1 which is 1,7-dimethyl-4-hydroxy-3-nitro-pyrido[2,3-b]pyridine-2(1H)-one.
- 5. The compound of claim 1 which is 1-allyl-7-methyl-4-hydroxy-3-nitro-pyrido[2,3-b]pyridine-2(1H)-one.
- 6. A pharmaceutical composition comprising an inert pharmaceutically acceptable carrier and a symptomatic allergy treating effective amount of a compound of claim 1.
- 7. The method of symptomatically treating allergic conditions due to histamine release comprising administering to a mammal in need of such treatment an allergy treating effective amount of a compound of claim 1.
- 8. The method of claim 7 in which R' is hydrogen.
- 9. The method of claim 7 in which the compound is 1,7-dimethyl-4-hydroxy-3-nitro-pyrido[2,3-b]pyridine-2(1H)-one.
- 10. The method of claim 7 in which the compound is 1-allyl-7-methyl-4-hydroxy-3-nitro-pyrido[2,3-b]pyridine-2(1H)-one.
Parent Case Info
This application is a continuation-in-part of application Ser. No. 605,152, filed Aug. 15, 1975, now abandoned.
US Referenced Citations (4)
Non-Patent Literature Citations (2)
Entry |
Buckle, D. R., et al., "4-Hydroxy-3-nitro-2-quinolones and Related Compounds as Inhibitors of Allergic Reaction, J. Medicinal Chem. '75, vol. 18, #7, pp. 726-732. |
Physicians Desk Reference (PDR), (1974), pp. 760-761. |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
605152 |
Aug 1975 |
|