Claims
- 1. A compound of the formula ##STR13## wherein R.sup.O is alkenyl of 3 to 6 carbon atoms,
- or ##STR14## R and R' are independently hydrogen, fluoro, chloro, bromo, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro, or trifluoromethyl, or R and R' together form 6,7-methylenedioxy, with proviso that only one of R and R' can be from the group of nitro and trifluoromethyl,
- Mp is hydrogen or a pharmaceutically acceptable cation,
- Yc is hydrogen, fluoro or chloro, and
- Y.sub.c ' is fluoro, chloro, bromo or trifluoromethyl, with the further proviso that the unsaturation in said alkenyl is on other than the alpha carbon atom.
- 2. A pharmaceutical composition comprising an inert pharmaceutically acceptable carrier and an allergy treating effective amount of a compound of claim 1.
- 3. A compound of the formula: ##STR15## wherein R.sub.a.sup.o is alkenyl of 3 to 6 carbon atoms with the proviso that the unsaturation in said alkenyl is on other than the alpha carbon atom,
- M.sub.p is hydrogen or a pharmaceutically acceptable cation, and
- R and R' are independently hydrogen, fluoro, chloro, bromo, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro or trifluoromethyl, or R and R' together from 6,7-methylenedioxy, with the further proviso that only one of R and R' are from the group consisting of nitro and trifluoromethyl.
- 4. A compound of claim 3 in which R.sub.a.sup.o is allyl.
- 5. A compound of claim 3 in which M.sub.p is hydrogen.
- 6. A compound of claim 3 in which R and R' are both alkoxy.
- 7. A compound of claim 6 in which R and R' represent together 6,7-dialkoxy.
- 8. A compound of claim 7 in which R and R' represent together 6,7-dimethoxy.
- 9. The compound of claim 8 which is 1-allyl-6,7-dimethoxy-4-hydroxy-3-nitro-quinoline-2(1H)-one.
- 10. The compound of claim 3 which is 1-(3-methyl-2-butenyl)-6,7-dimethoxy-4-hydroxy-3-nitro-quinoline-2(1H)-one
- 11. The compound of claim 3 which is 1-(3-butenyl)-6,7-dimethoxy-4-hydroxy-3-nitro-quinoline-2(1H)-one.
- 12. The method of treating allergic conditions due to histamine release comprising administering to a mammal in need of such treatment an allergy treating effective amount of a compound of claim 3.
- 13. The method of claim 12 in which R and R' are both alkoxy.
- 14. The method of claim 13 in which R.sub.a.sup.o is allyl.
- 15. The method of claim 14 in which R and R' represent together 6,7-dialkoxy.
- 16. The method of claim 15 in which the compound is 1-allyl-6,7-dimethoxy-4-hydroxy-3-nitro-quinolone-2(1H)-one.
- 17. A pharmaceutical composition comprising an inert pharmaceutically acceptable carrier and an allergy treating effective amount of a compound of claim 3.
- 18. A compound of the formula: ##STR16## wherein Y.sub.c is hydrogen, fluoro, chloro,
- Y.sub.c ' if fluoro, chloro, bromo, or trifluoromethyl,
- M.sub.p is hydrogen or a pharmaceutically acceptable cation,
- n is 1, and
- R and R' are independently hydrogen, fluoro, chloro, bromo, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro or trifluoromethyl, or R and R' together form 6,7-methylenedioxy, with the proviso that only one of R and R' are selected from the group consisting of nitro and trifluoromethyl.
- 19. A compound of claim 18 in which R and R' represent together 6,7-dialkoxy.
- 20. The compound of claim 19 which is 1-(p-fluorobenzyl)-6,7-dimethoxy-4-hydroxy-3-nitro-quinoline-2(1H)-one.
- 21. The method of treating allergic conditions due to histamine release comprising administering to a mammal in need of such treatment an allergy treating effective amount of a compound of claim 18.
- 22. A pharmaceutical composition comprising an inert pharmaceutically acceptable carrier and an allergy treating effective amount of a compound of claim 18.
Parent Case Info
This application is a continuation-in-part of application Ser. No. 707,266, filed July 21, 1976, which in turn is a continuation-in-part of application Ser. No. 598,539, filed July 23, 1975, now both abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3524858 |
Kaminsky et al. |
Aug 1970 |
|
Foreign Referenced Citations (4)
Number |
Date |
Country |
2229414 |
Dec 1974 |
FRX |
326398 |
Mar 1930 |
GBX |
1121411 |
Jul 1968 |
GBX |
1453863 |
Oct 1976 |
GBX |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
707266 |
Jul 1976 |
|
Parent |
598539 |
Jul 1975 |
|