Claims
- 1. A compound of the formula ##STR22## wherein X.sub.2 is hydrogen or bromo
- A is oxygen or sulfur
- Z is oxygen or NOH
- or a pharmaceutically acceptable alkaline or amine addition salt thereof.
- 2. A compound of claim 1 wherein X.sub.2 is bromo.
- 3. A compound of claim 1 wherein Z is oxygen.
- 4. A compound of claim 1, wherein Z is sulfur.
- 5. A compound of claim 3 which is 4-(2-thenoyl)-2,6-dibromo-phenoxyacetic acid or its oxime or pharmaceutically acceptable alkaline or amine addition salt thereof.
- 6. A method of inducing a uricosic effect in a patient without significant diuresis, which comprises administering to said patient an effective amount of a compound of claim 1 to induce said uricosic effect.
- 7. A compound of the formula ##STR23## wherein X.sub.2 is iodo or hydrogen
- A is oxygen or sulfur
- Z is oxygen or NOH
- or a pharmaceutically acceptable alkaline or amine addition salt thereof.
- 8. A compound of claim 7 wherein X.sub.2 is iodo.
- 9. A compound of claim 7 wherein A is oxygen.
- 10. A compound of claim 7 wherein A is sulfur.
- 11. A compound of claim 7 wherein Z is NOH.
- 12. A compound of claim 10 wherein said compound is 4-(2-thenoyl)-2-iodo-phenoxy-acetic acid, its oxime or a pharmaceutically acceptable alkaline or amine addition salt thereof.
- 13. A compound of claim 10 wherein said compound is 4-(2-thenoyl)-2,6-diido-phenoxyacetic acid, its oxime or a pharmaceutically acceptable alkaline or amine addition salt thereof.
- 14. A method of inducing a uricosic effect in a patient without significant diuresis, which comprises administering to said patient an effective amount of a compound of claim 7 to induce said uricosic effect.
- 15. A compound of the formula ##STR24## wherein A is oxygen or sulfur
- Z is oxygen or NOH
- each of X and X.sub.2 is independently hydrogen or methyl or a pharmaceutically acceptable alkaline or amine addition salt thereof.
- 16. A method of inducing a uricosic effect in a patient without significant diuresis, which comprises administering to said patient an effective amount of a compound of claim 15 to induce said uricosic effect.
- 17. A compound of the formula ##STR25## wherein A is oxygen or sulfur
- Z is oxygen or NOH
- or a pharmaceutically acceptable alkaline or amine addition salt thereof.
- 18. A method of inducing a uricosic effect in a patient without significant diuresis, which comprises administering to said patient an effective amount of a compound of claim 17 to induce said uricosic effect.
- 19. A compound of the formula ##STR26## wherein A is oxygen or sulfur
- Z is oxygen or NOH
- or a pharmaceutically acceptable alkaline or amine addition salt thereof.
- 20. A method of inducing a uricosic effect in a patient without significant diuresis, which comprises administering to said patient an effective amount of a compound of claim 19 to induce said uricosic effect.
- 21. A pharmaceutical composition capable of inducing a uricosic effect to a patient without significant diuresis, which comprises an effective amount of a compound of claim 1 to provide said uricosic effect.
- 22. A pharmaceutical composition capable of inducing a uricosic effect to a patient without significant diuresis, which comprises an effective amount of a compound of claim 7 to provide said uricosic effect.
- 23. A pharmaceutical composition capable of inducing a uricosic effect to a patient without significant diuresis, which comprises an effective amount of a compound of claim 12 to provide said uricosic effect.
- 24. A pharmaceutical composition capable of inducing a uricosic effect to a patient without significant diuresis, which comprises an effective amount of a compound of claim 15 to provide said uricosic effect.
- 25. A pharmaceutical composition capable of inducing a uricosic effect to a patient without significant diuresis, which comprises an effective amount of a compound of claim 17 to provide said uricosic effect.
- 26. A pharmaceutical composition capable of inducing a uricosic effect to a patient without significant diuresis, which comprises an effective amount of a compound of claim 19 to provide said uricosic effect.
Priority Claims (1)
Number |
Date |
Country |
Kind |
76 30584 |
Oct 1976 |
FRX |
|
Parent Case Info
This is a continuation of application Ser. No. 763,722 filed Jan. 13, 1977, now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3758506 |
Godfroid et al. |
Sep 1973 |
|
3989838 |
Maass |
Nov 1976 |
|
4017632 |
Thuillier et al. |
Apr 1977 |
|
Continuations (1)
|
Number |
Date |
Country |
Parent |
763722 |
Jan 1977 |
|