Claims
- 1. A compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: whereinR1 represents a hydrogen atom or a carboxyl-protecting group, R2 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a hydroxyl group, R3 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a nitro group, a cyano group, a hydroxyl group or an amino group; R4 represents a hydrogen atom, an amino-protecting group, an alkyl group or a cycloalkyl group, and R5 represents a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, a cycloalkyl group, an aryl group, an alkoxy group, an alkylthio group, a hydroxyl group, an imino group or an amino group.
- 2. The compound or the pharmaceutically acceptable salt thereof of claim 1, wherein in Formula (I), R2 is a lower alkyl group or a lower alkoxy group.
- 3. The compound or the pharmaceutically acceptable salt thereof of claim 1, wherein in Formula (I), R3 is a hydrogen atom or a lower alkoxy group.
- 4. The compound or the pharmaceutically acceptable salt thereof of claim 1, wherein in Formula (I), R5 is a hydrogen atom or a lower alkyl group.
- 5. The compound or the pharmaceutically acceptable salt thereof of claim 1, wherein in Formula (I), R1 is a hydrogen atom.
- 6. An antimicrobial agent comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof as an effective component.
- 7. The antimicrobial agent of claim 6 against a Gram-positive bacterium.
- 8. The antimicrobial agent of claim 7, wherein said Gram-positive bacterium is Streptococcus aureus or Streptococcus pneumoniae.
- 9. The antimicrobial agent of claim 6 against a Gram-negative bacterium.
- 10. The antimicrobial agent of claim 9, wherein said Gram-negative bacterium is Escherichia coli or Pseudomonas aeruginosa.
- 11. The antimicrobial agent of claim 6 against an anaerobic bacterium.
- 12. The antimicrobial of claim 11, wherein the anaerobic bacterium is Bacteriodes fragilis.
- 13. A method of preparing the compound of claim 1, comprising reacting a compound represented by the following Formula (I): whereinR1 represents a hydrogen atom or a carboxyl-protecting group, R2 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a hydroxyl group; and X represents a halogen atom, with a compound represented by the following Formula (3), wherein R3 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a nitro group, a cyano group, a hydroxyl group, or an amino group, R4 represents a hydrogen atom, an amino-protecting group, an alkyl group or a cycloalkyl group, R5 represents a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, a cycloalkyl group, an aryl group, an alkoxy group, an alkylthio group, a hydroxyl group, an imino group, or an amino group, and L1 represents tin(an alkyl group)3 or boron(a lower alkoxy group)2.
- 14. A method of preparing the compound of claim 1, comprising reacting a compound represented by the following Formula (2): whereinR1 represents a hydrogen atom or a carboxyl-protecting group, R2 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a hydroxyl group, and L1 represents tin(an alkyl group)3 or boron(an lower alkoxy group)2, with a compound represented by the following Formula (4) wherein R3 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a nitro group, a cyano group, a hydroxyl group, or an amino group, R4 represents a hydrogen atom, an amino-protecting group, an alkyl group or a cycloalkyl group, R5 represents a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, a cycloalkyl group, an aryl group, an alkoxy group, an alkylthio group, a hydroxyl group, an imino group, or an amino group, and
Priority Claims (1)
Number |
Date |
Country |
Kind |
11-296383 |
Oct 1999 |
JP |
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Parent Case Info
This application is a continuation of international application number PCTJP00/07256, filed Oct. 19, 2000.
Foreign Referenced Citations (2)
Number |
Date |
Country |
0 775 702 |
May 1997 |
EP |
09-136886 |
May 1997 |
JP |
Non-Patent Literature Citations (1)
Entry |
Ma et al., Synthesis and Antimicrobial Activity of 4H-4-Oxoquinolizine Derivatives: Consequences of Structual Modification at the C-8 Position, pp. 4202-4213, 1999, J. Med. Chem., 42. |
Continuations (1)
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Number |
Date |
Country |
Parent |
PCT/JP00/07256 |
Oct 2000 |
US |
Child |
10/124485 |
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US |