5-HT7 receptor antagonists

Abstract

The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

Description

FIELD OF THE INVENTION

The present invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment and or prophylaxis of a disease in which 5-HT₇ is involved, such as CNS disorders.

BACKGROUND OF THE INVENTION

The search for new therapeutic agents has been greatly aided in recent years by better understanding of the structure of proteins and other biomolecules associated with target diseases. One important class of proteins that has been the subject of extensive study is the family of 5-hydroxytryptamine (serotonin, 5-HT) receptors. The 5-HT₇ receptor discovered in 1993 belongs to this family and has attracted great interest as a valuable new drug target (Terrón, J. A. Idrugs, 1998, vol. 1, no. 3, pages 302-310: “The 5HT₇ receptor: A target for novel therapeutic avenues?”).

5-HT₇ receptors have been cloned from rat, mouse, guinea pig and human cDNA and exhibit a high degree of interspecies homology (approx. 95%), but it is unique in that it has a low sequence homology with other 5-HT receptors (less than 40%). Its expression pattern, in particular structures of the central nervous system (CNS) (highest in hypothalamus (in particular suprachiasmatic nuclei) and thalamus) and other peripheral tissues (spleen, kidney, intestinal, heart and coronary arthery), implicates the 5-HT₇ receptor in a variety of functions and pathologies. This idea is reinforced by the fact that several therapeutic agents, such as tricyclic antidepressants, typical and atypical antipsychotics and some 5-HT₂ receptor antagonists, display moderate to high affinity for both recombinant and functional 5-HT₇ receptors. Functionally, the 5-HT₇ receptor has been implicated in regulation of circadian rhythms in mammals (Lovenberg, T. W. et al. Neuron, 1993, 11:449-458 “A novel adenylyl cyclase-activating serotonin receptor (5-HT₇) implicated in the regulation of circadian rhythms”). It is known that disruption of circadian rhythms is related to a number of CNS disorders including depression, seasonal affective disorder, sleep disorders, shift worker syndrome and jet lag among others.

Distribution and early pharmacological data also suggest that the 5-HT₇ receptor is involved in the vasodilatation of blood vessels. This has been demonstrated in vivo (Terrón, J. A., Br J Pharmacol, 1997, 121:563-571 “Role of 5-HT₇ receptors in the long lasting hypotensive response induced by 5-hydroxytryptamine in the rat”). Thus selective 5-HT₇ receptor agonists have a potential as novel hypertensive agents.

The 5-HT₇ receptor has also been related with the pathophysiology of migraine through smooth muscle relaxation of cerebral vessels (Schoeffter, P. et al., 1996, Br J Pharmacol, 117:993-994; Terrón, J. A., 2002, Eur. J. Pharmacol., 439:1-11 “Is the 5-HT₇ receptor involved in the pathogenesis and prophylactic treatment of migraine?”). In a similar manner, involvement of 5-HT₇ in intestinal and colon tissue smooth muscle relaxation makes this receptor a target for the treatment of irritable bowel syndrome (De Ponti, F. et al., 2001, Drugs, 61:317-332 “Irritable bowel syndrome. New agents targeting serotonin receptor subtypes”). Recently, it has also been related to urinary incontinence (British J. of Pharmacology, September 2003, 140(1) 53-60: “Evidence for the involvement of central 5HT-7 receptors in the micurition reflex in anaeshetized female rats”).

In view of the potential therapeutic applications of agonists or antagonists of the 5HT₇ receptor, a great effort has been directed to find selective ligands. Despite intense research efforts in this area, very few compounds with selective 5-HT₇ antagonist activity have been reported (Wesolowska, A., Polish J. Pharmacol., 2002, 54: 327-341, “In the search for selective ligands of 5-HT5, 5-HT₆ and 5-HT₇ serotonin receptors”).

WO 97/48681 discloses sulfonamide derivatives, which are 5-HT₇ receptor antagonists, for the treatment of CNS disorders. The sulphur atom is linked to an aromatic group and to a N-containing heterocyclic group, optionally containing a further heteroatom selected from oxygen or sulphur.

WO 97/29097 describes sulfonamide derivatives for the treatment of disorders in which antagonism of the 5-HT₇ receptor is beneficial. The sulphur atom is linked to an aromatic group and to a C₁-C₆ alkyl substituted N atom.

WO97/49695 describes further sulfonamide derivatives in which the N linked to the sulphur atom is also fully substituted, for example forming part of a piperidine.

WO 03/048118 describes another group of 5HT₇ receptor antagonists. In this case aryl and heteroaryl sulfonamide derivatives wherein the sulfonamide group is a substituent on a cycloalkane or cycloalkene ring which additionally bears an amino susbtituent. The N linked to sulphur atom is fully substituted.

WO99/24022 discloses tetrahydroisoquinoline derivatives for use against CNS disorders and binding to serotonin receptors, in particular 5-HT₇.

WO 00/00472 refers to compounds which are 5-HT7 receptor antagonists. The compounds contain a N-containing fused heterocycle such as tetrahydroisoquinoline.

EP 21580 and EP 76072 describe sulfonamide compounds having antiarrhythmic activity, corresponding to the formula R₂N(CH₂)_n—NH—SO₂R₁, 5-HT₇ activity is not mentioned.

There is still a need to find compounds that have pharmacological activity towards the receptor 5-HT₇, being both effective and selective, and having good “drugability” properties, i.e. good pharmaceutical properties related to administration, distribution, metabolism and excretion.

SUMMARY OF THE INVENTION

We have now found a family of structurally distinct class of sulfonamide compounds which are particularly selective inhibitors of the 5-HT₇ receptor. The compounds present a tetrahydroisoquinoline moiety, linked through a straight alkylene chain of a certain size with a sulfonamide moiety. We have found that when the N of the sulfonamide is a secondary amine and the linker has 4, 5 or 6 CH₂— units the compounds display IC-50 values in the nM range (>10 nM) at human 5-HT7 receptors and exhibit at least 30-fold selectivity for these receptors vs 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT4, 5-HT5A, D1, D2, D3, D4, adrenergic α1A, α1B, α1B, β1, and β2 receptors. In one aspect the invention is directed to a compound of the formula I: wherein

• W is a susbtituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, susbtituted or unsubstituted cycloalkyl, susbtituted or unsubstituted aryl, susbtituted or unsubstituted heterocyclyl;
• R₁, R₂, R₃, R₄, R₅, R₆ and R₇ are each independently selected from the group formed by hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, —COR₈, —C(O)OR₈, —C(O)NR₈R₉—C═NR₈, —CN, —OR₈, —OC(O)R₈, —S(O)_t—R₈, —NR₈R₉, —NR₈C(O)R₉, —NO₂, —N═CR₈R₉ or halogen, wherein
• t is 1, 2 or 3;
• R₈ and R₉ are each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, halogen;
• n is 4, 5 or 6; or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof. In one embodiment n is preferably 4 or 5, most preferably n is 4.

It is preferred that W is substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, preferably substituted or unsubstituted phenyl. Good results were obtained when W is alkyl or halo substituted phenyl.

It is preferred that in the tetrahydrosioquinoline moiety R₅, R₆ and R₇ are H.

In one embodiment R₁ and R₄ are also H.

Good results are obtained when R₂ and R₃ are alkoxy, in particular methoxy.

In another aspect the invention is directed to a pharmaceutical composition which comprises a compound as above defined or a pharmaceutically acceptable salt, enantiomer, prodrug or solvate thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

In a further aspect the invention is directed to the use of a compound as defined above in the manufacture of a medicament for the treatment of a 5-HT₇ mediated disease or condition, i.e. diseases caused by failures in central and peripheral serotonin-controlling functions, such as pain, sleep disorder, shift worker syndrome, jet lag, depression, seasonal affective disorder, migraine, anxiethy, psychosis, schizophrenia, cognition and memory disorders, neuronal degeneration resulting from ischemic events, cardiovascular diseases such as hypertension, irritable bowel syndrome, inflammatory bowel disease, spastic colon or urinary incontinence.

DETAILED DESCRIPTION OF THE INVENTION

The typical compounds of this invention effectively and selectively inhibit the 5-HT7 receptor without inhibition of other 5-HT receptors such as 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3,5-HT4,5-HT5A, D1, D2, D3, D4, adrenergic α1A, α1B, α1B, β1, and β2 receptors, Tachykinin NK-1 opiate, GABA, estrogen, glutamate, adenosine, nicotinic, muscarinic receptors and calcium, potassium and sodium channels and neurotransmitter transporters (serotonin, dopamine, norepinephrine, GABA).

In the above definition of compounds of formula (I) the following terms have the meaning indicated:

“Alkyl” refers to a straight or branched hydrocarbon chain radical consisting of carbon and hydrogen atoms, containing no saturation, having one to eight carbon atoms, and which is attached to the rest of the molecule by a single bond, e.g., methyl, ethyl, n-propyl, i-propyl, n-butyl, t-butyl, n-pentyl, etc. Alkyl radicals may be optionally substituted by one or more substituents such as a aryl, halo, hydroxy, alkoxy, carboxy, cyano, carbonyl, acyl, alkoxycarbonyl, amino, nitro, mercapto, alkylthio, etc. If substituted by aryl we have an “Aralkyl” radical, such as benzyl and phenethyl.

“Alkenyl” refers to an alkyl radical having at least 2 C atoms and having one or more unsaturated bonds.

“Cycloalkyl” refers to a stable 3-to 10-membered monocyclic or bicyclic radical which is saturated or partially saturated, and which consist solely of carbon and hydrogen atoms, such as cyclohexyl or adamantyl. Unless otherwise stated specifically in the specification, the term “cycloalkyl” is meant to include cycloalkyl radicals which are optionally substituted by one or more substituents such as alkyl, halo, hydroxy, amino, cyano, nitro, alkoxy, carboxy, alkoxycarbonyl, etc.

“Aryl” refers to single and multiple ring radicals, including multiple ring radicals that contain separate and/or fused aryl groups. Typical aryl groups contain from 1 to 3 separated or fused rings and from 6 to about 18 carbon ring atoms, such as phenyl, naphthyl, indenyl, fenanthryl or anthracyl radical. The aryl radical may be optionally substituted by one or more substituents such as hydroxy, mercapto, halo, alkyl, phenyl, alkoxy, haloalkyl, nitro, cyano, dialkylamino, aminoalkyl, acyl, alkoxycarbonyl, etc.

“Heterocyclyl” refers to a stable 3-to 15 membered ring radical which consists of carbon atoms and from one to five heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, preferably a 4-to 8-membered ring with one or more heteroatoms, more preferably a 5-or 6-membered ring with one or more heteroatoms. For the purposes of this invention, the heterocycle may be a monocyclic, bicyclic or tricyclic ring system, which may include fused ring systems; and the nitrogen, carbon or sulfur atoms in the heterocyclyl radical may be optionally oxidised; the nitrogen atom may be optionally quaternized; and the heterocyclyl radical may be partially or fully saturated or aromatic. Examples of such heterocycles include, but are not limited to, azepines, benzimidazole, benzothiazole, furan, isothiazole, imidazole, indole, piperidine, piperazine, purine, quinoline, thiadiazole, tetrahydrofuran, coumarine, morpholine; pyrrole, pyrazole, oxazole, isoxazole, triazole, imidazole, etc.

“Alkoxy” refers to a radical of the formula —ORa where Ra is an alkyl radical as defined above, e.g., methoxy, ethoxy, propoxy, etc.

“Alkoxycarbonyl” refers to a radical of the formula-C(O)ORa where Ra is an alkyl radical as defined above, e.g., methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, etc.

“Alkylthio” refers to a radical of the formula-SRa where Ra is an alkyl radical as defined above, e.g., methylthio, ethylthio, propylthio, etc.

“Amino” refers to a radical of the formula-NH2, —NHRa or —NRaRb, optionally quaternized.

“Halo” or “hal” refers to bromo, chloro, iodo or fluoro.

References herein to substituted groups in the compounds of the present invention refer to the specified moiety that may be substituted at one or more available positions by one or more suitable groups, e.g., halogen such as fluoro, chloro, bromo and iodo; cyano; hydroxyl; nitro; azido; alkanoyl such as a C1-6 alkanoyl group such as acyl and the like; carboxamido; alkyl groups including those groups having 1 to about 12 carbon atoms or from 1 to about 6 carbon atoms and more preferably 1-3 carbon atoms; alkenyl and alkynyl groups including groups having one or more unsaturated linkages and from 2 to about 12 carbon or from 2 to about 6 carbon atoms; alkoxy groups having one or more oxygen linkages and from 1 to about 12 carbon atoms or 1 to about 6 carbon atoms; aryloxy such as phenoxy; alkylthio groups including those moieties having one or more thioether linkages and from 1 to about 12 carbon atoms or from 1 to about 6 carbon atoms; alkylsulfinyl groups including those moieties having one or more sulfinyl linkages and from 1 to about 12 carbon atoms or from 1 to about 6 carbon atoms; alkylsulfonyl groups including those moieties having one or more sulfonyl linkages and from 1 to about 12 carbon atoms or from 1 to about 6 carbon atoms; aminoalkyl groups such as groups having one or more N atoms and from 1 to about 12 carbon atoms or from 1 to about 6 carbon atoms; carbocylic aryl having 6 or more carbons, particularly phenyl or naphthyl and aralkyl such as benzyl. Unless otherwise indicated, an optionally substituted group may have a substituent at each substitutable position of the group, and each substitution is independent of the other.

Particular individual compounds of the invention include the compounds 1-323 in the examples, either as salts or as free bases.

In an embodiment the tetrahydroisoquinoline in the compounds of formula I above is not substituted, R₁ to R₇ are all H. Good activity results are obtained with such compounds.

In another embodiment R₂ and R₃ are alkoxy, preferably methoxy and the rest of the substituents of the tetrahydroisoquinoline (R₁ and R₄ to R₇) are H. In this case it appears that the selectivity is improved.

In another embodiment the group W linked to the sulfonamide is aromatic, such as substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, preferably substituted or unsubstituted phenyl. Good results were obtained when W is alkyl, alkoxy or halo substituted phenyl. In particular halo substituted phenyl, having one or more halo substituents being the same or different are preferred.

In another embodiment it is important that n is 4, best results were obtained with this length of the chain linking the tetrahydroisoquinoline and the sulfonamide.

The above embodiments and preferences for W, R₁ to R₇ and n can be combined to give further preferred compounds.

Representative compounds of the above embodiments which are preferred are Naphthalene-2-sulfonic acid [4-(3,4-dihydro-1H-isoquinolin-2-yl)-butyl]-amide hydrochloride; N-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-butyl]-benzenesulfonamide hydrochloride; 5-Chloro-N-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-butyl]-2,4-difluoro-benzenesulfonamide; 2-Chloro-N-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-butyl]-benzenesulfonamide hydrochloride; N-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-butyl]-2,5-difluoro-benzenesulfonamide hydrochloride; N-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-butyl]-2,4,5-trifluoro-benzenesulfonamide hydrochloride; 2-Chloro-N-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-butyl]-4,5-difluoro-benzenesulfonamide hydrochloride; 2-Bromo-N-[4-(3,4-dihydro-1H-isoquinolin-2-yl)-butyl]-4,6-difluoro-benzenesulfonamide hydrochloride; N-[4-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-butyl]-3-methyl-benzenesulfonamide hydrochloride; 4-Chloro-N-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-butyl]-2,5-dimethyl-benzenesulfonamide hydrochloride; N-[4-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-butyl]-2,5-dimethoxy-benzenesulfonamide hydrochloride or 2-Bromo-N-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-butyl]-benzenesulfonamide hydrochloride. Although the hydrochloride salts are listed, other salts or the free bases also form part of this group of preferred compounds.

Unless otherwise stated, the compounds of the invention are also meant to include compounds which differ only in the presence of one or more isotopically enriched atoms. For example, compounds having the present structures except for the replacement of a hydrogen by a deuterium or tritium, or the replacement of a carbon by a ¹³C- or 14C-enriched carbon or ¹⁵N-enriched nitrogen are within the scope of this invention.

The term “pharmaceutically acceptable salts, solvates, prodrugs” refers to any pharmaceutically acceptable salt, ester, solvate, or any other compound which, upon administration to the recipient is capable of providing (directly or indirectly) a compound as described herein. However, it will be appreciated that non-pharmaceutically acceptable salts also fall within the scope of the invention since those may be useful in the preparation of pharmaceutically acceptable salts. The preparation of salts, prodrugs and derivatives can be carried out by methods known in the art.

For instance, pharmaceutically acceptable salts of compounds provided herein are synthesized from the parent compound which contains a basic or acidic moiety by conventional chemical methods. Generally, such salts are, for example, prepared by reacting the free acid or base forms of these compounds with a stoichiometric amount of the appropriate base or acid in water or in an organic solvent or in a mixture of the two. Generally, nonaqueous media like ether, ethyl acetate, ethanol, isopropanol or acetonitrile are preferred. Examples of the acid addition salts include mineral acid addition salts such as, for example, hydrochloride, hydrobromide, hydroiodide, sulphate, nitrate, phosphate, and organic acid addition salts such as, for example, acetate, maleate, fumarate, citrate, oxalate, succinate, tartrate, malate, mandelate, methanesulphonate and p-toluenesulphonate. Examples of the alkali addition salts include inorganic salts such as, for example, sodium, potassium, calcium, ammonium, magnesium, aluminium and lithium salts, and organic alkali salts such as, for example, ethylenediamine, ethanolamine, N,N-dialkylenethanolamine, triethanolamine, glucamine and basic aminoacids salts.

Particularly favored derivatives or prodrugs are those that increase the bioavailability of the compounds of this invention when such compounds are administered to a patient (e.g., by allowing an orally administered compound to be more readily absorbed into the blood) or which enhance delivery of the parent compound to a biological compartment (e.g., the brain or lymphatic system) relative to the parent species.

Any compound that is a prodrug of a compound of formula (I) is within the scope of the invention. The term “prodrug” is used in its broadest sense and encompasses those derivatives that are converted in vivo to the compounds of the invention. Such derivatives would readily occur to those skilled in the art, and include, depending on the functional groups present in the molecule and without limitation, the following derivatives of the present compounds: esters, amino acid esters, phosphate esters, metal salts sulfonate esters, carbamates, and amides.

The compounds of the invention may be in crystalline form either as free compounds or as solvates and it is intended that both forms are within the scope of the present invention. Methods of solvation are generally known within the art. Suitable solvates are pharmaceutically acceptable solvates. In a particular embodiment the solvate is a hydrate.

The compounds of formula (I) or their salts or solvates are preferably in pharmaceutically acceptable or substantially pure form. By pharmaceutically acceptable form is meant, inter alia, having a pharmaceutically acceptable level of purity excluding normal pharmaceutical additives such as diluents and carriers, and including no material considered toxic at normal dosage levels. Purity levels for the drug substance are preferably above 50%, more preferably above 70%, most preferably above 90%. In a preferred embodiment it is above 95% of the compound of formula (I), or of its salts, solvates or prodrugs.

The compounds of the present invention represented by the above described formula (I) may include enantiomers depending on the presence of chiral centres or isomers depending on the presence of multiple bonds (e.g. Z, E). The single isomers, enantiomers or diastereoisomers and mixtures thereof fall within the scope of the present invention.

The compounds of formula (I) defined above can be obtained by available synthetic procedures. For example, they can be prepared by the coupling of a compound of Formula (II): in which R1-R7 and n are as defined in Formula (I), with a compound of Formula (III): in which W is as defined in Formula (I) and X is an halogen, typically Cl.

The reaction of compounds of formulas (II) and (III) is preferably carried out in an aprotic solvent, but not limited to, such as dichloromethane in the presence of an organic base, such as diisopropylethylamine or triethylamine.

Compounds of Formula (III) are commercially available or can be prepared by conventional methods.

Compounds of Formula (II) can be prepared from compounds of Formula (IV) using the reactions and techniques described below. Compounds of Formula (IV) are commercially available or may be prepared according to known methods.

The reactions are performed in a solvent appropriate to the reagents and materials employed and suitable for the transformations. The functionality present on the molecule should be consistent with the transformations proposed. This will sometimes require a selection of a particular process scheme over another in order to obtain the desired compound of the invention. Preferred methods included, but are not limited to, those described below. References for cited described methods are incorporated.

Compounds of Formula (II) can be prepared by alkylation as shown in Scheme 1.

In the first step, the amine of Formula (IV) is allowed to react with a commercially available N-(n-haloalkyl)phtalimide (1-1) in the presence of an appropriate base and solvent. Useful bases include, but are not limited to, metal carbonates such as K₂CO₃ or Cs₂CO₃, metal hydroxides, hindered alkoxides or tertiary organic amines.

Typical solvents include polar aprotic liquids such as DMF or THF, or protic liquids such as alcohols. The use of buthanol or xylene have been previously described (J. Med. Chem. 1996, 39(5), 1125-1129, J. Med. Chem. 1999, 42(4), 730-741) but the yield is improved, (from 50% to 90%), with the use of N,N-dimethylformamide and K₂CO₃ as the base.

In a second step, the hydrazinolysis of the alkylated compound 1-2 using hydrazine in a polar protic solvent, such as ethanol, and hydrochloric acid gives the desired compound of Formula (II).

A similar route to compounds of Formula (II) is illustrated in Scheme 2.

The acylation of compounds of Formula (IV) with carboxyalkylphtalimides derivatives (2-1), instead of the alkylation with N-(n-haloalkyl)phtalimides (1-1), may be convenient in some cases. When X is a Cl, the base used for acylation could be a tertiary organic amine such as triethylamine or N,N-diisopropylethylamine and the hydrazinolysis can be performed as cited in Scheme 1. When X is an OH, a coupling reagent must be used for the activation of carboxy group. Many coupling reagents are known in the literature to form amide bonds from carboxylic acids and amines, including DCC, HBTU, TBTU, BOP, PyBOP, etc. Appropriate bases for such coupling reactions include tertiary amines such as N,N-diisopropylethylamine, triethylamine, etc. The activated species are usually not isolated, but are allowed to react in situ with the amine partner (IV).

After the hydrazinolysis of phtalimide 2-2, the reduction of the amide intermediate 2-3 may be performed with a reducing agent, such as borane or lithium aluminum hydride in appropriate solvent, typically THF (J. Med. Chem. 1987, 30, 1186-1193, Anales Quimica, 1983, 80, 283-290).

A similar method to compounds of Formula (II) is illustrated in Scheme 3.

A reductive amination with phtalimidoalkylaldehydes (3-1), following by hydrazinolysis may also be performed. Condensation of the amine (IV) with aldehydes 3-1 can be performed in the presence of an hydride, such as sodium triacethoxyborohydride NaBH(OAc)₃ or sodium cyanoborhydride (NaBH₄CN) (Bioorg. Med. Chem. Lett. 1999, 9, 179-184). Phtalimide intermediate 3-2 is treated as is described in Schemes 1 and 2 in order to obtain the desired compound of Formula (II).

In all these Schemes, other protecting groups for the nitrogen atom, instead of the phtalimide, may be used. Some examples include other cyclic imide derivatives, such as maleimides or succinimides, a variety of carbamates, such as BOC; Fmoc, etc. a variety of amides, such as acetamides, and alkyl and aryl amine derivatives, such as N-benzyl or N-allyl. Additional examples of Nitrogen protecting groups can be found in reference books such as Greene and Wuts' “Protective Groups in Organic Synthesis”, John Wiley & Sons, Inc., New York, 1999.

An alternate sequence for the preparation of some compounds of Formula (II) is illustrated in Scheme 4.

Compounds of Formula (II) can be prepared in a sequential way by treatment of a dialkylating agent (4-1) with the corresponding amine (IV) in the presence of a base in an appropriate solvent, followed by the alkylation of another amine (4-2).

Examples of useful alkylating agents (4-1) are those where Y is a good to excellent leaving group, such as Br, 1, aryl or alkylsulfonate, etc. and X is a good leaving group, such as Br or Cl. Useful bases include, but are not limited to, metal carbonates such as K₂CO₃ or Cs₂CO₃, metal hydroxides, hindered alkoxides or tertiary organic amines.

Typical solvents include polar aprotic liquids such as DMF or THF, or protic liquids such as alcohols. The rate of the second alkylation may be enhanced, particulary when X is Cl, by the addition of a catalytic amount of an iodide salt, such as NaI or KI. The required alkylating agents (4-1) are generally commercially available.

Where convenient, compounds of Formula (II) can be prepared as shown in Scheme 5.

The alkylation of compounds of Formula (IV) with commercially available haloalkylnitriles (5-1) can be performed in the presence of a variety of bases and solvents cited in schemes above. For the reduction of the cyano group of 5-2, common reducing agents, such as LiAlH₄ in THF, can be used. A catalytic hydrogenation with Pd/C in ethanol is also possible (Bioorg. Med. Chem. Lett. 2004, 14, 195-202, J. Med. Chem. 1999, 42(4), 730-741).

In some cases, an acylation with carboxynitriles to form an amide is preferred instead of the alkylation with the corresponding haloalkylnitriles (Scheme 6).

The acylation with compounds 6-1, where X is a good leaving group, such as I, Br, aryl or alkylsulphonate, is carried out in the presence of an appropriate base and solvent, which were described in schemes above. The reduction of cyano an keto group of 6-2 can be performed simultaneously in the presence of an excess of a reducing agent such as LiAlH₄ or borane. When X is OH, a coupling reagent must also be used for the activation of carboxy group. The coupling reagents used are the same as are cited in Scheme 2.

Scheme 6 is also possible when X is an H. Reductive amination is carried out by a condensation of amine of Formula (IV) with aldehyde 6-1 in appropriate base and solvent, to form an imine or enamine intermediate, followed by a reduction with a reducing agent, such as an hydride.

An alternate sequence for the preparation of some compounds of Formula (II) is illustrated in Scheme 7.

Amines of Formula (IV) may be alkylated with haloalkylamides 7-1 in an appropriate solvent and base, the same as are cited in Schemes above. Intermediate (7-2) may be reduced in the presence of an hydride, such as LiAlH₄ or borane.

The obtained reaction products may, if desired, be purified by conventional methods, such as crystallisation, chromatography and trituration. Where the above described processes for the preparation of compounds of the invention give rise to mixtures of stereoisomers, these isomers may be separated by conventional techniques such as preparative chromatography. If there are chiral centers the compounds may be prepared in racemic form, or individual enantiomers may be prepared either by enantiospecific synthesis or by resolution.

One preferred pharmaceutically acceptable form is the crystalline form, including such form in pharmaceutical composition. In the case of salts and solvates the additional ionic and solvent moieties must also be non-toxic. The compounds of the invention may present different polymorphic forms, it is intended that the invention encompasses all such forms.

Another aspect of this invention relates to a method of treating or preventing an 5-HT₇ mediated disease which method comprises administering to a patient in need of such a treatment a therapeutically effective amount of a compound of formula (I) or a pharmaceutical composition thereof. Among the 5-HT₇ mediated diseases that can be treated are diseases caused by failures in central and peripheral serotonin-controlling functions, such as pain, sleep disorder, shift worker syndrome, jet lag, depression, seasonal affective disorder, migraine, anxiethy, psychosis, schizophrenia, cognition and memory disorders, neuronal degeneration resulting from ischemic events, cardiovascular diseases such as hypertension, irritable bowel syndrome, inflammatory bowel disease, spastic colon or urinary incontinence.

The present invention further provides pharmaceutical compositions comprising a compound of this invention, or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomers thereof together with a pharmaceutically acceptable carrier, adjuvant, or vehicle, for administration to a patient.

Examples of pharmaceutical compositions include any solid (tablets, pills, capsules, granules etc.) or liquid (solutions, suspensions or emulsions) composition for oral, topical or parenteral administration.

In a preferred embodiment the pharmaceutical compositions are in oral form, either solid or liquid. Suitable dose forms for oral administration may be tablets, capsules, syrops or solutions and may contain conventional excipients known in the art such as binding agents, for example syrup, acacia, gelatin, sorbitol, tragacanth, or polyvinylpyrrolidone; fillers, for example lactose, sugar, maize starch, calcium phosphate, sorbitol or glycine; tabletting lubricants, for example magnesium stearate; disintegrants, for example starch, polyvinylpyrrolidone, sodium starch glycollate or microcrystalline cellulose; or pharmaceutically acceptable wetting agents such as sodium lauryl sulfate.

The solid oral compositions may be prepared by conventional methods of blending, filling or tabletting. Repeated blending operations may be used to distribute the active agent throughout those compositions employing large quantities of fillers. Such operations are conventional in the art. The tablets may for example be prepared by wet or dry granulation and optionally coated according to methods well known in normal pharmaceutical practice, in particular with an enteric coating.

The pharmaceutical compositions may also be adapted for parenteral administration, such as sterile solutions, suspensions or lyophilized products in the apropriate unit dosage form. Adequate excipients can be used, such as bulking agents, buffering agents or surfactants.

The mentioned formulations will be prepared using standard methods such as those described or referred to in the Spanish and US Pharmacopoeias and similar reference texts.

Administration of the compounds or compositions of the present invention may be by any suitable method, such as intravenous infusion, oral preparations, and intraperitoneal and intravenous administration. Oral administration is preferred because of the convenience for the patient and the chronic character of the diseases to be treated.

Generally an effective administered amount of a compound of the invention will depend on the relative efficacy of the compound chosen, the severity of the disorder being treated and the weight of the sufferer. However, active compounds will typically be administered once or more times a day for example 1, 2, 3 or 4 times daily, with typical total daily doses in the range of from 0.1 to 1000 m-g/kg/day.

The compounds and compositions of this invention may be used with other drugs to provide a combination therapy. The other drugs may form part of the same composition, or be provided as a separate composition for administration at the same time or at different time.

The following examples are given only as further illustration of the invention, they should not be taken as a definition of the limits of the invention.

EXAMPLES

The starting materials of general formula (II) were prepared by means of conventional organic chemistry methods known to those skilled in the art. The preparation of some of the intermediates of general formulas (II) and (IV) is shown below:

Example A

The starting materials of general formulas (IV) were prepared by means of conventional organic chemistry methods known to those skilled in the art.

Synthesis of a Compound of General Formula (IV)

7-Nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride

This compound is described in the literature for Buolamwini et al. J. Med. Chem. 2003, 46, 831-837, which are hereby incorporated by reference and form part of the disclosure.

A cold solution of 1,2,3,4-tetrahydroisoquinoline (13.3 g, 0.1 mol) in concentrated sulfuric acid (50 mL) was treated with potassium nitrate (11.12 g, 1.1 mol) in small portions, keeping the temperature below 5° C. The reaction was left overnight at room temperature and poured onto ice. The resulting solution was basified with ammonium hydroxide, extracted with CH₂Cl₂, dried and evaporated to dryness in vacuo. The crude was dissolved in 100 mL ethanol. A 2.8 M solution of hydrogen chloride in ethanol (40 mL) was then added. The precipitate formed was collected by filtration and crystallized from methanol to give the product (10.30 g, 48% yield) as a white solid.

Melting point: 268-270° C.

IR cm⁻¹(KBr): 2944, 2764, 1589, 1523, 1429, 1345, 1090.

¹H NMR (300 MHz, DMSO-d6) d ppm: 3.13 (t, f-6.15 Hz, 2H), 3.35 (t, J=6.22 Hz, 2H), 4.35 (s, 2H), 7.50 (d, J=8.49 Hz, 1H), 8.08 (dd, J=8.49, 2.49 Hz, 1H), 8.19 (d, J=2.34 Hz, 1H), 9.96 (s, 2H)

Example B

Synthesis of a Compound of General Formula (II)

a) 2-(4-N-phtalimidobutyl)-7-nitro-1,2,3,4-tetrahydroisoquinoline

A mixture of 7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride (9.87 g, 0.046 mol), N-(4-Bromobutyl)phtalimide (12.97 g, 0.046 mol), potassium carbonate (25.43 g, 0.184 mol) in dry N,N-dimethylformamide (150 mL), was stirred overnight at room temperature. The mixture was vacuum concentrated and the residue was dissolved in water (150 mL) and extracted with ethyl acetate (3×50 mL), washed with water, the organic layer was dried and evaporated to give the product (16.58 g, 95% yield) which was used without further purification.

¹H NMR (300 MHz, DMSO-D6) d ppm 1.64 (m, 2H), 1.79 (m, 2H), 2.60 (m, 2H), 2.78 (m, 2H), 2.96 (m, 2H), 3.72 (m, 4H), 7.23 (m, 1H), 7.71 (m, 2H), 7.79 (m, 3H), 8.01 (m, 1H)

b) 2-(4-aminobutyl)-7-nitro-1,2,3,4-tetrahydroisoquinoline dihydrochloride

A solution of 2-(4-N-Phtalimidobutyl)-7-nitro-1,2,3,4-tetrahydroisoquinoline (16.30 g, 0.043 mol) and hydrazine hydrate (13.4 mL, 0.43 mol) in ethanol (350 mL) was refluxed for 1 h. The reaction mixture was cooled down and treated with an additional amount of ethanol (350 mL) and concentrated HCl (45 mL). Then the reaction mixture was refluxed for 4 h and left overnight in a refrigerator. The precipitate was filtered off, and the solvent was evaporated. The residue was basified with ammonium hydroxide (120 mL) and was extracted with CH₂Cl₂ (3×120 mL), the organic layer was dried over Na₂SO₄, and evaporated to dryness. The crude was dissolved in 100 mL ethanol. A 2.8 M solution of hydrogen chloride in ethanol (35 mL) was then added. The precipitate formed was collected by filtration and crystallized from methanol and 2-propanol to give the product (8.59 g, 62% yield) as a brown solid.

Melting point: 220-224° C.

IR cm⁻¹(KBr): 3024, 2934, 2561, 1529, 1344, 1095, 740.

¹H NMR (300 MHz, DMSO-d6) d ppm: 1.66 (m, 2H), 1.89 (m, 2H), 2.83 (m, 2H), 3.21 (m, 3H), 3.32 (m, 2H), 3.72 (m, 1H), 4.38 (dd, J=15.96, 7.61 Hz, 1H), 4.68 (d, J=14.50 Hz, 1H), 7.55 (d, J=8.35 Hz, 1H), 8.05 (s, 2H), 8.14 (m, 2H), 11.51 (s, 1H).

Example C

The compounds of general formula (I) were prepared by the coupling of a compound of formula (II) with a compound of formula (III) by means of conventional organic chemistry methods known to those skilled in the art.

Naphthalene-1-sulfonic acid [4-(3,4-dihydro-1H-isoquinolin-2-yl)-butyl]amide hydrochloride

A solution of 2-(4-aminobutyl)-1,2,3,4-tetrahydroisoquinoline dihydrochloride (272 mg, 1 mmol), N,N-diisopropylethylamine (517 mg, 4 mmol) in CH₂Cl₂ (10 mL), was added naphtalene-1-sulfonyl chloride (238 mg, 1.05 mmol) and was stirred overnight at room temperature. The resulting solution was washed with water (3×15 mL) and dried over Na₂SO₄, and evaporated to dryness. The free base was dissolved in 2-propanol (5 mL). A 2.8 M solution of hydrogen chloride in ethanol (0.40 mL) was then added. The product was crystallized and collected by filtration, and vacuum dried to give a white solid (310 mg, 72%).

Melting point: 203-206° C.

IR cm⁻¹(KBr): 3087, 2941, 2679, 2601, 1446, 1420, 1314, 1153, 1132, 801, 775, 747.

¹H NMR (300 MHz, DMSO-d6) d ppm 1.38 (m, 2H), 1.66 (d, J=6.77 Hz, 2H), 2.81 (q, J=6.47 Hz, 2H), 2.91 (s, 1H), 2.99 (d, J=9.34 Hz, 2H), 3.18 (m, 2H), 3.52 (d, J=6.41 Hz, 1H), 4.12 (m, 1H), 4.36 (m, 1H), 7.21 (m, 4H), 7.69 (m, 3H), 8.10 (m, 3H), 8.23 (d, J=8.24 Hz, 1H), 8.66 (d, J=8.61 Hz, 1H), 11.02 (s, 1H).

The spectroscopic data for the identification of some of the sulfonamides compounds of the invention having general formula (I), prepared analogously to the methods described in the above examples, are shown in the following table 1:

				MS (APCI
No	STRUCTURE	Name	1H-NMR	(M + H)+)
1		Naphthalene-1-sulfonic acid [4- (3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.38 (m, 2 H), 1.66 (d, J=6.77 Hz, 2 H), 2.81 (q, J=6.47 Hz, 2 H), 2.91 (s, 1 H), 2.99 (d, J=9.34 Hz, 2 H), 3.18 (m, 2 H), 3.52 (d, J=6.41 Hz, 1 H), 4.12 (m, 1 H), 4.36 (m, 1 H), 7.21 (m, 4 H), 7.69 (m, 3 H), 8.10 (m, 3 H), 8.23 (d, J=8.24 Hz, 1 H), 8.66 (d,
# J=8.61 Hz, 1 H), 11.02 (s, 1 H)	395
2		Naphthalene-2-sulfonic acid [4- (3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.72 (s, 2 H), 2.79 (d, J=6.41 Hz, 2 H), 2.96 (m, 1H), 3.09 (s, 2 H), 3.20 (s, 2 H), 3.59 (s, 1H), 4.17 (m, 1 H), 4.43 (m, 1 H), 7.21 (m, 4 H), 7.68 (m, 2 H), 7.82 (m, 2 H), 8.04 (d, J=8.42 Hz, 1 H), 8.15 (m, 2 H), 8.43 (s, 1 H), 10.64 (s, 1 H)	395
3		N-[4-(3,4-Dihydro-1H-isoquinolin- 2-yl)-butyl]-3- trifluoromethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.76 (d, J=6.41 Hz, 2 H), 2.79 (q, J=6.59 Hz, 2 H), 3.00 (m, 1H), 3.11 (s, 2 H), 3.23 (m, 2 H), 3.62 (d, J=7.14 Hz, 1 H), 4.20 (m, 1 H), 4.45 (m, 1 H), 7.23 (m, 4 H), 7.87 (t, J=7.78 Hz, 1 H), 8.07 (m, 4 H), 10.78 (s, 1H)	413
4		N-[4-(3,4-Dihydro-1H-isoquinolin- 2-yl)-butyl]-4-methoxy- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.43 (m, 2 H), 1.76 (m, 2 H), 2.72 (q, J=6.59 Hz, 2 H), 2.98 (m, 1 H), 3.10 (s, 2 H), 3.22 (m, 2 H), 3.61 (s, 1 H), 3.79 (m, 3 H), 4.21 (dd, J=15.11, 7.42 Hz, 1 H), 4.45 (m, 1 H), 7.12 (m, 2 H), 7.22 (m, 4 H), 7.57 (t, J=5.86 Hz, 1H), 7.73 (m, 2 H), 10.81 (s, 1 H)	375
5		N-[4-(3,4-Dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.45 (m, 2 H), 1.75 (m, 2 H), 2.76 (q, J=6.71 Hz, 2 H), 2.98 (m, 1 H), 3.10 (s, 2 H), 3.18 (s, 1 H), 3.26 (s, 1 H), 3.60 (m, 1 H), 4.20 (m, 1 H), 4.45 (d, J=15.75 Hz, 1 H), 7.23 (m, 4 H), 7.62 (m, 3 H), 7.77 (m, 3 H), 10.71 (s, 1 H)	345
6		4-(4-Bromo-phenoxy)-N-[4- (3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzensulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.43 (m, 2 H), 1.75 (m, 2 H), 2.75 (q, J=6.23 Hz, 2 H), 3.01 (m, 1 H), 3.11 (s, 2 H), 3.23 (m, 2 H), 3.61 (s, 1 H), 4.21 (m, 1 H), 4.46 (m, 1 H), 7.13 (m, 5 H), 7.24 (d, J=5.68 Hz, 2 H), 7.61 (m, 2 H), 7.71 (m, 1 H), 7.79 (d, J=6.96 Hz, 2 H), 10.78 (s, 1 H)	515
7		Thiophene-2-sulfonic acid [4-(3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.51 (m, 2 H),1.76 (m, 2 H), 2.80 (m, 2 H), 3.00 (m, 1 H), 3.13 (m, 2 H), 3.25 (m, 2 H), 3,61 (s, 1 H), 4.25 (m, 1 H), 4.48 (m, 1 H), 7.23 (m, 5 H), 7.58 (dd, J=2.93, 1.65 Hz, 1 H), 7.90 (m, 2 H), 10.48 (s, 1 H)	351
8		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- C-(7,7-dimethyl-2- oxo-bicyclo[2.2.1]hept-1-yl)-hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 0.83 (m, 3 H), 1.02 (m, 4 H), 1.36 (m, 1 H), 1.51 (m, 3 H), 1.82 (m, 2 H), 1.91 (m, 1H), 2.01 (m, 1H), 2.33 (m, 2 H), 3.01 (m, 2 H), 3.17 (m, 3 H), 3.31 (m, 2 H), 3.71 (m, 1 H), 4.27 (dd, J=15.66, 8.15 Hz, 1 H), 4.50 (d, J=14.65 Hz, 1H), 7.09
# (m, 1H), 7.24	419
9		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 2-nitro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.48 (m, 2 H), 1.74 (m, 2 H), 2.94 (m, 2 H), 3.04 (m, 1 H), 3.14 (m, 2 H), 3.24 (m, 2 H), 3.62 (d, J=4.39 Hz, 1 H) 4.22 (m, 1 H), 4.46 (m, 1 H), 7.22 (m, 4 H), 7.86 (m, 2 H), 7.98 (m, 2 H), 8.24 (m, 1H), 10.68 (s, 1H)	390
10		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 3-nitro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.45 (m, 2 H), 1.72 (m, 2 H), 2.79 (m, 2 H), 3.02 (s, 1 H), 3.10 (m, 2 H), 3.23 (m, 2 H), 3.60 (m, 1 H), 4.21 (m, 1 H), 4.45 (m, 7.23 (m, 4 H), 7.92 (m, 1 H), 8.11 (m, 1H), 8.23 (m, 1 H), 8.49 (m, 2 H), 10.52 (s, 1 H)	390
11		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 4-methanesulfonyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.46 (m, J=7.12 Hz, H), 1.76 (m, 2 H), 2.81 (q, J=6.59 Hz, 2 H), 2.98 (m, 1H), 3.10 (m, 2 H), 3.23 (m, 2 H), 3.30 (s, 3H), 3.60 (m, 1 H), 4.19 (m, 1 H), 4.44 (m, 1H), 7.23 (m, 4 H), 8.10 (m, 5 H), 10.91 (s, 1 H)	423
12		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 4-methyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.75 (m, 2 H), 2.36 (s, 3 H), 2.72 (q, J=6.59 Hz, 2 H), 2.97 (m, 1 H), 3.08 (d, J=5.31 Hz, 2 H), 3.22 (m, 2 H), 3.60 (s, 1 H), 4.21 (m, 1 H), 4.44 (d, J=15.20 Hz, 1 H), 7.23 (m, 4 H), 7.39 (d, J=7.87 Hz, 2 H), 7.65 (m, 3 H), 10.75 (s, 1 H)	359
13		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 4-fluoro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.46 (m, 2 H), 1.75 (d, J=7.14 Hz, 2 H), 2.76 (q, J=6.53 Hz, 2 H), 2.99 (m, 1H), 3.10 (s, 2 H), 3.23 (m, 2 H), 3.60 (s, 1 H), 4.19 (m, 1H), 4.43 (m, 1 H), 7.23 (m, 4 H), 7.44 (m, 2 H), 7.84 (m, 3 H), 10.81 (s, 1 H)	363
14		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 2,4-dimethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.43 (m, 2 H), 1.72 (m, 2 H), 2.31 (s, 3 H), 2.52 (s, 3 H), 2.74 (d, J=6.23 Hz, 2 H), 2.96 (m, 1 H), 3.08 (m, 2 H), 3.24 (m, 2 H), 3.60 (m, 1 H), 4.20 (m, 1 H), 4.43 (m, 1H), 7.22 (m, 6 H), 7.67 (m, 2 H), 10.87 (s, 1 H)	373
15		2-Naphthalen-1-yl- ethanesulfonic acid [4-(3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.54 (m, 2 H),1.84 (m, 2 H), 3.03 (m, 3 H), 3.17 (m, 4 H), 3.37 (m, 2 H), 3.42 (m, 2 H), 3.66 (d, J=11.54 Hz, 1 H), 4.25 (m, 1 H), 4.48 (m, 1 H), 7.22 (m, 4 H), 7.42 (m, 3 H), 7.56 (m, 2 H), 7.82 (dd, J=6.87, 2.84 Hz, 1 H), 7.93 (d, J=1.10 Hz, 1 H),
# 8.01 (d, J=8.24 Hz, 1 H), 10.59 (s, 1 H)	423
16		5-Chloro-3-methyl- benzo[b]thiophene-2- sulfonic acid [4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.47 (m, 2 H), 1.71 (d, J=7.14 Hz, 2 H), 2.60 (s, 3 H), 2.94 (m, 3 H), 3.11 (m, 3 H), 3.23 (d, J=8.24 Hz, 1H), 3.60 (d, J=10.99 Hz, 1H), 4.20 (dd, J=15.38, 7.87 Hz, 1H), 4.44 (m, 1 H), 7.20 (m, 4 H), 7.53 (dd, J=8.79, 2.01 Hz, 1 H),
# 8.02 (m, 2 H), 8.22 (m, 1 H), 10.07 (s, 1 H)	449
17		4-Acetyl-N-[4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) □ ppm 1.44 (m, 2 H), 1.72 (m, 2 H), 2.59 (s, 3 H), 2.80 (s, 2 H), 3.00 (m, 1 H), 3.12 (s, 3 H), 3.28 (s, 1 H), 3.64 (d, J=11.72 Hz, 1 H), 4.23 (dd, J15.29, 7.96 Hz, 1 H), 4.47 (d, J=14.65 Hz, 1 H), 7.22 (m, 4 H), 7.91 (d, J=8.24 Hz, 3 H), 8.11 (d, J=8.42 Hz,
# 2 H), 10.02 (s, 1 H)	387
18		4-Bromo-N-[4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.43 (m, 2 H), 1.71 (m, 2 H), 2.76 (s, 2 H), 3.07 (m, 4 H), 3.28 (m, 1 H), 3.65 (d, J=12.08 Hz, 1 H), 4.24 (dd, J=15.11, 8.15 Hz, 1 H), 4.48 (d, J=15.38 Hz, 1 H), 7.22 (m, 3 H), 7.51 (m, 2 H), 7.76 (m, 4 H), 9.84 (s, 1 H)	423
19		Ethanesulfonic acid [4-(3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.17 (t, J=7.42 Hz, 3 H), 1.51 (m, 2 H), 1.80 (m, 2 H), 2.96 (m, 5 H), 3.17 (dd, J=10.44, 5.31 Hz, 3 H), 3.31 (d, J=6.23 Hz, 1 H), 3.68 (d, J=10.99 Hz, 1 H), 4.26 (dd, J=15.66, 7.97 Hz, 1 H), 4.50 (d, J=13.92 Hz, 1 H), 7.22 (m, 5 H), 10.08 (s, 1 H)	297
20		Propane-2-sulfonic acid [4-(3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.17 (s, 3 H), 1.20 (s, 3 H), 1.49 (m, 2 H), 1.80 (m, 2 H), 2.95 (m, 2 H), 3.05 (m, 1 H), 3.13 (m, 4 H), 3.32 (m, 1 H), 3.68 (d, J=11.90 Hz, 1 H), 4.26 (m, 1 H), 4.50 (m, 1 H), 7.04 (m, 1H), 7.20 (m, 4 H), 9.98 (s, 1 H)	311
21		Quinoline-8-sulfonic acid [4-(3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.41 (m, 2 H), 1.68 (m, 2 H), 2.81 (s, 2 H), 3.01 (m, 1H), 3.09 (m, 2 H), 3.16 (m, 2 H), 3.60 (d, J=10.62 Hz, 1H), 4.20 (m, 1 H), 4.44 (d, J=16.85 Hz, 1 H), 7.20 (m, 5 H), 7.72 (m, 2 H), 8.30 (m, 2 H), 8.54 (d, J=7.69 Hz, 1H), 9.07 (dd, J=4.21,
# 1.65 Hz, 1 H), 9.96 (s, 1 H)	396
22		Naphthalene-1-sulfonic acid [5-(3,4-dihydro- 1H-isoquinolin-2-yl)- pentyl]-amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.21 (m, 2 H), 1.34 (m, 2 H), 1.57 (d, J=7.87 Hz, 2 H), 2.78 (s, 2 H), 3.04 (m, 3 H), 3.23 (m, 2 H), 3.60 (m, 1 H), 4.19 (dd, J=15.29, 8.15 Hz, 1 H), 4.44 (d, J=14.46 Hz, 1H), 7.18 (m, 5 H), 7.63 (m, 4 H), 7.92 (s, 1 H), 8.02 (m, 1 H), 8.13 (dd, J=16.57, 7.78 Hz,
# 3 H), 8.65 (d, J=8.42 Hz, 1H), 9.87 (s, 1 H)	409
23		Naphthalene-2-sulfonic acid [5-(3,4-dihydro- 1H-isoquinolin-2-yl)- pentyl]-amide	1H NMR (300 MHz, CHLOROFORM-D) δ ppm 1.34 (m, 2 H), 1.52 (qt, J=7.23 Hz, 4 H), 1.63 (s, 1 H), 2.41 (m, 2 H), 2.66 (t, J=5.95 Hz, 2 H), 2.88 (t, J=5.86 Hz, 2 H), 2.99 (t, J=6.23 Hz, 2 H), 3.55 (s, 2 H), 4.82 (s, 1H), 6.99 (m, 1 H), 7.10 (m, 3 H), 7.62 (m, 2 H), 7.75 (dd, J8.61, 1.83 Hz, 1 H), 7.93 (m, 3 H),
# 8.40 (d, J=1.28 Hz, 1 H)	409
24		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)- pentyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.25 (m, 2 H), 1.39 (d, J=7.14 Hz, 2 H), 1.68 (d, J7.69 Hz, 2 H), 2.73 (s, 2 H), 2.96 (s, 1 H), 3.14 (m, 3 H), 3.27 (d, J=10.25 Hz, 1 H), 3.66 (d, J=11.35 Hz, 1 H), 4.23 (dd, J=15.47, 7.96 Hz, 1 H), 4.49 (d, J=13.92 Hz, 1 H), 7.20 (m, 4 H), 7.58 (m, 4 H), 7.77 (m,
# 2 H), 10.04 (s, 1H)	359
25		3-(4-Bromo-phenoxy)- N-[5-(3,4-dihydro- 1H-isoquinolin-2-yl)- pentyl]-benzenesulfonamide	1H NMR (300 MHz, CHLOROFORM-D) δ ppm 1.38 (m, 2 H), 1.54 (m, 4 H), 1.67 (s, 1 H), 2.47 (m, 2 H), 2.71 (t, J=5.86 Hz, 2 H), 2.93 (m, 3 H), 3.59 (s, 2 H), 4.74 (t, J=5.68 Hz, 1H), 6.94 (m, 2 H), 7.00 (m, 3 H), 7.11 (m, 3 H), 7.51 (m, 2 H), 7.75 (m, 2 H)	529
26		Thiophene-2-sulfonic acid [5-(3,4-dihydro- 1H-isoquinolin-2-yl)- pentyl]-amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.31 (d, J=6.96 Hz, 2 H), 1.44 (m, 2 H), 1.69 (s, 2 H), 2.82 (s, 2 H), 3.14 (m, 5 H), 3.67 (d, J=9.70 Hz, 1 H), 4.24 (m, 1 H), 4.50 (d, J=17.21 Hz, 1 H), 7.18 (m, 5 H), 7.55 (m, 1 H), 7.83 (m, 2 H), 10.05 (s, 1 H)	365
27		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]-2- nitro-benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.30 (d, J=6.96 Hz, 2 H), 1.47 (d, J=6.77 Hz, 2 H), 1.68 (m, 2 H), 2.89 (d, J=5.49 Hz, 3 H), 3.11 (m, 3 H), 3.26 (d, J=7.32 Hz, 1H), 3.65 (d, J=10.62 Hz, 1 H) 4.22 (m, 1 H), 4.48 (m, 1 H), 7.18 (m, 4 H), 7.81 (m, 3 H), 7.97 (ddd, J=5.22, 3.94, 1.46 Hz, 2 H),
# 9.99 (s, 1 H)	404
28		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]-3- nitro-benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.28 m, 2 H), 1.41 (d, J=7.32 Hz, 2 H), 1.68 (m, 2 H), 2.79 (s, 2 H), 3.08 (m, 4 H), 3.26 (m, 1 H), 3.67 (m, 1 H), 4.23 (m, 1H), 4.49 (d, J=15.38 Hz, 1 H), 7.19 (m, 4 H), 7.85 (t, J=7.96 Hz, 1H), 7.98 (s, 1 H), 8.18 (m, 1 H), 8.43 (dt, J=8.29, 1.17 Hz, 1 H), 8.52 (t,
# J=1.92 Hz, 1 H), 10.04 (s, 1 H)	404
29		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]-4- fluoro-benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.28 (m, 2 H), 1.40 (m, 2 H), 1.67 (m, 2 H), 2.72 (m, 2 H), 3.02 (m, 1 H), 3.11 (m, 3 H), 3.27 (m, J=8.24 Hz, 1 H), 3.66 (m, J=11.35 Hz, 1 H), 4.24 (dd, J=15.47, 8.33 Hz, 1 H), 4.49 (d, J=14.83 Hz, 1 H), 7.21 (m, 4 H), 7.37 (d, J=6.77 Hz, 2 H), 7.64 (s, 1 H), 7.83
# (m, 2 H), 9.96 (s, 1 H)	377
30		4-Bromo-N-[5-(3,4-dihydro- 1H-isoquinolin-2-yl)- pentyl]-benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.25 (m, 2 H), 1.40 (m, 2 H), 1.68 (ddd, J=15.38, 7.96, 7.78 2 H), 2.73 (m, 2 H), 2.99 (m, 1 H), 3.12 (d, J=6.96 Hz, 3 H), 3.27 (m, J=9.16 Hz, 1H), 3.68 (m, 1 H), 4.23 (dd, J=15.38, 8.06 Hz, 1 H), 4.50 (m, 1 H), 7.21 (m, 4 H), 7.72 (m, 5 H), 10.04 (s, 1 H)	437
31		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]- 4-methyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.28 (d, J=6.41 Hz, 2 H), 1.41 (d, J=6.96 Hz, 2 H), 1.68 (m, 2 H), 2.33 (s, 3 H), 2.70 (t, J=6.23 Hz, 2 H), 2.98 (m, 1H), 3.13 (d, J=5.68 Hz, 3 H), 3.26 (m, J=8.97 Hz, 1 H), 3.65 (d, J=10.80 Hz, 1 H), 4.22 (m, 1 H), 4.48 (d, J=15.38 Hz, 1 H), 7.20 (m,
# 4 H), 7.34 (d, J=8.06 Hz, 2 H), 7.50 (s, 1 H), 7.65 (d, J=7.87 Hz, 2 H), 10.11 (s, 1H)	373
32		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]- 2,4-dimethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.25 (m, 2 H), 1.40 (m, 2 H), 1.64 (m, 2 H), 2.27 (s, 3 H), 2.49 (s, 3H), 2.72 (m, 2 H), 3.01 (m, 1 H), 3.11 (m, 3 H), 3.26 (m, J=8.06 Hz, 1 H), 3.65 (d, J=11.35 Hz, 1H), 4.23 (dd, J=15.66, 8.33 Hz, 1 H), 4.48 (d, J=15.56 Hz, 1 H), 7.16 (m, 6 H), 7.51 (s,
# 1H), 7.65 (d, J=7.87 Hz, 1H), 9.83 (s, 1 H)	387
33		2-Naphthalen-1-yl- ethanesulfonic acid [5- (3,4-dihydro-1H- isoquinolin-2-yl)- pentyl]-amide hydrochloride	1H NMR (300 MHz, DMSO-06) δ ppm 1.36 (m, 2 H), 1.51 (m, 2 H), 1.76 (m, 2 H), 3.00 (m, 3 H), 3.15 (m, 3 H), 3.33 (m, 3 H), 3.43 (m, 2 H), 3.69 (m, 1 H), 4.25 (dd, J=15.38, 8.24 Hz, 1 H), 4.50 (d, J=14.65 Hz, 1H), 7.21 (m, 5 H), 7.42 (m, 2 H), 7.55 (m, 2 H), 7.79 (m, 1 H), 7.91 (d,
# J=8.24 Hz, 1 H), 8.00 (d, J=8.42 Hz, 1 H), 10.11 (s, 1 H)	437
34		Quinoline-8-sulfonic acid [5-(3,4-dihydro-1H- isoquinolin-2-yl)- pentyl]-amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.20 (m, 2 H), 1.36 (m, 2 H), 1.59 (m, 2 H), 2.78 (t, J=6.50 Hz, 2 H), 3.04 (m, 4 H), 3.23 (m, 1H), 3.61 (m, 1 H), 4.20 (dd, J15.47, 8.15 Hz, 1 H), 4.45 (d, J=15.20 Hz, 1 H), 7.18 (m, 5 H), 7.69 (m, 2 H), 8.27 (dd, J=15.29, 7.60 Hz, 2 H), 8.52 (m, 1 H), 9.05 (dd,
# J=4.12, 1.56 Hz, 1 H), 9.80 (s, 1H)	410
35		5-Chloro-3-methyl- benzo[b]thiophene-2- sulfonic acid [5-(3,4- dihydro-1H-isoquinolin- 2-yl)-pentyl]-amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.27 (m, 2 H), 1.42 (m, 2 H), 1.65 (m, 2 H), 2.62 (s, 3 H), 2.89 (m, 2 H), 3.06 (m, 4 H), 3.25 (m, 1H), 3.62 (d, J=10.25 Hz, 1 H), 4.20 (dd, J=15.56, 8.06 Hz, 1 H), 4.45 (d, J=15.20 Hz, 1 H), 7.19 (m, 4 H), 7.51 (dt, J=8.70,
# 1.88 Hz, 1 H), 8.00 (m, 2 H), 8.14 (s, 1 H), 9.88 (s, 1 H)	463
36		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 4-methoxy-2,3,6- trimethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.42 (m, 2 H), 1.66 (m, 2 H), 2.04 (m, 6 H), 2.56 (s, 3 H), 2.73 (t, J=6.41 Hz, 2 H), 3.01 (m, 1 H), 3.09 (m, 3 H), 3.23 (m, 1 H), 3.61 (d, J=11.17 Hz, 1 H), 3.76 (s, 3 H), 4.20 (dd, J=15.47, 7.96 Hz, 1 H), 4.44 (d, J=14.65 Hz, 1 H), 6.76 (s, 1 H),
# 7.20 (m, 4 H), 7.37 (s, 1H), 10.16 (s, 1 H)	417
37		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]- 4-methoxy-2,3,6- trimethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.25 (m, J=6.59 Hz, 2 H), 1.38 (m, 2 H), 1.63 (m, J=7.32 Hz, 2 H), 2.06 (m, 6 H), 2.56 (s, 3 H), 2.70 (m, 2 H), 3.05 (m, 4 H), 3.25 (m, 1 H), 3.64 (d, J=11.35 Hz, 1 H), 3.75 (s, 3 H), 4.22 (dd, J15.11, 8.15 Hz, 1 H), 4.47 (d, J=14.65 Hz, 1 H),
# 6.76 (s, 1 H), 7.21 (m, 5 H), 10.03 (s, 1 H)	431
38		2-Bromo-N-[4-(3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.45 (m, 2 H), 1.72 (m, 2 H), 2.87 (q, J=6.04 Hz, 2 H), 2.99 (m, 1 H), 3.12 (m, 3 H), 3.26 (m, 1H), 3.64 (d, J=12.08 Hz, 1 H), 4.23 (dd, J=15.29, 7.96 Hz, 1 H), 4.46 (m, 1 H), 7.20 (m, 4 H), 7.50 (m, 2 H), 7.81 (d, J=7.32 Hz, 1 H), 7.90 (s, 1 H), 7.97 (d, J=7.51 Hz,
# 1 H), 9.93 (s, 1H)	423
39		2-Bromo-N-[5-(3,4-dihydro-1H- isoquinolin-2-yl)-pentyl]- benzenesulfonamide hydrochloride		437
40		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 4-trifluoromethoxy- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.45 (m, 2 H), 1.73 (m, 2 H), 2.78 (s, 2 H), 2.99 (m, 1 H), 3.14 (m, 3 H), 3.26 (d, J=6.96 Hz, 1 H), 3.65 (m, 1 H), 4.24 (m, 1 H), 4.48 (d, J=15.20 Hz, 1 H), 7.19 (m, 4 H), 7.53 (d, J=8.61 Hz, 2 H), 7.90 (m, 3 H), 10.12 (s, 1 H)	429
41		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 2-nitro-4-trifluoromethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.50 (m, 2 H), 1.75 (m, 2 H), 2.97 (m, 3 H), 3.14 (m, 3 H), 3.31 (m, 1 H), 3.65 (m, 1 H), 4.24 (dd, J=15.38, 8.30 Hz, 1 H), 4.48 (d, J=14.65 Hz, 1 H), 7.20 (m, 4 H), 8.20 (m, 2 H), 8.47 (s, 2 H), 10.01 (s, 1 H)	458
42		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 3-fluoro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.72 (m, 2 H), 2.78 (s, 2 H), 2.99 (m, 1 H), 3.12 (m, 3 H), 3.27 (m, 1 H), 3.65 (m, 1 H), 4.23 (dd, J=14.92, 8.33 Hz, 1H), 4.47 (d, J=16.11 Hz, 1 H), 7.18 (m, 4 H), 7.41 (m, J=7.64, 5.36, 1 H), 7.58 (m, 3 H), 7.79 (s, 1 H), 9.91 (s, 1 H)	363
43		2,4-Dichloro-N-[4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.70 (m, 2 H), 2.86 (q, J=6.51 Hz, 2 H), 2.95 (m, 1 H), 3.12 (m, 3 H), 3.26 (m, 1 H), 3.63 (d, J=11.23 Hz, 1H), 4.22 (dd, J=15.38, 7.57 Hz, 1 H), 4.45 (m, 1 H), 7.20 (m, 4 H), 7.55 (m, 1 H), 7.75 (m, 1H), 7.93 (m, 1H), 8.03 (s, 1 H), 10.06 (s, 1 H)	413
44		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 2,4,6-trimethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.41 (m, 2 H), 1.68 (m, 2 H), 2.18 (s, 3 H), 2.53 (s, 6 H), 2.74 (m, 2 H), 3.06 (m, 4 H), 3.25 (m, 1 H), 3.63 (m, 1 H), 4.21 (dd, J=15.56, 7.51 Hz, 1 H), 4.45 (d, J=14.28 Hz, 1 H), 6.98 (s, H), 7.20 (m, 4 H), 7.45 (s, 1 H), 9.96 (s, 1 H)	387
45		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]-2- trifluoromethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.50 (m, 2 H), 1.74 (d, J=6.59 Hz, 2 H), 2.91 (m, 2 H), 3.02 (m, 1H), 3.14 (m, J=6.59 Hz, 3 H), 3.27 (m, 1 H), 3.64 (m, 1H), 4.24 (dd, J=15.38, 8.42 Hz, 1H), 4.47 (d, J=15.20 Hz, 1 H), 7.20 (m, 4 H), 7.79 (m, 2 H), 7.90 (d, J=7.51 Hz, 1 H), 8.06
# (d, J=7.51 Hz, 2 H), 9.92 (s, 1H)	413
46		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]-4- trifluoromethoxy- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.26 (m, 2 H),1.40 (m, 2 H), 1.66 (m, 2 H), 2.74 (t, J=6.87 Hz, 2 H), 2.97 (m, 1 H), 3.11 (m, 3 H), 3.26 (m, 1 H), 3.64 (m, 1H), 4.22 (dd, J=15.38, 8.24 Hz, 1 H) 4.47 (m, 1 H), 7.18 (m, 4 H), 7.45 (d, J=8.61 Hz, 2 H), 7.68 (s, 1H), 7.87 (m, 2 H), 9.80
# (s, 1 H)	443
47		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]-2- nitro-4-trifluoromethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.29 (m, 2 H),1.47 (m, 2 H), 1.68 (m, 2 H), 2.92 (q, J=6.53 Hz, 2 H), 3.01 (m, 1 H), 3.11 (m, 3 H), 3.28 (m, 1 H), 3.66 (m, 1 H), 4.23 (dd, J=15.20, 8.42 Hz, 1 H), 4.48 (d, J=15.56 Hz, 1 H), 7.17 (m, 4 H), 8.18 (m, 2 H), 8.38 (s, 2 H), 9.74 (s, 1 H)	472
48		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]-3- fluoro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.28 (m, 2 H), 1.40 (m, 2 H), 1.66 (m, 2 H), 2.75 (d, J=6.35 Hz, 2 H), 2.98 (m, 1H), 3.09 (m, 3 H), 3.25 (m, 1 H), 3.66 (m, 1H), 4.25 (d, J=8.06 Hz, 1 H), 4.47 (d, J=14.40 Hz, 1 H), 7.19 (m, 4 H), 7.36 (m, 1 H), 7.57 (m, 4 H), 9.86 (s, 1 H)	377
49		2,4-Dichloro-N-[5-(3,4- dihydro-1H-isoquinolin- 2-yl)-pentyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.26 (m, 2 H), 1.40 (m, 2 H), 1.64 (m, 2 H), 2.80 (m, 2 H), 2.95 (m, 1 H), 3.09 (m, 3 H), 3.26 (m, 1 H), 3.63 (d, J=10.01 Hz, 1H), 4.21 (dd, J=15.26, 7.93 Hz, 1 H), 4.45 (d, J=15.38 Hz, 1 H), 7.15 (m, 4 H), 7.48 (dd, J=8.55, 2.20 Hz, 1 H), 7.67 (d,
# J=2.20 Hz, 1H), 7.90 (d, J=8.55 Hz, 2 H), 9.88 (s, 1 H)	427
50		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]- 2,4,6-trimethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.25 (m, 2 H), 1.37 (m, 2 H), 1.64 (m, 2 H), 2.19 (s, 3 H), 2.51 (s, 6 H), 2.71 (t, J=6.35 Hz, 2 H), 3.06 (m, 4 H), 3.22 (m, 1H), 3.63 (d, J=10.74 Hz, 1 H), 4.21 (dd, J=15.26, 8.18 Hz, 1 H), 4.46 (d, J=14.89 Hz, 1 H), 6.95 (s, 2 H), 7.20 (m, 4 H),
# 7.36 (s, 1H), 10.04 (s, 1 H)	401
51		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]- 2-trifluoromethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.30 (m, 2 H), 1.46 (m, 2 H), 1.69 (m, 2 H), 2.87 (m, 2 H), 2.97 (m, 1 H), 3.12 (m, 3 H), 3.27 (d, J=11.47 Hz, 1 H), 3.66 (d, J=10.74 Hz, 1 H), 4.23 (dd, J=15.50, 8.18 Hz, 1 H), 4.48 (d, J=14.89 Hz, 1 H), 7.19 (m, 4 H), 7.77 (m, 2 H), 7.88 (d, J=7.81 Hz,
# 2 H), 8.04 (d, J=7.81 Hz, 1H), 9.94 (s, 1 H)	427
52		2,3-Dichloro-N-[4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.46 (m, 2 H), 1.77 (m, 2 H), 2.88 (q, J=6.71 Hz, 2 H), 3.00 (s, 1 H), 3.15 (s, 4 H), 3.60 (m, 1 H), 4.20 (dd, J=15.29, 7.60 Hz, 1 H), 4.43 (m, 1 H), 7.20 (m, 4 H) 7.56 (t, J=7.96 Hz, 1H), 7.95 (m, 2 H), 8.21 (m, 1H), 10.98 (s, 1H)	413
53		2,4,5-Trichloro-N-[4- (3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.46 (m, 2 H), 1.75 (m, 2 H), 2.87 (s, 2 H), 3.01 (m, 1H), 3.12 (m, 3 H), 3.23 (m, 1H), 3.61 (m, 1 H), 4.21 (dd, J=15.01, 8.06 Hz, 1 H), 4.44 (d, J=15.93 Hz, 1H), 7.23 (m, 4 H), 8.07 (m, 1 H), 8.13 (m, 1 H), 8.28 (s, 1 H), 10.83 (s, 1 H)	447
54		5-Bromo-N-[4-(3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-2-methoxy- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.77 (m, 2 H), 2.81 (q, J=6.77 Hz, 2 H), 2.98 (m, 1 H), 3.10 (m, 2 H), 3.24 (m, 2 H), 3.61 (m, 1 H), 3.89 (s, 3 H), 4.20 (m, 1 H), 4.44 (m, 1 H), 7.22 (m, 5 H), 7.56 (t, J=5.95 Hz, 1 H), 7.78 (m, 2 H), 11.03 (s, 1 H)	453
55		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 2,5-dimethoxy- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.76 (m, 2 H), 2.79 (q, J=6.65 Hz, 2 H), 2.98 (m, 1 H), 3.09 (m, 2 H), 3.22 (m, 2 H), 3.61 (m, 1 H), 3.74 (s, 3 H), 3.84 (s, 3 H), 4.21 (m, 1H), 4.44 (d, J=15.20 Hz, 1 H), 7.22 (m, 7 H), 7.33 (t,	405
56		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 2,3,4,5,6-pentamethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.43 (m, 2 H), 1.73 (m, 2 H), 2.18 (s, 6 H), 2.22 (s, 3 H), 2.48 (s, 6 H), 2.74 (q, J=6.59 Hz, 2 H), 2.97 (m, 1H), 3.09 (s, 2 H), 3.19 (d, J=9.34 Hz, 2 H), 3.58 (m, 1 H), 4.18 (dd, J=15.66, 7.78 Hz, 1 H), 4.43 (m, 1 H), 7.23 (m, 4 H),
# 7.48 (t, J=5.86 Hz, 1 H), 10.80 (s, 1H)	415
57		2-(2,2,2-Trifluoro-acetyl)-1,2,3,4- tetrahydro-isoquinoline-7- sulfonic acid [4-(3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide fumarate		496
58		2,3-Dichloro-N-[5-(3,4-dihydro- 1H-isoquinolin-2-yl)- pentyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.25 (m, 2 H), 1.42 (m, 2 H), 1.71 (m, 2 H), 2.86 (q, J=6.71 Hz, 2 H), 2.95 (m, 1 H), 3.07 (m, 2 H), 3.21 (m, 2 H), 3.62 (m, 1 H), 4.19 (d, J=7.69 Hz, 1H), 4.23 (s, 1 H), 4.47 (d, J=15.93 Hz, 4 H), 7.22 (m, 4 H), 7.56 (t, J=8.06 Hz, 1 H), 7.93 (ddd, J=7.92,
# 6.36, 1.46 Hz, 2 H), 8.14 (m, 1 H), 10.70 (s, 1H)	427
59		2,4,5-Trichloro-N-[5-(3,4- dihydro-1H-isoquinolin- 2-yl)-pentyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.27 (m, 2 H), 1.44 (m, 2 H), 1.73 (m, 2 H), 2.88 (m, J=6.04 Hz, 2 H), 2.99 (m, 1 H), 3.08 (m, 2 H), 3.23 (m, 2 H), 3.61 (m, 1H), 4.21 (dd, J=15.20, 7.51 Hz, 1 H), 4.46 (d, J=15.01 Hz, 1H), 7.22 (m, 4 H), 8.06 (s, 1H), 8.13 (s, 1 H), 8.22 (m, 1 H), 10.93
# (s, 1 H)	461
60		5-Bromo-N-[5-(3,4-dihydro- 1H-isoquinolin-2-yl)- pentyl]-2-methoxy- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.28 (m, 2 H), 1.41 (m, 2 H), 1.70 (m, 2 H), 2.79 (m, 2 H), 2.98 (m, 1 H), 3.08 (m, 2 H), 3.21 (m, 2 H), 3.61 (m, 1 H), 3.89 (s, 3 H), 4.22 (dd, J=14.83, 8.24 Hz, 1 H), 4.47 (d, J=16.66 Hz, 1H), 7.19 (s, 2 H), 7.24 (dd, J=6.32, 3.39 Hz, 3 H), 7.50 (m,
# 1 H), 7.78 (m, 2 H), 10.63 (s, 1 H)	467
61		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]- 2,5-dimethoxy- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.26 (m, 2 H), 1.40 (m, 2 H), 1.69 (m, 2 H), 2.77 (q, J=6.41 Hz, 2 H), 3.08 (m, 3 H), 3.22 (m, 2 H), 3.66 (m, 1 H), 3.74 (s, 3 H), 3.83 (s, 3 H), 4.22 (dd, J=15.84, 8.88 Hz, 1 H), 4.47 (d, J=15.01 Hz, 1 H), 7.23 (m, 8 H), 10.51 (s, 1 H)	419
62		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]- 2,3,4,5,6-pentamethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.26 (m, 2 H), 1.41 (m, 2 H), 1.69 (m, 2 H), 2.18 (s, 6 H), 2.22 (s, 3 H), 2.47 (s, 6 H), 2.72 (q, J=6.47 Hz, 2 H), 3.03 (m, 3 H), 3.23 (m, 2 H), 3.63 (m, 1 H), 4.20 (dd, J=15.66, 7.78 Hz, 1 H), 4.46 (d, J=15.56 Hz, 1 H), 7.23 (m, 4 H), 7.41 (t,
# J=5.77 Hz, 1 H), 10.67 (s, 1H)	429
63		2-(2,2,2-Trifluoro-acetyl)- 1,2,3,4-tetrahydro- isoquinoline-7- sulfonic acid [5-(3,4- dihydro-1H- isoquinolin-2-yl)- pentyl]-amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.29 (m, 2 H), 1.41 (m, H), 1.45 (s, 2 H), 1.73 (m, 2 H), 2.74 (m, 2 H), 2.99 (m, 1H), 3.08 (m, 2 H), 3.24 (m, 2 H), 3.63 (m, 1 H), 3.81 (m, 2 H), 4.21 (m, 1 H), 4.47 (m, 1 H), 4.84 (m, 2 H), 7.24 (m, 4 H), 7.42
# (d, J=8.24 Hz, 1H), 7.63 (m, 3 H), 10.82 (s, 1 H)	510
64		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)- butyl]-2-methyl-5-nitro- benzenesulfonamide hydrochloride		404
65		4-Bromo-N-[4-(3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-2,5-difluoro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.46 (m, 2 H), 1.75 (m, 2 H), 2.91 (m, 2 H), 3.02 (m, 1 H), 3.15 (m, 2 H), 3.24 (m, 2 H), 3.63 (m, 1 H), 4.23 (dd, J=14.79, 7.32 Hz, 1H), 4.46 (d, J=14.35 Hz, 1 H), 7.25 (m, 4 H), 7.72 (dd, J=7.76, 6.15 Hz, 1 H), 8.06 (dd, J=9.15, 5.34 Hz, 1 H), 8.27
# (m, 1 H), 10.44 (s, 1 H)	459
66		4-Chloro-N-[4-(3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-2,5-dimethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSQ-D6) δ ppm 1.42 (m, 2 H), 1.69 (m, 2 H), 2.28 (s, 3 H), 2.48 (s, 3 H), 2.77 (t, J=5.37 Hz, 2 H), 2.97 (m, 1 H), 3.10 (d, J=6.35 Hz, 3 H), 3.25 (d, J=9.03 Hz, 1H), 3.61 (m, 1 H), 4.21 (dd, J=15.63, 8.30 Hz, 1 H), 4.44 (m, 1 H), 7.16 (m, 4 H), 7.36 (s, 1 H), 7.71
# (s, 2 H), 9.91 (s, 1 H)	407
67		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 3-methoxy- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.43 (m, 2 H), 1.72 (m, 2 H), 2.76 (t, J=6.59 Hz, 2 H), 2.98 (m, 1 H), 3.12 (m, 3 H), 3.26 (m, 1 H), 3.63 (m, 1 H), 3.77 (s, 3 H), 4.22 (dd, J=15.14, 8.06 Hz, 1 H), 4.46 (m, 1H), 7.18 (m, 5 H), 7.31 (m, 2 H), 7.43 (t, J=7.93 Hz, 1 H), 7.62 (s, 1 H), 9.95 (s, 1H)	375
68		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]-4- isopropyl- benzenesulfonamide hydrochloride		387
69		3-Chloro-N-[4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-4-fluoro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.72 (m, 2 H), 2.78 (t, J=6.84 Hz, 2 H), 2.99 (m, 1 H), 3.11 (m, 3 H), 3.27 (m, 1 H), 3.65 (m, 1 H), 4.23 (m, 1 H), 4.47 (m, 1 H), 7.19 (m, 4 H), 7.56 (t, J=8.91 Hz, 1 H), 7.78 (ddd, J=8.67, 4.52, 2.20 Hz, 2 H), 7.93 (dd, J=6.84, 2.44 Hz,
# 1 H), 9.82 (s, 1 H)	397
70		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 3-methyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.72 (m, 2 H), 2.37 (s, 3 H), 2.75 (m, 2 H), 3.00 (m, 1 H), 3.12 (m, 3 H), 3.27 (m, 1 H), 3.64 (m, 1 H), 4.24 (dd, J=14.77, 8.42 Hz, 1 H), 4.48 (d, J=14.40 Hz, 1 H), 7.24 (d, J=6.10 Hz, 4 H), 7.43 (s, 2 H), 7.59 (s, 3 H), 9.90 (s, 1 H)	359
71		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 5-fluoro-2-methyl- benzenesulfonamide hydrochloride		377
72		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 4-isopropoxy- benzenesulfonamide hydrochloride		403
73		3-Chloro-N-[4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride		379
74		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)- butyl]-3,4-dimethoxy- benzenesulfonamide hydrochloride		405
75		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]-2,3,4,5,6- pentafluoro- benzenesulfonamide hydrochloride		435
76		2-Oxo-2H-chromene-6- sulfonic acid [5-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)- pentyl]-amide		487
77		2-Oxo-2H-chromene-6- sulfonic acid [4-(3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-amide hydrochloride		413
78		3,5-Dichloro-N-[4-(3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-benzenesulfonamide hydrochloride		413
79		2,5-Dichloro-N-[4-(3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.45 (m, 2 H), 1.75 (m, 2 H), 2.89 (q, J=6.74 Hz, 2 H), 2.96 (m, 1H), 3.10 (m, 3 H), 3.21 (m, 1H), 3.63 (m, 1 H), 4.21 (dd, J=15.23, 8.05 Hz, 1 H), 4.44 (d, J=14.94 Hz, 1 H), 7.22 (m, 4 H), 7.73 (m, 2 H), 7.91 (d, J=2.34 Hz, 1 H), 8.19 (t, J=5.71 Hz,
# 1 H), 10.62 (s, 1 H)	413
80		5-Bromo-6-chloro-pyridine- 3-sulfonic acid [4-(3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-amide hydrochloride		458
81		4-Chloro-N-[4-(3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.43 (m, 2 H), 1.74 (m, 2 H), 2.76 (q, J=6.74 Hz, 2 H), 2.98 (m, 1 H), 3.10 (m, 3 H), 3.14 (m, 1H), 3.63 (m, 1 H), 4.21 (dd, J=15.74, 7.83 Hz, 1 H), 4.44 (d, J=14.06 Hz, 1H), 7.21 (m, 4 H), 7.67 (ddd, J=8.86, 2.42, 2.20 Hz, 2 H), 7.79 (ddd, J=8.86, 2.42,
# 2.20 Hz, 2 H), 7.84 (t, J=5.86 Hz, 1H), 10.62 (s, 1 H)	379
82		2,6-Dichloro-N-[4-(3,4- dihydro-1H-isoquinoiin-2- yl)-butyl]- benzenesulfonamide hydrochloride		413
83		1-Methyl-1H-imidazole-4-sulfonic acid [4-(3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- amide hydrochloride		349
84		5-Bromo-N-[4-(3,4-isoquinolin- 2-yl)-dihydro-1H- isoquinolin-2-yl)- butyl]-2,4-difluoro- benzenesulfonamide hydrochloride		459
85		6-Chloro-imidazo[2,1- b]thiazole-5-sulfonic acid [4-(3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide chloride		425
86		2-Oxo-2H-chromene-6-sulfonic acid [5-(3,4-dihydro-1H- isoquinolin-2-yl)- pentyl]-amide hydrochloride		427
87		3,5-Dichloro-N-[5-(3,4-dihydro- 1H-isoquinolin-2-yl)- pentyl]- benzenesulfonamide hydrochloride		427
88		2,5-Dichloro-N-[5-(3,4-dihydro- 1H-isoquinolin-2-yl)- pentyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.28 (m, 2 H), 1.42 (m, 2 H), 1.70 (m, 2 H), 2.88 (m, 2 H), 2.98 (m, 1 H), 3.08 (m, 3 H), 3.20 (m, 1 H), 3.66 (m, 1 H), 4.22 (dd, J=15.45, 5.78 Hz, 1 H), 4.47 (m, 1 H), 7.21 (m, 4 H), 7.71 (m, 2 H), 7.91 (s, 1 H), 8.12 (t, J=5.42 Hz, 1 H), 10.59 (s, 1 H)	427
89		5-Bromo-6-chloro-pyridine- 3-sulfonic acid [5-(3,4-dihydro- 1H-isoquinolin-2-yl)- pentyl]-amide		473
90		4-Chloro-N-[5-(3,4-dihydro- 1H-quinolin-2-yl)- pentyl]- benzenesulfonamide hydrochloride		393
91		3,5-Dichloro-N-[5-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)-pentyl]- benzenesulfonamide		487
92		2,5-Dichloro-N-[5-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)-pentyl]- benzenesulfonamide hydrochloride		487
93		5-Bromo-6-chloro-pyridine-3- sulfonic acid [5-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)- pentyl]-amide hydrochloride		532
94		4-Chloro-N-[5-(6,7-dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- pentyl]- benzenesulfonamide hydrochloride		453
95		2-Oxo-2H-chromene-6-sulfonic acid [4-(6,7-dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-amide hydrochloride		473
96		3,5-Dichloro-N-[4-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride		473
97		2,5-Dichloro-N-[4-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.46 (m, 2 H), 1.74 (m, 2 H), 2.89 (m, 3 H), 3.06 (m, 3 H), 3.23 (m, 1 H), 3.57 (m, 1H), 3.70 (s, 3 H), 3.72 (s, 3 H), 4.09 (m, 1H), 4.33 (d, J=14.94 Hz, 1 H), 6.77 (d, J=1 1.27 Hz, 2 H), 7.73 (m, 2 H), 7.91 (d, J=2.20 Hz, 1 H),
# 8.18 (t, J=5.71 Hz, 1 H), 10.49 (s, 1 H)	473
98		5-Bromo-6-chloro-pyridine-3- sulfonic acid [4-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]-amide		518
99		4-Chloro-N-[4-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-benzenesulfonamide		439
100		2-Oxo-2H-chromene-6-sulfonic acid [6-(3,4-dihydro-1H- isoquinolin-2-yl)- hexyl]-amide hydrochloride		441
101		3,5-Dichloro-N-[6-(3,4- dihydro-1H-isoquinolin-2-yl)- hexyl]- benzenesulfonamide hydrochloride		441
102		2,5-Dichloro-N-[6-(3,4- dihydro-1H-isoquinolin-2-yl)- hexyl]- benzenesulfonamide hydrochloride		441
103		5-Bromo-6-chloro-pyridine-3- sulfonic acid [6-(3,4- dihydro-1H-isoquinolin-2-yl)- hexyl]-amide hydrochloride		486
104		2,6-Dichloro-N-[6-(3,4- dihydro-1H-isoquinolin-2-yl)- hexyl]- benzenesulfonamide hydrochloride		441
105		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)- pentyl]-2-methyl-5-nitro- benzenesulfonamide hydrochloride		418
106		4-Bromo-N-[5-(3,4-dihydro- 1H-isoquinolin-2-yl)- pentyl]-2,5-difluoro- benzenesulfonamide hydrochloride		473
107		4-Chloro-N-[5-(3,4-dihydro- 1H-isoquinolin-2-yl)- pentyl]-2,5-dimethyl- benzenesulfonamide hydrochloride		421
108		N-[5-(3,4-Dihydro-1H- isoquinoiin-2-yl)-pentyl]- 4-isopropyl- benzenesulfonamide hydrochloride		401
109		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]- 3-methyl- benzenesulfonamide hydrochloride		373
110		3-Chloro-N-[5-(3,4-dihydro-1H- isoquinoiin-2-yl)-pentyl]- 4-fluoro- benzenesulfonamide hydrochloride		411
111		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]- 5-fluoro-2-methyl- benzenesulfonamide hydrochloride		391
112		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]- 3-methoxy- benzenesulfonamide hydrochloride		389
113		3-Chloro-N-[5-(3,4-dihydro-1H- isoquinolin-2-yl)-pentyl]- benzenesulfonamide hydrochloride		393
114		N-[5-(3,4-Dihydro-1H- isoquinolin-2-yl)-pentyl]- 3,4-dimethoxy- benzenesulfonamide hydrochloride		419
115		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-2,5-difluoro- benzenesulfonamide hydrochloride		441
116		5-Chloro-N-[4-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- 2,4-difluoro- benzenesulfonamide	1H NMR (300 MHz, DMSO-D6) δ ppm 1.42 (m, 4 H), 2.30 (m, 2 H), 2.52 (m, 2 H), 2.63 (m, 2 H), 2.89 (m, 2 H), 3.23 (m, 2 H), 3.65 (s, 3 H), 3.66 (s, 3 H), 6.56 (s, 1H), 6.61 (s, 1H), 7.80 (t, J=9.66 Hz, 1 H), 7.89 (t, J=7.69 Hz, 1 H), 8.20 (s, 1H)	475
117		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-2,3,4-trifluoro- benzenesulfonamide hydrochloride		459
118		2-Chloro-N-[4-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)- butyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.70 (m, 2 H), 2.86 (m, 3 H), 3.07 (m, 2 H), 3.18 (m, 2 H), 3.56 (m, 1 H), 3.70 (s, 3 H), 3.71 (s, 3 H), 4.10 (dd, J=14.86, 7.25 Hz, 1H), 4.33 (m, 1 H), 6.77 (d, J=11.57 Hz, 2 H), 7.53 (m, 1 H), 7.65 (ddd, J=14.86, 7.98,
# 1.76 Hz, 2 H), 7.97 (m, 2 H), 10.40 (s, 1 H)	439
119		N-[5-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-pentyl]-2,5- difluoro- benzenesulfonamide hydrochloride		455
120		5-Chloro-N-[5-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)- pentyl]-2,4-difluoro- benzenesulfonamide		489
121		N-[5-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-pentyl]-2,3,4- trifluoro- benzenesulfonamide hydrochloride		473
122		2-Chloro-N-[5-(6,7-dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- pentyl]- benzenesulfonamide hydrochloride		453
123		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-2,6-difluoro- benzenesulfonamide hydrochloride		441
124		2-Chloro-N-[4-(6,7-dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-4,5-difluoro- benzenesulfonamide		475
125		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H- isoquinolin-2-yl)- butyl]-2,4,5-trifluoro- benzenesulfonamide		459
126		3-Chloro-N-[4-(6,7-dimethoxy-3,4- dihydro-1H-isoquinolin-2- yl)-butyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.74 (m, 2 H), 2.78 (q, J=6.59 Hz, 2 H), 2.89 (m, 1H), 3.09 (m, 3 H), 3.19 (m, 1H), 3.59 (m, 1 H), 3.70 (s, 3 H), 3.72 (s, 3 H), 4.09 (m, 1 H), 4.35 (m, 1 H), 6.78 (d, J=9.52 Hz, 2 H), 7.64 (m, 1 H), 7.75 (m, 3 H), 7.90 (t, J=5.78 Hz, 1 H),
# 10.47 (s, 1 H)	439
127		N-[5-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2- yl)-pentyl]-2,6-difluoro- benzenesulfonamide hydrochloride		455
128		2-Chloro-N-[5-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)-pentyl]- 4,5-difluoro- benzenesulfonamide		489
129		N-[5-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2- yl)-pentyl]-2,4,5- trifluoro- benzenesulfonamide		473
130		3-Chloro-N-[5-(6,7- dimethoxy-3,4-dihydro- 1H-isoquinolin-2- yl)-pentyl]- benzenesulfonamide		453
131		Biphenyl-4-sulfonic acid [4-(6,7-dimethoxy-3,4- dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride		481
132		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-2-methyl-5-nitro- benzenesulfonamide hydrochloride		464
133		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-C-phenyl- methanesulfonamide hydrochloride		419
134		Biphenyl-4-sulfonic acid [5-(6,7-dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-pentyl]-amide		495
135		N-[5-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-pentyl]-C-phenyl- methanesulfonamide hydrochloride		433
136		Benzo[b]thiophene-3- sulfonic acid [4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-amide hydrochloride		401
137		7-Chloro-benzo[1,2,5]oxadiazole-4-sulfonic acid [4-(3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide		421
138		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)- butyl]-2,4-dinitro- benzenesulfonamide hydrochloride		435
139		Benzo[b]thiophene-2- sulfonic acid [4-(3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-amide hydrochloride		401
140		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 2,5-difluoro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.46 (m, 2 H), 1.75 (m, 2 H), 2.90 (m, 2 H), 3.01 (m, 1 H), 3.13 (m, 3 H), 3.24 (m, 1 H), 3.64 (m, 1 H), 4.21 (m, 1 H), 4.45 (m, 1 H), 7.23 (m, 4 H), 7.56 (m, 3 H), 8.19 (t, J=5.64 Hz, 1 H), 10.59 (s, 1 H)	381
141		4-Chloro-N-[4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-2,5- difluoro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.47 (m, 2 H), 1.75 (m, 2 H), 2.91 (q, J=6.69 Hz, 2 H), 3.01 (m, 1 H), 3.12 (m, 2 H), 3.23 (m, 2 H), 3.64 (m, 1 H), 4.21 (dd, J=14.64, 7.32 Hz, 1 H), 4.45 (d, J=15.67 Hz, 1H), 7.22 (m, 4 H), 7.77 (dd, J=8.27, 6.22 Hz, 1 H), 7.97 (dd, J=9.44,
# 5.78 Hz, 1 H), 8.28 (t, J=5.78 Hz, 1 H), 10.59 (s, 1H)	415
142		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 2,4,5-trifluoro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.45 (m, 2 H), 1.74 (m, 2 H), 2.92 (m, 3 H), 3.15 (m, 2 H), 3.24 (m, 2 H), 3.63 (m, 1 H), 4.21 (dd, J=15.23, 7.47 Hz, 1 H), 4.45 (m, 1 H), 7.22 (m, 4 H), 7.86 (m, 2 H), 8.22 (m, 1 H), 10.65 (s, 1 H)	399
143		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 2,6-difluoro- benzenesulfonamide hydrochloride		381
144		5-Chloro-N-[4-(3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-2,4-difluoro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.46 (m, 2 H), 1.76 (m, 2 H), 2.89 (q, J=6.74 Hz, 2 H), 3.01 (m, 1 H), 3.18 (m, 4 H), 3.61 (m, 1 H), 4.21 (dd, J=15.23, 7.47 Hz, 1 H), 4.45 (m, 1H), 7.16 (s, 1 H), 7.24 (m, 3 H), 7.85 (t, J=9.66 Hz, 1 H), 7.93 (t, J=7.69 Hz, 1 H), 8.24 (t, J=5.64 Hz,
# 1 H), 10.60 (s, 1 H)	415
145		2-Chloro-N-[4-(3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.73 (m, 2 H), 2.85 (q, J=6.74 Hz, 2 H), 3.01 (m, 1 H), 3.09 (m, 2 H), 3.23 (m, 2 H), 3.59 (m, 1 H), 4.20 (m, 1H), 4.43 (m, 1 H), 7.22 (m, 4 H), 7.53 (m, 1H), 7.63 (m, 2 H), 7.96 (m, 2 H), 10.57 (s, 1 H)	379
146		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)- butyl]-2,3-difluoro- benzenesulfonamide hydrochloride		381
147		2-Chloro-N-[4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-2,5- difluoro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.74 (m, 2 H), 2.87 (m, 2 H), 2.98 (m, 1 H), 3.11 (s, 3 H), 3.21 (s, 1 H), 3.60 (m, 1H), 4.21 (dd, J=14.28, 6.81 Hz, 1 H), 4.44 (m, 1H), 7.22 (m 4 H), 7.98 (m, 2 H), 8.19 (t, J=5.34 Hz, 1 H), 10.58 (s, 1 H)	415
148		Benzo[1,2,5]oxadiazole- 4-sulfonic acid [4- (3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride		387
149		3,4-Dichloro-N-[4-(3,4- dihydro-1H-isoquinolin-2-yl)- butyl]- benzenesulfonamide hydrochloride		413
150		N-[4-(6,7-Dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- 3,4-difluoro- benzenesulfonamide hydrochloride		441
151		2-Chloro-N-[4-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-4,5-difluoro- benzenesulfonamide hydrochloride		475
152		Benzo[1,2,5]oxadiazole- 4-sulfonic acid [4- (6,7-dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-amide		447
153		Benzo[1,2,5]thiadiazole- 4-sulfonic acid [4- (6,7-dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-amide		463
154		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-2,4- difluoro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.72 (m, 2 H), 2.86 (d, J=6.44 Hz, 2 H), 2.89 (m, 1 H), 3.10 (m, 4 H), 3.57 (m, 1 H), 3.69 (s, 3 H), 3.70 (s, 3 H), 4.09 (dd, J=15.08, 7.17 Hz, 1H), 4.32 (d, J=14.20 Hz, 1H), 6.76 (d, J=10.25 Hz, 2 H), 7.28 (t, J=8.35 Hz, 1 H), 7.53
# (m, 1H), 7.83 (m, 1H), 8.05 (t, J=5.42 Hz, 1 H), 10.47 (s, 1 H)	441
155		3,4-Dichloro-N-[4-(6,7- dimethoxy-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.73 (m, 2 H), 2.77 (m, 2 H), 2.88 (m, 1 H), 3.09 (m, 4 H), 3.58 (m, 1H), 3.69 (s, 3 H), 3.70 (s, 3 H), 4.09 (m, 1 H), 4.34 (m, 1 H), 6.76 (d, J=9.96 Hz, 2 H), 7.74 (d, J=8.20 Hz, 1 H), 7.88 (d, J=7.91 Hz, 1 H), 7.97 (s, 2 H), 10.47
# (s, 1H)	473
156		2,3,4-Trichloro-N-[4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.46 (m, 2 H), 1.75 (m, 2 H), 2.87 (m, 2 H), 3.00 (m, 1 H), 3.14 (d, J=5.27 Hz, 2 H), 3.24 (m, 2 H), 366 (d, J=2.34 Hz, H), 4.23 (dd, J=15.52, 7.76 Hz, 1H), 4.46 (d, J=15.08 Hz, 1 H), 7.23 (m, 4 H), 7.87 (m, 1 H), 7.96 (m, 1 H), 8.28 (t, J=5.56 Hz, 1 H),
# 10.44 (s, 1 H)	447
157		2-Chloro-N-[4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-6-methyl- benzenesulfonamide hydrochloride		393
158		Thiophene-3-sulfonic acid [4-(3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.47 (m, 2 H), 1.76 (m, 2 H), 2.81 (q, J=6.39 Hz, 2 H), 3.03 (m, 1 H), 3.12 (m, 2 H), 3.26 (m, 2 H), 3.66 (m, 1 H), 4.21 (m, 1 H), 4.46 (m, 1 H), 7.25 (ddd, J=6.26, 3.51, 3.26 Hz, 4 H), 7.20 (m, 1 H), 7.25 (m, 3 H), 7.33 (m, 1 H), 7.66 (m, 1H), 7.76 (dd, J=5.12, 2.93 Hz,
# 1 H), 8.15 (dd, J=2.93, 1.32 Hz, 1H), 10.49 (s, 1H)	351
159		2,4,6-Trichloro-N-[4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.49 (m, 2 H),1.77 (m, 2 H), 2.93 (q, J=6.64 Hz, 2 H), 3.01 (m, 1 H), 3.12 (m, 2 H), 3.26 (m, 2 H), 3.64 (m, 1 H), 4.21 (m, 1 H), 4.45 (m, 1 H), 7.23 (m, 4 H), 7.88 (s, 2 H), 8.33 (t, J=5.71 Hz, 1 H), 10.60 (s, 1 H)	447
160		2-Bromo-N-[4-(3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-4,6-difluoro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.49 (m, 2 H), 1.76 (m, 2 H), 2.94 (q, J=6.39 Hz, 2 H), 3.04 (m, 1 H), 3.15 (m, 2 H), 3.29 (m, 2 H), 3.65 (m, 1 H), 4.25 (m, 1H), 4.47 (m, 1 H), 7.22 (m, 4 H), 7.62 (ddd, J=1 1.57, 8.93, 2.64 Hz, 1 H), 7.76 (m, 1 H), 8.29 (t, J=5.86 Hz, 1 H), 10.28 (s, 1 H)	459
161		4-Bromo-N-[4-(3,4-dihydro- 1H-isoquinoiin-2-yl)- butyl]-2-trifluoromethoxy- benzenesulfonamide		507
162		2,3,4-Trichloro-N-[4-(6,7- dimethoxy-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-benzenesulfonamide		507
163		2-Chloro-N-[4-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-6-methyl- benzenesulfonamide		453
164		Thiophene-3-sulfonic acid [4-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- amide hydrochloride		411
165		2,4,6-Trichloro-N-[4-(6,7- dimethoxy-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]- benzenesulfonamide hydrochloride		507
166		2-Bromo-N-[4-(6,7-dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-4,6-difluoro- benzenesulfonamide hydrochloride		519
167		4-Bromo-N-[4-(6,7-dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-2- trifluoromethoxy- benzenesulfonamide		567
168		2,3,4-Trichloro-N-[5-(7-nitro- 3,4-dihydro-1H- isoquinolin-2-yl)-pentyl]- benzenesulfonamide hydrochloride		506
169		2-Chloro-6-methyl-N-[5-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)-pentyl]- benzenesulfonamide hydrochloride		452
170		Thiophene-3-sulfonic acid [5-(7-nitro-3,4-dihydro- 1H-isoquinolin-2-yl)- pentyl]-amide hydrochloride		410
171		2,4,6-Trichloro-N-[5-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)- pentyl]-benzenesulfonamide hydrochloride		506
172		2-Bromo-4,6-difluoro-N-[5- (7-nitro-3,4-dihydro-1H- isoquinolin-2-yl)- pentyl]- benzenesulfonamide hydrochloride		518
173		4-Bromo-N-[5-(7-nitro-3,4- dihydro-1H-isoquinolin- 2-yl)-pentyl]-2- trifluoromethoxy- benzenesulfonamide hydrochloride		566
174		3,4-Difluoro-N-[5-(7-nitro- 3,4-dihydro-1H- isoquinolin-2-yl)-pentyl]- benzenesulfonamide hydrochloride		440
175		2-Chloro-4,5-difluoro- N-[5-(7-nitro-3,4- dihydro-1H-isoquinolin- 2-yl)-pentyl]- benzenesulfonamide		474
176		Benzo[1,2,5]oxadiazole- 4-sulfonic acid [5- (7-nitro-3,4-dihydro- 1H-isoquinolin-2-yl)- pentyl]-amide hydrochloride		446
177		Benzo[1,2,5]thiadiazole- 4-sulfonic acid [5-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)- pentyl]-amide hydrochloride		462
178		2,4-Difluoro-N-[5-(7-nitro- 3,4-dihydro-1H- isoquinolin-2-yl)-pentyl]- benzenesulfonamide hydrochloride		440
179		3,4-Dichloro-N-[5-(7-nitro- 3,4-dihydro-1H- isoquinolin-2-yl)-pentyl]- benzenesulfonamide hydrochloride		472
180		2,3,4-Trichloro-N-[4-(7-nitro- 3,4-dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide		494
181		2-Chloro-6-methyl-N-[4-(7-nitro- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide		438
182		Thiophene-3-sulfonic acid [4-(7-nitro-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-amide		396
183		2,4,6-Trichloro-N-[4-(7-nitro- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide		492
184		2-Bromo-4,6-difluoro-N-[4-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide		504
185		4-Bromo-N-[4-(7-nitro-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-2- trifluoromethoxy- benzenesulfonamide		552
186		3,4-Difluoro-N-[4-(7-nitro- 3,4-dihydro-1H-isoquinolin-2- yl)-butyl]- benzenesulfonamide		426
187		2-Chloro-4,5-difluoro-N-[4- (7-nitro-3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-benzenesulfonamide		460
188		Benzo[1,2,5]oxadiazole- 4-suifonic acid [4- (7-nitro-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-amide		432
189		Benzo[1,2,5]thiadiazole- 4-sulfonic acid [4- (7-nitro-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-amide		448
190		2,4-Difluoro-N-[4-(7-nitro- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide		426
191		3,4-Dichloro-N-[4-(7-nitro- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide		458
192		4-Methyl-N-[4-(7-nitro-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-benzenesulfonamide		404
193		2-Naphthalen-1-yl- ethanesulfonic acid [4-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide		468
194		Quinoline-8-sulfonic acid [4-(7-nitro-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-amide		441
195		3-Nitro-N-[4-(7-nitro-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-benzenesulfonamide		435
196		2-Methyl-5-nitro-N-[4-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide		449
197		4-Bromo-2,5-difluoro-N-[4- (7-nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide		504
198		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-4-methyl- benzenesulfonamide		419
199		2-Naphthalen-1-yl- ethanesulfonic acid [4- (6,7-dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-amide		483
200		Quinoline-8-sulfonic acid [4-(6,7-dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-amide		456
201		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-3-nitro- benzenesulfonamide		450
202		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-2-methyl-5-nitro- benzenesulfonamide		464
203		4-Bromo-N-[4-(6,7-dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-2,5-difluoro- benzenesulfonamide		519
204		3-Methyl-N-[4-(7-nitro- 3,4-dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride		404
205		5-Fluoro-2-methyl-N-[4-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride		422
206		4-Isopropoxy-N-[4-(7-nitro- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride		448
207		3-Chloro-N-[4-(7-nitro-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]- benzenesulfonamide hydrochloride		424
208		3,4-Dimethoxy-N-[4-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride		450
209		2,3,4,5,6-Pentafluoro-N-[4- (7-nitro-3,4-dihydro- 1H-isoquinolin hydrochloride		480
210		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-3-methyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.43 (m, 2 H), 1.73 (m, 2 H), 2.38 (s, 3 H), 2.74 (q, J=6.59 Hz, 2 H) 2.87 (m, 1 H), 3.07 (m, 3 H), 3.17 (m, 1 H), 3.58 (m, 1 H), 3.70 (s, 3 H), 3.72 (s, 3 H), 4.11 (s, 1 H), 4.35 (m, 1 H), 6.77 (d, J=9.66 Hz, 2 H), 7.46 (m, 2 H), 7.60 (m,
# 3 H), 10.52 (s, 1 H)	419
211		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-5-fluoro-2- methyl-benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.43 (m, 2 H), 1.72 (m, 2 H), 2.53 (s, 3 H), 2.82 (q, J=6.74 Hz, 2 H), 2.91 (m, 1 H), 3.10 (m, 3 H), 3.25 (m, 1 H), 3.58 (m, 1H), 3.70 (s, 3 H), 3.72 (s, 3 H), 4.07 (m, 1 H), 4.33 (m, 1 H), 6.75 (s, 1H), 6.79 (s, 1 H) 7.42 (m, 2 H),
# 7.56 (dd, J=8.93, 2.78 Hz, 1H), 7.94 (t, J=5.86 Hz, 1 H), 10.47 (s, 1H)	437
212		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-4-isopropoxy- benzenesulfonamide hydrochloride		463
213		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-3,4-dimethoxy- benzenesulfonamide hydrochloride		465
214		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-2,3,4,5,6-pentafluoro- benzenesulfonamide hydrochloride		495
215		4-Chloro-2,5-dimethyl-N-[4- (7-nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride		452
216		3-Methoxy-N-[4-(7-nitro- 3,4-dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride		420
217		4-Isopropyl-N-[4-(7-nitro- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride		432
218		3-Chloro-4-fluoro-N-[4-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride		442
219		2,3,4,5,6-Pentamethyl-N-[4-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide		460
220		4-Chloro-N-[4-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- 2,5-dimethyl- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.43 (m, 2 H), 1.71 (m, 2 H), 2.34 (s, 3 H), 2.77 (q, J=6.78 Hz, 2 H), 2.91 (m, 1H), 3.09 (m, 3 H), 3.24 (m, 1 H), 3.55 (m, 1 H), 3.70 (s, 3 H), 3.72 (s, 3 H), 4.09 (m, 1 H), 4.33 (m, 1 H), 6.75 (s, 1H), 6.79 (s, 1 H),
# 7.50 (s, 1 H), 7.75 (s, 1 H), 7.81 (t, J=5.78 Hz, 1 H), 10.51 (s, 1 H)	467
221		N-[5-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2- yl)-butyl]-3-methoxy- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.75 (m, 2 H), 2.76 (q, J=6.59 Hz, 2 H), 2.90 (m, 1H), 3.09 (m, 2 H), 3.18 (m, 2 H), 3.61 (m, 1 H), 3.71 (s, 3 H), 3.72 (s, 3 H), 3.82 (s, 3 H), 4.08 (m, 1 H), 4.34 (d, J=14.64 Hz, 1H), 6.76 (s, 1H), 6.80 (s,
# 1 H), 7.21 (d, J=8.20 Hz, 1 H), 7.29 (m, 1 H), 7.35 (d, J=7.91 Hz 1 H), 7.52 (t, J=7.91 Hz, 1 H), 7.71 (s, 1 H), 10.25 (s, 1 H)	435
222		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2- yl)-butyl]-4-isopropyl- benzenesulfonamide hydrochloride		447
223		3-Chloro-N-[4-(6,7-dimethoxy- 3,4-dihydro-1H-isoquinolin- 2-yl)-butyl]-4-fluoro- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.44 (m, 2 H), 1.75 (m, 2 H), 2.79 (q, J=6.59 Hz, 2 H), 2.89 (m, 1H), 3.09 (m, 3 H), 3.23 (m, 1 H), 3.58 (m, 1 H), 3.70 (s, 3 H), 3.72 (s, 3 H), 4.09 (m, 1 H), 4.34 (d, J=14.20 Hz, 1 H), 6.76 (s, 1H), 6.79 (s, 1 H), 7.67 (t, J=8.93 Hz,
# 1 H), 7.82 (m, 1 H), 7.92 (s, 1 H), 7.98 (dd, J=6.88, 2.20 Hz, 1 H), 10.51 (s, 1 H)	457
224		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-2,3,4,5,6-pentamethyl- benzenesulfonamide		475
225		5-Dimethylamino- naphthalene-1-sulfonic acid [4-(6,7-dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-amide dihydrochloride		498
226		2-(2,2,2-Trifluoro-acetyl)-1,2,3,4- tetrahydro-isoquinoline-6- sulfonic acid [4-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- amide hydrochloride		541
227		4-Acetyl-N-[4-(7-nitro-3,4- dihydro-1H-isoquinolin-2- yl)-butyl]- benzenesulfonamide hydrochloride		432
228		4-Methanesulfonyl-N-[4-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride		468
229		Biphenyl-4-sulfonic acid [4-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride		466
230		N-[4-(7-Nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- C-phenyl-methanesulfonamide hydrochloride		404
231		2,5-Dimethoxy-N-[4-(7-nitro- 3,4-dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride		450
232		2-(2,2,2-Trifluoro-acetyl)-1,2,3,4- tetrahydro-isoquinoline-6- sulfonic acid [4-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- amide hydrochloride		556
233		4-Acetyl-N-[4-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride		447
234		N-[4-(6,7-Dimethoxy-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-4-methanesulfonyl- benzenesulfonamide hydrochloride		483
235		N-[4-(6,7-Dimethoxy-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-2,5-dimethoxy- benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.42 (m, 2 H), 1.72 (m, 2 H), 2.78 (q, J=6.44 Hz, 2 H), 2.91 (m, 1 H), 3.09 (m, 3 H), 3.25 (m, 1H), 3.55 (m, 1 H), 3.70 (s, 3 H), 3.71 (s, 3 H), 3.73 (s, 3 H), 3.83 (s, 3 H), 4.10 (m, 1 H), 4.34 (m, 1 H), 6.75 (s, 1 H), 6.79 (s, 1 H),
# 7.17 (m, 2 H), 7.22 (m, 1 H), 7.32 (m, 1 H), 10.29 (s, 1 H)	465
236		2,3-Dichloro-N-[4-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride		458
237		2,4,5-Trichloro-N-[4-(7-nitro- 3,4-dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride		492
238		5-Bromo-2-methoxy-N-[4-(7-nitro- 3,4-dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride		498
239		N-[4-(7-Nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- 4-trifluoromethoxy- benzenesulfonamide hydrochloride		474
240		2-Nitro-N-[4-(7-nitro-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-4- trifluoromethyl- benzenesulfonamide hydrochloride		503
241		3-Fluoro-N-[4-(7-nitro-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride		408
242		2,3-Dichloro-N-[4-(6,7- dimethoxy-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.45 (m, 2 H), 1.72 (m, 2 H), 2.87 (m, 3 H), 3.09 (m, 3 H), 3.22 (m, 1 H), 3.57 (m, 1H), 3.70 (s, 3 H), 3.71 (s, 3 H), 4.07 (m, 1 H), 4.33 (m, 1 H), 6.75 (s, 1 H), 6.79 (s, 1H), 7.56 (t, J=7.98 Hz, 1H), 7.94 (ddd, J=7.98, 5.42, 1.54 Hz, 2 H),
# 8.18 (t, J=5.64 Hz, 1 H), 10.29 (s, 1H)	473
243		2,4,5-Trichloro-N-[4- (6,7-dimethoxy-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-benzenesulfonamide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.45 (m, 2 H), 1.69 (m, 2 H), 2.89 (m, 3 H), 3.10 (m, 3 H), 3.24 (m, 1 H), 3.58 (m, 1 H), 3.70 (s, 3 H), 3.71 (s, 3 H), 4.10 (m, 1 H), 4.34 (m, 1 H), 6.75 (s, 1 H), 6.79 (s, 1 H), 8.06 (s, 1 H), 8.13 (s, 1 H), 8.26 (t, J=5.64 Hz, 1 H), 10.18 (s, 1 H)	507
244		4-Bromo-N-[4-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- 2-methoxy- benzenesulfonamide hydrochloride		513
245		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-4- trifluoromethoxy- benzenesulfonamide hydrochloride		489
246		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-2-nitro-4- trifluoromethyl- benzenesulfonamide		518
247		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-3-fluoro- benzenesulfonamide hydrochloride		423
248		2,4-Dichloro-N-[4-(7-nitro- 3,4-dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride		458
249		2,4,6-Trimethyl-N-[4-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride		432
250		N-[4-(7-Nitro-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-2-trifluoromethyl- benzenesulfonamide hydrochloride		458
251		2-Bromo-N-[4-(7-nitro-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide hydrochloride		468
252		4-Methoxy-2,3,6-trimethyl-N- [4-(7-nitro-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]- benzenesulfonamide hydrochloride		462
253		2-Cyano-N-[4-(7-nitro-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]- benzenesulfonamide		415
254		2,4-Dichloro-N-[4-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride		473
255		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-2,4,6- trimethyl- benzenesulfonamide hydrochloride		447
256		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-2- trifluoromethyl- benzenesulfonamide hydrochloride		473
257		2-Bromo-N-[4-(6,7- dimethoxy-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]- benzenesulfonamide hydrochloride		483
258		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-4-methoxy- 2,3,6-trimethyl- benzenesulfonamide hydrochloride		477
259		2-Cyano-N-[4-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)- butyl]- benzenesulfonamide hydrochloride		430
260		5-Bromo-N-[4-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-2-methoxy- benzenesulfonamide oxalate		527
261		5-Bromo-N-[4-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-2-methoxy- benzenesulfonamide oxalate		513
262		N-[6-(3,4-Dihydro-1H- isoquinolin-2-yl)-hexyl]- 3-methyl- benzenesulfonamide hydrochloride		387
263		N-[6-(3,4-Dihydro-1H- isoquinolin-2-yl)-hexyl]- 3-fluoro- benzenesulfonamide hydrochloride		391
264		2,4-Dichloro-N-[6-(3,4- dihydro-1H-isoquinolin- 2-yl)-hexyl]- benzenesulfonamide hydrochloride		441
265		2,4,5-Trichloro-N-[6-(3,4- dihydro-1H-isoquinolin- 2-yl)-hexyl]- benzenesulfonamide hydrochloride		475
266		5-Bromo-N-[6-(3,4-dihydro- 1H-isoquinolin-2-yl)- hexyl]-2-methoxy- benzenesulfonamide hydrochloride		481
267		4-Chloro-N-[6-(3,4-dihydro- 1H-isoquinoiin-2-yl)- hexyl]-2,5-dimethyl- benzenesulfonamide hydrochloride		435
268		Naphthalene-1-sulfonic acid [6-(3,4-dihydro-1H- isoquinolin-2-yl)- hexyl]-amide hydrochloride		423
269		Naphthalene-2-sulfonic acid [6-(3,4-dihydro-1H- isoquinolin-2-yl)- hexyl]-amide oxalate		423
270		Benzo[b]thiophene-2- sulfonic acid [6-(3,4- dihydro-1H-isoquinolin- 2-yl)-hexyl]-amide oxalate		429
271		Thiophene-2-sulfonic acid [6-(3,4-dihydro-1H- isoquinolin-2-yl)-hexyl]- amide hydrochloride		379
272		N-[6-(3,4-Dihydro-1H- isoquinolin-2-yl)-hexyl]- 2-nitro- benzenesulfonamide hydrochloride		418
273		5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid [6-(3,4-dihydro-1H- isoquinolin-2-yl)- hexyl]-amide hydrochloride		477
274		4-Methyl-naphthalene-1- sulfonic acid [4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-amide hydrochloride		409
275		4-Methyl-naphthalene-1- sulfonic acid [5-(3,4- dihydro-1H-isoquinolin- 2-yl)-pentyl]-amide hydrochloride		423
276		4-Methyl-naphthalene-1- sulfonic acid [6-(3,4- dihydro-1H-isoquinolin- 2-yl)-hexyl]-amide hydrochloride		437
277		4-Methyl-naphthalene-1- sulfonic acid [4-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride		469
278		4-Methyl-naphthalene-1- sulfonic acid [5-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)- pentyl]-amide hydrochloride		483
279		4-Methyl-naphthalene-1- sulfonic acid [4-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- amide hydrochloride		454
280		4-Methyl-naphthalene-1- sulfonic acid [5-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)-pentyl]- amide hydrochloride		468
281		5-Isoxazol-5-yl- thiophene-2-sulfonic acid [4-(3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- amide hydrochloride	1H NMR (300 MHz, DMSO-D6) δ ppm 1.50 (m, 2 H),1.78 (m, 2 H), 2.92 (q, J=6.74 Hz, 2 H), 3.01 (m, 1 H), 3.13 (m, 3 H), 3.22 (m, 1 H), 3.64 (m, 1 H), 4.22 (dd, J=15.45, 8.13 Hz, 1 H), 4.46 (m, 1 H), 7.10 (s, 1 H), 7.22 (m, 4 H), 7.69 (d, J=3.95 Hz, 1 H), 7.76 (d, J3.95 Hz, 1 H), 8.20
# (t, J=5.78 Hz, 1 H), 8.73 (d, J=1.90 Hz, 1 H), 10.54 (s, 1 H)	418
282		5-Isoxazol-5-yl-thiophene- 2-sulfonic acid [4-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride		478
283		5-Isoxazol-5-yl-thiophene- 2-sulfonic acid [5-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)- pentyl]-amide hydrochloride		492
284		5-Isoxazol-5-yl-thiophene- 2-sulfonic acid [4-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride		463
285		5-Isoxazol-5-yl-thiophene- 2-sulfonic acid [5-(7- nitro-3,4-dihydro-1H- isoquinolin-2-yl)- pentyl]-amide hydrochloride		477
286		3,5-Dichloro-N-[4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-4-hydroxy- benzenesulfonamide hydrochloride		429
287		3,5-Dichloro-N-[4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-2-hydroxy- benzenesulfonamide hydrochloride		429
288		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 2-methoxy-4-methyl- benzenesulfonamide hydrochloride		389
289		N-[4-(3,4-Dihydro-1H- isoquinolin-2-yl)-butyl]- 2,4-difluoro- benzenesulfonamide hydrochloride		381
290		3,5-Dichloro-4-hydroxy- benzenesulfonic acid 2,6-dichloro-4-[4-(3,4-dihydro- 1H-isoquinolin-2-yl)- butylsulfamoyl]- phenyl ester hydrochloride		653
291		3,5-Dichloro-2-hydroxy- benzenesulfonic acid 2,4-dichloro-6-[4-(3,4-dihydro- 1H-isoquinolin-2-yl)- butylsulfamoyl]- phenyl ester hydrochloride		653
292		4-Chloro-naphthalene-1- sulfonic acid [4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-amide hydrochloride		429
293		4-Fluoro-naphthalene-1- sulfonic acid [4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-amide hydrochloride		413
294		Dibenzofuran-2- sulfonic acid [4-(3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-amide hydrochloride		435
295		2,3-Dihydro-benzofuran-5- sulfonic acid [4-(3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-amide hydrochloride		387
296		Biphenyl-2-sulfonic acid [4-(3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- amide hydrochloride		421
297		1,2-Dimethyl-1H-imidazole- 4-sulfonic acid [4-(3,4- dihydro-1H-isoquinolin-2-yl)- butyl]-amide hydrochloride		363
298		5-Isoxazol-5-yl-thiophene-2- sulfonic acid [4-(7- pyrrol-1-yl-3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride		483
299		4-Chloro-N-[4-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- 2,5-difluoro- benzenesulfonamide hydrochloride		475
300		4-Bromo-N-[4-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- benzenesulfonamide hydrochloride		483
301		5-Chloro-3-methyl- benzo[b]thiophene-2- sulfonic acid [4-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- amide hydrochloride		509
302		Naphthalene-1-sulfonic acid [4-(6,7-dimethoxy-3,4- dihydro-1H-isoquinolin-2- yl)-butyl]-amide hydrochloride		455
303		Naphthalene-2-sulfonic acid [4-(6,7-dimethoxy-3,4- dihydro-1H-isoquinolin-2- yl)-butyl]-amide hydrochloride		455
304		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2- yl)-butyl]- benzenesulfonamide hydrochloride		405
305		Thiophene-2-sulfonic acid [4- (6,7-dimethoxy-3,4- dihydro-1H-isoquinolin-2- yl)-butyl]-amide hydrochloride		411
306		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2- yl)-butyl]-3-trifluoromethyl- benzenesulfonamide hydrochloride		473
307		2,6-Dichloro-N-[4-(6,7- dimethoxy-3,4-dihydro-1H- butyl]-benzenesulfonamide		473
308		5-Bromo-N-[4-(6,7-dimethoxy- 3,4-dihydro-1H- isoquinolin-2-yl)-butyl]- 2,4-difluoro- benzenesulfonamide hydrochloride		519
309		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2- yl)-butyl]-4-ethyl- benzenesulfonamide hydrochloride		433
310		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2- yl)-butyl]-2-methoxy- 4-methyl- benzenesulfonamide hydrochloride		449
311		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2- yl)-butyl]-4-methoxy- benzenesulfonamide hydrochloride		435
312		1-Methyl-1H-imidazole-4- sulfonic acid [4-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride		409
313		Benzo[b]thiophene-2- sulfonic acid [4-(6,7- dimethoxy-3,4-dihydro-1H- isoquinoiin-2-yl)- butyl]-amide hydrochloride		461
314		6-Chloro-imidazo[2,1-b]thiazole-5-sulfonic acid [4-(6,7-dimethoxy-3,4- dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride		485
315		Benzo[b]thiophene-3- sulfonic acid [4-(6,7- dimethoxy-3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride		461
316		7-Chloro-benzo[1,2,5]oxadiazole-4-sulfonic acid [4- (6,7-dimethoxy-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-amide		481
317		Thiophene-3-sulfonic acid [4-(6,7-dimethoxy-3,4- dihydro-1H- isouinolin-2-yl)- butyl]-amide		411
318		3-{4-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin-2-yl)- butylsulfamoyl]-phenyl}- propionic acid methyl ester hydrochloride		491
319		3-Bromo-N-[4-(6,7- dimethoxy-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]- benzenesulfonamide hydrochloride		483
320		4-tert-Butyl-N-[4-(6,7- dimethoxy-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]- benzenesulfonamide hydrochloride		461
321		N-[4-(6,7-Dimethoxy-3,4- dihydro-1H-isoquinolin- 2-yl)-butyl]-2- methanesulfonyl- benzenesulfonamide hydrochloride		483
322		3-Chloro-N-[4-(6,7- dimethoxy-3,4-dihydro- 1H-isoquinolin-2-yl)- butyl]-2-methyl- benzenesulfonamide hydrochloride		453
323		5-Dimethylamino- naphthalene-1-sulfonic acid [4-(7-nitro- 3,4-dihydro-1H- isoquinolin-2-yl)- butyl]-amide hydrochloride		483

Biological Assays Radioligand Binding

Radioligand binding assays were performed using the Cloned Human Serotonin Receptor, subtype 7 (h5HT₇), expressed in CHO cells, coated on Flashplate (Basic FlashPlate Cat.: SMP200) from PerkinElmer (Cat.: 6120512). The protocol assay was essentially the recommended protocol in the Technical Data Sheet by PerkinEmer Life and Analytical Sciences. The Mass membrane protein/well was typically 12 μg and the Receptor/well was about 9-10 fmoles. The Flashplate were let equilibrate at room temperature for one hour before the addition of the components of the assay mixture. The binding buffer was: 50 mM Trish-CHl, pH 7.4, containing 10 mM MgCl₂, 0.5 mM EDTA and 0.5% BSA. The radioligand was [¹²⁵I]LSD at a final concentration of 0.82 nM. Nonspecific binding was determined with 50 μM of Clozapine. The assay volume was 25 μl. TopSeal-A were applied onto Flashplate microplates and they were incubated at room temperature for 240 minutes in darkness. The radioactivity were quantified by liquid scintillation spectrophotometry (Wallac 1450 Microbeta Trilux) with a count delay of 4 minutes prior to counting and a counting time of 30 seconds per well. Competition binding data were analyzed by using the LIGAND program (Munson and Rodbard, LIGAND: A versatile, computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107: 220-239, 1980) and assays were performed in triplicate determinations for each point. Results for representative compounds are given in the table 2 below:

TABLE 2
COMPOUND 5-HT7 IC-50 (nM)
2        59.2
5        33.2
116      31.1
118      39.2
140      60.8
142      80.4
151      39
160      74.4
210      37.3
220      67.4
235      68.4
257      57.2

Claims

1. A compound of the formula I:

2. A compound according to claim 1 characterized in that n is 4 or 5.

3. A compound according to claim 1 characterized in that W is an aromatic group selected from substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclyl.

4. A compound according to claim 3 characterized in that W is selected from alkyl, alkoxy and/or halo substituted phenyl.

5. A compound according to claim 1 characterized in that R5, R6 and R7 are H.

6. A compound according to claim 1 characterized in that R1 and R4 are H.

7. A compound according to claim 5 wherein R2 and R3 are alkoxy.

8. A process for the preparation of a compound of formula (I) or a salt, isomer or solvate thereof as claimed in claim 1, which comprises the coupling of a compound of Formula (II):

9. A pharmaceutical composition which comprises a compound as defined in claim 1 or a pharmaceutically acceptable salt, prodrug, isomer or solvate thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

10. A pharmaceutical composition according to claim 9 for oral administration.

11. A method of manufacturing a medicament comprising combining a compound as defined in claim 1 or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof and a pharmaceutically acceptable carrier, adjuvant or vehicle.

12. A method according to claim 11 wherein the medicament is for the treatment of a 5-HT7 mediated disease or condition.

13. A method according to claim 12 wherein the disease is sleep disorder, shift worker syndrome, jet lag, depression, seasonal affective disorder, migraine, anxiety, psychosis, schizophrenia, pain, cognition and memory disorders, neuronal degeneration resulting from ischemic events, cardiovascular disease, irritable bowel syndrome, inflammatory bowel disease, spastic colon or urinary incontinence.

14. A method for treating a central nervous disorder comprising administering to a patient in need thereof a therapeutically effective amount of a compound as defined in claim 1, or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof.

15. A compound according to claim 2 characterized in that n is 4.

16. A compound according to claim 3 characterized in that W is substituted or unsubstituted phenyl.

17. A compound according to claim 7 wherein R2 and R3 are methoxy.

18. A compound according to claim 6 wherein R2 and R3 are alkoxy.

19. A compound according to claim 18 wherein R2 and R3 are methoxy.

20. A process according to claim 8 wherein X is Cl.

21. A method according to claim 13 wherein the cardiovascular disease is hypertension.

22. A method for preventing a central nervous disorder comprising administering to a patient in need thereof a therapeutically effective amount of a compound as defined in claim 1, or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof.