Claims
- 1. A compound of the formula: ##STR13## where X' is chloro; R.sub.1 ' is lower alkyl having 1 to 4 carbon atoms;
- R.sub.2 ' and R.sub.3 ' are both hydrogen;
- R.sub.4 ' is fluoro, chloro, or trifluoromethyl, and
- R.sub.5 ' is hydrogen fluoro, chloro, or trifluoromethyl;
- provided that when R.sub.4 ' is fluoro or chloro, R.sub.5 ' is also independently fluoro or chloro and in the position on the ring para to R.sub.4 ' and that when R.sub.4 ' and R.sub.5 ' are both trifluoromethyl, they are on other than an adjacent carbon atom, or a pharmaceutically acceptable acid addition salt thereof.
- 2. The compound, which is 4-bromo-2-(3-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyridazin-3(2H)-one.
- 3. The compound according to claim 1, which is 4-chloro-2-(2-fluoro-5-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyridazin-3(2H)-one.
- 4. The compound of claim 1, which is 4-chloro-2-(2-chloro-5-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyridazin-3(2H)-one.
- 5. The compound of claim 1, which is 4-chloro-2-(4-chloro-3-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyridazin-3(2H)-one.
- 6. The compound of claim 1, which is 4-chloro-2-(3-trifluoromethylphenyl)-5-(1-ethylhydrazino)-pyridazin-3(2H)-one.
- 7. The compound, which is 4-chloro-2-(3trifluoromethylphenyl)-5-hydrazinopyridazin-3(2H)-one.
- 8. The compound of claim 1, which is 4-chloro-2-(3-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyridazin-3(2H)-one.
- 9. The compound of claim 1, which is 4-chloro-2-(2,5-dichlorophenyl)-5-(1-methylhydrazino)-pyridazin-3(2H)-one.
- 10. The compound of claim 1, which is 4-chloro-2-(3,5-ditrifluoromethylphenyl)-5-(1-methylhydrazino-pyridazin-3(2H)-one.
- 11. A pharmaceutical composition useful in inducing sleep comprising 37.5 to 2000 milligrams of a compound according to claim 1 and a pharmaceutically acceptable carrier therefore.
- 12. A method of inducing sleep which comprises administering 37.5 to 2000 milligrams of a compound according to claim 1.
Parent Case Info
This application is a continuation-in-part of copending U.S. Patent application, Ser. No. 442,748, abandoned, filed Feb. 15, 1974, which in turn is a continuation-in-part of our copending application, Ser. No. 409,921, filed Oct. 26, 1973, now abandoned, which in turn is a continuation-in-part of our copending application, Ser. No. 343,889, filed Mar. 22, 1973, now abandoned, which in turn is a continuation-in-part of our application, Ser. No. 291,760, filed Sept. 25, 1972, now abandoned, which in turn is a continuation-in-part of our application, Ser. No. 227,269, filed Feb. 17, 1972, now abandoned, which in turn is a continuation-in-part of application, Ser. No. 197,401, filed Nov. 10, 1971, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3193553 |
Reicheneder |
Jul 1965 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
2,254,564 |
May 1973 |
DT |
Continuation in Parts (6)
|
Number |
Date |
Country |
Parent |
442748 |
Feb 1974 |
|
Parent |
409921 |
Oct 1973 |
|
Parent |
343889 |
Mar 1973 |
|
Parent |
291760 |
Sep 1972 |
|
Parent |
227269 |
Feb 1972 |
|
Parent |
197401 |
Nov 1971 |
|