5-Iodo-6-oxo-3-(2'-arylmethoxy-1'-hydroxyethyl)-4-hydroxy-hexanoic acid, .gamma.-lactone dialkyl acetals

Abstract

The present specification provides novel intermediates and novel processes for the synthesis of Thromboxane B.sub.2 (11a-homo-11a-oxa-PGF.sub.2.alpha.), its 15-epimer, and various carboxy derivatives thereof. In particular, there are disclosed various bicyclic tetrahydrofuran-containing lactones useful in the above processes, and corresponding acyclic lactones.

Description

Claims

1. A thromboxane intermediate of the formula ##STR1## wherein R.sub.34 is an arylmethyl hydroxy-hydrogen replacing group selected from the group consisting of

(a) benzyl,

(b) benzyl substituted by 1 to 5 alkyl of 1 to 4 carbon atoms, inclusive, chloro, bromo, iodo, fluoro, nitro, phenylalkyl of 7 to 12 carbon atoms, inclusive,

(c) benzhydryl,

(d) benzhydryl substituted by one to ten alkyl of one to four carbon atoms, inclusive, chloro, bromo, iodo, fluoro, nitro, phenylalkyl of 7 to 12 carbon atoms, inclusive,

(e) trityl, and

(f) trityl substituted by 1 to 15 alkyl of 1 to 4 carbon atoms, inclusive, chloro, bromo, iodo, fluoro, nitro, phenylalkyl of 7 to 12 carbon atoms, inclusive; and

Wherein R.sub.33 is alkyl of 1 to 5 carbon atoms, inclusive.

2. A thromboxane intermediate according to claim 1, wherein R.sub.33 is methyl and R.sub.34 is benzyl.