Claims
- 1. A 4-R'-5-Q'-1,6-naphthyridin-2(1H)-one-6-oxide having the formula ##STR5## or acid-addition salt thereof, where R' is hydrogen or methyl and Q' is methyl or ethyl.
- 2. A compound according to claim 1 where R' is hydrogen.
- 3. 5-Methyl-1,6-naphthyridin-2(1H)-one-6-oxide according to claim 1.
- 4. 5-Ethyl-1,6-naphthyridin-2(1H)-one-6-oxide according to claim 1.
- 5. A cardiotonic composition for increasing cardiac contractility, said composition comprising a pharmaceutically acceptable inert carrier and, as the active component thereof, a cardiotonically effective amount of 4-R'-5-Q'-1,6-naphthyridin-2(1H)-one-6-oxide according to claim 1 or pharmaceutically acceptable acid-addition salt thereof.
- 6. The method for increasing cardiac contractility in a patient requiring such treatment which comprises administering orally or parenterally in a solid or liquid dosage form to such patient a cardiotonically effective amount of 4-R'-5-Q'-1,6-naphthyridin-2(1H)-one-6-oxide according to claim 1 or pharmaceutically acceptable acid-addition salt thereof.
- 7. The process which comprises reacting 4-R'-5-acetyl(or n-propanoyl)-6-[2-(di-lower-alkylamino)ethenyl]-2(1H)-one having the formula ##STR6## where Q' is methyl or ethyl, R' is hydrogen or methyl, and R.sub.1 and R.sub.2 are each lower alkyl, with hydroxylamine or salt thereof to produce 4-R'-5-Q'-1,6-naphthyridin-2(1H)-one-6-oxide according to claim 1.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a division of copending application Ser. No. 521,293, filed Aug. 8, 1983 now U.S. Pat. No. 4,532,247.
Non-Patent Literature Citations (2)
Entry |
Chemical Abstracts 72, 12,615d (1970). |
Ogata et al. [Chem. Pharm. Bull. 20, 2264 (1972)]. |
Divisions (1)
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Number |
Date |
Country |
Parent |
521293 |
Aug 1983 |
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