Claims
- 1. The process for producing compounds of formula (I) ##STR36## wherein R.sup.1 is lower alkyl or lower alkylene containing 3 to 6 straight chain or branched carbon atoms; cycloalkyl, bicycloalkyl, tricycloalkyl, or alicycloalkyl containing 4 to 10 carbon atoms; phenyl or phenyl substituted with lower alkyl, lower alkoxy, or halogen; R.sup.2 and R.sup.3 are each independently hydrogen or methyl; Y is oxygen which comprises the steps
- (a) reacting the compound of formula (XVIII) ##STR37## with R.sup.1 --NH.sub.2 wherein R.sup.1 is as defined above to produce the compound of formula (XIX) ##STR38## wherein R.sup.1 is as defined above (b) removing the protective group of said compound of formula (XIX) to produce the compound of formula (XX) ##STR39## wherein R.sup.1 is as defined above (c) reacting said compound of formula (XX) with isopropylisocyanate in the presence of a strong base to produce the compound of formula (XXI) ##STR40## wherein R.sup.1 is as defined above (d) oxidizing said compound of formula (XXI) to produce the compound of formula (XXII) ##STR41## wherein R.sup.1 is as defined above, and (e) reacting said compound of formula (XXII) with ##STR42## wherein R.sup.1 and R.sup.2 are as defined above to produce the compound of formula (I).
Priority Claims (1)
Number |
Date |
Country |
Kind |
542916 |
Jul 1987 |
CAX |
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Parent Case Info
This is a divisional of co-pending application Ser. No. 186,499 filed on April 26, 1988, now U.S. Pat. No. 4,853,387.
US Referenced Citations (3)
Non-Patent Literature Citations (2)
Entry |
J. Delarge et al, Ann. Pharm. Fr. 32 (12) 657-67 (1974). |
J. Delarge et al, Eur. J. Med. Chem.-Chimica Therapeutica 15, 299-304 (1980). |
Divisions (1)
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Number |
Date |
Country |
Parent |
186499 |
Apr 1988 |
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