Claims
- 1. A compound of the formula ##STR136## or a pharmaceutically acceptable acid addition salt thereof, wherein R.sub.1 and R.sub.2 are each independently selected from straight or branched chain alkyl of 1 to 15 carbon atoms; cycloalkyl having 3 to 8 carbon atoms; or substituted cycloalkyl which can be substituted one or more by alkyl of 1 to 6 carbon atoms;
- Y is phenyl or phenyl substituted by alkoxy having 1 to 6 carbon atoms;
- n is 1; R.sub.3 is a group substituted at one or more of the 4, 6, or 7 position of the pyridine ring said group being independently selected from hydrogen, alkyl having 1 to 6 carbon atoms and alkoxy having 1 to 6 carbon atoms; and R.sub.4 is hydrogen.
- 2. A compound according to claim 1 which is N-cyclohexyl-4-[[4-(1,1-dimethylethyl)-5H-imidazo[4,5-c]pyridin-5-yl]methyl]-3-methoxy-N-(1-methylethyl)benzamide.
- 3. A compound according to claim 1 which is N-cyclopentyl-N-(3,5-dimethylcyclohexyl)-2-methoxy-4-[(7-methoxy-4-methyl-5H-imidazo [4,5-c]pyridin-5-yl]methyl)benzamide.
- 4. A compound according to claim 1 which is N-cyclopentyl-N-(3,5-dimethylcyclohexyl)-2-methoxy-4-[(4-methyl-5H-imidazo[4,5-c]pyridin-5-yl)methyl]benzamide.
- 5. A compound according to claim 1 which is N-cyclohexyl-3-methoxy-N-(1-methylethyl)-4-[(4-methyl-5H-imidazo[4,5-c]pyridin-5-yl)methyl]benzamide.
- 6. A compound according to claim 1 which is N-cyclobutyl-N-cyclohexyl-2-methoxy-4-[(4-methyl-H-imidazo[4,5-c]pyridin-5-yl)methyl]benzamide.
- 7. A pharmaceutical composition useful for treating diseases or disorders mediated by Platelet-activating Factor comprising an effective amount of at least one compound according to claim 1, together with one or more non-toxic pharmaceutically acceptable carriers.
- 8. A pharmaceutical composition according to claim 7 wherein said compound is selected from the group consisting of
- N-cyclohexyl-4-[[4-(1,1-dimethylethyl)-5H-imidazo[4,5-c]pyridin-5-yl]methyl]-3-methoxy-N-(1-methylethyl)benzamide;
- N-cyclopentyl-N-(3,5-dimethylcyclohexyl)-2-methoxy-4-[(7-methoxy-4-methyl-5H-imidazo[4,5-c]pyridin-5-yl]methyl)benzamide;
- N-cyclopentyl-N-(3,5-dimethylcyclohexyl)-2-methoxy-4-[(4-methyl-5H-imidazo[4,5-c]pyridin-5-yl)methyl]benzamide; N-cyclohexyl-3-methoxy-N-(1-methylethyl)-4-[(4-methyl-5H-imidazo[4,5-c]pyridin-5-yl)methyl]benzamide; and
- N-cyclobutyl-N-cyclohexyl-2-methoxy-4-[(4-methyl-5H-imidazo[4,5-c]pyridin-5-yl)methyl]benzamide.
- 9. A method for treating diseases or disorders mediated by Platelet-activating Factor comprising administering a therapeutically effective dose of at least one compound of claim 1 to a mammal in need of such treatment.
- 10. A method according to claim 9 wherein said compound is selected from the group consisting of N-cyclohexyl-4-[[4-(1,1-dimethylethyl)-5H-imidazo[4,5-c]pyridin-5-yl]methyl]-3-methoxy-N-(1-methylethyl)benzamide;
- N-cyclopentyl-N-(3,5-dimethylcyclohexyl)-2-methoxy-4-[(7-methoxy-4-methyl-5H-imidazo[4,5-c]pyridin-5-yl]methyl)benzamide;
- N-cyclopentyl-N-(3,5-dimethylcyclohexyl)-2-methoxy-4-[(4-methyl-5H-imidazo[4,5-c]pyridin-5-yl)methyl]benzamide;
- N-cyclohexyl-3-methoxy-N-(1-methylethyl)-4-[(4-methyl-5H-imidazo[4,5-c]pyridin-5-yl)methyl]benzamide; and
- N-cyclobutyl-N-cyclohexyl-2-methoxy-4-[(4-methyl-5H-imidazo[4,5-c]pyridin-5-yl)methyl]benzamide.
Parent Case Info
This application is a continuation-in-part of U.S. Ser. No. 07/670,133, filed Mar. 15, 1991, now U.S. Pat. No. 5,227,385, which is a continuation-in-part of U.S. Ser. No. 07/317,871, filed Mar. 6, 1989, now U.S. Pat. No. 5,019,581, which is a continuation-in-part of U.S. Ser. No. 07/167,671, filed Mar. 14, 1988, now U.S. Pat. No. 4,914,108.
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Continuation in Parts (3)
|
Number |
Date |
Country |
Parent |
670133 |
Mar 1991 |
|
Parent |
317871 |
Mar 1989 |
|
Parent |
167671 |
Mar 1988 |
|