Claims
- 1. An isolated nucleic acid molecule selected from the group consisting of:
a) a nucleic acid comprising the nucleotide sequence of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4, or SEQ ID NO:6, or a full complement thereof; and b) a nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:5.
- 2. The nucleic acid molecule of claim 1, further comprising vector nucleic acid sequences.
- 3. The nucleic acid molecule of claim 1, further comprising nucleic acid sequences encoding a heterologous polypeptide.
- 4. A host cell which contains the nucleic acid molecule of claim 1.
- 5. An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:5.
- 6. The polypeptide of claim 5 further comprising heterologous amino acid sequences.
- 7. An antibody or antigen-binding fragment thereof that selectively binds to a polypeptide of claim 5.
- 8. A method for producing a polypeptide comprising the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:5, the method comprising culturing the host cell of claim 4 under conditions in which the nucleic acid molecule is expressed.
- 9. A method for detecting the presence of a polypeptide of claim 5 in a sample, comprising:
a) contacting the sample with a compound which selectively binds to a polypeptide of claim 8; and b) determining whether the compound binds to the polypeptide in the sample.
- 10. The method of claim 9, wherein the compound which binds to the polypeptide is an antibody.
- 11. A kit comprising a compound which selectively binds to a polypeptide of claim 5 and instructions for use.
- 12. A method for detecting the presence of a nucleic acid molecule of claim 1 in a sample, comprising the steps of:
a) contacting the sample with a nucleic acid probe or primer which selectively hybridizes to the nucleic acid molecule; and b) determining whether the nucleic acid probe or primer binds to a nucleic acid molecule in the sample.
- 13. The method of claim 12, wherein the sample comprises mRNA molecules and is contacted with a nucleic acid probe.
- 14. A kit comprising a compound which selectively hybridizes to a nucleic acid molecule of claim 1 and instructions for use.
- 15. A method for identifying a compound which binds to a polypeptide of claim 5 comprising the steps of:
a) contacting a polypeptide, or a cell expressing a polypeptide of claim 5 with a test compound; and b) determining whether the polypeptide binds to the test compound.
- 16. A method for modulating the activity of a polypeptide of claim 5, comprising contacting a polypeptide or a cell expressing a polypeptide of claim 5 with a compound which binds to the polypeptide in a sufficient concentration to modulate the activity of the polypeptide.
- 17. A method of inhibiting aberrant activity of a 21627 or 55562-expressing cell, comprising contacting a 21617 or 55562-expressing cell with a compound that modulates the activity or expression of a polypeptide of claim 5, in an amount which is effective to reduce or inhibit the aberrant activity of the cell.
- 18. The method of claim 17, wherein the compound is selected from the group consisting of a peptide, a phosphopeptide, a small organic molecule, and an antibody.
- 19. The method of claim 17, wherein the cell is a 21617-expressing cell located in a cancerous or pre-cancerous tissue.
- 20. The method of claim 19, wherein the cancerous or pre-cancerous tissue is found in the colon, lung, liver, or cervix.
- 21. A method of treating or preventing a disorder characterized by aberrant activity of a 21617 or 55562-expressing cell, in a subject, comprising:
administering to the subject an effective amount of a compound that modulates the activity or expression of a protein molecule of claim 5, such that the aberrant activity of the 21617 or 55562-expressing cell is reduced or inhibited.
- 22. The method of claim 21, wherein the cell is a 21617-expressing cell located in a cancerous or pre-cancerous tissue.
RELATED APPLICATIONS
[0001] This application claims priority to U.S. provisional application Nos. 60/256,249 and 60/256,405, both filed on Dec. 18, 2000, the contents of which are incorporated herein by reference.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60256249 |
Dec 2000 |
US |
|
60256405 |
Dec 2000 |
US |