Claims
- 1. A basic compound of the structure ##STR20## in which R.sub.1 is methyl or ethyl and R.sub.2 is a straight or branched alkyl of from 1-20 carbon atoms or cycloalkyl of 3 to 8 carbons; and its non-toxic pharmaceutically acceptable salts.
- 2. A compound in accordance with claim 1 wherein R.sub.2 is an alkyl of 1 to 20 carbons or a cycloalkyl of 3 to 8 carbons and R.sub.3 is hydroxy.
- 3. A compound in accordance with claim 2, 5,5-dimethyl-10-hydroxy-8-(3-methyl-2-octyl)-5H-[1]benzopyrano[3,4-d]pyridine.
- 4. A compound in accordance with claim 1 wherein ##STR21## and R.sub.3 is hydroxy.
- 5. A compound in accordance with claim 4, 5,5-dimethyl-8-[5-(4-fluorophenyl)-2-pentyl]-10-hydroxy-5H-[1]benzopyrano[3,4-d]pyridine.
- 6. A compound in accordance with claim 1 wherein R.sub.3 is an acyloxy selected from the group consisting of acetoxy, propionyloxy, and butyryloxy and R.sub.2 is ##STR22##
- 7. A compound in accordance with claim 1 wherein R.sub.3 is ##STR23## and R.sub.2 is an alkyl of 1 to 20 carbons or a cycloalkyl of 3 to 8 carbons.
- 8. A compound in accordance with claim 7, 5,5-dimethyl-8-(3-methyl-2-octyl)-10-[4-(piperidino)butyryloxy]5H-[1]benzopyrano[3,4-d]pyridine hydrochloride.
- 9. A compound in accordance with claim 1 wherein ##STR24##
- 10. A compound in accordance with claim 1 wherein R.sub.2 is an alkyl of 1 to 20 carbons or a cycloalkyl of 3 to 8 carbons and R.sub.3 is methoxy.
- 11. A compound in accordance with claim 10, 5,5-dimethyl-10-methoxy-8-(3-methyl-2-octyl)-5H-[1]benzopyrano[3,4-d]pyridine.
- 12. A compound in accordance with claim 1 wherein R.sub.2 is an alkyl of 1 to 20 carbons or a cycloalkyl of 3 to 8 carbons and R.sub.3 is 2-propynyloxy.
- 13. A compound in accordance with claim 12, 5,5-dimethyl-8-(3-methyl-2-octyl)-10-(2-propynyloxy)-5H-[1]benzopyrano[3,4-d]pyridine.
- 14. A compound in accordance with claim 1 wherein R.sub.2 is ##STR25## and R.sub.3 is methoxy.
- 15. A compound according to claim 14, 5,5-dimethyl-8-[5-(4-fluorophenyl)-2-pentyl]-10-methoxy-5H-[1]benzopyrano[3,4-d]pyridine.
- 16. A compound in accordance with claim 1 wherein R.sub.2 is ##STR26## and R.sub.3 is 2-propenyloxy.
- 17. A compound according to claim 16, 5,5-dimethyl-8-[5-(4-fluorophenyl)-2-pentyl]-10-(2-propenyloxy)-5H-[1]benzopyrano[3,4-d]pyridine.
- 18. A basic compound of the structure ##STR27## in which R.sub.1 is methyl or ethyl and R.sub.2 is a straight or branched alkyl of from 1-20 carbon atoms; and its non-toxic pharmaceutically acceptable salts.
- 19. The compounds of claim 18 in which R.sub.2 is a branched alkyl of 5-12 carbon atoms.
- 20. The compounds of claim 18 in which R.sub.2 is 1,2-dimethylheptyl together with their acid addition salts.
- 21. The compound of claim 20 in the form of the hydrochloride or hydrobromide salt.
- 22. A compound of the formula ##STR28## wherein each R.sub.1 is methyl or ethyl, R.sub.2 is a straight or branched chain alkyl of from 1-20 carbon atoms, a cycloalkyl of 3 to 8 carbons, or ##STR29## wherein Y is a straight or branched chain alkylene group having from 1 to 10 carbon atoms and each R.sub.4, R.sub.5 and R.sub.6 are the same or different members of the group consisting of hydrogen or halo; R.sub.3 is hydroxy, loweralkoxy, loweralkenyloxy, loweralkynyloxy or ##STR30## wherein X is a straight or branched chain alkylene group having from 1 to 8 carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, Z is CH.sub.2, O, S or NR.sub.10 with R.sub.10 being hydrogen or loweralkyl, with the limitation that when Z is O or S, the sum of a and b is 3 or 4; and when Z is NR.sub.10, the sum of a and b is 3-5; R.sub.9 is hydrogen or loweralkyl, and the pharmaceutically acceptable salts thereof.
- 23. A compound of the formula ##STR31## wherein each R.sub.1 is loweralkyl, R.sub.2 is an alkyl of 1 to 20 carbons, a cycloalkyl of 3 to 8 carbons or ##STR32## wherein Y is a straight or branched chain alkylene group having from 1 to 10 carbon atoms and each R.sub.4, R.sub.5 and R.sub.6 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and R.sub.3 is hydroxy, loweralkoxy, loweralkenyloxy, loweralkynyloxy, or ##STR33## X is a straight or branched chain alkylene group having from 1 to 8 carbon atoms, and wherein R.sub.7 and R.sub.8 are the same or different members of the group consisting of hydrogen or loweralkyl, or ##STR34## wherein X is a straight or branched chain alkylene group having from one to eight carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, Z is CH.sub.2, O, S or NR.sub.10 with R.sub.10 being hydrogen or loweralkyl, with the limitation that when Z is O or S, the sum of a and b is 3 or 4; and when Z is NR.sub.10, the sum of a and b is 3-5; R.sub.9 is hydrogen or loweralkyl, and the pharmaceutically acceptable salts thereof.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of copending application, Ser. No. 379,016 filed July 13, 1973 now U.S. Pat. No. 3,878,219.
US Referenced Citations (5)
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
379016 |
Jul 1973 |
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