Claims
- 1. A naphthyridine compound of the formula: ##STR15## wherein each Y represents hydrogen, halogen, alkyl of 1 through 4 carbon atoms, or alkoxy of 1 through 4 carbon atoms, .dbd.A-- represents .dbd.CH-- or .dbd.N--, n is zero and R represents alkyl of 1 through 4 carbon atoms, or n is 1 and R is methyl, or a non-toxic pharmaceutically acceptable acid addition salt thereof.
- 2. The naphthyridine compound according to claim 1 which is 6-(7-chloro-1,8-naphthyridin-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine or a non-toxic pharmaceutically acceptable acid addition salt thereof.
- 3. A naphthyridine compound according to claim 1 wherein one Y is hydrogen and the other is chlorine, methyl, or methoxy, n is zero and R is methyl.
- 4. The naphthyridine compound according to claim 1 which is 6-(5-methyl-1,8-naphthyridin-2-yl)-5-(4-methylpiperazin-1-yl)-carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine or a non-toxic pharmaceutically acceptable acid addition salt thereof.
- 5. The naphthyridine compound according to claim 1 which is 6-(7-chloro-1,8-naphthyridin-2-yl)-7-(4-methylpiperazin-1-yl)-carbonyloxy-5-oxo-pyrrolo[3,4-b]pyridine or a non-toxic pharmaceutically acceptable acid addition salt thereof.
- 6. The naphthyridine compound according to claim 1 which is 6-(7-methyl-1,8-naphthyridin-2-yl)-7-(4-methylpiperazin-1-yl)-carbonyloxy-5-oxo-pyrrolo[3,4-b]pyridine or a non-toxic pharmaceutically acceptable acid addition salt thereof.
- 7. The naphthyridine compound according to claim 1 which is 6-(7-methoxy-1,8-naphthyridin-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine or a non-toxic pharmaceutically acceptable acid addition salt thereof.
- 8. The naphthyridine compound according to claim 1 which is 6-(5,7-dimethyl-1,8-naphthyridin-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]-pyrazine or a non-toxic pharmaceutically acceptable acid addition salt thereof.
- 9. The naphthyridine compound according to claim 1 which is 4-{5-[6-(7-chloro-1,8-naphthyridin-2-yl)-7-oxo-6,7-dihydro-5-H-pyrrolo[3,4-b]pyrazinyl]oxycarbonyl{-1-methylpiperazine-1-oxide or a non-toxic pharmaceutically acceptable acid addition salt thereof.
- 10. The naphthyridine compound according to claim 1 which is 6-(7-chloro-1,8-naphthyridin-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo-[3,4-b]pyrazine or a non-toxic pharmaceutically acceptable acid addition salt thereof.
- 11. A pharmaceutical composition useful as a tranquilliser and anti-convulsant agent which comprises, as active ingredient, an effective amount of a naphthyridine compound of the formula depicted in claim 1 wherein the various symbols have the meanings specified in claim 1, or a non-toxic pharmaceutically acceptable acid addition salt thereof, in association with a significant amount of a pharmaceutical carrier.
Priority Claims (3)
Number |
Date |
Country |
Kind |
73.17516 |
May 1973 |
FR |
|
74.08728 |
Mar 1974 |
FR |
|
74.08730 |
Mar 1974 |
FR |
|
Parent Case Info
This is a Division of application Ser. No. 469,431 filed May 13, 1974, now abandoned.
Non-Patent Literature Citations (2)
Entry |
cotrel et al. Chemical Abstracts vol. 79, 92,284c, (1973). |
Challier et al. Chemical Abstracts vol. 79, 32,100e, (1973). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
469431 |
May 1974 |
|