Claims
- 1. A 6-(alkanoylaminoaryl)-3(2H)-pyridazinone derivative of the formula I ##STR558## where the substituents on the phenylene radical are para to one another, A and B are each hydrogen or together form a bond, R.sup.1 is hydrogen or methyl, R.sup.2 is hydrogen, or, where A and B are each hydrogen, R.sup.1 and R.sup.2 together form a C.sub.1 -C.sub.2 -alkylene radical, R.sup.3 is a straight-chain C.sub.2 -C.sub.4 -alkylene group which can be substituted by C.sub.1 -C.sub.3 -alkyl group or by two methyl groups, and R.sup.4 is
- (a) imidazol-1-yl, or
- (b) a group of the formula (II) ##STR559## where the broken line can be an additional bond, R.sup.5 is hydrogen, a C.sub.1 -C.sub.4 -alkyl radical which is unsubstituted or substituted by phenyl, or cyclohexyl, hydroxyl, or phenyl which is unsubstituted or substituted by one or two halogen atoms, C.sub.1 -C.sub.4 -alkyl groups and/or, C.sub.1 -C.sub.4 -alkoxy groups, or is a group of the formula R.sup.7 R.sup.8 N--, where R.sup.7 is hydrogen or phenyl which can be monosubstituted or disubstituted by halogen, C.sub.1 -C.sub.4 -alkyl, and/or C.sub.1 -C.sub.4 -alkoxy, R.sup.8 is C.sub.1 -C.sub.4 -alkanoyl or benzoyl, R.sup.6 is hydrogen, and m is 0, 1 or 2, or
- (c) a group of the formula (III) ##STR560## wherein R.sup.9 is a C.sub.1 -C.sub.3 -hydrocarbon radical which is substituted by a hydroxy group or a C.sub.4 -C.sub.14 -hydrocarbon radical which may be substituted by a hydroxyl group, and p is 2, and their salts with physiological tolerated acids.
- 2. A pharmaceutical composition having thrombocyte aggregation-inhibiting activity comprising an effective amount of a 6-(acylaminoaryl)-3(2H)-pyridazinone derivative as claimed in claim 1 as the active ingredient and a pharmaceutically acceptable carrier.
- 3. The method of treating disease caused by thrombocyte aggregation in a patient suffering therefrom which comprises administering an effective amount of a 6-(acylaminoaryl)-3(2H)-pyridazinone derivative as claimed in claim 1.
Priority Claims (1)
Number |
Date |
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Kind |
3302021 |
Jan 1983 |
DEX |
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Parent Case Info
This is a division of application Ser. No. 571,675, filed Jan. 17, 1984 now U.S. Pat. No. 4,636,504.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3806509 |
Lebkuecher et al. |
Apr 1974 |
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4636504 |
Rossy et al. |
Jan 1987 |
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Non-Patent Literature Citations (2)
Entry |
Chemical Abstracts, vol. 101, pp. 774-775 (1984), abstract no. 230558w. |
Abstracting German Offen. 3302021, dated Jul. 28, 1984. |
Divisions (1)
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Number |
Date |
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Parent |
571675 |
Jan 1984 |
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