6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives and their construction by parallel synthesis on solid-phase

Abstract

The present invention provides (i) 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives; (ii) a process for synthesizing benzopyran derivatives with high efficiency by parallel synthesis on a solid-phase as one of combinatorial chemical synthesis technologies; and (iii) a use of the benzopyran derivatives for preventing and treating diseases or disorders induced by promotion of lipid peroxidation or accumulation of oxidized products.

Description

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates to (i) 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives; (ii) a process for synthesizing the novel benzopyran derivatives with high efficiency by parallel synthesis on solid-phase as one of combinatorial chemical synthesis technologies; and (iii) a use of the novel benzopyran derivatives for preventing and treating diseases or disorders induced by promotion of lipid peroxidation or accumulation of oxidized products.

2. Description of the Related Art

It has been suggested that the injury or death (e.g., apoptosis) of nerve cells is mainly responsible for several neurologic diseases or disorders such as apoplexy, brain trauma, Alzheimer's disease and Parkinson's disease (G. J. Zoppo et al., Drugs 54, 9 (1997); and I. Sziraki et al., Neurosci. 85, 1101 (1998)). The factors involved in the injury of nerve cells have been known, which include the elevation of the levels of iron, activated oxygen species and oxidized molecules in nerve cells (M. P. Mattson et al., Methods Cell Biol. 46, 187 (1995); and Y. Goodman et al., Brain Res. 706, 328 (1996)).

The elevated level of iron in nerve cells leads to the formation of oxygen free radicals such as NO and then promotion of lipid peroxidation, which results in the accumulation of oxidized molecules in cells. The oxidized molecules accumulated in cells give rise to inflammatory diseases, cardiac infarction and dementia as well as neurologic diseases described above. In addition, the oxidized molecules have been reported to lead to acute or chronic tissue or organ injury. Such injuries include organ injury by endotoxins from bacteria infection or tissue injury occurring when the reperfusion in ischemic disease is performed.

Therefore, in order to prevent and treat several diseases due to the injury or death of nerve cells, many researchers have made extensive study to develop novel substances capable of preventing injury of nerve cells due to elevated irons in nerve cells, lipid peroxidation and generation of NO due to endotoxins. The antioxidants have been reported to alleviate injury and death of nerve cells due to irons, and the endeavor to develop novel drugs for preventing injury of nerve cells due to oxidative stress is under way (Y. Zhang et al., J. Cereb. Blood Flow Metab. 13, 378 (1993)).

Natural and synthetic products having benzopyran skeleton have been widely known and used as a basic skeletal structure for developing compounds exhibiting therapeutical efficacy in several diseases such as nerve-related diseases, hypertension and diabetes owing to their antioxidation activity.

Construction of benzopyran library having a wide variety of derivatives by means of the technology of combinatorial chemical synthesis is very useful in exploiting hit or lead compounds at the initial stage for developing new drugs.

In particular, it is very important that the library of small organic molecular compounds, wherein various substituents can be introduced and Lipinsky's Rule of 5 can be largely applied, is constructed in a massive and effective manner, in view of the strategy for obtaining molecular diversity useful in screening lead compounds.

The combinatorial chemical synthesis has been focused as a new technology for developing novel substances. Compared to conventional methods where a single compound is synthesized by a single reaction, the technology of combinatorial chemical synthesis allows to synthesize more diverse and abundant compounds simultaneously and to automate a multi-step synthesis, so that it is considered as a highly effective process of synthesizing compounds. The introduction of combinatorial chemical synthesis makes it easier to screen and optimize biological hit and lead compounds having novel structures.

Since the technology of combinatorial chemical synthesis is generally carried out on a solid support, a continuous multi-step process can be automated. In addition, because the isolation and purification of products in this technology is very simple, the high throughput screening for pharmacological efficacy is also made possible.

Although the approach of the combinatorial chemical synthesis appears to overcome the shortcomings of conventional synthesis methods as being uneconomical and ineffective, several bottlenecks still prevents it from being applied to the field of organic synthesis. One such reason is that undesired side reactions occur because most of chemical reactions on a solid support employ excess reagents. Another reason is that the selection of reaction conditions is very restricted because solvents that can be used depend on physical properties of a solid support. In the art of combinatorial chemical synthesis on a solid support, Merrifield resin and Wang resin have been often used as a solid support. However, these supports show negligible swelling effect in a high polar solvent such as alcohol and water, thereby restricting the selection of a solvent for a reaction. Therefore, in order to synthesize diverse derivatives by use of chemical reactions on a solid support, the selection of a solid support and a reaction reagent as well as the screening of reaction conditions become essential.

SUMMARY OF THE INVENTION

The present inventors have carried out intensive researches to develop a novel process for effectively constructing benzopyran library by use of combinatorial chemical synthesis technology on a solid-phase in consideration of the usefulness of benzopyran derivative in synthesis of pharmacologically effective compounds such as an antioxidant and drugs for treating neurologic diseases, hypertension and diabetes, etc. As a result, the present inventors have succeeded in developing a novel parallel synthetic process on a solid-phase by using a combinatorial chemical synthetic method in which 4 steps are performed in a successive manner to effectively produce 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran library with higher yield in a short period of time, whereas the conventional processes performing multi-step reactions in a solution synthesize compounds of interest through steps of a reaction; treatment and purification after the reaction; and an analysis of structure of the synthesized compound per each step.

Accordingly, it is an object of this invention to provide novel 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives useful in synthesizing drugs.

Another object of this invention to provide a process for preparing 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative by use of parallel synthesis on a solid-phase exhibiting advantages such as high yield and feasibility of automation of multi-step reaction and analysis of chemical structure.

It is still another object of this invention to provide a use of 6-amino-2,2-diethyl-3,4,6-trisubstituted benzopyran derivatives for preventing and eating diseases or disorders induced by promotion of lipid peroxidation and accumulation of oxidized molecules.

DETAILED DESCRIPTION OF THE INVENTION

In one aspect of this invention, there is provided a 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative represented by the following formula (5): wherein R¹ represents a C₁-C₁₀ alkyl, aryl, benzyl or substituted benzyl, or phenethyl group; R² represents a C₁-C₁₀ alkyl, benzyl or substituted benzyl, or phenethyl group; R³ represents a hydrogen atom, a C₁-C₁₀ alkyl group, a C₂-C₁₀ alkenyl group, a C₂-C₁₀ alkynyl, benzyl or substituted benzyl, naphthylmethyl group, or —C(O)R⁴; R⁴ represents a C₁-C₁₀ alkyl, phenyl or substituted phenyl groups or five-or seven-membered heterocyclic ring containing a heteroatom selected from the group consisting of oxygen and sulfur, and the substituted phenyl or benzyl group may be substituted with 1-4 substituents selected from the group consisting of a halogen atom, a nitro group, a C₁-C₁₀ alkoxy group and a C₁-C₁₀ haloalkyl group; and R¹ is not a C₁-C₁₀ alkyl group with the proviso that R³ is a hydrogen atom.

In addition, the 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative represented by the formula (5) has several chiral centers, and therefore, its optical isomers in synthesizing process can be obtained and included within the scope of the present compounds.

The present invention will be described in more detail hereunder.

The present invention provides (i) a 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative represented by the formula (5); (ii) a process according to parallel synthesis on solid-phase as one of combinatorial chemical synthesis technologies for permitting to effectively synthesize the novel benzopyran derivatives described above by use of parallel synthesis on solid-phase instead of chemical reaction in liquid-phase; and (iii) use of the novel benzopyran derivatives described above for preventing and treating diseases or disorders induced by lipid peroxidation promotion or accumulation of oxidized products.

The process for preparing a 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative represented by the formula (5) according to the technology of combinatorial chemical synthesis is illustrated in Scheme 1.Scheme 1wherein R¹, R² and R³ are the same as above; and {circumflex over (p)} is a polymeric solid support selected from the group consisting of polystyrene-divinylbenzene, methacrylic acid-dimethylacrylamide and hydroxyl methacrylic acid.

In the process according to the present invention, the intermediates including 2,2-dimethyl-3-hydroxy-6-alkyl amino benzopyran resin of the formula (3) and 2,2-dimethyl-3-substituted-4-alkoxy-6-alkyl amino benzopyran resin of the formula (4) also have several chiral centers, and if necessary, each optical isomer can be isolated.

The present process represented by the Scheme 1 comprises the following steps:

• • (a) synthesizing a N-alkyl substituted carbamate resin of the formula (2) by introducing an alkyl substituent selectively to a nitrogen atom of benzopyran linked to a carbamate linker represented by the formula (1);
  • (b) synthesizing a 2,2-dimethyl-3-hydroxy-6-alkyl amino benzopyran resin of the formula (3) by performing epoxidation and alkoxy addition simultaneously by adding metachloroperbenzoic acid (m-CPBA) and alcohol to the compound of the formula (2); (c) synthesizing a 2,2-dimethyl-3-substituted-4-alkoxy-6-alkyl amino benzopyran derivative of the formula (4) by introducing a substituent R³ to 3-hydroxyl group of the compound of the formula (3); and (d) synthesizing said 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative of the formula (5) by departing the compound of the formula (4) with a dichloromethane solution containing trifluoroacetic acid (TFA) or an organic solvent containing organic acid.

According to the findings of the present inventors, when N-alkylation and hydroxy alkoxylation are successively carried out by use of benzopyran resin having a carbamate linker on a solid support of the formula (1), the number of times for purification can be reduced to one from four in conventional reaction in a solution. Such advantage allows to synthesize a wide variety of 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives in a short period of time.

In the present process, the necessary steps, compositions of solvent systems and reaction conditions will be described in more detail hereunder:

The organic solvent showing excellent swelling effect on Wang resin or Merrifield resin is useful as solvent for the present process.

In step (a), dimethylsulfoxide (DMSO) or tetrahydrofuran (THF) may be used. Preferably, each of base and R¹ substituent is used in the amount of 3 equivalents, and more preferably, about 2 equivalents. As a base, lithium t-butoxide (LiOtBu) is preferred and as R₁ substituent, the halides such as alkyl halide or benzyl halide is preferred.

In step (b), to inhibit the occurrence of 3-chlorobenzoic acid as a by-product in oxidation, metachloroperbenzoic acid (m-CPBA) is introduced in the amount of less than 3 equivalents. In particular, it is preferred that prior to addition of m-CPBA, alcohols as alkoxy precursor is excessively added and mixed by agitating for above 15 min followed by addition of an oxidant. The reason is that an alkoxy group predominant over 3-chlorobenzoic acid makes it possible to inhibit the production of a by-product. The alcohols as alkoxy precursor refers to aliphatic alcohols, for example, includes methanol, ethanol, iso-propyl alcohol, benzyl alcohol, and amino acids having aliphatic alcohol at its side chain and protection group at its amine and carboxyl groups.

In step (c), the 3-hydroxy group generated is reacted with halogenated alkyls or carbonyl derivatives as electrophile to introduce R³ group, thereby converting to 2,2-dimethyl-3-substituted form. For example, for converting to 3-alkylether form, halogenated alkyl may be used as electophile and the reaction is performed in the presence of lithium t-butoxide and a solvent of dimethylformamide (DMF). The halogenated alkyls include, but not limited to, halogenated methane, ethane, propane, iso-propane and butane, benzyl halide and substituted benzyl halide. For example, for converting to 3-ester form, carbonyl halide compound containing R⁴ group may be used as electophile and the reaction is performed in the presence of base and a solvent of dichloromethane. The carbonyl derivative used includes, but not limited to, acetyl halide, t-butylacetyl halide, cyclohexanecarbonyl halide, 3,3 dimethylacryloyl halide, benzoyl halide, p-toluyl halide, 4-anisoyl chloride, 4-halobenzoyl halide, 2-thiopencarbonyl halide and 2-furoyl halide.

In step (d), the departure reaction is carried out using dichloromethane solution containing trifluoroacetic acid (TFA) or an organic solvent containing organic acid in order to produce 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran library of interest represented by the formula (5).

For elucidating the production of 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran library of the formula (5), the compound of interest departed from 2,2-dimethyl-3-substituted-4-alkoxy-6-alkyl amino benzopyran resin of the formula (4) may be purified and isolated in the final step by use of flash column chromatography having multiple columns and its structure is analyzed with NMR and/or Mass spectroscopy. The progress of reaction may be monitored with ATR-FFIR for detecting the intermediates, the resins of the formulae (1), (2), (3) and (4).

Furthermore, the compound of this invention can be used as an inhibitor against lipid peroxidation owing to its inhibitory potency to lipid peroxidation induced iron. Therefore, the present compound is very useful as a drug for preventing and treating several diseases or disorders elicited by promotion of lipid peroxidation and accumulation of oxidized molecules. That is, the present compound can be used as a drug for preventing and treating diseases or disorders such as cancer, arteriosclerosis, diabetes, apoplexy, dementia, Parkinson's disease and senescence that is induced by production of peroxidized lipid with cytotoxicity or destruction of cell membrane due to attack to lipid in cell membrane.

Therefore, in another aspect of this invention, there is provided a pharmaceutical composition for inhibiting lipid peroxidation, i.e., treating or preventing diseases induced by promotion of lipid peroxidation and accumulation of oxidized molecules, which comprises 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative or its pharmaceutically acceptable salt as an active ingredient.

The pharmaceutically acceptable salts of this invention may be prepared according to the conventional process known in the art, for example, by use of an inorganic acid such as hydrochloric acid, hydrogen bromide, sulfuric acid, sodium bisulfate, phosphoric acid and carbonic acid or an organic acid such as formic acid, acetic acid, oxalic acid, benzoic acid, citric acid, tartaric acid, gluconic acid, fumaric acid, lactobionic acid, salicylic acid and acetylsalicylic acid. In addition to this, pharmaceutically acceptable salts may be prepared in a form of metal salt with alkali metal ion such as sodium and potassium and other forms with ammonium ion.

Furthermore, the pharmaceutical composition of this invention may be formulated by using 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative or its pharmaceutically acceptable salt together with a pharmaceutically acceptable carrier, additive, vehicle, diluent and so on. Non-limiting examples of the formulations include, but not limited to, a solution, a suspension or an emulsion, a tablet, a capsule and troches. The pharmaceutical compositions of this invention may be administered orally or parenterally, and the parenteral administration comprises intravenous injection, subcutaneous injection and intramuscular injection. The dosage of pharmaceutical compositions of the present invention to be administered to humans can vary according to various factors such as the type of formulation, the mode of administration, age, body weight, sex, diet, sensitivities to drugs, severity of a disease and physical condition of a patient as well as the type of administration, etc. It is understood that the ordinary skilled physician will readily be able to determine and prescribe a correct dosage of the pharmaceutical compositions. In an embodiment of the present invention, a preferred dosage of the present composition is 0.01-1000 mg/day with reference to the application to an adult patient with a body weight of 70 kg. The present pharmaceutical composition may be administered at regular time intervals according to the instruction of a physician ranging from one to several times per day.

The following specific examples are intended to be illustrative of the invention and should not be construed as limiting the scope of the invention.

EXAMPLE I

Synthesis of 2,2-dimethyl-3-(4-fluorobenzyl)ether-4-methoxy-6-(4-methoxybenzyl)amino Benzopyran

(I-1) N-4-methoxybenzylation of Olefin Resin 1

Carbamate resin having a benzopyran structure of the formula (1) (200.00 mg, 0.11 mmol) was added to dimethylsulfoxide (DMSO; 3 ml) and agitated for 10 min at room temperature, followed by adding lithium t-butoxide (LiOtBu)(0.33 ml, 0.33 μmmol) in 1 M of tetrahydrofuran (THF) and agitating for 20 min at the same temperature. To the mixture, 4-methoxybenzylchloride (4-MeOBnCl; 0.045 ml, 0.33 mmol) was added and agitated to proceed with a reaction for 15 hr at 35 C. Upon completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding N4-methoxybenzyl-substituted carbamate resin of the formula (2a) as a light brown solid (ATR-FTIR analysis result: N-4-methoxy benzylation carbamate, 1700 cm⁻¹).(I-2) Addition of Hydroxy Methoxy to N-methoxybenzyl-substituted Olefin Resin (2a)

N-4-methoxybenzyl-substituted carbamate resin (200 mg, 0.11 mmol) of the formula (2a) was added to the mixed solution of dichloromethane (3 ml) and methanol (3 ml) and agitated for 30 min, after which metachloroperbenzoic acid (m-CPBA, 81 mg, 0.55 mmol) was added at room temperature and agitated to proceed with a reaction for 12 hr at room temperature. After the completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MEOH, thereby yielding the resin of the formula (3a-1) as a light yellow solid.(I-3) Etherification of N-4-methoxybenzyl-substituted Hydroxy Methoxy Resin (3a-1)

2,2-dimethyl-3-hydroxy-6-(4-methoxybenzyl)-ammo benzopyran resin (200.0 mg, 0.11 mmol) linked to a carbamate linker represented by the formula (3a-1) was added to a solution of dimethylformamide (3 ml) and agitated for 30 min at room temperature, followed by addition of lithium t-butoxide (LiOtBu)(1.1 ml, 1.1 mmol) in 1 M of tetrahydrofuran (THF) and agitation for 30 min at room temperature. To the mixture, 4-fluorobenzylbromide (0.274 ml, 0.22 mmol) was added and agitated to proceed with a reaction for 6 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding the resin of the formula (4a-1) as a light brown solid.(I-4) Departure Reaction of 2,2-dimethyl-3(4-fluorobenzyl)ether-4-methoxy-6-(4-methoxybenzyl)amino Benzopyran

The resin (200 mg) of the formula (4a-1) was added to a solution of dichloromethane (5 ml) and agitated, followed by addition of trifluoroacetic acid (TFA, 1 ml) and agitation for 3 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and the filtrate was washed repeatedly with dichloromethane and methyl alcohol. The filtrates were combined and concentrated. To the concentrates, ethylacetate (3 ml) was added, filtered thorough strong anion exchange resin (SAX) and washed repeatedly with ethylacetate to remove residual TFA. Following concentration of the filtrate under reduced pressure, the concentrate was purified with silica gel column chromatography in the presence of hexane/ethylacetate (4/1, v/v), thereby yielding the compound of the formula (5-338) as a light-yellow oil (22.75 mg, yield=45.8%; 4 step overall yield from resin 1; loading capacity of resin 1=0.55 mmol/g): ¹H NMR(200 MHz, CDCl₃) δ(PPM) 6.95-7.40 (m, 8H), 6.75 (m, 3H), 4.83(d, 1H, J=11.4 Hz), 4.65 (d, 1H, J=11.4 Hz), 4.15 (s, 2H), 4.28 (d, J=7.3 Hz), 3.67 (s, 3H), 3.53 (d, 1H, J=7.3 Hz), 3.50 (s, 3H), 1.40 (s, 3H), 1.23 (s, 3H); Mass, m/z: 451.54.

The 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives synthesized according to the method of parallel synthesis on the solid-phase as Example I are summarized in Table 1.

In construction of the library in Table I, the following precursors were employed to prepare combinations of each substituent: for example, R₁ precursor includes CH₃I, C₂H₅I, tBuI, 4-BuI, 4-F—C₄H₉I, 4-Me-C₄H₉I, 2-CH₃-C₄H₉I, 3-Cl—C₄H₉I, 4-tBu-C₄H₉I and 3-F—C₄H₉I; R² precursor includes CH₃OH, C₂H₅OH, iPrOH, tBuOH, C₄H₉OH, 2-Ph-EtOH and 2-cyclohexyl-EtOH; R³ precursor includes C₄H₉Br, 4-F—C₄H₉Br, 4-tBu-C₄H₉Br, 3-F—C₄H₉Br, 2-CH₃-C₄H₉Br, 2-Cl—C₄H₉Br, 3-Cl—C₄H₉Br, 4-CH₃-C₄H₉Br, 4-Br-2-F—C₄H₉Br, β-CH₃Br—NaOH, 3,5-CF₃-C₄H₉Br, CH₃OH, C₅H₁₁I, 1-bromo-2-butene, 3-bromopropene and 3-bromoprophine (Propargyl Br).

TABLE 1
      Compound No. NMR/MS Data
      1H NMR(200 MHz, CDCl3) δ 7.42˜7.29(m, 5H), 6.70˜6.50(m, 3H), 4.93(d, 1H, J=11.6 Hz), 4.73(1H, d, J=11.6 Hz), 4.45(d, 1H, J=7.3 Hz), 3.63(d, 1H, J=7.3 Hz), 3.51(s, 3H), 3.63(s, 3H), 1.42(s, 3H), 1.24(s, 3H); MS, m/z: 327.43
5-1
      1H NMR(200 MHz, CDCl3) δ 7.39˜7.32(m, 2H), 7.08˜6.99(m, 2H), 6.69˜6.52(m, 3H), 4.87(d, 1H, J=11.5 Hz), 4.68(d, 1H, J=11.3 Hz), 4.43(d, 1H, J=7.2 Hz), 4.60(s, 1H, J=7.2 Hz), 3.49(s, 3H), 2.81 (s, 3H), 1.40(s, 3H), 1.25(s, 3H); MS, m/z: 345.42
5-2
      1H NMR(200 MHz, CDCl3) δ 7.41˜7.16(m, 4H), 6.74˜6.52(m, 3H), 4.88(d, 1H, J=11.4 Hz), 4.70(d, 1H, J=11.4 Hz), 4.42(d, 1H, J=7.4 Hz), 3.61(d, 1H, J=7.3 Hz), 3.51(s, 3H), 2.82(s, 3H), 1.42(s, 3H), 1.32(m, 9H), 1.24(s, 3H); MS, m/z: 383.54
5-3
      1H NMR(200 MHz, CDCl3) δ .31(m, 1H), 7.16˜7.0(m, 2H), 6.99(m, 1H), 6.70˜6.50(m, 3H), 4.93(d, 1H, J=11.9 Hz), 4.72(d, 1H, J=11.8 Hz), 4.46(d, 1H, J=7.4 Hz), 3.62(d, 1H, J=7.5 Hz), 3.50(s, 3H), 2.81 (s, 3H), 1.43(s, 3H), 1.24(s, 3H); MS, m/z: 345.42
5-4
      1H NMR(200 MHz, CDCl3) δ .31(m, 1H), 7.16˜7.0(m, 2H), 6.99(m, 1H), 6.70˜6.50(m, 3H), 4.93(d, 1H, J=11.9 Hz), 4.72(d, 1H, J=11.8 Hz), 4.46(d, 1H, J=7.4 Hz), 3.62(d, 1H, J=7.5 Hz), 3.50(s, 3H), 2.81 (s, 3H), 1.43(s, 3H), 1.24(s, 3H); MS, m/z: 345.42
5-5
      1H NMR(200 MHz, CDCl3) δ 7.55(m, 1H), 7.39˜7.22(m, 3H), 6.71˜6.50(m, 3H), 5.03(d, 1H, J=12.8 Hz), 4.82(d, 1H, J=12.8 Hz), 4.47(d, 1H, J=7.3 Hz), 3.68(d, 1H, J=7.3 Hz), 3.52(s, 3H), 2.81 (s, 3H), 1.43(s, 3H), 1.27(s, 3H); MS, m/z: 361.87
5-6
      1H NMR(200 MHz, CDCl3) δ 7.41(m, 1H), 7.28(m, 3H), 6.70˜6.50(m, 3H), 4.90(d, 1H, J=12.0 Hz), 4.70(d, 1H, J=12.0 Hz), 4.46(d, 1H, J=7.5 Hz), 3.61(d, 1H, J=7.5 Hz), 3.50(s, 3H), 2.81 (s, 3H), 1.43(s, 3H), 1.24(s, 3H); MS, m/z: 361.87
5-7
      1H NMR(200 MHz, CDCl3) δ 7.28(d, 2H, J=7.9 Hz), 7.16(d, 2H, J=7.9 Hz), 6.74˜6.49(m, 3H), 4.87(d, 1H, J=11.2 Hz), 4.68(d, 1h, J=11.2 Hz), 4.42(d, 1H, J=7.4 Hz), 4.34(d, 1H, J=7.5 Hz), 3.51(s, 3H), 2.81(s, 3H), 2.81(s, 3H), 1.40(s, 3H), 1.23(s, 3H); MS, m/z: 341.45
5-8
      1H NMR(200 MHz, CDCl3) δ 7.40˜7.22(m, 3H), 6.69˜6.50(m, 3H), 4.90(d, 1H, J=11.8 Hz), 4.73(d, 1H, 1=11.8 Hz), 4.42(d, 1H, J=7.5 Hz), 3.61(d, 1H, J=7.5 Hz), 3.51(s, 3H), 2.81(s, 3H), 1.40(s, 3H), 1.21 (s, 3H); MS, m/z: 424.31
5-9
      1H NMR(200 MHz, CDCl3) δ 7.85(m, 4H), 7.50(m, 3H), 6.71˜6.51 (m, 3H), 5.08(d, 1H, J=11.6 Hz), 4.89(d, 1H, J=11.6 Hz), 4.49(d, 1H, J=7.2 Hz), 3.69(d, 1H, J=7.2 Hz), 3.51(s, 3H), 2.82(s, 3H), 1.43(s. 3H), 1.27(s, 3H) ; MS, m/z: 377.49
5-10
      MS, m/z: 355.48
5-11
      MS, m/z: 251.33
5-12
      MS, m/z: 307.44
5-13
      MS, m/z: 291.39
5-14
      MS, m/z: 277.37
5-15
      MS, m/z: 275.35
5-16
      1H NMR(200 MHz, CDCl3) δ 7.41˜7.27(m, 5H), 6.69˜6.52(m, 3H), 4.92(d, 1H, J=11.4H), 4.72(d, 1H, J=11.4 Hz), 4.47(d, 1H, J=7.6 Hz), 3.76(q, 2H, J=6.9 Hz), 3.61(d, 1H, J=7.6 Hz), 2.81(s, 3H), 1.41(s, 3H), 1.29(m, 3H), 1.24(s, 3H); MS, m/z: 341.45
5-17
      1H NMR(200 MHz, CDCl3) δ 7.40˜7.31(m, 2H), 7.10˜6.69(m, 2H), 6.67˜6.53(m, 3H), 4.87(d, 1H, J=11.5 Hz), 4.68(d, 1H, J=11.5 Hz), 4.46(d, 1H, J=7.4 Hz), 3.75(q, 2H, J=7.0 Hz), 3.59(d, 1H, J=5.4 Hz), 2.82(s, 3H), 1.40(s, 3H), 1.28(t, 3H, J=J=7.0 Hz), 1.22(s, 3H); MS, m/z: 359.44
5-18
      1H NMR(200 MHz, CDCl3) δ 7.41˜7.29(m, 4H), 6.69˜6.56(m, 3H), 4.87(d, 1H, J=11.1 Hz), 4.69(s, 1H, J=11.1 Hz), 4.45(d, 1H, J=7.3 Hz), 3.75(m, 2H), 3.60(d, 1H, J=7.5 Hz), 1.41(s, 3H), 1.32(s, 9H), 1.32(m, 3H), 1.24(s, 3H); MS, m/z: 397.56
5-19
      1H NMR(200 MHz, CDCl3) δ 7.37˜7.26(m, 1H), 7.15˜6.99(m, 3H), 6.70˜6.62(m, 3H), 4.91(d, 1H, J=11.8 Hz), 4.71(d, 1H, J=11.8 Hz), 4.48(d, 1H, J=7.5 Hz), 3.76(q, 2H, J=6.9 Hz), 3.60(d, 1H, J=7.5 Hz), 2.82(s, 3H), 1.42(s, 3H), 1.28(m, 3H), 1.25(s, 3H); MS, m/z: 359.44
5-20
      1H NMR(200 MHz, CDCl3) δ 7.39(m, 1H), 7.26˜7.19(m, 3H), 6.69˜6.58(m, 3H), 4.94(d, 1H, J=11.7 Hz), 4.70(d, 1H, J=11.7 Hz), 4.48(d, 1H, J=7.7 Hz), 3.74(q, 2H, J=7.1 Hz), 3.63(d, 1H, J=7.7 Hz), 2.82(s, 3H), 2.36(s, 3H), 1.39(s, 3H), 1.27(m, 3H), 1.23(s, 3H); MS, m/z: 355.48
5-21
      1H NMR(200 MHz, CDCl3) δ 7.55(m, 1H), 7.39˜7.18(m, 3H), 6.70˜6.52(m, 3H), 5.04(d, 1H, J12.7 Hz), 4.81(d, 1H, J=12.7 Hz), 4.50(d, 1H, J=7.5 Hz), 3.77(q, 2H, J=7.0 Hz), 3.67(d, 1H, J=7.6 Hz), 2.81 (s, 3H), 1.42(s, 3H), 1.27(m, 3H), 1.26(s, 3H) MS, m/z: 375.90
5-22
      1H NMR(200 MHz, CDCl3) δ 7.38˜7.17(m, 4H), 6.72˜6.50(m, 3H), 4.90(d, 1H, J=12.1 Hz), 4.69(d, 1H, J=12.1 Hz), 4.48(d, 1H, J=7.6 Hz), 3.75(q, 2H, J=7.0 Hz), 3.60(d, 1H, J=7.6 Hz), 1.42(s, 3H), 1.28(s, 3H), 1.28(t, 3H, J=7.0 Hz), 1.24(s, 3H); MS, m/z: 375.90
5-23
      1H NMR(200 MHz, CDCl3) δ 7.36˜7.06(m, 4H), 6.68˜6.49(mm, 3H), 4.8(d, 1H, J=11.4 Hz), 4.67(d, 1H, J=11.4 Hz), 4.45(d, 1H, J=7.4 Hz), 3.78(m, 2H), 3.59(d, 1H, J=7.4 Hz), 2.81(s, 1H), 2.35(s, 3H), 1.40(s, 3H), 1.28(m, 3H), 1.22(s, 3H); MS, m/z: 355.48
5-24
      1H NMR(200 MHz, CDCl3) δ 7.39˜7.23(m, 3H), 6.75˜6.49(m, 3H), 4.91 (d, 1H, J=12.5 Hz), 4.72(d, 1H, J=12.5 Hz), 4.46(d, 1H, J=7.4 Hz), 3.7(q, 2H, J=7.0 Hz), 3.60(d, 1H, J=7.4 Hz), 2.80(s, 3H), 1.40(s, 3H), 1.28(t, 3H, J=7.0 Hz), 1.21 (s, 3H); MS, m/z: 438.34
5-25
      1H NMR(200 MHz, CDCl3) δ 7.86˜7.82(m, 4H), 7.54˜7.46(m, 3H), 6.69˜6.50(m, 3H), 5.07(d, 1H, J=12.0 Hz), 4.8(d, 1H, J=12.0 Hz), 4.51(d, 1H, J=7.5 Hz), 3.76(q, 2H, J=6.9 Hz), 3.67(d, 1H, J=7.5 Hz), 2.81(s, 3H), 1.429(s, 3H), 1.28(m, 3H), 1.27(s, 3H); MS, m/z: 391.51
5-26
      1H NMR(200 MHz, CDCl3) δ 7.83(m, 3H), 6.72˜6.50(m, 3H), 5.06(d, 1H, J=12.4 Hz), 4.85(d, 1H, J=12.4 Hz), 4.54(d, 1H, J=7.9 Hz), 3.79˜3.65(m, 2H), 3.65(d, 1H, J=7.9 Hz), 2.81(s, 3H), 1.44(s, 3H), 1.26(m, 3H), 1.26(s, 3H); MS, m/z: 477.45
5-27
      1H NMR(200 MHz, CDCl3) δ 6.67˜6.48(m, 3H), 4.36(d, 1H, J=7.4 Hz), 3.80(q, 2H, J=6.9 Hz), 3.32(d, 1H, J=7.4 Hz), 2.80(s, 3H), 1.42(s, 3H), 1.31 (t, 3H, J=6.9 Hz), 1.20(s, 3H); MS, m/z: 265.36
5-28
      1H NMR(200 MHz, CDCl3) δ 6.67˜6.50(m, 3H), 4.36(d, 1H, J=7.6 Hz), 3.85˜3.75(m, 3H), 3.62˜3.58(m, 1H), 3.39(d, 1H, J=7.6 Hz), 2.80(s, 3H), 1.72˜1.51(m, 2H), 1.41(s, 3H), 1.33(m, 2H), 1.29(m, 3H), 1.20(s, 3H), 0.91 (m, 3H); MS, m/z: 321.46
5-29
      1H NMR(200 MHz, CDCl3) δ 6.67˜6.48(m, 3H), 5.80˜5.58(m, 2H), 4.44˜4.08(m, 3H), 3.87˜3.74(m, 2H), 3.48(d, 1H, J=7.5 Hz), 2.80(s, 3H), 1.72(d, 3H, J=4.9 Hz), 1.41(s, 3H), 1.30(m, 3H), 1.21(s, 3H); MS, m/z: 305.42
5-30
      1H NMR(200 MHz, CDCl3) δ 6.75˜6.49(m, 3H), 6.04˜5.87(m, 1H), 5.29(dd, 1H, 1=17.1 Hz, J=1.6 Hz), 5.18(dd, 1H, J=10.2 Hz, J=1.6 Hz), 4.40(d, 1H, J=7.7 Hz), 4.35˜4.14(m, 2H), 3.80(q, 2H, J=7.1 Hz), 3.49(d, 1H, 1=7.7 Hz), 2.81(s, 3H), 1.41(s, 3H), 1.30(t, 3H, J=7.1˜Hz), 1.22(s, 3H); MS, m/z: 291.39
5-31
      1H NMR(200 MHz, CDCl3) δ 6.87˜6.49(m, 3H), 4.61˜4.35(m, 3H), 3.83˜3.30(m, 3H), 2.80(s, 3H), 2.46(m, 1H), 1.44(s, 3H), 1.29(m, 3H), 1.22(s, 3H); MS, m/z: 289.38
5-32
      MS, m/z: 355.48
5-33
      MS, m/z: 373.47
5-34
      MS, m/z: 411.59
5-35
      MS, m/z: 373.47
5-36
      MS, m/z: 369.51
5-37
      MS, m/z: 389.93
5-38
      MS, m/z: 389.93
5-39
      MS, m/z: 369.51
5-40
      MS, m/z: 452.37
5-41
      MS, m/z: 405.54
5-42
      MS, m/z: 491.48
5-43
      MS, m/z: 279.38
5-44
      MS, m/z: 335.49
5-45
      MS, m/z: 319.45
5-46
      MS, m/z: 305.42
5-47
      MS, m/z: 303.40
5-48
      1H NMR(200 MHz, CDCl3) δ 7.41˜7.26(m, 5H), 6.68˜6.49(m, 3H), 4.91(d, 1H, J=11.6 Hz), 4.71(d, 1H, J=11.6 Hz), 4.45(d, 1H, J=7.3 Hz), 3.71(m, 2H), 3.61(d, 1H, J=7.3 Hz), 2.81(s, 3H), 1.60(m, 2H), 1.45(m, 2H), 1.40(s, 3H), 1.24(s, 3H), 0.93(t, 3H, J=7.2 Hz); MS, m/z: 369.51
5-49
      1H NMR(200 MHz, CDCl3) δ 7.38˜7.26(m, 2H), 7.08˜6.99(m, 2H), 6.68˜6.50(m, 3H), 4.86(d, 1H, J=11.6 Hz), 4.67(d, 1H, r=1.6 Hz), 4.45(d, 1H, J=7.3 Hz), 3.67(m, 2H), 3.59(d, 1H, J=7.3 Hz), 2.81(s, 3H), 1.62(m, 2H), 1.41(m, 2H), 1.39(s, 3H), 1.23(s, 3H), 0.93(t, 3H, J=7.2 Hz); MS, m/z: 387.50
5-50
      1H NMR(200 MHz, CDCl3) δ 7.41˜7.26(m, 4H), 6.76˜6.48(m, 3H), 4.86(d, 1H, J=11.0 Hz), 4.68(d, 1H, J=11.0 Hz), 4.44(d, 1H, J=7.4 Hz), 3.70(m, 2H), 3.60(d, 1H, J=7.4 Hz), 2.81(s, 3H), 1.61(m, 2H), 1.43(m, 2H), 1.41(s, 3H), 1.32(m, 9H), 1.24(s, 3H), 0.94(m, 3H); MS, m/z: 425.62
5-51
      1H NMR(200 MHz, CDCl3) δ 7.37˜7.29(m, 1H), 7.15˜6.99(m, 3H), 6.69˜6.49(m, 3H), 4.91(d, 1H, J=11.9 Hz), 4.71(d, 1H, J=12.0 Hz), 4.48(d, 1H, J=7.4 Hz), 3.69(t, 2H, J=6.5 Hz), 3.60(d, 1H, J=7.4 Hz), 2.81(s, 3H), 1.61((m, 2H), 1.45(m, 2H), 1.41(s, 3H), 1.24(s, 3H), 0.93(t, 3H, J=7.2 Hz); MS, m/z: 387.50
5-52
      1H NMR(200 MHz, CDCl3) δ 7.38(m, 1H), 7.23˜7.19(m, 3H), 6.68˜6.49(m, 3H), 4.93(d, 1H, J=11.7 Hz), 4.69(d, 1H, J=11.7 Hz), 4.47(d, 1H, J=7.3 Hz), 3.71˜3.61 (m, 3H), 2.81(s, 3H), 2.36(s, 3H), 1.62(m, 2H), 1.42m, 2H), 1.38(s, 3H), 1.24(s, 3H), 0.92(t, 3H, J=7.2 Hz); MS, m/z: 383.54
5-53
      MS, m/z: 403.95
5-54
      1H NMR(200 MHz, CDCl3) δ 7.38˜7.24(m, 4H), 6.69˜6.49(m, 3H), 4.89(d, 1H, J=11.7 Hz), 4.69(d, 1H, J=11.7 Hz), 4.47(d, 1H, J=7.4 Hz), 3.68(t, 2H, J=6.4 Hz), 3.59(d, 1H, J=7.4 Hz), 2.81(s, 3H), 1.63(m, 2H), 1.45(m, 2H), 1.41(s, 3H), 1.25(s, 3H), 0.93(t, 3H, J=7.2 Hz); MS, m/z: 403.95
5-55
      MS, m/z 383.54
5-56
      1H NMR(200 MHz, CDCl3) δ 7.34˜7.21(m, 3H), 6.69˜6.50(m, 3H), 4.90(d, 1H, J=11.8 Hz), 4.71 (d, 1H, J=11.8 Hz), 4.44(d, 1H, J=7.2 Hz), 3.73˜3.67(m, 2H), 3.60(d, 1H, J=7.2 Hz), 2.81(s, 3H), 1.60(m, 2H), 1.43(m, 2H), 1.39(m, 3H), 1.22(m, 3H), 0.93(t, 3H, J=7.2 Hz); MS, m/z: 466.39
5-57
      MS, m/z: 419.57
5-58
      MS, m/z: 505.51
5-59
      MS, m/z: 293.41
5-60
      MS, m/z: 349.52
5-61
      MS, m/z: 333.47
5-62
      1H NMR(200 MHz, CDCl3) δ 6.67˜6.48(m, 3H), 6.07˜5.87(m, 1H), 5.30(dd, 1H, J=17.1 Hz, J=1.6 Hz), 5.18(dd, 1H, J=10.1 Hz, J=1.6 Hz), 4.39(d, 1H, J=7.5 Hz), 4.35(m, 1H), 4.23(m, 1H), 3.75(m, 2H), 3.59(d, 1H, J=7.5 Hz), 2.80(s, 3H), 1.62(m, 2H), 1.43(m, 2H), 1.41(s, 3H), 1.23(s, 3H), 0.95(t, 3H, J= 7.2 Hz); MS, m/z 319.45
5-63
      1H NMR(200 MHz, CDCl3) δ 6.84(m, 3H), 4.45(d, 2H, J=2.5 Hz), 4.45(m, 1H), 3.72(m, 3H), 2.80(s, 3H), 2.45(t, 1H, J=2.5 Hz), 1.62(m, 2H), 1.47(m, 2H), 1.44(s, 3H), 1.23(s, 3H), 0.95(t, 3H, J=7.2 Hz); MS, m/z: 317.43
5-64
      1H NMR(200 MHz, CDCl3) δ 7.42˜7.29(m, 5H), 6.70˜6.49(m, 3H), 4.91 (d, 1H, J=11.4 Hz), 4.83˜4.68(m, 3H), 3.71(d, 1H J=7.1 Hz), 2.74(s, 3H), 1.44(s, 3H), 1.27(s, 3H); MS, m/z: 403.53
5-65
      MS, m/z: 421.52
5-66
      1H NMR(200 MHz, CDCl3) δ 7.42˜7.14(m, 9H), 6.72˜6.51(m, 3H), 4.87(d, 1H, J=11.2 Hz), 4.83˜4.67(m, 3H), 4.63(d, 1H, J=7.0 Hz), 3.70(d, 1H, J=7.0 Hz), 2.74(s, 3H), 1.45(s, 3H), 1.33˜1.29(m, 9H), 1.27(s, 3H); MS, m/z: 459.63
5-67
      1H NMR(200 MHz, CDCl3) δ 7.41˜7.25(m, 5H), 7.12˜6.71(m, 4H), 6.68(d, 1H, J=8.1 Hz), 6.55˜6.49(m, 2H), 4.90(d, 1H, J=12.0 Hz), 4.85˜4.64(m, 4H), 3.70(d, 1H, J=7.3 Hz), 2.75(s, 3H), 1.45(s, 3H), 1.28(s, 3H); MS, m/z: 359.44
5-68
      1H NMR(200 MHz, CDCl3) δ 7.40˜7.28(m, 5H), 7.24˜7.17(m, 4H), 6.68(d, 1H, J=8.2 Hz), 6.55˜6.49(m, 2H), 4.93(d, 1H, J=11.6 Hz), 4.88˜4.63(m, 4H), 3.74(d, 1H, J=7.1 Hz), 2.75(s, 3H), 2.32(s, 3H), 1.42(s, 3H), 1.27(s, 3H) MS, m/z: 417.55
5-69
      1H NMR(200 MHz, CDCl3) δ 7.56˜7.20(m, 9H), 6.71˜6.49(m, 3H), 5.04(d, 1H, J=12.6 Hz), 4.98˜4.669m, 4H), 3.78(d, 1H, J=7.1 Hz), 2.75(s, 3H), 1.45(s, 3H), 1.30(s, 3H); MS, m/z: 437.97
5-70
      1H NMR(200 MHz, CDCl3) δ 7.39˜7.21(m, 9H), 6.71˜6.49(m, 3H), 4.88(d, 1H, J=12.0 Hz), 4.81˜4.64(m, 4H), 3.70(d, 1H, J=7.4 Hz), 2.75(s, 3H), 1.45(s, 3H), 1.28(s, 3H); MS, m/z: 437.97
5-71
      1H NMR(200 MHz, CDCl3) δ 7.39˜7.06(m, 9H), 6.85˜6.51(m, 3H), 4.86(d, 1H, J=11.8 Hz), 4.77˜4.34(m, 4H), 3.69(d, 1H, J=7.1 Hz), 2.74(s, 3H), 2.35(s, 3H), 1.43(s, 3H), 1.26(s, 3H); MS, m/z: 417.55
5-72
      1H NMR(200 MHz, CDCl3) δ 7.40˜7.15(m, 8H), 6.75˜6.48(m, 3H), 4.88(d, 1H, J=12.0 Hz), 4.83˜4.61(m, 4H), 3.70(d, 1H, J=7.3 Hz), 2.74(s, 3H), 1.43(s, 3H), 1.24(s, 3H); MS, m/z: 500.41
5-73
      1H NMR(200 MHz, CDCl3) δ 7.85˜7.81(m, 4H), 7.79˜7.40(m, 3H), 7.40˜7.219m, 5H), 6.71˜6.50(m, 3H), 5.05(d, 1H, J=11.7 Hz), 4.89(d, 1H, J=11.7 Hz), 4.84˜4.68(m, 2H), 4.68(d, 1H, J=7.2 Hz), 3.77(d, 1H, J=7.2 Hz), 2.75s, 3H), 1.50(s, 3H), 1.30(s, 3H); MS, m/z: 453.59
5-74
      MS, m/z: 431.58
5-75
      MS, m/z: 327.43
5-76
      MS, m/z: 383.54
5-77
      1H NMR(200 MHz, CDCl3) δ 7.46˜7.29(m, 5H), 6.68˜6.46(m, 3H), 5.78˜5.63(m, 2H), 4.89˜4.72(m, 2H), 4.56(d, 1H, J=7.1 Hz), 4.45˜4.10(m, 2H), 3.59(d, 1H, J=7.1 Hz), 2.73(s, 3H), 1.72(m, 3H), 1.44(s, 3H), 1.25(s, 3H); MS, m/z: 357.49
5-78
      1H NMR(200 MHz, CDCl3) δ 7.47˜7.26(m, 5H), 7.18˜6.72(m, 3H), 6.05˜5.86(m, 1H), 5.29(dd, 1H, J=17.1 Hz, J=1.4 Hz), 5.19(dd, 1H, J=10.4 Hz, J=1.4 Hz), 4.82(m, 2H), 4.55˜4.12(m, 3H), 3.56(d, 1H, J=7.1 Hz), 2.81(s, 3H), 1.44(s, 3H), 1.28(s, 3H); MS, m/z: 353.47
5-79
      1H NMR(200 MHz, CDCl3) δ 7.46˜7.30(m, 5H), 6.70˜6.48(m, 3H), 4.78(s, 2H), 4.62(d, 1H, J=7.1 Hz), 4.45(d, 1H, J=2.5 Hz), 4.83(d, 1H, J=6.9 Hz), 2.73(s, 3H), 2.47(t, 1H, J=2.4 Hz), 1.47(s, 3H), 1.26(s, 3H); MS, m/z: 351.45
5-80
      MS, m/z: 417.55
5-81
      MS, m/z: 435.54
5-82
      MS, m/z: 473.66
5-83
      MS, m/z: 435.54
5-84
      MS, m/z: 431.58
5-85
      MS, m/z: 452.00
5-86
      MS, m/z: 452.00
5-87
      MS, m/z: 431.58
5-88
      MS, m/z: 514.44
5-89
      MS, m/z: 467.61
5-90
      MS, m/z: 553.55
5-91
      MS, m/z: 341.45
5-92
      MS, m/z: 397.56
5-93
      MS, m/z: 381.52
5-94
      MS, m/z: 367.49
5-95
      MS, m/z: 365.48
5-96
      MS, m/z: 423.60
5-97
      MS, m/z: 441 59
5-98
      MS, m/z: 479.71
5-99
      MS, m/z: 441.59
5-100
      MS, m/z: 437.63
5-101
      MS, m/z: 458.05
5-102
      MS, m/z: 458.05
5-103
      MS, m/z: 437.63
5-104
      MS, m/z: 506.46
5-105
      MS, m/z: 473.66
5-106
      MS, m/z: 559.60
5-107
      MS, m/z: 347.50
5-108
      MS, m/z: 403.61
5-109
      MS, m/z: 387.57
5-110
      MS, m/z: 373.54
5-111
      MS, m/z: 371.52
5-112
      1H NMR(200 MHz, CDCl3) δ 7.41˜7.26(m, 5H), 6.73˜6.59(m, 3H), 4.92(d, 1H, J=11.5 Hz), 4.72(d, 1H, J=11.5 Hz), 4.42(d, 1H, J=7.3 Hz), 3.50(s, 3H), 3.14(q, 2H, J=7.1Hz), 1.41(s, 3H), 1.30˜1.20(m, 6H); MS, m/z: 341.45
5-113
      1H NMR(200 MHz, CDCl3) δ 7.39˜7.32(m, 2H), 7.26˜6.99(m, 2H), 6.85(s, 1H), 6.71 (m, 2H), 4.86(d, 1H, J=11.3 Hz), 4.87(d, 1H, J=11.3 Hz), 4.40(d, 1H, J=7.3 Hz), 3.58(d, 1H, J=7.3 Hz), 3.51(s, 3H), 3.15(q, 2H, J=7.1 Hz), 1.40(s, 3H), 1.29˜1.20(m, 6H); MS, m/z 359.44
5-114
      1H NMR(200 MHz, CDCl3) δ 7.41˜7.15(m, 4H), 6.99˜6.68(m, 3H), 4.86(d, 1H, J=11.2 Hz), 4.68(d, 1H, J=11.2 Hz), 3.58(d, 1H, J=7.2 Hz), 3.53(s, 3H). 3.18(q, 2H, J=7.1 Hz), 1.41(s, 3H), 1.32˜1.13(m, 15H); MS, m/z: 397.56
5-115
      1H NMR(200 MHz, CDCl3) δ 7.37˜6.99(m, 6H), 6.74(d, 1H, J=8.7 Hz), 4.90(d, 1H, J=12.0 Hz), 4.69(d, 1H, J=12.0 Hz), 4.37(d, 1H, J=.7 Hz), 3.57(m, 1H), 3.56(s, 3H), 3.22(q, 2H, J=7.1 Hz), 1.42(s, 3H), 1.38˜1.21(m, 6H); MS, m/z: 359.44
5-116
5-117 1H NMR(200 MHz, CDCl3) δ 7.40˜7.14(m, h), 6.78˜6.67(m, 3H), 4.92(d, 1H, J=11.7 Hz), 4.70(d, 1H, J=11.7 Hz), 4.41(d, 1H, J=7.4 Hz), 3.63(d, 1H, J=7.3 Hz), 3.50(s, 3H), 3,14(q, 2H, J=7.2 Hz), 2.37(s, 3H), 1.39(s, 3H), 1.28˜1.17(m, 6H), 7.55˜7.23(m, 4H), 7.06(s, 1H), 6.94˜6.88(m, 1H), 6.73(d, 1H, J=8.7 Hz), 5.00(d, 1H, J=12.5 Hz), 4.80(d, 1H, J=12.5 Hz),
#4.40(d, 1H,, J=7.3 Hz), 3.64(d, 1H, J=7.3 Hz), 3.56(s, 3H), 3.20(q, 2H, J=7.1 Hz), 1.42(s, 3H), 1.32˜1.17(m, 6H); MS, m/z: 355.48
      MS, m/z: 375.90
5-118
      1H NMR(200 MHz, CDCl3) δ 7.38˜7.25(m, 4H), 6.73˜6.59(m, 3H), 4.90(d, 1H, J=11.9 Hz), 4.69(d, 1H, J=11.9 Hz), 4.44(d, 1H, J=7.4 Hz), 3.60(d, 1H, J=7.4 Hz), 3.50(s, 3H), 3.14(q, 2H, J=7.1 Hz), 1.42(s, 3H), 1.28˜1.21(m, 6H); MS, m/z: 375.90
5-119
      1H NMR(200 MHz, CDCl3) δ 7.36˜7.02(m, 5H), 6.94˜6.88(m, 2H), 6.72(d, 1H, J=8.9 Hz), 4.84(d, 1H, J=11.9 Hz), 4.65(d, 1H, J=11.9 Hz), 4.35(d, 1H, J=7.3 Hz), 3.57(d, 1H, J=7.3 Hz), 3.55(s, 3H), 3.29(q, 2H, J=7.1 Hz), 2.35(s, 3H), 1.39(s, 3H), 1.30˜1.15(m, 6H); MS, m/z: 355.48
5-120
      1H NMR(200 MHz, CDCl3) δ 7.39˜7.23(m, 3H), 6.73˜6.58(m, 3H), 4.89(d, 1H, J=11.8 Hz), 4.72(d, 1H, J=11.8 Hz), 4.41(d, 1H, J=7.3 Hz), 4.15(d, 1H, J=7.3 Hz), 3.51(s, 3H), 3.13(q, 2H, J=7.1 Hz), 1.40(s, 3H), 1.29˜1.20(m, 6H); MS,  m/z: 438.34
5-121
      1H NMR(200 MHz, CDCl3) δ 7.86˜7.81(m, 4H), 7.53˜7.46(m, 3H), 7.01(d, 1H, J=3.2 Hz), 6.84(m, 1H), 6.72(d, 1H, J=8.7 Hz), 5.05(d, 1H, J=11.6 Hz), 4.87(d, 1H, J=11.6 Hz), 4.43(d, 1H, J=7.2 Hz), 3.65(d, 1H, J=7.2 Hz), 3.55(s, 3H), 4.19(q, 2H, J=7.2 Hz), 2.04(s, 3H), 1.41(s, 3H), 1.29˜1.22(m, 6H); MS, m/z: 391.51
5-122
      1H NMR(200 MHz, CDCl3) δ 7.62(d, 2H, J=8.1 Hz), 7.50(d, 2H, J=8.1 Hz), 6.70˜6.54(m, 3H), 5.00(d, 1H, J=12.1 Hz), 5.78(d, 1H, J=12.1 Hz), 4.47(d, 1H, J=7.6 Hz), 3.63(d, 1H, =7.6 Hz), 3.48(s, 3H), 3.13(q, 2H, J=7.1 Hz), 1.43(s, 3H), 1.28˜1.21(m, 6H); MS, m/z: 409.45
5-123
      1H NMR(200 MHz, CDCl3) δ 6.68˜6.53(m, 3H), 4.32(d, 1H, J=7.3 Hz), 3.61(s, 3H), 3.55(s, 3H), 3.34(d, 1H, J=7.3 Hz), 3.12(q, 2H, J=7.1 Hz), 1.41(s, 3H), 1.27˜1.20(m, 6H); MS, m/z: 265.36
5-124
      1H NMR(200 MHz, CDCl3) δ 6.92˜6.66(m, 3H), 4.28(d, 1H, J=7.3 Hz), 3.88˜3.74(m, 2H), 3.70˜3.53(m, 2H), 3.61 (s, 3H), 3.39(d, 1H, J=7.3 Hz), 3.16(q, 2H, J=7.2 Hz), 1.80˜1.10(m, 13H), 0.91(m, 3H); MS, m/z: 321.46
5-125
      1H NMR(200 MHz, CDCl3) δ 6.91˜6.74(m, 2H), 6.68(d, 1H, J=8.4 Hz), 5.73˜5.63(m, 2H), 4.33˜4.23(m, 2H), 4.16˜4.05(m, 1H), 3.56(s, 3H), 3.48(d, 1H, J=7.1 Hz), 3.16(q, 2H, J=7.1 Hz), 1.72(d, 3H, J=6.9 Hz), 1.40(s, 3H), 1.32˜1.23(m, 6H); MS, m/z: 35.42
5-126
      1H NMR(200 MHz, CDCl3) δ 6.67˜6.04(m, 3H), 5.99˜5.90(m, 1H), 5.30(dd, 1H, J=17.3 Hz, J=1.5 Hz), 5.18(dd, 1H, J=10.4 Hz, J=1.5 Hz), 4.42˜4.33(m, 2H), 4.23˜4.14(m, 1H), 3.53(s, 3H), 3.52(m, 1H), 3.12(q, 2H, J=7.1 Hz), 1.41(s, 3H), 1.30˜1.20(m, 6H); MS, m/z: 291.39
5-127
      1H NMR(200 MHz, CDCl3) δ 6.71˜6.58(m, 3H), 4.46(d, 2H, J=2.4 Hz), 4.41(d, 1H, J=7.1 Hz), 3.74(d, 1H, J=7.1 Hz), 3.52(s, 3H), 3.13(q, 2H, J=7.2 Hz), 2.46(t, 1H, J=2.4 Hz), 1.44(s, 3H), 1.28˜1.20(m, 6h); MS, m/z: 289.38
5-128
      MS, m/z: 355.48
5-129
      MS, m/z: 373.47
5-130
      MS, m/z: 411.59
5-131
      MS, m/z: 373.47
5-132
      MS, m/z: 369.51
5-133
      MS, m/z: 389.93
5-134
      MS, m/z: 389.93
5-135
      MS, m/z: 369.51
5-136
      MS, m/z: 452.37
5-137
      MS, m/z: 405.54
5-138
      MS, m/z: 423.48
5-139
      MS, m/z: 279.38
5-140
      MS, m/z: 335.49
5-141
      MS, m/z: 319.45
5-142
      MS, m/z: 305.42
5-143
      MS, m/z: 303.40
5-144
      MS, m/z: 369.51
5-145
      MS, m/z: 387.50
5-146
      MS, m/z: 425.62
5-147
      MS, m/z: 387.50
5-148
      MS, m/z: 383.54
5-149
      MS, m/z: 403.95
5-150
      MS, m/z: 403.95
5-151
      MS, m/z: 383.54
5-152
      MS, m/z: 466.39
5-153
      MS, m/z: 419.54
5-154
      MS, m/z: 505.51
5-155
      MS, m/z: 293.41
5-156
      MS, m/z: 349.52
5-157
      MS, m/z: 333.47
5-158
      MS, m/z: 319.45
5-159
      MS, m/z: 317.43
5-160
      MS, m/z: 383.54
5-161
      MS, m/z: 401.53
5-162
      MS, m/z: 439.64
5-163
      MS, m/z: 401.53
5-164
      MS, m/z: 397.56
5-165
      MS, m/z: 417.98
5-166
      MS, m/z: 417.98
5-167
      MS, m/z: 397.56
5-168
      MS, m/z: 480.42
5-169
      MS, m/z: 433.60
5-170
      MS, m/z: 451.53
5-171
      MS, m/z: 307.44
5-172
      MS, m/z: 363.55
5-173
      MS, m/z: 347.50
5-174
      MS, m/z: 333.47
5-175
      MS, m/z: 331.46
5-176
      MS, m/z: 417.55
5-177
      MS, m/z: 435.54
5-178
      MS, m/z: 473.66
5-179
      MS, m/z: 435.54
5-180
      MS, m/z: 431.58
5-181
      MS, m/z: 452.00
5-182
      MS, m/z: 452.00
5-183
      MS, m/z: 431.58
5-184
      MS, m/z: 514.44
5-185
      MS, m/z: 467.61
5-186
      MS, m/z: 485.55
5-187
      MS, m/z: 341.45
5-188
      MS, m/z: 397.56
5-189
      MS, m/z: 381.52
5-190
      MS, m/z: 367.47
5-191
      MS, m/z: 365.48
5-192
      MS, m/z: 431.58
5-193
      MS, m/z: 449.57
5-194
      MS, m/z: 487.693
5-195
      MS, m/z: 449.57
5-196
      MS, m/z: 445.61
5-197
      MS, m/z: 466.03
5-198
      MS, m/z: 466.03
5-199
      MS, m/z: 445.61
5-200
      MS, m/z: 528.47
5-201
      MS, m/z: 481.64
5-202
      MS, m/z: 567.58
5-203
      MS, m/z: 355.48
5-204
      MS, m/z: 411.59
5-205
      MS, m/z: 395.55
5-206
      MS, m/z: 381.52
5-207
      MS, m/z: 379.50
5-208
      MS, m/z: 437.633
5-209
      MS, m/z: 455.62
5-210
      MS, m/z: 493.47
5-211
      MS, m/z: 455.62
5-212
      MS, m/z: 451.66
5-213
      MS, m/z: 472.07
5-214
      MS, m/z: 472.07
5-215
      MS, m/z: 451.66
5-216
      MS, m/z: 534.51
5-217
      MS, m/z: 487.69
5-218
      MS, m/z: 873.62
5-219
      MS, m/z: 361.53
5-220
      MS, m/z: 417.64
5-221
      MS, m/z: 401.59
5-222
      MS, m/z: 387.57
5-223
      MS, m/z: 385.55
5-224
      MS, m/z: 403.53
5-225
      1H NMR(500 MHz, CDCl3) δ 7.34˜7.10(m, 9H), 7.06˜7.03(m, 2H), 6.73(d, 1H, J=8.8 Hz), 4.82(d, 1H, J=11.4 Hz), 4.63(d, 1H, J=11.4 Hz), 4.25(d, 1H, J=6.9 Hz), 4.21(s, 3H), 3.51(d, 1H, J=6.9 Hz), 3.49(s, 3H), 1.40(s, 3H), 1.26(s, 3H); MS, m/z: 421.52˜
5-226
      1H NMR(500 MHz, CDCl3) δ 7.39˜7.26(m, 9H), 6.69˜6.56(m, 3H), 4.87(d, 1H, J=11.2 Hz), 4.53(d, 1H J=11.2 Hz), 4.40(d, 1H, J=7.3 Hz), 4.28(s, 2H), 3.60(d, 1H, J=7.3 Hz), 3.45(s, 3H), 1.41(s, 3H), 1.32(s, 9H), 1.23(s, 3H); MS, m/z: 459.63
5-227
      1H NMR(500 MHz, CDCl3) δ 7.38˜7.26(m, 6H), 7.14˜7.10(m, 2H), 7.00(m, 1H), 6.72˜6.60(m, 3H), 4.91(d, 1H, J=11.9 Hz), 4.71(d, 1H, J=11.7 Hz), 4.42(d, H, J=7.4 Hz), 4.27(s, 2H), 3.55(d, 1H, J=7.45 Hz), 3.44(s, 3H), 1.42(s, 3H), 1.24(s, 3H); MS, m/z: 421.52
5-228
      1H NMR(200 MHz, CDCl3) δ 7.37˜7.18(m, 9H), 6.68˜6.51(m, 3H), 4.92(d, 1H, J=11.8 Hz), 4.69(d, 1H, J=11.8 Hz), 4.41(d, 1H, J=7.2 Hz), 4.27(s, 2H), 3.62(d, 1H, J=7.2 Hz), 3.42(s, 3H), 2.37(s, 3H), 1.39(s, 3H), 1.22(s, 3H); MS, m/z: 417.55
5-229
      MS, m/z: 437.97
5-230
      1H NMR(200 MHz, CDCl3) δ 7.38˜7.23 (m, 9H), 6.98˜6.51(m, 3H), 4.92(d, 1H, J=11.3 Hz), 4.73 (d, 1H, J=11.3 Hz), 4.36(d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.58(d, 1H, J=7.3 Hz), 3.42(m, 3H), 1.57˜1.23 (m, 9H); MS, m/z: 437.97
5-231
      1H NMR(500 MHz, CDCl3) δ 7.34˜7.26(7H), 7.16(d, 2H, J=7.8 Hz), 6.94(s, 1H), 6.78(m, 1H), 6.67(d, 1H, J=8.7 Hz), 4.84(d, 1H, J=11.3 Hz), 4.65(d, 1H, J=11.3 Hz), 4.33(d, 1H, J=7.1 Hz), 4.25(s, 2H), 3.56(d, 1H, J=7.1 Hz), 3.47(s, 3H), 2.35(s, 3H), 1.38(s, 3H), 1.22(s, 3H); MS, m/z: 417.55
5-232
      1H NMR(500 MHz, CDCl3) δ 7.38˜7.23(m, 8H), 6.66˜6.57(m, 3H), 4.89(d, 1H, J=11.9 Hz), 4.72(d, 1H, J=11.9 Hz), 4.40(d, 1H, J=7.4 Hz), 4.27(s, 2H), 3.59(d, 1H, J=7.4 Hz), 3.45(s, 3H), 1.39(s, 3H), 1.20(s, 3H); MS, m/z: 500.41
5-233
      MS, m/z: 453.59
5-234
      MS, m/z: 431.58
5-235
      MS, m/z: 327.43
5-236
      MS, m/z: 383.54
5-237
      MS, m/z: 367.49
5-238
      MS, m/z: 353.47
5-239
      MS, m/z: 351.45
5-240
      MS, m/z: 417.55
5-241
      MS, m/z: 435.54
5-242
      MS, m/z:
5-243
      MS, m/z: 473.66
5-244
      MS, m/z: 435.54
5-245
      MS, m/z: 431.58
5-246
      MS, m/z: 452.00
5-247
      MS, m/z: 452.00
5-248
      MS, m/z: 431.58
5-249
      MS, m/z: 514.44
5-250
      MS, m/z: 467.61
5-251
      MS, m/z: 553.55
5-252
      MS, m/z: 341.45
5-253
      MS, m/z: 397.56
5-254
      MS, m/z: 381.52
5-255
      MS, m/z: 367.49
5-256
      MS, m/z: 365.48
5-257
      MS, m/z: 431.58
5-258
      MS, m/z: 449.57
5-259
      MS, m/z: 487.69
5-260
      MS, m/z: 449.57
5-261
      MS, m/z: 445.61
5-262
      MS, m/z: 466.03
5-263
      MS, m/z: 466.03
5-264
      MS, m/z: 445.61
5-265
      MS, m/z: 528.47
5-266
      MS, m/z: 481.64
5-267
      MS, m/z: 567.59
5-268
      MS, m/z: 355.48
5-269
      MS, m/z: 411.59
5-270
      MS, m/z: 395.55
5-271
      MS, m/z: 381.52
5-272
      MS, m/z: 445.61
5-273
      MS, m/z: 463.60
5-274
      MS, m/z: 501.72
5-275
      MS, m/z: 463.60
5-276
      MS, m/z: 459.63
5-277
      MS, m/z: 480.05
5-278
      MS, m/z: 480.05
5-279
      MS, m/z: 459.63
5-280
      MS, m/z: 542.49
5-281
      MS, m/z: 495.67
5-282
      MS, m/z: 581.60
5-283
      MS, m/z: 369.51
5-284
      MS, m/z: 425.62
5-285
      MS, m/z: 409.57
5-286
      MS, m/z: 395.55
5-287
      MS, m/z: 393.53
5-288
      1H NMR(200 MHz, CDCl3) δ 7.34˜7.25 (m, 15H), 6.68˜6.52 (m, 3H), 4.89 (d, 1H, J=11.4 Hz), 4.78˜4.60 (m, 3H), 4.20 (s, 2H), 3.69 (d, 1H, J=7.2 Hz), 1.43 (s, 3H), 1.27 (s, 3H); MS, m/z: 479.62
5-289
      1H NMR(200 MHz, CDCl3) δ 7.35˜7.24 (m, 10H), 7.06˜6.97 (m, 4H), 6.98˜6.57 (m, 3H), 4.85 (d, 1H, J=11.5 Hz), 4.70 (m, 4H), 4.21 (s, 2H), 3.68 (d, 1H, J=7.0 Hz), 1.43 (s, 3H), 1.26 (s, 3H); MS, m/z: 497.62
5-290
      1H NMR(200 MHz, CDCl3) δ 7.42˜7.25 (m, 14H), 6.68˜6.55 (m, 3H), 4.85 (d, 1H, J=11.2 Hz), 4.73˜4.58 (m, 4H), 4.12 (s, 2H), 3.69 (d, 1H, J=7.2 Hz), 1.33 (s, 3H), 1.32 (s, 9H), 1.26 (s, 3H); MS, m/z: 535.73
5-291
      1H NMR(200 MHz, CDCl3) δ 7.35˜7.25 (m, 10H), 7.11˜6.94 (m, 4H), 6.65˜6.52 (m, 3H), 4.87 (d, 1H, J=12.2 Hz), 4.70 (m, 2H), 4.21 (s, 2H), 3.69 (d, 1H, J=7.2 Hz), 1.45 (s, 3H), 1.28 (s, 3H); MS, m/z: 497.62
5-292
      1H NMR(200 MHz, CDCl3) δ 7.40˜7.18 (m, 13H), 6.65˜6.56 (m, 3H), 4.92 (d, 1H, J=11.6 Hz), 4.73˜4.61 (m, 2H), 4.21 (s, 2H), 3.73 (d, 1H, J=7.2 Hz), 2.31 (s, 3H), 1.42 (s, 9H), 1.28 (s, 3H); MS, m/z: 493.65
5-293
      MS, m/z: 393.65
5-294
      1H NMR(200 MHz, CDCl3) δ 7.35˜7.19 (m, 14H), 6.68˜6.55 (m, 3H), 4.80 (d, 1H, J=11.2 Hz), 4.69˜4.61 (m, 3H), 4.20 (s, 2H), 3.67 (d, 1H, J=7.2 Hz), 1.44 (s, 3H), 1.27 (s, 3H); MS, m/z: 514.07
5-295
      1H NMR(200 MHz, CDCl3) δ 7.34˜7.12 (m, 13H), 6.63˜6.58 (m, 3H), 4.90 (d, 1H, J=11.6 Hz), 4.73˜4.61 (m, 2H), 4.19 (s, 2H), 3.67 (d, 1H, J=7.0 Hz), 2.34 (s, 3H), 1.42 (s, 9H), 1.25 (s, 3H); MS, m/z: 493.65
5-296
      1H NMR(200 MHz, CDCl3) δ 7.35˜7.20 (m, 13H), 6.63˜6.56 (m, 3H), 4.78 (d, 1H, J=11.4 Hz), 4.72˜4.69 (m, 3H), 4.59 (d, 1H, J=7.2 Hz), 4.20 (s, 2H), 3.68 (d, 1H, J=7.2 Hz), 1.42 (s, 3H), 1.24 (s, 3H); MS, m/z: 576.51
5-297
      1H NMR(200 MHz, CDCl3) δ 7.84˜7.76 (m, 14H), 7.50˜7.45 (m, 3H), 7.32˜7.25 (m, 10H), 6.70˜6.55 (m, 3H), 5.03 (d, 1H, J=11.6 Hz), 4.86 (d, 1H, J=11.6 Hz), 4.70 (m, 2H), 4.20 (s, 2H), 3.74 (d, 1H, J=7.0 Hz), 1.44 (s, 3H), 1.29 (s, 3H); MS, m/z: 529.69
5-298
      1H NMR(200 MHz, CDCl3) δ 7.79˜7.74 (m, 3H), 7.37˜7.22 (m, 10H), 6.70˜6.55 (m, 3H), 4.96 (d, 1H, J=12.6 Hz), 4.77 (d, 1H, J=12.6 Hz), 4.70 (m, 4H), 4.22 (s, 2H), 3.71 (d, 1H, J=7.6 Hz), 1.46 (s, 3H), 1.28 (s, 3H); MS, m/z: 507.68
5-299
      1H NMR(200 MHz, CDCl3) δ 7.39˜7.26 (m, 10H), 6.67˜6.50 (m, 3H), 4.81 (d, 1H, J=11.4 Hz), 4.72 (d, 1H, J=11.4 Hz), 4.50 (d, 1H, J=7.0 Hz), 4.20 (s, 2H), 3.60 (s, 2H), 3.41 (d, 1H, J=7.0 Hz), 1.44 (s, 3H), 1.23˜(s, 3H); MS, m/z: 403.53
5-300
      MS, m/z: 459.63
5-301
      MS, m/z: 443.59
5-302
      MS, m/z: 429.56
5-303
      MS, m/z: 427.55
5-304
      MS, m/z: 493.65
5-305
      1H NMR(200 MHz, CDCl3) δ 7.30˜6.91 (m, 14H), 6.57˜6.30 (m, 3H), 4.62 (d, 1H, J=11.2 Hz), 4.48 (d, 1H, J=11.2 Hz), 4.35 (d, 1H, J=8.0 Hz), 4.12 (s, 2H), 3.80˜3.74 (m, 2H), 3.46 (d, (d, 1H, J=8.0 Hz), 2.79 (t, 2H, J=6.2 Hz), 1.28 (s, 3H), 1.12 (s, 3H); MS, m/z: 511.64
5-306
      1H NMR(200 MHz, CDCl3) δ 7.32˜7.27 (m, 14H), 6.57˜6.30 (m, 3H), 4.64 (d, 1H, J=11.2 Hz), 4.50 (d, 1H, J=11.2 Hz), 4.36 (d, 1H, J=8.0 Hz), 4.11 (s, 2H), 3.80˜3.74 (m, 2H), 4.46 (d, 1H, J=8.0 Hz), 2.80 (t, 2H, J=6.2 Hz), 1.34 (s, 3H), 1.25 (s, 3H); MS, m/z: 549.76
5-307
      1H NMR(300 MHz, CDCl3) δ 7.30˜7.19 (m, 11H), 7.13(m, 1H), 7.04(m, 2H), 6.98(m, 1H), 6.62 (d, 1H, J=5.2 Hz), 6.52 (dd, 1H, J=5.2 Hz, J=1.5 Hz), 6.36 (d, 1H, J=1.5 Hz), 4.72 (d, 1H, J=7.1 Hz), 4.58 (d, 1H, J=7.1 Hz), 4.44 (d, 1H, J=4.6 Hz), 4.19 (s, 2H), 3.55 (m, 2H), 3.85 (d, 1H, J=4.6 Hz), 2.86 (t, 2H, J= 4.0 Hz), 1.38 (s, 3H), 1.21 (s, 3H); MS, m/z: 511.64
5-308
      1H NMR(200 MHz, CDCl3) δ 7.30˜7.04 (m, 14H), 6.55(d, 1H, J=8.6 Hz), 6.45 (dd, 1H, J=8.6 Hz, J=2.4 Hz), 6.29 (d, 1H, J=2.4 Hz), 4.75 (d, H, J=11.8 Hz), 4.56 (d, 1H, J=11.8 Hz), 4.36 (d, 1H, J=7.8 Hz), 4.11 (s, 2H), 3.78 (m, 2H), 3.52 (d, 1H, J=7.8 Hz), 2.79 (t, 2H, J=6.6 Hz), 2.25 (s, 3H), 1.28 (s, 3H), 1.13 (s, 3H); MS, m/z: 507.68
5-309
      1H NMR(200 MHz, CDCl3) δ 7.42˜7.03 (m, 14H), 6.60˜6.29 (m, 3H), 4.85 (d, 1H, J=12.8 Hz), 4.72 (d, 1H, J=12.8 Hz), 4.38 (d, 1H, J=7.6 Hz), 4.12 (s, 2H), 3.82˜3.76 (m, 2H), 3.55 (d, 1H, J=7.6 Hz), 2.79 (t, 2H, J=6.2 Hz), 1.28 (s, 3H), 1.12 (s, 3H); MS, m/z: 528.10
5-310
      1H NMR(200 MHz, CDCl3) δ 7.30˜7.05 (m, 14H), 6.57˜6.28 (m, 3H), 4.63 (d, 1H, J=12.0 Hz), 4.47 (d, 1H, J=12.0 Hz), 4.36 (d, 1H, J=7.8 Hz), 4.12 (s, 2H), 3.80˜3.73 (m, 2H), 3.46 (d, 1H, J=7.8 Hz), 2.78 (t, 2H, J=6.4 Hz), 1.30 (s, 3H), 1.13 (s, 3H); MS, m/z: 528.10
5-311
      1H NMR(200 MHz, CDCl3) δ 7.28˜7.04 (m, 14H), 6.60˜6.27 (m, 3H), 4.63 (d, 1H, J=11.2 Hz), 4.39 (d, 1H, J=11.2 Hz), 4.42 (d, 1H, J=7.6 Hz), 4.12 (s, 2H), 3.80˜3.75 (m, 2H), 3.46 (d, 1H, J=7.6 Hz), 2.78 (t, 2H, J=6.4 Hz), 2.27 (s, 3H), 1.28 (s, 3H), 1.15 (s, 3H); MS, m/z: 507.68
5-312
      1H NMR(300 MHz, CDCl3) δ 7.38˜7.19 (m, 12H), 6.98˜6.62 (m, 3H), 4.47 (d, 1H, J=5.5 Hz), 4.60 (d, 1H, J=5.5 Hz), 4.40 (d, 1H, J=4.6 Hz), 4.18 (s, 2H), 3.90˜3.84 (m, 2H), 3.54 (d, 1H, J=4.6 Hz), 2.87 (t, 2H, J=4.0 Hz), 1.33 (s, 3H), 1.18 (s, 3H); MS, m/z: 590.54
5-313
      MS, m/z: 543.71
5-314
      MS, m/z: 629.65
5-315
      1H NMR(300 MHz, CDCl3) δ 7.37˜7.13 (m, 10H), 6.98˜6.62 (m, 3H), 4.31 (d, 1H, J=4.6 Hz), 4.17 (s, 2H), 3.98˜3.88 (m, 2H), 3.51 (s, 3H), 3.27 (d, 1H, J=4.6 Hz), 2.87 (t, 2H, J=4.1 Hz), 1.38 (s, 3H), 1.18 (s, 3H); MS, m/z: 417.55
5-316
      MS, m/z: 473.66
5-317
      MS, m/z: 457.62
5-318
      MS, m/z: 443.59
5-319
      MS, m/z: 441.58
5-320
      MS, m/z: 499.70
5-321
      1H NMR(300 MHz, CDCl3) δ 7.35˜7.23 (m, 9H), 7.07˜6.67 (m, 3H), 4.82 (d, 1H, J=11.4 Hz), 4.64 (d, 1H, J=11.4 Hz), 4.34 (d, 1H, J=7.0 Hz), 3.70˜3.64 (m, 2H), 3.53 (d, 1H, J=7.0 Hz), 1.70˜1.15 (m, 19H); MS, m/z: 517.69
5-322
      1H NMR(300 MHz, CDCl3) δ 7.40˜7.15 (m, 9H), 6.73˜6.68 (m, 3H), 4.81 (d, 1H, J=11.3 Hz), 4.64 (d, 1H, J=11.3 Hz), 4.30 (d, 1H, J=6.7 Hz), 4.22 (s, 2H), 3.72˜3.68 (m, 2H), 3.52 (d, 1H, J=76.7 Hz), 1.71˜0.92 (m, 33H); MS, m/z: 555.81
5-323
      1H NMR(300 MHz, CDCl3) δ 7.32˜7.25 (m, 6H), 7.12˜6.67 (m, 6H), 4.87 (d, 1H, J=11.9 Hz), 4.68 (d, 1H, J=11.9 Hz), 4.36 (d, 1H, J=7.1 Hz), 4.23 (s, 2H), 3.68 (t, 2H, J=6.9 Hz), 3.54 (d, 1H, J=7.1 Hz), 1.68˜0.87 (m, 19H); MS, m/z: 517.69
5-324
      1H NMR(300 MHz, CDCl3) δ 7.35˜7.10 (m, 9H), 6.93˜6.68 (m, 3H), 4.86 (d, H, J=11.7 Hz), 4.67 (d, 1H, J=11.7 Hz), 4.33 (d, 1H, J=6.8 Hz), 4.23 (s, 2H), 3.69˜3.63 (m, 2H), 3.56 (d, 1H, J=6.8 Hz), 1.53˜0.90 (m, 19H): MS, m/z: 513.73
5-325
      1H NMR(300 MHz, CDCl3) δ 7.39˜7.25 (m, 9H), 6.70˜6.64 (m, 3H), 5.00 (d, 1H, J=12.8 Hz), 4.79 (d, 1H, J=12.8 Hz), 4.35 (d, 1H, J=7.4 Hz), 4.27 (s, 2H), 3.70˜3.64 (m, 2H), 1.66˜0.84 (m, 19H); MS, m/z: 534.14
5-326
      1H NMR(200 MHz, CDCl3) δ 7.36˜7.26 (m, 9H), 6.68˜6.54 (m, 3H), 4.87 (d, 1H, J=12.0 Hz), 4.68 (d, 1H, J=12.0 Hz), 4.40 (d, 1H, J=6.7 Hz), 4.28 (s, 2H), 3.70˜3.56 (m, 3H), 1.65˜1.24 (m, 19H); MS, m/z: 596.59
5-327
      MS, m/z: 513.73
5-328
      MS, m/z: 596.59
5-329
      MS, m/z: 549.76
5-330
      MS, m/z: 635.70
5-331
      1H NMR(200 MHz, CDCl3) δ 7.36˜6.97 (m, 7H), 6.75˜6.67 (m, 1H), 4.25 (d, 1H, J=6.4 Hz), 4.21 (m, 2H), 3.83˜3.62 (m, 4H), 3.32 (d, 1H, J=6.4 Hz), 1.70˜0.95 (m, 28H); MS, m/z: 479.71
5-332
      MS, m/z: 479.71
5-333
      MS, m/z: 463.67
5-334
      MS, m/z: 449.64
5-335
      MS, m/z: 447.62
5-336
      1H NMR(200 MHz, CDCl3) δ 7.30(m 4.90(d, 1H, J=11.1Hz), 4.72(d, 1H, J=11.1 Hz), 4.40(d, J=7.3 Hz), 4.20(s, 2H), 3.79(s, 3H) 3.60(d, 1H, J=7.3 Hz), 3.45(s, 3H), 1.40(s, 3H), 1.23(s, 3H); MS, m/z: 433.55 5-337
5-337
      1H NMR(200 MHz, CDCl3) δ 6.95˜7.40(m, 8H), 6.75(m, 3H), 4.83(d, 1H, J=11.4 Hz), 4.65(d, 1H, J=11.4 Hz), 4.15(s, 2H), 4.2 3.50(s, 3H), 1.40(s, 3H), 1.23(s, 3H); MS, m/z: 451.54
5-338
      1H NMR(200 MHz, CDCl3) δ 7.10˜7.40(m, 7H), 6.90(d, 1H, J=8.6 Hz), 6.75(m, 3H), 4.83(d, 1H, J=11.3 Hz), 4.65(d, 1H, J=11 3.53(d, 1H, J=6.9 Hz), 3.50(s, 3H), 1.32(m, 15H) MS, m/z: 489.66
5-339
      1H NMR(200 MHz, CDCl3) δ 7.30(m 6.75(m, 3H), 4.90(d, 1H, J=11.3 Hz), 4.70(d, 1H, J=11.3 Hz), 4.40(d, J=6.9 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.61(d, 1H, J=6.9 Hz), 3.45(s, 3H), 1.41(s, 3H), 1.23(s, 3H); MS, m/z: 451.54
5-340
      1H NMR(200 MHz, CDCl3) δ 7.18˜7.42(m, 6H)6.87(d, 2H, J=8.5 Hz), 6.65(m, 2H), 6.56(dd, 1H, J=9.0 Hz, J=2.6 Hz), 4.90(d, 1H, J=11.6 Hz), 4.70(d, 1H, J=11.6 Hz), 4.41 (d, J= 7.5 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.63(d, 1H, J=7.5 Hz), 3.45(s, 3H), 2.38(s, 3H), 1.40(s, 3H), 1.23(s, 3H); MS, m/z: 447.58
5-341
      1H NMR(200 MHz, CDCl3) δ 7.84(m, 2H), 7.26(m, 2H), 6.88(d, 2H, J=8.5 Hz), 6.70˜6.59(m, 3H), 5.06(d, 1H, J=12.5 Hz), 4.84(d, 1H, J=12.5 Hz), 4.50(d, 1H, J=7.7 Hz), 4.22(s, 2H), 3.81(s, 3H), 3.65(d, 1H, J=7.7 Hz), 3.43(s, 3H), 1.46(s, 3H), 1.26(s, 3H); MS, m/z: 468.00
5-342
      1H NMR(200 MHz, CDCl3) δ 7.20˜7.42(m, 6H), 6.87(d, 2H, J=8.5 Hz), 6.65(m, 2H), 6.56(dd, 1H, J=9.1 Hz, J=2.2 Hz), 4.88(d, 1H, J=12.5 Hz), 4.69(d, 1H, J=12.5 Hz), 4.20(s, 2H), 4.40(d, J=7.7 Hz), 3.60(d, 1H, J=7.7 Hz), 3.80(s, 3H), 3.46(s, 3H), 1.30(m, 6H); MS, m/z: 468.00
5-343
      1H NMR(200 MHz, CDCl3) δ 7.10˜7.42(m, 6H)677(d, 2H, J=8.5 Hz), 6.56˜6.70(m, 3H), 4.86(d, 1H, J=11.4 Hz), 4.66(d, 1H, J=11.4 Hz), 4.39(d, J=7.3 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.58(d, 1H, J=7.3 Hz), 3.47(s, 3H), 2.35(s, 3H), 1.30(m, 6H); MS, m/z: 447.58
5-344
      1H NMR(200 MHz, CDCl3) d 7.34˜7.22(m, 5H), 6.86(d, 2H), 6.71˜6.60(m, 3H), 4.90(d, 1H, J=11.9 Hz), 4.72(d, 1H, J= 11.9 Hz), 4.39(d, 1H, J=7.2 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.59(d, 1H, J=7.2 Hz), 3.47(s, 3H), 1.40(s, 3H), 1.21 (s, 3H); MS, m/z: 530.44
5-345
      1H NMR(200 MHz, CDCl3) δ 7.57(m, 1H), 7.39˜7.19(m, 8H), 6.86(d, 2H, J=10.2 Hz), 6.73˜6.56(m, 3H), 5.02(d, 1H, J= 12.5 Hz), 4.71(d, 1H, J=12.5 Hz), 4.44(d, 1H, J=7.2 Hz), 3.80(s, 3H), 3.66(d, 1H. J=7.3 Hz0, 3.48(s, 3H), 1.42(s, 3H), 1.26(s, 3H); MS, m/z: 483.61
5-346
      1H NMR(200 MHz, CDCl3) δ 7.82(m, 3H), 7.21(m, 2H), 6.87(d, 2H, J=9.5 Hz), 6.50˜6.70(m, 3H), 5.06(d, 1H,. J=12.4 Hz), 4.84(d, 1H, J=12.4 Hz), 4.49(d, J=7.7 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.64(d, 1H, J=7.7 Hz), 3.42(s, 3H), 1.45(s, 3H), 1.25(s, 3H); MS, m/z: 461.61
5-347
      1H NMR(200 MHz, CDCl3) δ 7.28(m, 2H), 6.87(d, 2H, J=9.0 Hz), 6.65(d, 1H, J=2.5 Hz), 6.62(s, 1H), 6.54(dd, 1H, J=9.0 Hz, J=2.5 Hz), 4.31(d, 1H, J=7.3 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.61(s, 3H), 3.52(s, 3H), 3.34(d, 1H, J=7.3 Hz), 1.41(s, 3H), 1.20(s, 3H); MS, m/z: 357.45
5-348
      1H NMR(200 MHz, CDCl3) δ 7.28(d, 2H, J=8.4 Hz), 6.87(d, 2H, J=8.4 Hz), 6.65(d, 1H, J=2.8 Hz), 6.61(s, 1H), 6.52(dd, 1H, J=8.6 Hz, J=2.8 Hz), 4.30(d, J=7.3 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.50(s, 3H), 3.40(d, 1H, J=7.3 Hz), 1.60(br, 2H), 1.40(s, 3H), 1.21˜1.45(m, 4H), 1.20(s, 3H), 0.91 (br, 3H); MS, m/z: 413.61
5-349
      1H NMR(200 MHz, CDCl3) δ 7.28(d, 2H, J=9.5 Hz), 6.87(d, 2H, J=9.5 Hz), 6.65(m, 2H), 6.52(dd, 1H, J=8.6 Hz, J=2.7 Hz), 5.70(m, 2H), 4.00˜4.40(m, 2H), 4.19(s, 2H), 3.80(s, 3H), 3.50(s, 3H), 1.71 (d, 3H, J=6 Hz), 1.40(s, 3H), 1.21 (s, 3H); MS, m/z: 357.45
5-350
      1H NMR(200 MHz, CDCl3) δ 7.34(d, 1H, J=2.6 Hz), 7.16˜7.16(m, 3H), 6.70(m, 3H), 5.92(m, 1H), 5.34˜5.17(m, 2H), 5.30(dd, 1H, J=17.3 Hz, J=1.6 Hz), 5.19(dd, 1H, J= 10.3 Hz, J=1.6 Hz), 4.20(s, 2H), 3.68(s, 3H), 3.54(s, 3H), 4.43(d, 1H, J=7.1 Hz), 1.40(s, 3H), 1.24(s, 3H); MS, m/z: 383.49
5-351
      1H NMR(200 MHz, CDCl3) δ 7.26(d, 2H, J=8.6 Hz), 6.86(d, 2H, J=8.6 Hz), 6.67˜6.55(m, 3H), 4.46˜4.38(m, 3H), 4.19(s, 2H), 3.79(s, 3H), 3.73(d, 1H, J=7.3 Hz), 3.47(s, 3H), 2.54(t, 1H, J=2.4 Hz), 1.43(s, 3H), 1.21 (s, 3H); MS, m/z: 381.48
5-352
      1H NMR(200 MHz, CDCl3) δ 7.41˜7.25(m, 7H), 6.88(d, 2H, J=8.7 Hz), 6.69˜6.51(m, 3H), 4.91(d, 1H, J=11.4 Hz), 4.71(d, 1H, J=11.4 Hz), 4.45(d, 1H, J=7.5 Hz), 4.21(s, 2H), 3.81(s, 3H), 3.74(m, 2H), 3.61(d, 1H, J=7.5 Hz), 1.41(s, 3H), 1.26(s, 3H), 1.26(t, 3H, J=7.0 Hz); MS, m/z: 447.58
5-353
      1H NMR(200 MHz, CDCl3) δ 7.36˜7.25(m, 4H), 7.06(d, 2H, J=8.6 Hz), 6.87(d, 2H, J=8.6 Hz), 4.86(d, 1H, J=11.5 Hz), 4.67(d, 1H, J=11.5 Hz), 4.43(d, 1H, J=7.6 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.70(q, 2H, J=7.1), 3.58(d, 1H, J=7.6 Hz), 1.39(s, 3H), 1.25(s, 3H), 1.21(m, 3H); MS, m/z: 465.57
5-354
      1H NMR(200 MHz, CDCl3) δ 7.40˜7.28(m, 6H), 6.87(d, 2H, J=8.6 Hz), 6.68˜6.57(m, 3H), 4.86(d, 1H, J=11.2 Hz), 4.68(d, 1H, J=11.2 Hz), 4.429d, 1H, J=7.5 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.71(q, 1H, J=7.1 Hz), 3.59(d, 1H, J=7.5 Hz), 1.41(s, 3H), 1.32(m, 9H), 1.26(s, 3H), 1.27(m, 3H); MS, m/z: 503.69
5-355
      1H NMR(200 MHz, CDCl3) δ 7.37˜7.24(m, 4H), 7.08˜6.91(m, 4H), 6.88(d, 2H, J=8.7 Hz), 6.68˜6.51(m, 3H), 4.92(d, 1H, J=11.7 Hz), 4.71 (d, 1H, J=11.7 Hz), 4.46(d, 1H, J=7.5 Hz), 4.219(s, 2H), 3.81(s, 3H), 3.69(q, 2H, J=7.0 Hz), 3.59(d, 1H, J=7.5 Hz), 1.42(s, 3H), 1.24(s, 3H), 1.23(m, 3H); MS, m/z: 465.57
5-356
      1H NMR(200 MHz, CDCl3) δ 7.41˜7.14(m, 6H), 6.87(d, 2H, J=8.8 Hz), 6.69˜6.54(m, 3H), 4.93(d, 1H, J=11.7 Hz), 4.70(d, 1H, J=11.7 Hz), 4.459(d, 1H, J=7.7 Hz), 3.80(s, 3H), 3.70(q, 2H, J=7.0 Hz), 3.62(d, 1H, J=7.7 Hz), 1.39(s, 3H), 1.23(s, 3H), 1.23(t, 3H, J=7.7 Hz); MS, m/z: 461.61
5-357
      1H NMR(200 MHz, CDCl3) δ 7.56˜7.52(m, 1H), 7.39˜7.9(m, 5H), 6.87(d, 2H, J=8.7 Hz), 6.70˜6.54(m, 3H), 5.04(d, 1H, J=12.9 Hz), 4.80(d, 1H, J=12.9 Hz), 4.47(d, 1H, J=7.3 Hz), 4.21(s, 2H), 3.80(s, 3H), 3.70(m, 3H), 1.42(s, 3H), 1.26˜1.17(m, 6H); MS, m/z: 482.02
5-358
      11H NMR(200 MHz, CDCl3) δ 7.38˜7.17(m, 6H), 6.88(d, 2H, J=8.7 Hz), 6.68˜6.51(m, 3H), 4.89(d, 1H, J=11.9 Hz), 4.69(d, 1H, J=11.9 Hz), 4.46(d, H, J=7.6 Hz), 4.21(s, 2H), 3.81(s, 3H), 3.78(m, 2H), 3.59(d, 1H, J=7.6 Hz), 1.42(s, 3H), 1.24(s, 3H), 1.23(m, 3H); MS, m/z: 482.02
5-359
      1H NMR(200 MHz, CDCl3) δ 7.37˜7.08(m, 6H), 6.87(d, 2H, J=8.6 Hz), 6.676.51(m, 3H), 4.86(d, 1H, J=11.2 Hz), 4.65(d, 1H, J=11.2 Hz), 4.42(d, 1H, J=7.5 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.71 (m, 2H), 3.58(d, 1H, J=7.5 Hz), 2.35(s, 3H), 1.40(s, 3H), 1.23(s, 3H), 1.22(m, 3H); MS, m/z: 461.61
5-360
      1H NMR(200 MHz, CDCl3) δ 7.38˜7.22(m, 5H), 6.87(d, 2H, J=8.4 Hz), 6.67˜6.51(m, 3H), 4.90(d, 1H, J=12.1 Hz), 4.71(d, 1H, J=12.1 Hz), 4.43(d, 1H, J=7.5 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.70(m, 2H), 3.59(d, 1H, J=7.5 Hz), 1.40(s, 3H), 1.23(m, 3H), 1.21 (s, 3H); MS, m/z: 544.47
5-361
      1H NMR(200 MHz, CDCl3) δ 7.82(m, 4H), 7.53˜7.46(m, 3H), 7.30(d, 2H, J=8.7Hz), 6.88(d, 2H, J=8.7 Hz), 6.68˜6.52(m,  3H), 5.07(d, 1H, J=11.4 Hz)m, 4.88(d, 1H, J=11.4 Hz), 4.48(d, 1H, J=7.4 Hz), 4.21(s, 2H), 3.80(s, 3H), 3.74(m, 2H), 3.66(d, 1H, J=7.4 Hz), 1.42(s, 3H), 1.26(m, 3H), 1.23(s, 3H); MS, m/z: 497.64
5-362
      1H NMR(200 MHz, CDCl3) δ 7.82(m, 3H), 7.30(d, 2H, J=8.4 Hz), 6.88(d, 2H, J=8.4 Hz), 6.68˜6.52(m, 3H), 5.05(d, 1H, J=12.4 Hz), 4.84(d, 1H, J=12.4 Hz), 4.52(d, 1H, J=7.7 Hz), 4.21(s, 2H), 3.80(s, 3H), 3.74(m, 3H), 1.44(s, 3H), 1.26(m, 3H), 1.20(s, 3H); MS, m/z: 583.58
5-363
      1H NMR(200 MHz, CDCl3) δ 7.29(d, 2H, J=8.4 Hz), 6.87(d, 2H, J=8.4 Hz), 6.66˜6.49(m, 3H), 4.33(d, 1H), 4.20(s, 2H), 3.80(s, 3H), 3.76(m, 2H), 3.60(s, 3H), 3.31(d, 1H, J=7.3 Hz), 1.41(s, 3H), 1.25(t, 3H, J=70 Hz), 1.20(s, 3H); MS, m/z: 371.48
5-364
      1H NMR(200 MHz, CDCl3) δ 7.29(d, 2H, J=8.5 Hz), 6.87(d, 2H, J=8.5 Hz), 6.65˜6.49(m, 3H), 4.33(d, 1H, J=7.8 Hz, 3.80(s, 3H), 3.81(m, 2H), 3.61(m, 2H), 3.38(d, 1H, J=7.8 Hz), 1.61(m, 2H), 1.40(s, 3H), 1.20(s, 3H), 1.50˜1.16(m, 9H), 0.91(m, 3H); MS, m/z: 427.59
5-365
      1H NMR(200 MHz, CDCl3) δ 7.29(d, 2H, J=8.7 Hz), 6.87(d, 2H, J=8.7 Hz), 6.65˜6.49(m ,3H), 5.68(m, 2H), 4.40˜4.10(m, 2H), 4.19(s, 2H), 3.80(s, 3H), 3.76(m, 2H), 3.47(d, 1H, J=7.7 Hz), 1.72(d, 3H, J=5.1 Hz), 1.40(s, 3H), 1.29(m, 3H), 1.20(s, 3H); MS, m/z: 411.55
5-366
      1H NMR(200 MHz, CDCl3) δ 7.29(d, 2H, J=8.7 Hz), 6.87(d, 2H, J=8.7 Hz), 6.60˜6.50(m, 3H), 6.94(m, 2H), 5.29(dd, 1H, J=17.1 Hz, J=1.6 Hz), 5.18(dd, 1H, J=10.3 Hz, J=1.8 Hz), 4.38(m, 2H), 4.19(s, 2H), 4.18(m, 1H), 3.80(s, 3H), 3.76(m, 2H), 3.48(d, 1H, J=7.7 Hz); MS, m/z: 397.52
5-367
      1H NMR(200 MHz, CDCl3) δ 7.28(d, 2H, J=8.7 Hz), 6.86(d, 2H, J=8.7 Hz), 6.67˜6.57(m, 3H), 4.45(d, 2H, J=2.2 Hz), 4.19(s, 2H), 3.80(s, 3H), 3.70(m, 2H), 2.45(t, 1H, J=2.3 Hz), 1.44s, 3H), 1.24(m, 3H), 1.22(s, 3H); MS, m/z: 395.50
5-368
      MS, m/z: 461.61
5-369
      MS, m/z: 479.60
5-370
      MS, m/z: 517.71
5-371
      MS, m/z 479.60
5-372
      MS, m/z: 475.63
5-373
      MS, m/z: 496.05
5-374
      MS, m/z: 496.05
5-375
      MS, m/z: 475.63
5-376
      MS, m/z: 558.49
5-377
      MS, m/z: 511.67
5-378
      MS, m/z: 597.60
5-379
      MS, m/z: 385.51
5-380
      MS, m/z: 441.62
5-381
      MS, m/z: 425.57
5-382
      MS, m/z: 597.60
5-383
      MS, m/z: 409.53
5-384
      1H NMR(200 MHz, CDCl3) δ 7.36˜7.25(m, 7H), 6.86(d, 2H, J=8.5 Hz), 6.69˜6.58(m, 3H), 4.89(d, 1H, J=11.4 Hz), 4.69(d, 1H, J=11.4 Hz), 4.42(d, 1H, J=7.1 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.70(m, 2H), 3.58(d, 1H, J=7.1 Hz), 1.60(m, 2H), 1.50(m, 2H), 1.40(s, 3H), 1.23(s, 3H), 0.91(t, 3H, J=7.3 Hz); MS, m/z: 475.63
5-385
      1H NMR(200 MHz, CDCl3) δ 7.37˜7.23(m, 4H), 7.09˜6.99(m, 2H), 6.86(d, 2H, J=8.6 Hz), 6.70˜6.57(m, 3H), 4.85(d, 1H, J=11.4 Hz), 4.66(d, 1H, J=11.4 Hz), 4.40(d, 1H, J=7.3 Hz), 4.19(s, 2H), 3.79(s, 3H), 3.68˜3.60(m, 2H), 3.57(d, 1H, J= 7.3 Hz), 1.58(m, 2H), 1.38(s, 3H), 1.42˜1.25(m, 2H), 1.22(s, 3H), 0.92(t, 3H, J=7.2 Hz); MS, m/z: 493.62
5-386
      1H NMR(200 MHz, CDCl3) δ 7.32˜7.22(m, 3H), 7.18˜6.99(m, 3H), 6.87(d, 2H, J=8.5 Hz), 6.67˜6.56(m, 3H), 4.90(d, 1H, J=12.0 Hz), 4.69(d, 1H, J=12.0 Hz), 4.43(d, 1H, J=7.3z), 4.20(s, 2H), 3.79(s, 3H), 3.64(m, 2H), 3.58(d, 1H, J=7.3 Hz), 1.57(m, 2H), 1.41(s, 3H), 1.41(m, 2H), 1.24(s, 3H), 0.91(t, 3H, J=7.1 Hz); MS, m/z: 531.74
5-387
      1H NMR(200 MHz, CDCl3) δ 7.32˜7.25(m, 3H), 7.20˜6.99(m, 3H), 6.87(d, 2H, J=8.5 Hz), 6.67˜6.56(m, 3H), 4.90(d, 1H, J=12.0 Hz), 4.69(d, 1H), 4.44(d, 1H, J=7.3 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.61(q, 2H, J=7.5 Hz), 1.58(m, 2H), 1.41(s, 3H), 1.43˜1.24(m, 2H), 1.24(s, 3H), 0.91(t, 3H, J=7.3 Hz): MS, m/z: 493.62
5-388
      1H NMR(200 MHz, CDCl3) δ 7.36˜7.16(m, 6H), 6.86(d, 2H, J=8.7 Hz), 6.67˜6.56(m, 3H), 4.93(d, 1H, J=11.8 Hz), 4.68(d, 1H, J=11.8 Hz), 4.43(d, 1H, J=7.3 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.64˜3.55(m, 3H), 2.35(s, 3H), 1.57(m, 2H), 1.42˜1.30(m, 2H), 1.37(s, 3H), 1.23(s, 3H), 0.90(t, 3H, J=7.2 Hz); MS, m/z: 489.66
5-389
      1H NMR(200 MHz, CDCl3) δ 7.90˜7.73(m, 4H), 7.29(d, 2H, J=8.5 Hz), 6.86(d, 2H, J=8.5 Hz), 5.04(d, 1HJ=12.3 Hz), 4.84(d, 1H, J=12.3 Hz), 4.49(d, 1H, J=7.7 Hz), 4.21(s, 2H), 3.80(s, 3H), 3.70˜3.58(m, 3H), 1.62˜1.20(m, 4H), 1.44(s, 3H), 1.25(s, 3H), 0.89(t, 3H, J=7.1 Hz); MS, m/z: 510.08
5-390
      1H NMR(200 MHz, CDCl3) δ 7.40˜7.25(m, 6H), 7.87(d, 2H, J=6.7 Hz), 6.68˜6.57(m, 3H), 4.87(d, 1H, J=11.8 Hz), 4.68(d, 1H, J=11.8 Hz), 4.43(d, 1H, J=7.4 Hz), 4.20(s, 2fH), 3.79(s, 3H), 3.61 (m, 2H), 4.43(d, 1H, J=7.4H), 1.58(m, 2H), 1.41(3, 3H), 1.41 (m, 2H), 1.24(s, 3H), 0.91(t, 3H, J=7.2 Hz); MS, m/z: 510.08
5-391
      1H NMR(200 MHz, CDCl3) δ 7.32˜7.14(m, 6H), 6.85(d, 2H, J=8.6 Hz), 6.80˜6.60(m, 3H), 4.84(d, 1H, J=11.3 Hz), 4.65(d, 1H, J=11.3 Hz), 4.39(d, 1H, J=7.3 Hz), 4.19(s, 2H), 3.79(s, 3H), 3.76˜3.55(m, 3H), 2.35(s, 3H), 1.59(m, 2H), 1.38(s, 3H), 1.39(m, 2H), 1.22(s, 3H), 0/92(t, 3H, J=7.2 Hz); MS, m/z: 489.66
5-392
      1H NMR(200 MHz, CDCl3) δ 7.38˜7.20(m, 5H), 6.86(d, 2H, J=7.6 Hz), 6.67˜6.55(m, 3H), 4.86(d, 1H, J=11.2 Hz), 4.73(d, 1H, J=11.2 Hz), 4.39(d, 1H, J=7.4 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.64(m, 2H), 3.58(d, 1H, J=7.4H), 1.59(m, 3H), 1.38(s, 3H), 1.39(m, 2H), 1.21(s, 3H), 0.92(t, 3H, J=7.2 Hz); MS, m/z: 572.52
5-393
      1H NMR(200 MHz, CDCl3) δ 7.81(m, 4H), 7.49(m, 3H), 7.2((d, 2H, J=8.7 Hz), 6.87(d, 2H, J=8.7 Hz), 6.68˜6.50(m, 3H), 5.02(d, 1H, J=11.2 Hz), 4.89(d, 1H, J=11.2 Hz), 4.44(d, 1H, J=7.1 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.95(d, 1H, J=7.1 Hz), 3.95(m, 2H), 1.59(m, 2H), 1.41(s, 3H), 1.45(m, 2H), 1.26(s, 3H), 0.89(t, 3H, J=7.2 Hz); MS, m/z: 525.69
5-394
      1H NMR(200 MHz, CDCl3) δ 7.54(m, 1H), 7.41˜7.20(m, 4H), 6.85(d, 2H, J=8.6 Hz), 6.80˜6.60(m, 3H), 5.50(d, 1H, J= 11.4 Hz), 4.81(d, 1H, J=11.4 Hz), 4.20(d, 1H, J=7.3 Hz), 3.78(s, 3H), 3.62(m, 3H), 1.58(m, 2H), 1.41(s, 3H), 1.42(m, 2H), 1.26(s, 3H), 0.89(t, 3H, J=7.2 Hz); MS, m/z: 611.63
5-395
      1H NMR(200 MHz, CDCl3) δ 7.27(d, 2H, J=8.6 Hz), 6.86(d, 2H, J=8.6 Hz), 6.67˜6.57(m, 3H), 4.31(d, 1H, J=7.3 Hz), 419(s, 2H), 3.79(s, 3H), 3.33(m, 3H), 3.60(s, 3H), 6.31(d, 1H, J= 7.3 Hz), 1.60(m, 2H), 1.42(m, 2H), 1.41(s, 3H), 1.20(s, 3H), 0.94(t, 3H, J=7.2 Hz); MS, m/z: 399.53
5-396
      1H NMR(200 MHz, CDCl3) δ 7.27(d, 2H, J=9.0 Hz), 6.86(d, 2H, J=9.0 Hz), 6.78˜6.50(m, 3H), 4.32(d, 1H, J=7.3 Hz), 4.19(s, 2H), 3.79(s, 3H), 3.84˜3.50(m, 4H), 3.38(d, 1H, J=7.3 Hz), 1.60(m, 4H), 1.40(s, 3H), 1.41(m, 6H), 1.20(s, 3H), 0.94(m, 6H); MS, m/z: 455.64
5-397
      1H NMR(200 MHz, CDCl3) δ 7.28(d, 2H, J=8.5 Hz), 6.86(d, 2H, J=8.5 Hz), 5.80˜5.51(m, 2H), 4.35(d, 1H, J=7.3 Hz), 4.19(s, 2H), 4.21(m, 2H), 3.79(s, 3H), 3.75(m, 2H), 3.46(d, 1H, J=7.3H), 1.72(d, 3H, J=5.0 Hz), 1.65(m, 2H), 1.39(s, 3H), 1.40(m, 2H), 1.21(s, 3H), 0.94(t, 3H, J=7.2 Hz); MS, m/z: 439.60
5-398
      1H NMR(200 MHz, CDCl3) δ 7.28(d, 2H, J=8.5 Hz), 6.86(d, 2H, J=8.5 Hz), 6.67˜6.57(m, 3H), 5.97(m, 1H), 5.28(d, 1H, J=18.9 Hz), 5.20(d, 1H, J=10.4˜Hz), 4.35(d, 1H, J=7.2 Hz), 4.19(s, 2H), .20(m, 2H), 3.79(s, 3H), 3.69(m, 2H), 3.48(d, 1H, J=7.2H), 1.60(m, 2H), 1.40(s, 3H), 1.41(m, 2H), 1.22(s, 3H), 0.93(t, 3H, J=7.1 Hz); MS, m/z: 425.57
5-399
      1H NMR(200 MHz, CDCl3) δ 7.28(d, 2H, J=8.7 Hz), 6.86(d, 2H, J=8.7), 6.70˜6.50(m, 3H), 4.43(m, 3H), 4.19(s, 2H), 3.79(s, 3H), 3.67(m, 3H), 2.45(m, 1H), 1.58(m, H), 1.43(s, 3H), 1.44(m, 2H), 1.23(s, 3H), 0.93(t, 3H, J=7.2 Hz); MS, m/z: 423.56
5-400
      1H NMR(200 MHz, CDCl3) δ 7.37˜7.28(m, 12H), 6.86(d, 2H), J=8.5 Hz), 6.69˜6.56(m, 3H), 4.91(d, 1H, J=11.4 Hz), 4.75˜4.61(m, 4H), 4.14(s, 2H), 3.80(s, 3H), 3.71(d, 1H, J= 8.1 Hz), 1.45(s, 3H), 1.28(s, 3H); MS, m/z: 509.65
5-401
      1H NMR(200 MHz, CDCl3) δ 7.36˜7.24(m, 9H), 7.02(m, 2H), 6.84(d, 2H, J=8.8 Hz), 6.70˜6.56(m, 3H), 4.84(d, 1H, J=11.2 Hz), 4.72˜4.59(m, 2H), 4.70(s, 2H), 4.13(s, 2H), 3.77(s, 3H), 3.68(d, 1H, J=7.1 Hz), 1.43(s, 3H), 1.26(s, 3H); MS, m/z: 527.64
5-402
      1H NMR(200 MHz, CDCl3) δ 7.41˜7.24(m, 11H), 6.86(d, 2H, J=8.7 Hz), 6.69˜6.58(m, 3H), 4.86(d, 1H, J=11.4 Hz), 4.79˜4.58(m, 4H), 4.13(s, 2H), 3.78(s, 3H), 1.44(s, 3H), 1.32(m, 9H), 1.27(s, 3H); MS, m/z: 565.76
5-403
      1H NMR(200 MHz, CDCl3) δ 7.35˜7.25(m, 7H), 7.11˜6.89(m, 4H), 6.86(d, 2H, 8.8 Hz), 6.61˜6.57(m, 3H), 4.88(d, 1H, J=11.4 Hz), 4.71˜4.62(m, 4H), 4.14(s, 2H), 3.79(s, 3H), 3.70(d, 1H, J=7.1 Hz), 1.45(s, 3H), 1.28(s, 3H); MS, m/z: 465.57
5-404
      1H NMR(200 MHz, CDCl3) δ 7.38˜7.17(m, 11H), 6.83(d, 2H, J=8.5 8.5 Hz), 6.70˜6.63(m, 3H), 4.90(d, 1H, J=11.6 Hz), 4.71˜4.59(m, 4H), 4.10(s, 2H), 3.76(s, 3H), 3.71(d, 1H, J= 7.1 Hz), 2.30(s, 3H), 1.41(s, 3H), 1.27(s, 3H); MS, m/z: 523.68
5-405
      1H NMR(200 MHz, CDCl3) δ 7.49˜7.09(m, 11H), 6.94˜6.87(m, 2H), 6.79˜6.69(m, 3H), 4.95(d, 1H, J=12 Hz), 4.91˜4.72(m, 3H), 4.58(d, 1H, J=6.7 Hz), 4.12(s, 2H), 3.67(s, 3H), 3.67(m, 1H), 1.43(s, 3H), 1.31(s, 3H); MS, m/z: 544.10
5-406
      1H NMR(200 MHz, CDCl3) δ 7.35˜7.19(m, 11H), 6.84(d, 2H, J=8.7 Hz), 6.71˜6.63(m, 3H), 4.85(d, 1H, J=12.0 Hz), 4.70(s, 2H), 4.70˜4.60(M, 2H), 4.13(s, 2H), 3.76(s, 3H), 3.67(d, 1H, J=7.3 Hz), 1.44(s, 3H), 1.28(s, 3H); MS, m/z: 544.10
5-407
      1H NMR(200 MHz, CDCl3) δ 7.36˜7.13(m, 11H), 6.84˜6.67(m, 5H), 4.83(d, 1H, J=11.4 Hz), 4.72˜4.56(m, 2H), 4.12(s, 2H), 3.75(s, 3H), 3.66(d, 1H, J=6.9 Hz), 2.35(s, 3H), 1.42(s, 3H), 1.26(s, 3H); MS, m/z: 523.68
5-408
      1H NMR(200 MHz, CDCl3) δ 7.36˜7.21 (m, 10H), 6.85(d, 2H, J=8.7 Hz), 6.69˜6.59(m, 3H), 4.84˜4.58(m, 5H), 4.12(s, 2H), 3.78(s, 3H), 3.69(d, 1H, J=7.1 Hz), 1.42(s, 3H), 1.24(s, 3H); MS, m/z 606.54
5-409
      1H NMR(200 MHz, CDCl3) δ 7.82(m, 4H), 7.47(m, 3H), 7.34˜7.24(m, 7H), 6.85(d, 2H, J=8.5 Hz), 6.72˜6.59(m, 3H), 5.04(d, 1H, J=11.5 Hz), 4.87(d, 1H, J=11.5 Hz), 4.74˜4.64(m, 3H), 4.149s, 2H), 3.78(s, 3H), 3.74(d, 1H, J=7.1 Hz), 1.46(s, 3H), 1.31(s, 3H); MS, m/z: 559.71
5-410
      MS, m/z: 537.71
5-411
      MS, m/z: 433.55
5-412
      1H NMR(200 MHz, CDCl3) δ 7.41˜7.20(m, 7H), 6.84˜6.65(m, 5H), 4.76(d, 2H, J=4.0 Hz), 4.49(q, 1H, J=17.4 Hz), 4.16(s, 2H), 3.76(m, 1H), 3.75(s, 3H), 3.66(m, 1H), 3.59(d, 1H, J=7.2 Hz), 1.60(br, 2H), 1.43(s, 3H), 1.44˜1.23(m, 4H), 1.24(s, 3H), 0.90(m, 3H); MS, m/z: 489.66
5-413
      1H NMR(200 MHz, CDCl3) δ 7.42˜7.25(m, 7H), 6.86(m, 2H), 6.67˜6.48(m, 3H), 5.68(m, 2H), 4.77(m, 2H), 4.54(d, 1H, J=7.2 Hz), 4.40˜4.15(m, 2H), 4.13(s, 2H), 3.79(s, 3H), 3.58(d, 1H, J=7.2 Hz), 1.73(m, 3H), 1.44(s, 3H), 1.25(s, 3H); MS, m/z: 473.62
5-414
      1H NMR(200 MHz, CDCl3) δ 7.41˜7.23(m, 7H), 6.85(d, 2H, J=8.7 Hz), 6.68˜6.55(m, 3H), 5.98(m, 1H), 5.30(d, 1H, J=18.9 Hz), 5.19(d, 1H, J=10.4 Hz), 4.75(q, 2H, J=17.4 Hz), 4.55(d, 1H, J=7.2 Hz), 4.42˜4.16(m, 2H), 4.13(s, 2H), 3.79(s, 3H), 3.59(d, 1H, J=7.2 Hz), 1.44(s, 3H), 1.26(s, 3H); MS, m/z: 459.59
5-415
      MS, m/z: 457.57
5-416
      MS, m/z: 523.68
5-417
      MS, m/z: 541.67
5-418
      MS, m/z: 579.79
5-419
      MS, m/z: 541.67
5-420
      MS, m/z: 537.71
5-421
      MS, m/z: 558.12
5-422
      MS, m/z: 558.12
5-423
      MS, m/z: 537.71
5-424
      MS, m/z: 620.56
5-425
      MS, m/z: 573.74
5-426
      MS, m/z: 659.68
5-527
      MS, m/z: 447.58
5-428
      MS, m/z: 503.69
5-429
      MS, m/z: 487.64
5-430
      MS, m/z: 473.62
5-431
      MS, m/z: 471.60
5-432
      1H NMR(200 MHz, CDCl3) δ 7.88˜7.26(m, 7H), 6.87(d, 2H, J=8.8 Hz), 6.71˜6.589m, 3H), 4.90(d, 1H, J=11.4 Hz), 4.70(d, 1H, J=11.4 Hz), 4.42(d, 1H, J=7.3 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.69(m, 2H), 3.59(d, 1H, J=7.3 Hz), 1.80˜1.19(m, 11H), 1.39(s, 3H), 1.24(s, 3H), 0.91(m, 2H); MS, m/z: 529.73
5-433
      1H NMR(200 MHz, CDCl3) δ 7.40˜7.20(m, 4H), 7.14˜6.96(m, 4H) 6.87(d, 1H, J=8.7 Hz), 6.70˜6.55(m, 3H), 4.85(d, 1H, J=11.5 Hz), 4.67(d, 1H, J=11.5 Hz), 4.41 (d, 1H, J=7.3 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.67(m, 2H), 3.57(d, 1H, J=7.3 Hz0, 1.80˜1.10(m, 11H), 1.39(s, 3H), 1.23(s, 3H), 0.92(m, 2H); MS, m/z: 547.72
5-434
      1H NMR(200 MHz, CDCl3) δ 7.41˜7.26(m, 6H), 6.86(d, 2H, J=8.5 Hz), 6.71˜6.55(m, 3H), 4.85(d, 1H, J=11.2 Hz), 4.68(d, 1H, J=11.2 Hz), 4.40(d, 1H, J=7.5 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.70(m, 2H), 3.58(d, 1H, J=7.5 Hz), 1.80˜1.05(m, 11h)1.41(s, 3H), 1.32(m, 9H), 1.23(s, 3H), 0.91(m, 2H); MS, m/z: 585.83
5-435
      1H NMR(200 MHz, CDCl3) δ 7.33˜7.26(m, 4H), 7.14˜6.98(m, 2H), 6.88(d, 2H, J=8.7 Hz), 6.67˜6.56(m ,3H), 4.90(d, 1H, J=11.9 Hz), 4.70(d, 1H, J=11.9 Hz), 4.44(d, 1H, K=7.5 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.68(t, 2H, J=6.6 Hz), 3.59(d, 1H, J=7.5 Hz), 1.80˜1.05(m, 11H), 1.40(s, 3H), 1.24(s, 3H), 0.91 (2H); MS, m/z: 547.72
5-436
      MS, m/z: 543.75
5-437
      1H NMR(200 MHz, CDCl3) δ 7.82(m, 4H), 7.29(d, 2H, J=8.6 Hz), 6.87(d, 2H, J=8.6 Hz), 5.04(d, 1H, J=12.7 Hz), 4.83(d, 1H, J=12.7 Hz), 4.48(d, 1H, J=7.6 Hz), 4.20(s, 2H), 3.80(s, 3H), 3.64(m, 2H), 3.63(d, 1H, J=7.6 Hz), 1.80˜1.05(m, 11H), 1.43(s, 3H), 1.25(s, 3H), 0.88(m, 2h); MS, m/z: 564.17
5-438
      1H NMR(200 MHz, CDCl3) δ 7.37˜7.20(m, 6H), 6.86(d, 2H, J=8.6 Hz), 6.73˜6.62(m, 3H), 4.87(d, 1H, J=11.8 Hz), 4.68(d, 1H, J=11.8 Hz), 4.41 (d, 1H, J=7.7 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.68(t, 2H, J=6.6 Hz), 3.57(d, 1H, J=7.7 Hz), 1.80˜1.05(m, 11H), 1.41(s, 3H), 1.24(s, 3H), 0.90(m, 2H); MS, m/z: 564.17
5-439
      1H NMR(200 MHz, CDCl3) δ 7.29˜7.14(m, 6H), 6.87˜6.78(m, 3H), 6.65(s, 2H), 4.83(d, 1H, J=11.3 Hz), 4.65(d, 1H, J=11.3 Hz), 4.38(d, 1H, J=7.0 Hz), 4.19(s, 2H), 3.78(s, 3H), 3.66(m, 2H), 3.56(d, 1H, J=7.1 Hz), 1.38(s, 3H), 1.80˜1.04(m, 11H), 1.38(s, 3H), 1.23(s, 3H), 0.94(m, 2H)543.75
5-440
      1H NMR(200 MHz, CDCl3) δ 7.38˜7.22(m, 5H), 6.87(d, 2H, J=8.6 Hz), 6.67˜6.51(m, 3H), 4.87(d, 1H, J=12.0 Hz), 4.71(d, 1H, J=12.0 Hz), 3.80(s, 2H), 2.17(s, 3H), 1.80˜1.05(m, 11H), 1.39(s, 3H), 1.21(s, 3H), 0.93(m, 2H); MS, m/z: 626.61
5-441
      1H NMR(200 MHz, CDCl3) δ 7.86˜7.80(m, 4H), 7.51˜7.46(m, 3H), 7.27˜7.23(d, 2H, J=8.1 Hz), 7.01˜6.65(m, 5H), 5.03(d, 1H, J=11.7 Hz), 4.36(d, 1H, J=11.7 Hz), 4.41(d, 1H, J=7.0 Hz), 4.18(s, 2H), 3.75(s, 3H), 3.68(m, 2H), 3.62(d, 1H, J=7.0 Hz), 1.78˜0.76(m, 13 Hz), 1.39(s, 3H), 1.27(s, 3H); MS, m/z: 579.79
5-442
      1H NMR(200 MHz, CDCl3) δ 7.54(m, 1H), 7.38˜7.23(m, 4H), 6.86(d, 2H, J=8.7 Hz), 6.79˜6.60(m, 3H), 5.01(d, 1H, J=12.8 Hz), 4.80(d, 1H, J=12.8 Hz), 4.4(d, 1H, J=7.3 Hz), 4.20(s, 2H), 3.79(s, 3H), 3.77˜3.63(m, 3H), 1.80˜1.05(m, 11H), 1.41(s, 3H), 1.26(s, 3H), 0.88(m, 2H); MS, m/z: 665.72
5-443
      1H NMR(200 MHz, CDCl3) δ 7.27(d, 2H, J=8.5 Hz), 6.85(d, 2H, J=8.5 Hz), 6.73˜6.59(m, 3H), 4.30(d, 1H, J=7.5 Hz), 4.19(s ,2H), 3.79(s, 3H), 3.77(m, 2H), 3.59(m, 2H), 3.98(d, 1H, J=7.5 Hz), 1.80˜1.05(m, 17H), 0.90(m, 5H); MS, m/z: 509.74
5-444
      1H NMR(200 MHz, CDCl3) δ 7.27(d, 2H, J=8.5 Hz), 6.85(d, 2H, J=8.5 Hz), 6.73˜6.59(m, 3H), 4.30(d, 1H, J=7.5 Hz), 4.19(s ,2H), 3.79(s, 3H), 3.77(m, 2H), 3.59(m, 2H), 3.98(d, 1H, J=7.5 Hz), 1.80˜1.05(m, 17H), 0.90(m, 5H); MS, m/z: 509.74
5-445
      1H NMR(200 MHz, CDCl3) δ 7.25(d, 2H, J=8.7 Hz), 6.93˜6.23(m, 5H), 5.80˜5.50(m, 2H), 4.28(d, 1H, J=6.9 Hz), 4.17(s, 2H), 4.13(m, 2H), 3.75(s, 3H), 3.73(m, 2H), 3.43(d, 1H, J=7.1 Hz), 1.80˜1.05(m, 11H), 1.72(d, 3H, J=5.9 Hz), 1.39(s, 3H), 1.22(s, 3H), 0.94(m, 2H); MS, m/z: 493.69
5-446
      1H NMR(200 MHz, CDCl3) δ 7.25(d, 2H, J=8.5 Hz), 6.88˜6.62(m, 5 Hz), 5.84(m, 1H), 5.29(dd, 1H, J=17.1 Hz, J=1.5 Hz), 5.18(dd, 1H, J=10.2 Hz, J=1.4 Hz), 4.32(d, 1h, J=7.3 Hz), 4.17(s, 2H), 3.76(s, 3H), 3.74(m, 2H), 3.46(d, 1H, J=7.3 Hz), 1.80˜1.05(m, 11H), 1.40(s, 3H), 1.23(s, 3H), 0.90(m, 2H); MS, m/z: 479.67
5-447
      1H NMR(200 MHz, CDCl3) δ 7.25(d, 2H, J=8.5 Hz), 6.85˜6.68(m, 5H), 4.42(d, 2H, J=2.4 Hz), 4.37(d, 1H, J= 7.1 Hz), 4.17(s, 2H), 3.76(s, 3H), 3.75˜3.65(m, 3H), 2.46(t, 1H, J=2.3 Hz), 1.80˜1.05(m, 11H), 1.43(s, 3H), 1.23(s, 3H), 0.95(m, 2H); MS, m/z: 477.65
5-448
      1H NMR(200 MHz, CDCl3) δ 7.03˜7.41(m, 7H), 6.98˜7.06(m, 2H), 6.64(s, 1H), 6.67(d, 1H, J=6.3 Hz), 6.53(dd, 1H, J=2.8 Hz, J=8.7 Hz), 4.92(d, 1H, J=11.4 Hz), 4.72(d, 1H, J=11.5 Hz), 4.41(d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.61(d, 1H, J=7.3 Hz), 3.45(s, 3H), 1.41(s, 3H), 1.24(s, 3H); MS, m/z: 421.52
5-449
      1H NMR(200 MHz, CDCl3) δ 7.30˜7.39(m, 4H), 6.97˜7.08(m, 4H), 6.64(s, 1H), 6.50˜6.68(m, 2H), 4.87(d, 1H, J=11.4 Hz), 4.68(d, 1H, J=11.4 Hz), 4.41 (d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.59(d, 1H, J=7.3 Hz), 3.44(s, 3H), 1.40(s, 3H), 1.22(s, 3H); MS, m/z: 439.51
5-450
      MS, m/z: 477.63
5-451
      1H NMR(200 MHz, CDCl3) δ 7.29˜7.37(m, 3H), 6.97˜7.14(m, 5H), 6.64(s, 1H), 6.51˜6.69(m, 2H), 4.92(d, 1H, J=11.9 Hz), 4.71(d, 1H, J=11.9 Hz), 4.43(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.60(d, 1H, J=7.5 Hz), 3.44(s, 3H), 1.42(s, 3H), 1.24(s, 3H); MS, m/z: 439.51
5-452
      1H NMR(200 MHz, CDCl3) δ 7.30˜7.41(m, 4H), 7.19˜7.24(m, 2H), 6.97˜7.06(m, 2H), 6.69(s, 1H), 6.66(d, 1H, J=7.1 Hz), 6.57(dd, 1H, J=2.6 Hz, J=8.7 Hz), 4.92(d, 1H, J=11.6 Hz), 4.70(d, 1H, J=11.6 Hz), 4.40(d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.62(d, 1H, J=7.3 Hz), 3.44(s, 3H), 2.37(s, 3H), 1.39(s, 3H), 1.23(s, 3H); MS, m/z: 435.54
5-453
      MS, m/z: 455.96
5-454
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.38(m, 6H), 6.95˜7.04(m, 2H), 6.63˜6.74(m, 3H), 4.92(d, 1H, J=11.6 Hz), 4.70(d, 1H, J=11.6 Hz), 4.40(d, 1H, J=7.3 Hz), 4.24(s, 2H), 3.58(d, 1H, J=7.3 Hz), 1.41(s, 3H), 1.24(s, 3H); MS, m/z: 455.96
5-455
      1H NMR(200 MHz, CDCl3) δ 7.82˜7.86(m, 2H), 7.31˜7.54(m, 2H), 7.31˜7.26(m, 2H), 6.96˜7.05(m, 2H), 6.92˜6.73(m, 3H), 5.06(d, 1H, J=11.6 Hz), 4.87(d, 1H, J=11.6 Hz), 4.44(d, 1H, J=7.1 Hz), 4.26(s, 2H), 3.66(d, 1H, J=7.1 Hz), 3.46(s, 3H), 1.42(s, 3H), 1.26(s, 3H); MS, m/z: 435.54
4-456
      1H NMR(200 MHz, CDCl3) δ 7.22˜7.38(m, 5H), 6.97˜7.06(m, 2H), 6.66(d, 1H, J=6.7 Hz), 6.63(s, 1H), 6.53(dd, 1H, J=2.8, J=8.5 Hz), 4.89(d, 1H, J=12.0 Hz), 4.72(d, 1H, J=12.0 Hz), 4.39(d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.60(d, 1H, J=7.3 Hz), 3.45(s, 3H), 1.39(s, 3H), 1.20(s, 3H); MS, m/z: 518.40
5-457
      MS, m/z: 471.58
5-458
      1H NMR(200 MHz, CDCl3) δ 7.83(s, 3H), 7.29˜7.36(m, 2H), 6.96˜7.05(m, 2H), 6.63˜6.73(m, 3H), 5.05(d, 1H, J=12.6 Hz), 4.83(d, 1H, J=12.6 Hz), 4.46(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.63(d, 1H, J=7.5 Hz), 3.42(s, 3H), 1.45(s, 3H), 1.25(s, 3H); MS, m/z: 557.51
5-459
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.36(m, 2H), 6.97˜7.05(m, 2H), 6.62˜6.68(m, 2H), 6.53(dd, 1H, J=2.8, J=8.7 Hz), 4.29(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.60(s, 3H), 3.50(s, 3H), 1.41(s, 3H), 1.20(s, 3H); MS, m/z: 345.42
5-460
      1H NMR(200 MHz, CDCl3) δ 7.27˜7.36(m, 2H), 6.96˜7.04(m, 2H), 6.54˜6.69(m, 3H), 4.27(d, 1H, J=7,5 Hz), 4.24(s, 2H), 3.51˜3.88(m, 2H), 3.50(s, 3H), 3.39(d, 1H, J=7.5 Hz), 1.57˜1.61(m, 2H), 1.40(s, 3H), 1.25˜1.36(m, 4H), 1.20(s, 3H), 0.90˜0.94(m, 3H); MS, m/z: 401.53
5-461
      1H NMR(200 MHz, CDCl3) δ 7.30˜7.37(m, 2H), 6.97˜7.05(m, 2H), 6.65(d, 1H, J=4.1 Hz), 6.62(s, 1H), 6.65(dd, 1H, J=2.6 Hz, J=8.7 Hz), 5.58˜5.73(m, 2H), 4.31(d, 1H, J=7.1 Hz), 4.07˜4.26(m, 2H), 4.24(s, 2H), 3.48(d, 1H, J=7.1 Hz), 3.49(s, 3H), 1.72(d, 3H, J=6.1), 1.40(s, 3H), 1.21(s, 3H); MS, m/z: 385.48
5-462
      1H NMH(200 MHz, CDCl3) δ 7.29˜7.38(m, 2H), 6.96˜7.04(m, 2H), 6.59˜6.71(m, 3H), 5.87˜6.01 (m, 1H), 5.16˜5.34(m, 2H), 4.18˜4.43(m, 2H), 4.24(s, 2H), 3.49(s, 3H), 1.41(s, 3H), 1.22(s, 3H); MS, m/z: 371.46
5-463
      MS, m/z: 369.44
5-464
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.38(m, 7H), 6.95˜6.04(m, 2H), 6.51˜6.68(m, 3H), 4.90(d, 1H, J=12.0 Hz), 4.71(d, 1H, J=12.0 Hz), 4.43(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.64˜3.23(m, 2H), 3.59(d, 1H, J=7.5 Hz), 1.40(s, 3H), 1.23(s, 3H), 1.18˜1.21(m, 3H); MS, m/z: 435.54
5-465
      1H NMR(200 MHz, CDCl3) δ 7.22˜7.38(m, 4H), 6.96˜7.08(m, 4H), 6.49˜6.69(m, 3H), 4.87(d, 1H, J=11.4 Hz), 4.67(d, 1H, J=11.4 Hz), 4.43(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.64˜3.75(m, 2H), 3.58(d, 1H, J=7.5 Hz), 1.40(s, 3H), 1.22(s, 3H), 1.18˜1.25(m, 3H); MS, m/z: 453.53
5-466
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.41(m, 6H), 6.95˜7.04(m, 2H), 6.65˜6.75(m, 3H), 4.86(d, 1H, J=11.4 Hz), 4.68(d, 1H, J=11.4 Hz), 4.39(d, 1H, J=7.5 Hz), 4.24(s, 2H), 3.64˜3.74(m, 2H), 3.58(d, 1H, J=7.5 Hz), 1.41(s, 3H), 1.33(s, 9H), 1.31(s, 3H), 1.18˜1.25(m, 3H); MS, m/z: 491.65
5-467
      1H NMR(200 MHz, CDCl3) δ 7.24˜7.38(m, 3H), 6.95˜7.14(m, 5H), 6.50˜6.70(m, 3H), 4.90(d, 1H, J=11.6 Hz), 4.70(d, 1H, J=11.6 Hz), 4.44(d, 1H, J=7.7 Hz), 4.25(s, 2H), 3.63˜3.74(m, 2H), 3.58(d, 1H, J=7.7 Hz), 1.41(s, 3H), 1.23(s, 3H), 1.17˜1.27(m, 3H); MS, m/z: 453.53
5-468
      1H NMR(200 MHz, CDCl3) δ 7.16˜7.40(m, 6H), 6.98˜7.06(m, 2H), 4.50˜6.67(m, 3H), 4.92(d, 1H, J=11.8 Hz), 4.69(d, 1H, J=11.8 Hz), 4.43(d, 1H, J=7.7 Hz), 4.25(s, 2H), 3.63˜3.74(m, 2H), 3.62(d, 1H, J=7.7 Hz), 2.35(s, 3H), 1.38(s, 3H), 1.22(s, 3H), 1.17˜1.20(m, 3H); MS, m/z: 449.57
5-469
      1H NMR(200 MHz, CDCl3) δ 7.18˜7.38(m, 5H), 6.97˜7.06(m, 2H), 6.50˜6.68(m, 3H), 4.02(d, 1H, J=12.4 Hz), 4.79(d, 1H, J=12.4 Hz), 4.46(d, 1H, J=7.5 hz), 4.25(s, 2H), 3.63˜3.75(m, 3H0, 1.41(s, 3H), 1.25(s, 3H), 1.17˜1.24(m, 3H); MS, m/z: 469.99
5-470
      1H NMR(200 MHz, CDCl3) δ 7.14˜7.38(m, 6H), 6.95˜7.06(m, 2H), 6.50˜6.67(m, 3H), 4.88(d, 1H, J=11.8 Hz), 4.64(d, 1H, J=11.8 Hz), 4.43(d, 1H, J=7.9 Hz), 4.25(s, 2H), 3.63˜3.73(m, 2H), 3.58(d, 1H, J=7.9 Hz), 1.41(s, 3H), 1.23(s, 3H), 1.17˜1.21(m, 3H); MS, m/z: 469.99
5-471
      1H NMR(200 MHz, CDCl3) δ 7.14˜7.37(m, 6H), 6.96˜7.05(m, 2H), 6.53˜6.67(m, 3H), 4.85(d, 1H, J=11.2 Hz), 4.65(d, 1H, J=11.2 Hz), 4.40(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.60˜3.75(m, 2H0, 3.57(d, 1H, J=7.5 Hz), 2.35(s, 3H), 1.39(s, 3h), 1.22(s, 3H), 1.18˜1.25(m, 3H); MS, m/z: 449.57
5-472
      1H NMR(200 MHz, CDCl3) δ 7.20˜7.38(m, 5H), 6.95˜7.03(m, 2H), 6.49˜6.68(m, 3H), 4.89(d, 1H, J=11.0 Hz), 4.71(d, 1H, J=11.0 Hz), 4.41(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.65˜3.75(m, 2H), 3.59(d, 1H, J=7.5 Hz), 1.39(s, 3H), 1.20(s, s. 3H), 1.18˜1.21(m, 3H); MS, m/z: 532.43
5-473
      1H NMR(200 MHz, CDCl3) δ 7.76˜7.87(m, 4H), 7.44˜7.53(m, 3H), 7.32˜7.43(m, 2H), 6.96˜7.31(m, 2H), 6.59˜6.69(m, 3H), 5.06(d, 1H, J=11.8 Hz), 4.88(d, 1H, J=11.8 Hz), 4.47(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.69˜3.77(m, 2H), 3.66(d, 1H, J= 7.5 Hz), 1.42(s, 3H), 1.27(s, 3H), 1.19˜1.26(m, 3H); MS, m/z: 485.60
5-474
      MS, m/z: 571.54
5-475
      MS, m/z: 359.44
5-476
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.37(m, 2H), 6.96˜7.05(m, 2H), 6.50˜6.65(m, 3H), 4.31(d, 1H, J=7.5 Hz), 4.24(s, 2H), 3.57˜3.84(m, 4H), 3.38(d, 1H, J=7.5 Hz), 1.57˜1.63(m, 2H), 1.40(s, 3H), 1.21˜1.37(m, 7H), 1.19(s, 3H), 0.88˜0.94(m, 3H); MS, m/z: 415.55
5-477
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.37(m, 2H), 6.97˜7.06(m, 2H), 6.47˜6.65(m, 3H), 5.63˜5.71(m, 2H), 4.34(d, 1H, J= 7.9 Hz), 4.24(s, 2H), 4.12˜4.31(m, 2H), 3.70˜3.78(m, 2H), 3.46(d, 1H, J=7.5 hz), 1.72(d, 3H, J=5.3 Hz), 1.40(s, 3H), 1.23˜1.27(m, 3H), 3H), 1.20(s, 3H); MS, m/z: 399.51
5-478
      1H NMR(200 MHz, CDCl3) δ 7.30˜7.37(m, 2H), 6.97˜7.06(m, 2H), 6.01˜6.66(m, 3H), 5.87˜5.98(m, 1H), 5.14˜5.35(m, 2H), 4.36(d, 1H, J=7.5 Hz), 4.24(s, 2H), 4.12˜4.32(m, 2H), 3.66˜3.79(m, 2H), 3.48(d, 1H, J=7.5 Hz), 1.41(s, 3H), 1.23(s, 3H), 1.19˜1.22(m, 3H); MS, m/z: 385.48
5-479
      MS, m/z: 383.47
5-480
      1H NMR(200 MHz, CDCl3) δ 0.76˜0.38(m, 7H), 6.96˜7.07(m, 2H), 6.48˜6.68((m, 3H), 4.88(d, 1H, J=11.4 Hz), 4.69(d, 1H, J=11.4 Hz), 4.37(d, 1H, J=7.1 Hz), 4.25(s, 2H), 3.96˜4.02(m, 1H), 3.52(d, 1H, J=7.1 Hz), 1.38(s, 3H), 1.27(s, 3H), 1.24(d, 3H, J=1.6 Hz), 1.20(d, 3H, J=1.2 Hz); MS, m/z: 449.57
5-481
      1H NMR(200 MHz, CDCl3) δ 7.21˜7.38(m, 4H), 6.94˜7.08(m, 4H), 6.48˜6.69(m, 3H), 4.56˜4.86(m, 2H), 4.36(d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.95˜4.01(m, 1H), 3.50(d, 1H, J=7.2 Hz), 1.37(s, 3H), 1.26(2, 3H), 1.21˜1.25(m, 6H); MS, m/z: 467.56
5-482
      MS, m/z: 505.68
5-483
      1H NMR(200 MHz, CDCl3) δ 7.23˜7.38(m, 3H), 6.95˜7.09(m, 5H), 6.48˜6.62(m, 3H), 4.88(d, 1H, J=11.8 Hz), 4.68(d, 1H, J=12.2 Hz), 4.38(d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.95˜4.01(m, 1H), 3.51 (d, 1H, J=7.3 Hz), 1.39(s, 3H), 1.28(s, 3H), 1.23(d, 3H, J=2.4 Hz), 1.20(d, 3H, J=2.6 Hz); MS, m/z: 467.56
5-484
      1H NMR(200 MHz, CDCl3) δ 7.16˜7.40(m, 6H), 6.97˜7.06(m, 2H), 6.48˜6.66(m, 3H), 4.87(d, 1H, J=12.0 Hz), 4.70(d, 1H, J=12.0 Hz), 4.36(d, 1H, J=7.3 Hz), 4.25(s, 2H), 3.92˜3.99(m, 1H), 3.54(d, 1H, J=7.3 Hz), 2.32(s, 3H), 1.34(s, 3H), 1.28(s, 3H), 1.18˜1.26(m, 6H); MS, m/z: 463.60
5-485
      1H NMR(200 MHz, CDCl3) δ 7.15˜7.48(m, 6H), 6.92˜7.05(m, 2H), 6.54˜6.70(m, 3H), 4.99(d, 1H, J=12.9 Hz), 4.78(d, 1H, J=12.8 Hz), 4.40(d, 1H, J=7.3 Hz), 4.24(s, 2H), 3.82˜4.02(m, 1H), 3.58(d, 1H, J=7.3 Hz), 1.39(s, 3H), 1.30(s, 3H), 1.18˜1.26(m, 6H); MS, m/z: 484.02
5-486
      1H NMR(200 MHz, CDCl3) δ 7.16˜7.37(m, 6H), 6.93˜7.03(m, 2H), 6.66˜6.75(m, 3H), 4.85(d, 1H, J=12.0 Hz), 4.67(d, 1H, J=12.0 Hz), 4.36(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.94˜4.03(m, 1H), 3.49(d, 1H, J=7.1 Hz), 1.39(s, 3H), 1.28(s, 3H), 1.19˜1.25(m, 6H); MS, m/z: 484.02
5-487
      1H NMR(200 MHz, CDCl3) δ 7.13˜7.38(m, 6H), 6.79˜7.10(m, 2H), 6.49˜6.65(m, 3H), 4.83(d, 1H, J=11.4 Hz), 4.65(d, 1H, J=11.4 Hz), 4.35(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.96˜4.02(m, 1H), 3.50(d, 1H, J=7.1 Hz), 2.30(s, 3H), 1.37(s, 3H), 1.25(s, 3H), 1.23(d, 3H, J=3.9 Hz), .1.20(o 3H, J=3.9 Hz); MS, m/z: 463.60
5-488
      1H NMR(200 MHz, CDCl3) δ 7.20˜7.37(m, 5H), 6.94˜7.05(m, 2H), 6.53˜6.69(m, 3H), 4.87(d, 1H, J=11.6 Hz), 4.68(d, 1H, J=12.0 Hz), 4.35(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.96˜4.02(m, 1H), 3.51(d, 1H, J=7.1 Hz), 1.37(s, 3H), 1.24(s, 3H), 1.20˜1.22(m, 6H); MS, m/z: 546.46
5-489
      1H NMR(200 MHz, CDCl3) δ 7.75˜7.86(m, 4H), 7.46˜7.51(m, 3H), 7.20˜7.37(m, 2H), 6.96˜7.05(m, 2H), 6.57˜6.69(m, 3H), 5.03(d, 1H, J=11.6 Hz), 4.85(d, 1H, J=11.6 Hz), 4.39(d, 1H, J=7.1 Hz), 4.25(s, 2H), 3.96˜4.03(m, 1H), 3.57(d, 1H, J= 7.1 Hz), 1.39(s, 3H), 1.31 (s, 3H), 1.24(d, 3H, J=3.7 Hz), 1.19(d, 3H, J=3.5 Hz); MS, m/z: 499.63
5-490
      1H NMR(200 MHz, CDCl3) δ 7.80(b, 3H), 7.26˜7.38(m, 2H), 6.97˜6.06(m, 2H), 6.53˜6.68(m, 3H), 5.02(d, 1H, J=12.8 Hz), 4.81(d, 1H, J=12.8 Hz), 4.41(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.92˜3.98(m, 1H), 3.54(d, 1H, J=7.5 Hz), 1.45(s, 3H), 1.30(s, 3H), 1.23(d, 3H, J=6.1 Hz), 1.17(d, 3H, J=6.3 Hz); MS, m/z: 585.57
5-491
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.38(m, 2H), 6.97˜7.05(m, 2H), 6.48˜6.64(m, 3H), 4.28(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.98˜4.10(m, 1H), 3.58(s, 3H), 3.22(d, 1H, J=7.1 Hz), 1.40(s, 3H), 1.28(s, 3H), 1.26(d, 3H, J=2.2 Hz), 1.23(d, 3H, J=2.2 Hz); MS, m/z: 373.47
5-492
      1H NMR(200 MHz, CDCl3) δ 7.31˜7.38(m, 2H), 6.96˜7.07(m, 2H), 6.49˜6.64(m, 3H), 4.28(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.99˜4.11(m, 1H), 3.78˜3.86(m, 1H), 3.58˜3.76(m, 1H), 3.52˜3.56(m, 1H), 3.31(d, 1H, J=7.1 Hz), 1.44˜1.62(m, 2H), 1.39(s, 3H), 1.30˜1.35(m, 4h), 1.25˜1.26(m, 6H), 1.23(s, 3H); MS, m/z: 429.58
5-493
      MS, m/z: 413.54
5-494
      1H NMR(200 MHz, CDCl3) δ 7.11˜7.36(m, 2H), 6.86˜7.06(m, 2H), 6.72˜6.76(m, 3H), 5.86˜5.99(m, 1H), 5.17˜5.33(m, 2H), 4.23(s, 2H), 4.12˜4.34(m, 3H), 3.98˜4.09(m, 1H), 3.35(d, 1H, J=6.9 Hz), 1.40(s, 3H), 1.23˜1.26(m, 9H); MS, m/z: 399.51
5-495
      1H NMR(200 MHz, CDCl3) δ 7.22˜7.29(m, 2H), 6.89˜6.98(m, 2H), 6.67˜6.88(m, 3H), 4.38˜4.40(m, 2H), 4.34(d, 1H, J= 6.7 Hz), 4.21(s, 2H), 3.99˜4.06(m, 1H), 3.51(d, 1H, J=6.7 Hz), 2.45˜2.47(m, 1H), 1.45(s, 3H), 1.28(b, 6H0, 1.25(s, 3H); MS, m/z: 397.49
5-496
      1H NMR(200 MHz, CDCl3) δ 7.27˜7.38(m, 7H), 6.97˜7.06(m, 2H), 6.54˜6.68(m, 3H), 4.71(d, 1h, J=11.5 Hz), 4.40(d, 1H, J=11.5 Hz), 4.40(d, 1H, J=11.1), 3.57˜4.25(m, 3H), 1.54˜2.17(m, 2H), 1.24˜1.43(m, 2H), 1.40(s, 3H), 1.24(s, 3H), 0.91(t, 3H, J=7.2 Hz); MS, m/z: 463.60
5-497
      1H NMR(200 MHz, CDCl3) δ 7.23˜7.37(m, 4H), 6.92˜7.09(m, 4H), 6.59˜6.73(m, 3h), 4.84(d, 1H, J=11.4 Hz), 4.65(d, 1H, J=11.4 Hz), 4.38(d, 1H, J=7.3 Hz), 4.24(s, 2H), 3.58˜3.69(m, 2H), 3.56(d, 1H, J=7.3 Hz), 1.46˜1.61(m, 2H), 1.25˜1.42(m, 2H), 1.38(s, 3H), 1.25(s, 3H), 0.92(t, 3H, J=7.1 Hz); MS, m/z: 481.59
5-498
      1H NMR(200 MHz, CDCl3) δ 7.27˜7.40(m, 6H), 6.93˜7.26(m, 2H), 6.66˜6.82(m, 3H), 4.83(d, 1H, J=11.2 Hz), 4.65(d, 1H, J=11.2 Hz), 4.36(d, 1H, J=6.0 Hz), 4.24(s, 2H0, 3.59˜1.61(m, 2H), 1.24˜1.39(m, 2H), 1.39(s, 3H), 1.32(s, 9H), 1.24(s, 3H), 0.92(t, 3H, J=7.2 Hz); MS, m/z: 519.71
5-499
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.36(m, 3H), 6.94˜7.13(m, 5H), 6.34˜6.73(m, 3H), 4.89(d, 1H, J=12.0 Hz), 4.69(d, 1H, J=12.0 Hz), 4.40(d, 1H, J=7.3 Hz), 4.24(s, 2H), 3.63˜4.19(m, 2H), 3.57(d, 1H, J=7.3 Hz), 1.50˜1.60(m, 2H), 1.27˜1.45(m, 2H), 1.40(s, 3H), 1.24(s, 3H), 0.91(t, 3H, J=7.1 Hz); MS, m/z: 481.59
5-500
      1H NMR(200 MHz, CDCl3) δ 7.16˜7.39(m, 6H), 6.92˜7.05(m, 2H), 6.61˜6.73(m, 3H), 4.91 (d, 1H, J=11.4 Hz), 4.69(d, 1H, J=11.4), 4.40(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.56˜3.73(m, 3H), 2.35(s, 3H), 1.49˜1.60(m, 2H), 1.26˜1.45(m, 2H), 1.40(s, 3H), 1.24(s, 3H), 0.90(t, 3H, J=7.2); MS, m/z: 477.62
5-501
      MS, m/z: 498.04
5-502
      1H NMR(200 MHz, CDCl3) δ 7.16˜7.36(m, 6H), 6.92˜7.04(m, 2H), 6.78(s, 1H), 6.67(d, 2H, J=1.4 Hz), 4.86(d, 1H, J= 11.8 Hz), 4.67(d, 1H, J=11.0 Hz), 4.39(d, 1H, J=7.3 Hz), 3.60˜4.18(m, 2H), 3.56(d, 1H, J=7.3 Hz), 1.50˜1.61(m, 2H), 1.24˜1.44(m, 2H), 1.40(s, 3H), 1.24(s, 3H), 0.91(t, 3H, J= 7.1 Hz); MS, m/z 498.04
5-503
      1H NMR(200 MHz, CDCl3) δ 7.14˜7.35(m, 6H), 6.94˜6.99(m, 2H), 6.78(s, 1H), 6.66(d, 2H, J=1.4 Hz), 4.83(d, 1H, J= 11.2 Hz), 4.64(d, 1H, J=11.2), 4.37(d, 1H, J=7.7), 4.24(s, 2H), 3.57˜3.70(m, 2H), 3.55(d, 1H, J=7.7), 3.54˜3.70(m, 2H), 2.35(s, 3H), 1.54˜1.61(m, 2H), 1.25˜1.51(m, 2H), 1.38(s, 3H), 1.22(s, 3H), 0.92(t, 3H, J=7.1 Hz); MS, m/z: 477.62
5-504
      MS, m/z: 560.48
5-505
      1H NMR(200 MHz, CDCl3) δ 7.80˜7.86(m, 4H), 7.45˜7.50(m, 3H), 7.25˜7.34(m, 2H), 6.93˜6.80(m, 2H), 6.80(s, 1H), 6.67(d, 2H, J=2.0 Hz), 5.03(d, 1H, J=11.6), 4.86(d, 1H, J= 11.6 Hz), 4.42(d, 1H, J=7.1 Hz), 4.23(s, 2H), 3.63˜3.76(m, 2H), 3.28(d, 1H, J=7.1 Hz), 1.50˜1.64(m, 2H), 1.27˜1.46(m, 2H), 1.40(s, 3H), 1.21(s, 3H), 0.85˜0.98(m 3H); MS, m/z: 513.66
5-506
      MS, m/z: 599.59
5-507
      1H NMR(200 MHz, CDCl3) δ 7.14˜7.30(m, 4H), 6.87˜7.01(m, 3H), 4.24(d, 1H, J=6.9 Hz), 4.22(s, 2H), 3.68˜3.78(m, 2H), 3.58(s, 3H), 3.25(d, 1H, J=6.9 Hz), 1.47˜1.66(m, 2H), 1.40˜1.43(m, 2H0, 1.40(s, 3H), 1.23(s, 3H), 0.90˜0.98(m, 3H); MS, m/z: 387.50
5-508
      1H NMR(200 MHz, CDCl3) δ 7.28˜7.36(m, 2H), 6.89˜7.03(m, 2H), 6.62˜6.81(m, 3H), 4.32(d, 1H, J=7.3 Hz), 4,24(s, 2H), 3.55˜3.82(m, 4H), 3.36(d, 1H, J=7.3 Hz), 1.52˜1.75(m, 4H), 1.39(s, 3H), 1.26˜1.49(m, 6h), 1.21(s, 3H), 0.90˜0.98(m, 6H); MS, m/z: 443.61
5-509
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.37(m, 2H), 6.96˜7.04(m, 2H), 6.56˜6.70(m, 2H), 5.62˜5.71(m, 2H), 4.31(d, 1H, J= 7.1 Hz), 4.24(s, 2H), 4.05˜4.28(m, 2H), 3.48˜3.75(m, 2H), 3.45(d, 1H, J=7.1 Hz), 1.69˜1.73(m, 3H), 1.53˜1.66(m, 2H), 1.39(s, 3H), 1.21(s, 3H), 1.26˜1.45(m, 2H), 0.94(t, 3H, J= 7.1 Hz); MS, m/z: 427.56
5-510
      1H NMR(200 MHz, CDCl3) δ 7.27˜7.37(m, 2H), 6.95˜7.06(m, 2H), 6.52˜6.66(m, 3H), 5.86˜6.05(m, 1H), 5.14˜5.35(m, 2H), 4.34(d, 1H, J=7.3 Hz), 4.11˜4.40(m, 2H), 4.24(s, 2H), 3.58˜3.77(m, 2h), 3.47(d, 1H, J=7.3 Hz), 1.52˜1.66(m, 2H), 1.34˜1.48(m, 2H), 1.40(s, 3H), 1.22(s, 3H), 0.93(t, 3H, J= 7.1 Hz); MS, m/z: 413.54
5-511
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.37(m, 2H), 6.97˜7.06(m, 2H), 6.50˜6.67(m, 3H), 4.43(dd, 2H, J=0.81, J=2.7), 4.39(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.59˜3.69(m, 3H), 2.44˜2.46(m, 1H), 1.51˜1.61(m, 2H), 1.43(s, 3H), 1.29˜1.40(m, 2H), 1.22(s, 3H), 0.93(t, 3H, J=7.1 Hz); MS, m/z: 411.52
5-512
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.37(m, 12H), 6.95˜7.04(m, 2H), 6.52˜6.68(m, 3H), 4.89(d, 1H, J=11.4 Hz), 4.67(d, 1H, J=11.6 Hz), 4.73(d, 2H, J=2.8 Hz), 4.60(d, 1H, J=7.3 Hz), 4.17(s, 2H), 3.69(d, 1H, J=7.1 Hz), 1.43(s, 3H), 1.27(s, 3H); MS, m/z: 497.61
5-513
      1H NMR(200 MHz, CDCl3) δ 7.33˜7.56(m, 9H), 6.96˜7.06(m, 4H), 6.49˜6.68(m, 3H), 4.85(d, 1H, J=11.6 Hz), 4.70(d, 2H, J=4.3 Hz), 7.17(s, 2H), 4.17˜4.54(m, 2H), 3.69(d, 1H, J= 7.1 Hz), 1.43(s, 3H), 1.26(s, 3H); MS, m/z: 515.61
5-514
      1H NMR(200 MHz, CDCl3) δ 7.27˜7.40(m, 10H), 6.68˜7.04(m, 2H), 6.50˜6.63(m, 3h0, 4.86(d, 1H, J=11.0 Hz), 4.63˜4.79(m, 3H), 4.59(d, 1H, J=7.5 Hz), 4.17(s, 2H), 3.69(d, 1H, J=7.1 Hz), 1.44(s, 3H), 1.32(s, 9H), 1.26(s, 3H); MS, m/z: 553.72
5-515
      1H NMR(200 MHz, CDCl3) δ 7.34˜7.56(m, 8H), 6.95˜7.11(m, 5H), 6.49˜6.69(m, 3H), 4.89(d, 1H, J=11.8 Hz), 4.67˜4.83(m, 3H), 4.63(d, 1H, J=7.5 Hz), 4.18(s, 2H), 3.69(d, 1H, J=7.5 Hz), 1.45(s, 3H), 1.28(s, 3H); MS, m/z: 535.68
5-516
      1H NMR(200 MHz, CDCl3) δ 7.19˜7.39(m, 11H), 6.96˜7.17(m, 2H), 6.51˜6.69(m, 3H), 4.91 (d, 1H, J=11.6 Hz), 4.67˜4.73(m, 3H), 4.62(d, 1H, J=7.1 Hz), 4.18(s, 2H), 3.73(d, 1H, J=7.1 Hz), 2.30(s, 3H), 1.42(s, 3H), 1.27(s, 3H): MS, m/z: 531.72
5-517
      MS, m/z: 532.06
5-518
      1H NMR(200 MHz, CDCl3) δ 7.17˜7.34(m, 11H), 6.96˜7.04(m, 2H), 6.51˜6.69(m, 3H), 4.86(d, 1H, J=12.0 Hz), 4.61˜4.71(m, 4H), 4.18(s, 2H), 3.68(d, 1H, J=7.3 Hz), 1.45(s, 3H), 1.28(s, 3H); MS, m/z: 532.06
5-519
      MS, m/z: 511.64
5-520
      1H NMR(200 MHz, CDCl3) δ 7.21˜7.33(m, 10H), 6.95˜7.04(m, 2H), 6.50˜6.68(m, 3H), 4.87(d, 1H, J=12.2), 4.68˜4.74(m, 3H), 4.60(d, 1H, J=7.3 Hz), 4.17(s, 2H), 3.69(d, 1H, J=7.3 Hz), 1.42(s, 3H), 1.24(s, 3H); MS, m/z: 594.50
5-521
      1H NMR(200 MHz, CDCl3) δ 7.76˜7.86(m, 4H), 7.45˜7.50(m, 3H), 7.15˜7.34(m, 7H), 6.95˜7.04(m, 2h), 6.50˜6.69(m, 3H), 5.05(d, 1H, J=11.6 Hz), 4.87(d, 1H, J=11.6 Hz), 4.71(d, 2H, J=7.7 Hz), 4.64(d, 1H, J=6.9 Hz), 4.18(s, 2H), 3.76(d, 1H, J=6.9 Hz), 1.45(s, 3H), 1.30(s, 3H); MS, m/z: 547.68
5-522
      1H NMR(200 MHz, CDCl3) δ 7.79(s, 2H), 7.74(s, 1H), 7.27˜7.34(m, 7H), 6.95˜7.04(m, 2H), 6.51˜6.70(m, 3H), 4.97(d, 1H, J=12.4 Hz), 4.78(d, 1H, J=12.4 Hz), 4.69(d, 1H, J=7.5 Hz), 4.68(s, 2H), 4.19(s, 2H), 3.72(d, 1H, J=7.5 Hz), 1.46(s, 3H), 1.28(s, 3H); MS, m/z: 633.61
5-523
      1H NMR(200 MHz, CDCl3) δ 7.27˜7.39(m, 7H), 6.94˜7.26(m, 2H), 6.57˜6.68(m, 3H), 4.82(d, 1H, J=12.0 Hz), 4.72(d, 1H, J=12.0 Hz), 4.49(d, 1H, J=7.1 Hz), 4.17(s, 2H), 3.60(s, 3H), 3.41(d, 1H, J=7.1 Hz), 1.44(s, 3H), 1.24(s, 3H); MS, m/z: 421.52
5-524
      1H NMR(200 MHz, CDCl3) δ 7.23˜7.38(m, 7H), 6.90˜6.98(m, 2H), 6.66˜6.77(m, 3h), 4.71(d, 1H, J=12.0 Hz), 4.67(d, 1H, J=12.0 Hz), 4.47(d, 1H, J=7.3 Hz), 4.16(s, 2H), 3.52˜3.83(m, 2H), 3.47(d, 1H, J=7.1 Hz), 1.43˜1.60(b, 2H), 1.42(s, 3H), 1.24(s, 3H), 1.30˜1.42(m, 4H), 0.89˜0.93(m, 3H), MS, m/z: 477.62
5-525
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.38(m, 7H), 6.95˜7.06(m, 2H), 6.48˜6.65(m, 3H), 5.62˜5.70(m, 2H), 4.82(d, 1H, J= 11.6 Hz), 4.71(d, 1H, J=11.6 Hz), 4.52(d, 1H, J=7.1 Hz), 4.08˜4.31(m, 2H), 4.16(s, 2H), 3.57(d, 1H, J=7.1 Hz), 1.63˜1.74(m, 3H), 1.43(s, 3H), 1.24(s, 3H); MS, m/z: 461.58
5-526
      1H NMR(200 MHz, CDCl3) δ 7.14˜7.41(m, 7H), 6.84˜7.06(m, 2H), 6.49˜6.69(m, 3H), 5.87˜6.06(m, 1H), 5.15˜5.34(m, 2H), 4.80(d, 1H, J=11.4 Hz), 4.70(d, 1H, J=11.4 Hz), 4.54(d, 1H, J=7.3 Hz), 4.20˜4.45(m, 2H), 4.17(s, 2H), 3.59(d, 1H, J= 7.3 Hz), 1.44(2, 3H), 1.25(s, 3H); MS, m/z: 447.55
5-527
      1H NMR(200 MHz, CDCl3) δ 7.29˜7.38(m, 7H), 6.94˜7.03(m, 2H), 6.59˜6.69(m, 3H), 4.73(b, 2H), 4.42(d, 2H, J=2.4 Hz), 4.17(s, 2H), 3.80(d, 1H, J=6.5 Hz), 2.46(t, 1H, J=2.3 Hz); MS, m/z: 445.54
5-528
      MS, m/z: 511.64
5-529
      1H NMR(200 MHz, CDCl3) δ 7.22˜7.37(m, 12 H), 6.90˜7.11(m, 2H), 6.59˜6.84(m, 3H), 4.68(d, 1H, J=11.0 Hz), 4.54(d, 1H, J=11.2 Hz), 4.39(d, 1H, J=7.5 Hz), 4.17(s, 2H), 3.87(t, 2H, J=6.9 Hz), 3.51 (d, 1H, J=7.5 Hz), 2.89(t, 2H, J=6.7 Hz), 1.34(s, 3H), 1.19(s, 3H); MS, m/z: 529.63
5-530
      1H NMR(200 MHz, CDCl3) δ 7.20˜7.35(m, 9H), 6.94˜7.06(m, 4H), 6.43˜6.60(m, 3H), 4.69(d, 1H, J=11.6 Hz), 4.55(d, 1H, J=11.6 Hz), 4.41(d, 1H, J=7.5 Hz), 4.15(s, 2H), 3.82˜3.92(m, 2H), 3.53(d, 1H, J=7.5 Hz), 2.88(t, 2H, J=6.5 Hz), 1.36(s, 3H), 1.19(s, 3H); MS, m/z: 567.75
5-531
      1H NMR(200 MHz, CDCl3) δ 7.64˜7.84(m, 3H), 7.15˜7.39(m, 7H), 6.94˜7.02(m, 2H), 6.69˜6.79(m, 3H), 4.88(d, 1H, J= 11.6 Hz), 4.62(d, 1H, J=11.6 Hz), 4.52(d, 1H, J=9.6 Hz), 4.46(d, 1H, J=7.5 Hz), 4.21(s, 2H), 3.81˜3.92(m, 2H), 3.52(d, 1H, J= 7.9 Hz), 2.87(t, 2H, J=6.9 Hz), 1.38(s, 3H), 1.21(s, 3H); MS, m/z: 529.63
5-532
      1H NMR(200 MHz, CDCl3) δ 7.11˜7.36(m, 11H), 7.01˜7.06(m, 2H), 6.40˜6.97(m, 3H), 4.81(d, 1H, J=11.8 Hz), 4.63(d, 1H, J=11.8 Hz), 4.41(d, 1H, d˜7.5 Hz), 4.15(s, 2H), 3.80˜3.96(m, 2H), 3.59(d, 1H, J=7.5 Hz), 2.87(t, 2H, J=6.7 Hz), 2.32(s, 3H), 1.34(s, 3H), 1.21(s, 3H); MS, m/z: 525.67
5-533
      1H NMR(200 MHz, CDCl3) δ 7.10˜7.37(m, 11H), 6.96˜7.04(m, 2H), 6.52˜6.67(m, 3H), 4.67(d, 1H, J=11.8 Hz), 4.55(d, 1H, J=11.8 Hz), 4.41(d, 1H, J=7.7 Hz), 4.17(s, 2H), 3.83˜3.90(m, 2H), 3.52(d, 1H, J=7.7 Hz), 2.88(t, 2H, J=6.3 Hz), 1.37(s, 3H), 1.21(s, 3H); MS, m/z: 546.09
5-534
      1H NMR(200 MHz, CDCl3) δ 7.15˜7.35(m, 11H), 6.93˜7.10(m, 2H), 6.50˜6.67(m, 3H), 4.67(d, 1H, J=12.2 Hz), 4.54(d, 1H, J=12.0 Hz), 4.42(o 1H, J=7.5 Hz), 4.16(s, 2H), 3.87(t, 2H, J=6.3 Hz), 3.52(d, 1H, J=7.5 Hz), 2.87(t, 2H, J=6.5 Hz), 1.37(s, 3H), 1.21(s, 3H); MS, m/z: 546.09
5-535
      MS, m/z: 525.67
5-536
      1H NMR(200 MHz, CDCl3) δ 7.46˜7.51(m, 1H), 7.13˜7.39(m, 9H), 6.94˜7.06(m, 2H), 6.38˜6.76(m, 3H), 4.92(d, 1H, J= 12.6 Hz), 4.74(d, 1H, J=12.6 Hz), 4.45(d, 1H, J=7.7 Hz), 4.15(s, 2H), 3.87˜3.91(m, 2H), 3.62(d, 1H, J=7.7 Hz), 2.88(t, 2H, J=6.7 Hz), 1.38(s, 3H), 1.23(s, 3H); MS, m/z: 608.53
5-537
      1H NMR(200 MHz, CDCl3) δ 7.73˜7.86(m, 4H), 7.34˜7.50(m, 3H), 7.09˜7.32(m, 7H), 6.95˜7.04(m, 2H), 6.53˜6.63(m, 3H), 4.89(d, 1H, J=11.6 Hz), 4.76(d, 1H, J=11.6 Hz), 4.44(d, 1H, J=7.5 Hz), 4.16(s, 2H), 3.83˜3.94(m, 2H), 3.60(d, 1H, J= 7.5 Hz), 2.87(t, 2H, J=6.5 Hz), 1.37(s, 3H), 1.24(s, 3H); MS, m/z: 531.70
5-538
      1H NMR(200 MHz, CDCl3) δ 7.66˜7.79(m, 3H), 7.11˜7.37(m, 7H), 6.97˜7.06(m, 2H), 6.47˜6.68(m, 3H), 4.66(d, 1H, J= 12.8 Hz), 4.54(d, 1H, J=12.8 Hz), 4.49(d, 1H, J=8.1 Hz), 4.19(s, 2H), 3.78˜3.88(m, 2H), 3.56(d, 1H, J=8.1 Hz), 2.84(t, 2H, J=6.5 Hz), 1.39(s, 3H), 1.21 (s, 3H); MS, m/z: 647.64
5-539
      MS, m/z: 435.54
5-540
      MS, m/z: 491.65
5-541
      1H NMR(200 MHz, CDCl3) δ 7.11˜7.35(m, 7H), 6.97˜7.06(m, 2H), 6.30˜6.62(m 3H) 6.51˜5.72(m, 2H) 4.13(s, 2H), 3.86˜4.13(m, 5H), 3.44(d, 1H, J=7.5 Hz), 2.91(t, 2H, J= 6.7 Hz), 1.64˜1.73(m, 3H), 1.37(s, 3H), 1.18(s, 3H); MS, m/z: 475.60
5-542
      1H NMR(200 MHz, CDCl3) δ 7.22˜7.37(m, 7H), 6.97˜7.06(m, 2H), 6.34˜6.66(m, 3H), 5.84˜5.98(m, 1H), 5.14˜5.34(m, 2H), 4.14(s, 2H), 3.85˜4.44(m, 5H), 3.44(o 1H, J=7.7 Hz), 2.91(t, 2H, J=6.7 Hz), 1.38(s, 3H), 1.19(s, 3H); MS, m/z: 461.58
5-543
      1H NMR(200 MHz, CDCl3) δ 7.22˜7.35(m, 7H), 6.98˜7.06(m, 2H), 6.30˜6.64(m, 3H), 4.40(d, 1H, J=7.5 Hz), 4.31(d, 2H,J=2.2 Hz), 4.14(s, 2H), 3.84˜3.93(m, 2H), 3.64(d, 1H, J= 7.5 Hz), 2.90(t, 2H, J=6.7 Hz), 2.44(t, 1H, J=2.2 Hz), 1.40(s, 3H), 1.18(s, 3H); MS, m/z: 459.57
5-544
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.38(m. 7H), 6.94˜7.03(m, 2H), 6.66˜6.78(m, 2H), 4.88(d, 1H, J=11.4 Hz), 4.69(d, 1H, J=11.6 Hz), 4.38(d, 1H, J=7.1 Hz), 1.39(s, 3H), 1.18(s, 3H), 1.14˜1.70(m, 11H), 0.86˜0.92(m, 2H); MS, m/z: 517.69
5-545
      1H NMR(200 MHz, CDCl3) δ 7.28˜7.37(m, 4h), 6.95˜7.08(m, 4H), 6.64˜6.74(m, 3H0, 4.84(d, 1H, J=11.4 Hz), 4.66(d, 1H, J=11.2 Hz), 4.38(d, 1H, J=7.3 Hz), 4.24(s, 2H), 3.63˜3.70(m, 2H), 3.56(d, 1H, J=7.1 Hz), 1.38(s, 3H0, 1.23(s, 3H), 1.15˜1.69(m, 11H), 0.80˜0.92(m, 2H); MS, m/z: 535.68
5-546
      MS, m/z: 573.80
5-547
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.38(m, 3H), 6.98˜7.13(m, 5H), 6.49˜6.67(m, 3H), 4.89(d, 1H, J=12.0 Hz), 4.70(d, 1H, J=12.0 Hz), 4.42(d, 1H, J=7.5 Hz), 4.25(s, 2H), 3.62˜3.89(m, 2H0, 3.58(d, 1H, J=7.5 Hz), 1.14˜1.68(m, 11H), 0.85˜0.90(m, 2H); MS, m/z: 535.68
5-548
      1H NMR(200 MHz, CDCl3) δ 7.22˜7.39(m, 6H), 6.94˜7.02(m, 2H0, 6.66˜6.79(m, 3h), 4.90(d, 1H, J=12.0 Hz), 4.69(d, 1H, J=12.0 Hz), 4.39(d, 1H, J=7.3 Hz), 4.24(s, 2H), 3.63˜4.19(m, 2H), 3.60(d, 1H, J=7.1 Hz), 2.34(s, 3H), 1.36(s, 3H), 1.24(s, 3H), 1.14˜1.69(m, 11H), 0.85˜0.91(m, 2H); MS, m/z: 531.71
5-549
      MS, m/z: 552.14
5-550
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.37(m, 6H), 6.96˜7.05(m, 2H), 6.64˜6.72(m, 3H), 4.87(d, 1H, J=12.2 Hz), 4.48(d, 1H, J=12.2 Hz), 4.41(d, 1H, J=7.1 Hz), 4.24(s, 2H), 3.63˜3.70(m, 2H), 3.57(d, 1H, J=7.3 Hz), 1.41(s, 3H), 1.25(s, 3H), 1.14˜1.50(m, 11H), 0.86˜0.92(m, 2H); MS, m/z: 552.14
5-551
      MS, m/z: 531.71
5-552
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.37(m, 5H), 6.98˜7.08(m, 2H), 6.49˜6.66(m, 3H), 4.88(d, 1H, J=12.0 Hz), 4.71(d, 1H, J=12.0 Hz), 4.40(d, 1H, J=7.5 Hz), 4.24(s, 2H), 3.62˜3.68(m, 2H), 3.59(d, 1H, J=7.5 Hz), 1.39(s, 3H), 1.21(s, 3H), 1.14˜1.65(m, 11H), 0.85˜0.96(m, 2H); MS, m/z: 614.58
5-553
      MS, m/z: 567.75
5-554
      1H NMR(200 MHz, CDCl3) δ 7.81(b, 3H). 7.28˜7.38(m, 2H), 6.98˜7.25(m, 2H), 6.50˜6.68(m, 3H), 5.03(d. 1H, J=12.6 Hz), 4.83(d, 1H, J=12.4 Hz), 4.48(d, 1H, J=7.9 Hz), 3.59˜3.67(m, 3H), 1.43(s, 3H), 1.25(s, 3H), 1.11˜1.65(m, 11H), 0.82˜0.88(m, 2H); MS, m/z: 653.69
5-555
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.35(m, 2H), 6.94˜7.02(m, 2H), 6.65˜6.77(m, 3H), 4.28(d, 1H, J=6.7 Hz), 4.23(s, 2H), 6.64˜6.78(m, 2H), 3.59(s, 3H), 3.29(d, 1H, J=6.7 Hz), 1.40(s, 3H), 1.21(s, 3H), 1.21˜1.75(m, 1H), 0.89˜0.95(m, 2H); MS, m/z 441.59
5-556
      MS, m/z: 497.70
5-557
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.33(m, 2H), 6.85˜7.01(m, 2H), 6.63˜6.70(m, 3H), 5.61˜5.72(m, 2H). 4.29(d, 1H, J= 6.9 Hz), 4.22(s, 2H), 4.11˜4.22(m, 2H), 3.72˜3.76(m, 2H), 3.44(d, 1H, J=7.1 Hz), 1.39(s, 3H), 1.23(s, 3H), 1.43˜1.74(m, 11H), 0.86˜0.92(m, 2H); MS, m/z: 481.66
5-558
      1H NMR(200 MHz, CDCl3) δ 7.30˜7.37(m, 2H), 6.96˜7.05(m, 2H), 6.57˜6.66(m, 3H), 6.16˜5.34(m, 1H), 5.82˜6.02(m, 1H), 4.34(d, 1H, J=7.1 Hz), 4.24(s, 2H), 4.18˜4.36(m, 2H), 3.66˜3.76(m, 2H), 3.47(d, 1H, J=7.5 Hz), 1.40(s, 3H), 1.22(s, 3H), 1.22˜1.69(m, 11H), 0.86˜0.92(m, 2H); MS, m/z: 467.63
5-559
      1H NMR(200 MHz, CDCl3) δ 7.25˜7.36(m, 2H), 6.94˜7.02(m, 2H), 6.68˜6.82(m, 3H), 4.42(d, 2H, J=2.4 Hz), 4.36(d, 1H, J=7.3 Hz), 4.24(s, 2H), 3.65˜3.73(m, 3H), 2.04˜2.47(m, 1H), 1.43(s, 3H), 1.23(s, 3H), 1.23˜1.69(m, 11H), 0.86˜0.96(m, 2H); MS, m/z: 465.61
5-560
      1H NMR(200 MHz, CDCl3) δ 7.24˜7.38(m, 5H), 7.14(m, 2H), 6.50˜6.66(m, 3H), 4.91(d, 1H, J=11.6 Hz), 4.71(d, 1H, J= 11.6 Hz), 4.42(d, 1H, J=7.3 Hz), 4.23(s, 2H), 3.61(d, 1H, J=7.3 Hz), 3.45(s, 3H), 2.34(s, 3H), 1.40(s, 3H), 1.23(s, 3H); MS, m/z: 417.55
5-561
      1H NMR(200 MHz, CDCl3) δ 7.26˜7.40(m, 4H), 7.00˜7.25(m, 4H), 6.54˜6.68(m, 3H), 4.87(d, 1H, J=11.4 Hz), 4.67(d, 1H, J=11.6 Hz), 4.42(d, 1H, J=7.5 Hz), 4.23(s, 2H), 3.60(d, 1H, J=7.5 Hz), 3.45(s, 3H), 2.34(s, 3H), 1.41(s, 3H), 1.23(s, 3H); MS, m/z: 435.54
5-562
      MS, m/z: 473.66
5-563
      1H NMR(200 MHz, CDCl3) δ 7.24˜7.33(m, 4H), 7.08˜7.16(m, 4H), 6.60˜6.72(m, 3H), 4.92(d, 1H, J=12.0 Hz), 4.70(d, 1H, J=12.0 Hz), 4.42(d, 1H, J=7.3 Hz), 4.23(s, 2H), 3.60(d, 1H, J=7.3 Hz), 3.45(s, 3H), 2.33(s, 3H), 1.42(s, 3H), 1.24(s, 3H); MS, m/z: 435.54
5-564
      1H NMR(200 MHz, CDCl3) δ 7.38˜7.41(m, 3H), 7.13˜7.29(m, 7H), 6.53˜6.69(m, 3H), 4.93(d, 1H, J=11.6 Hz), 4.70(d, 1H, J=11.6 Hz), 4.42(d, 1H, J=7.3 Hz), 4.23(s, 2H), 3.64(d, 1H, J=7.3 Hz), 3.45(s, 3H), 2.37(s, 3H), 2.34(s, 3H), 1.39(s, 3H), 1.23(s, 3H); MS, m/z: 431.58
5-565
      1H NMR(200 MHz, CDCl3) δ 7.52˜7.57(m, 1H), 7.12˜7.39(m, 7H), 6.60˜6.73(m, 3H), 5.02(d, 1H, J=12.4 Hz), 4.81(d, 1H, J=12.4 Hz), 4.44(d, 1H, J=7.3 Hz), 4.23(s, 2H), 3.67(d, 1H, J=7.3 Hz), 3.48(s, 3H), 2.33(s, 3H), 1.42(s, 3H), 1.26(s, 3H); MS, m/z: 452.00
5-566
      1H NMR(200 MHz, CDCl3) δ 7.38˜7.39(m, 1H), 7.21˜7.30(m, 6H), 7.12˜7.16(m, 1H), 6.59˜6.70(m, 3H), 4.90(d, 1H, J= 12.0 Hz), 4.69(d, 1H, J=12.0 Hz), 4.43(d, 1H, J=7.5 Hz), 4.23(s, 2H), 3.60(d, 1H, J=7.5 Hz), 3.45(s, 3H), 2.34(s, 3H), 1.42(s, 3H), 1.24(s, 3H); MS, m/z: 452.00
5-567
      1H NMR(200 MHz, CDCl3) δ 7.23˜7.30(m, 4H), 7.11˜7.18(m, 4H), 6.55˜6.72(m, 3H), 4.86(d, 1H, J=11.2 Hz), 4.66(d, 1H, J=11.2 Hz), 4.39(d, 1H, J=6.9 Hz), 4.22(s, 2H), 3.58(d, 1H, J=6.9 Hz), 3.47(s, 3H), 2.35(s, 3H), 2.33(s, 3H), 1.39(s, 3H), 1.22(s, 3H); MS, m/z: 431.58
5-568
      1H NMR(200 MHz, CDCl3) δ 7.17˜7.39(m, 7H), 6.51˜6.68(m, 3H), 4.90(d, 1H, J=12.0 Hz), 4.73(d, 1H, J=12.0 Hz), 4.41(d, 1H, J=7.3 Hz), 4.23(s, 2H), 3.61(d, 1H, J=7.3 Hz), 3.46(s, 3H), 2.35(s, 3H), 1.40(s, 3H), 1.21(s, 3H); MS, m/z: 514.44
5-569
      MS, m/z: 467.61
5-570
      1H NMR(200 MHz, CDCl3) δ 7.83(b, 3H), 7.13˜7.29(m, 4H), 6.52˜6.69(m, 3H), 5.06(d, 1H, J=12.4 Hz), 4.83(d, 1H, J= 12.4 Hz), 4.50(d, 1H, J=7.7 Hz), 4.24(s, 2H), 3.65(d, 1H, J=7.7 Hz), 3.41 (s, 3H), 2.34(s, 3H), 1.45(s, 3H), 1.26(s, 3H); MS, m/z: 445.61
5-571
      MS, m/z: 341.45
5-572
      1H NMR(200 MHz, CDCl3) δ 7.12˜7.28(m, 4H), 6.49˜6.66(m, 3H), 4.30(d, 1H, J=7.1 Hz), 4.22(s, 2H), 3.81˜3.86(m, 1H), 3.56˜3.78(m, 2H), 3.50(s, 3H), 3.40(s, 3H), 2.34(s, 3H), 1.57˜1.61(m, 2H), 1.40(s, 3H), 1.26˜1.38(m, 4H), 1.20(s, 3H), 0.90˜0.94(m 3H); MS, m/z: 397.56
5-573
      1H NMR(200 MHz, CDCl3) δ 7.24˜7.28(m, 2H), 7.12˜7.24(m, 2H), 6.65(d, 1H, J=3.3 Hz), 6.62(s, 1H), 6.52(dd, 1H, J=2.8 Hz, J=8.9 Hz), 5.63˜5.73(m, 2H), 4.33(d, 1H, J=7.3 Hz), 4.22(s, 2H), 4.08˜4.27(m, 2H), 3.50(d, 1H, J=7.3 Hz), 3.50(s, 3H), 2.34(s, 3H), 1.71(d, 3H, J=0.8 Hz), 1.40(s, 3H), 1.21(s, 3H); MS, m/z: 381.52
5-574
      1H NMR(200 MHz, CDCl3) δ 7.25˜7.29(m, 2H), 7.12˜7.16(m, 2H), 6.02˜6.67(m, 3H), 5.88˜5.99(m, 1H), 5.37(dd, 1H, J= 1.6 Hz, J=17.3 Hz), 5.19(dd, 1H, J=1.4 Hz, j=10.4 Hz), 4.35(d, 1H, J=7.5 Hz), 4.23(s, 2H), 4.18˜4.36(m, 2H), 3.51(d, 1H, J= 7.5 Hz), 3.49(s, 3H), 2.34(s, 3H), 1.42(s, 3H), 1.22(s, 3H); MS, m/z: 367.49
5-575
      1H NMR(200 MHz, CDCl3) δ 7.24˜7.28(m, 2H), 7.12˜7.16(m, 2H), 6.57˜6.68(m, 3H), 4.46(d, 2H, J=2.2 Hz), 4.41(d, 1H, J=7.1 Hz), 4.22(s, 3H), 3.74(d, 1H, J=7.1 Hz), 3.46(s, 3H), 2.46(t, 1H, J=2.4 Hz), 2.34(s, 3H), 1.44(s, 3H), 1.22(s, 3H); MS, m/z: 365.48
5-576
      MS, m/z: 431.58
5-577
      MS, m/z: 449.57
5-578
      MS, m/z: 487.69
5-579
      MS, m/z: 449.57
5-580
      MS, m/z: 445.61
5-581
      MS, m/z: 466.03
5-582
      MS, m/z: 466.03
5-583
      MS, m/z: 445.61
5-584
      MS, m/z: 528.47
5-585
      MS, m/z: 481.64
5-586
      MS, m/z: 567.58
5-587
      MS, m/z: 355.48
5-588
      MS, m/z: 411.59
5-589
      MS, m/z: 395.55
5-590
      MS, m/z: 381.52
5-591
      MS, m/z: 379.50
5-592
      MS, m/z 445.61
5-593
      MS, m/z: 463.60
5-594
      MS, m/z: 501.72
5-595
      MS, m/z: 463.60
5-596
      MS, m/z: 459.63
5-597
      MS, m/z: 480.05
5-598
      MS, m/z: 480.05
5-599
      MS, m/z: 459.63
5-600
      MS, m/z: 542.49
5-601
      MS, m/z: 495.67
5-602
      MS, m/z: 581.60
5-603
      MS, m/z: 369.51
5-604
      MS, m/z: 425.62
5-605
      MS, m/z: 409.57
5-606
      MS, m/z: 395.55
5-607
      MS, m/z: 393.53
5-608
      MS, m/z: 459.63
5-609
      MS, m/z: 477.62
5-610
      MS, m/z: 515.74
5-611
      MS, m/z: 477.62
5-612
      MS, m/z: 473.66
5-613
      MS, m/z: 494.08
5-614
      MS, m/z: 494.08
5-615
      MS, m/z: 473.66
5-616
      MS, m/z: 556.52
5-617
      MS, m/z: 509.69
5-618
      MS, m/z: 595.63
5-619
      MS, m/z: 383.54
5-620
      MS, m/z: 439.64
5-621
      MS, m/z: 423.60
5-622
      MS, m/z: 409.57
5-623
      MS, m/z: 407.56
5-624
      MS, m/z: 493.65
5-625
      MS, m/z: 511.64
5-626
      MS, m/z: 549.76
5-627
      MS, m/z: 511.64
5-628
      MS, m/z: 507.68
5-629
      MS, m/z: 528.10
5-630
      MS, m/z: 528.10
5-631
      MS, m/z: 507.68
5-632
      MS, m/z: 590.54
5-633
      MS, m/z: 543.71
5-634
      MS, m/z: 521.71
5-635
      MS, m/z: 417.55
5-636
      MS, m/z: 473.66
5-637
      MS, m/z: 457.62
5-638
      MS, m/z: 443.59
5-639
      MS, m/z: 441.58
5-640
      MS, m/z: 507.68
5-641
      MS, m/z: 525.67
5-642
      MS, m/z: 563.79
5-643
      MS, m/z: 525.67
5-644
      MS, m/z: 521.71
5-645
      MS, m/z: 542.12
5-646
      MS, m/z: 542.12
5-647
      MS, m/z: 521.71
5-648
      MS, m/z: 604.57
5-649
      MS, m/z: 557.74
5-650
      MS, m/z: 643.68
5-651
      MS, m/z: 431.58
5-652
      MS, m/z: 487.69
5-653
      MS, m/z: 471.65
5-654
      MS, m/z: 457.62
5-655
      MS, m/z: 455.60
5-656
      MS, m/z: 513.73
5-657
      MS, m/z: 531.72
5-658
      MS, m/z: 569.84
5-659
      MS, m/z: 531.72
5-660
      MS, m/z: 527.75
5-661
      MS, m/z: 548.17
5-662
      MS, m/z: 548.17
5-663
      MS, m/z: 527.75
5-664
      MS, m/z: 610.61
5-665
      MS, m/z: 563.79
5-666
      MS, m/z: 649.72
5-667
      MS, m/z: 437.63
5-668
      MS, m/z: 493.74
5-669
      MS, m/z: 477.69
5-670
      MS, m/z: 463.67
5-671
      MS, m/z: 461.65
5-672
      MS, m/z: 421.52
5-673
      MS, m/z: 439.51
5-674
      MS, m/z: 477.62
5-675
      MS, m/z: 439.51
5-676
      MS, m/z: 435.54
5-677
      MS, m/z: 455.96
5-678
      MS, m/z: 455.96
5-679
      MS, m/z: 435.54
5-680
      MS, m/z: 518.40
5-681
      MS, m/z: 471.58
5-682
      MS, m/z: 449.57
5-683
      MS, m/z: 345.42
5-684
      MS, m/z: 401.53
5-685
      MS, m/z: 385.48
5-686
      MS, m/z: 371.46
5-687
      MS, m/z: 369.44
5-688
      MS, m/z: 435.54
5-689
      MS, m/z: 453.53
5-690
      MS, m/z: 491.65
5-691
      MS, m/z: 453.53
5-692
      MS, m/z: 449.57
5-693
      MS, m/z: 469.99
5-694
      MS, m/z: 469.99
5-695
      MS, m/z: 449.57
5-696
      MS, m/z: 532.43
5-697
      MS, m/z: 485.60
5-698
      MS, m/z: 571.54
5-699
      MS, m/z: 359.44
5-700
      MS, m/z: 415.55
5-701
      MS, m/z: 399.51
5-702
      MS, m/z: 385.48
5-703
      MS, m/z: 383.47
5-704
      MS, m/z: 449.57
5-705
      MS, m/z: 467.56
5-706
      MS, m/z: 505.68
5-707
      MS, m/z: 467.56
5-708
      MS, m/z: 463.60
5-709
      MS, m/z: 484.02
5-710
      MS, m/z: 484.02
5-711
      MS, m/z: 463.60
5-712
      MS, m/z: 546.46
5-713
      MS, m/z: 499.63
5-714
      MS, m/z: 585.57
5-715
      MS, m/z: 373.47
5-716
      MS, m/z: 429.58
5-717
      MS, m/z: 413.54
5-718
      MS, m/z: 399.51
5-719
      MS, m/z: 397.49
5-720
      MS, m/z: 463.60
5-721
      MS, m/z: 481.59
5-722
      MS, m/z: 519.71
5-723
      MS, m/z: 481.59
5-724
      MS, m/z: 477.62
5-725
      MS, m/z: 498.04
5-726
      MS, m/z: 498.04
5-727
      MS, m/z: 477.62
5-728
      MS, m/z: 560.48
5-729
      MS, m/z: 513.66
5-730
      MS, m/z: 599.59
5-731
      MS, m/z: 387.50
5-732
      MS, m/z: 443.61
5-733
      MS, m/z: 427.56
5-734
      MS, m/z: 413.54
5-735
      MS, m/z: 411.52
5-736
      MS, m/z: 497.62
5-737
      MS, m/z: 515.61
5-738
      MS, m/z: 553.72
5-739
      MS, m/z: 515.61
5-740
      MS, m/z: 511.64
5-741
      MS, m/z: 532.06
5-742
      MS, m/z: 532.06
5-743
      MS, m/z: 511.64
5-744
      MS, m/z: 594.50
5-745
      MS, m/z: 547.68
5-746
      MS, m/z: 525.67
5-747
      MS, m/z: 421.52
5-748
      MS, m/z: 477.62
5-749
      MS, m/z: 461.58
5-750
      MS, m/z: 447.55
5-751
      MS, m/z: 445.54
5-752
      MS, m/z: 511.64
5-753
      MS, m/z: 529.63
5-754
      MS, m/z: 567.75
5-755
      MS, m/z: 529.63
5-756
      MS, m/z: 525.67
5-757
      MS, m/z: 546.09
5-758
      MS, m/z: 546.09
5-759
      MS, m/z: 525.67
5-760
      MS, m/z: 608.53
5-761
      MS, m/z: 561.70
5-762
      MS, m/z: 647.64
5-763
      MS, m/z: 435.54
5-764
      MS, m/z: 491.65
5-765
      MS, m/z: 475.61
5-766
      MS, m/z: 461.58
5-767
      MS, m/z: 459.57
5-768
      MS, m/z: 517.69
5-769
      MS, m/z: 535.68
5-770
      MS, m/z: 573.80
5-771
      MS, m/z: 535.68
5-772
      MS, m/z: 531.72
5-773
      MS, m/z: 552.14
5-774
      MS, m/z: 552.14
5-775
      MS, m/z: 531.72
5-776
      MS, m/z: 614.58
5-777
      MS, m/z: 567.75
5-778
      MS, m/z: 653.69
5-779
      MS, m/z: 441.59
5-780
      MS, m/z: 497.70
5-781
      MS, m/z: 481.66
5-782
      MS, m/z: 467.63
5-783
      MS, m/z: 465.61
5-784
      MS, m/z: 417.55
5-785
      MS, m/z: 435.54
5-786
      MS, m/z: 473.66
5-787
      MS, m/z: 435.54
5-788
      MS, m/z: 431.58
5-789
      MS, m/z: 452.00
5-790
      MS, m/z: 452.00
5-791
      MS, m/z: 431.58
5-792
      MS, m/z: 514.44
5-793
      MS, m/z: 467.61
5-794
      MS, m/z: 445.61
5-795
      MS, m/z: 341.45
5-796
      MS, m/z: 397.56
5-797
      MS, m/z: 381.52
5-798
      MS, m/z: 367.49
5-799
      MS, m/z: 365.45
5-800
      MS, m/z: 431.58
5-801
      MS, m/z: 449.57
5-802
      MS, m/z: 487.69
5-803
      MS, m/z: 449.57
5-804
      MS, m/z: 445.61
5-805
      MS, m/z: 466.03
5-806
      MS, m/z: 466.03
5-807
      MS, m/z: 445.61
5-808
      MS, m/z: 528.47
5-809
      MS, m/z: 481.64
5-810
      MS, m/z: 567.58
5-811
      MS, m/z: 355.48
5-812
      MS, m/z: 411.59
5-813
      MS, m/z: 395.55
5-814
      MS, m/z: 381.52
5-815
      MS, m/z: 379.50
5-816
      MS, m/z: 445.61
5-817
      MS, m/z: 463.60
5-818
      MS, m/z: 501.72
5-819
      MS, m/z: 463.60
5-820
      MS, m/z: 459.63
5-821
      MS, m/z: 480.05
5-822
      MS, m/z: 480.05
5-823
      MS, m/z: 459.63
5-824
      MS, m/z: 542.49
5-825
      MS, m/z: 495.67
5-826
      MS, m/z: 581.60
5-827
      MS, m/z: 369.51
5-828
      MS, m/z: 425.62
5-829
      MS, m/z: 409.57
5-830
      MS, m/z: 395.55
5-831
      MS, m/z: 393.53
5-832
      MS, m/z: 459.63
5-833
      MS, m/z: 477.62
5-834
      MS, m/z: 515.74
5-835
      MS, m/z: 477.62
5-836
      MS, m/z: 473.66
5-837
      MS, m/z: 494.08
5-838
      MS, m/z: 494.08
5-839
      MS, m/z: 473.66
5-840
      MS, m/z: 556.52
5-841
      MS, m/z: 509.69
5-842
      MS, m/z: 595.63
5-843
      MS, m/z: 383.54
5-844
      MS, m/z: 439.64
5-845
      MS, m/z: 423.60
5-846
      MS, m/z: 409.57
5-847
      MS, m/z: 407.56
5-848
      MS, m/z: 493.65
5-849
      MS, m/z: 511.64
5-850
      MS, m/z: 549.76
5-851
      MS, m/z: 511.64
5-852
      MS, m/z: 507.68
5-853
      MS, m/z: 528.10
5-854
      MS, m/z: 528.10
5-855
      MS, m/z: 507.68
5-856
      MS, m/z: 590.54
5-857
      MS, m/z: 543.71
5-858
      MS, m/z: 521.71
5-859
      MS, m/z: 417.55
5-860
      MS, m/z: 473.66
5-861
      MS, m/z: 457.62
5-862
      MS, m/z: 443.59
5-863
      MS, m/z: 441.58
5-864
      MS, m/z: 507.68
5-865
      MS, m/z: 525.67
5-866
      MS, m/z: 563.79
5-867
      MS, m/z: 525.67
5-868
      MS, m/z: 521.71
5-869
      MS, m/z: 542.12
5-870
      MS, m/z: 542.12
5-871
      MS, m/z: 521.71
5-872
      MS, m/z: 604.57
5-873
      MS, m/z: 557.74
5-874
      MS, m/z: 643.68
5-875
      MS, m/z: 431.58
5-876
      MS, m/z: 487.69
5-877
      MS, m/z: 471.65
5-878
      MS, m/z: 457.62
5-879
      MS, m/z: 455.60
5-880
      MS, m/z: 513.73
5-881
      MS, m/z: 531.72
5-882
      MS, m/z: 569.84
5-883
      MS, m/z: 531.72
5-884
      MS, m/z: 527.75
5-885
      MS, m/z: 548.17
5-886
      MS, m/z: 548.17
5-887
      MS, m/z: 527.75
5-888
      MS, m/z: 610.61
5-889
      MS, m/z: 563.79
5-890
      MS, m/z: 649.72
5-891
      MS, m/z: 437.63
5-892
      MS, m/z: 493.74
5-893
      MS, m/z: 477.69
5-894
      MS, m/z: 463.67
5-895
      MS, m/z: 461.65
5-896
      MS, m/z: 437.97
5-897
      MS, m/z: 455.96
5-898
      MS, m/z: 494.08
5-899
      MS, m/z: 455.96
5-900
      MS, m/z: 452.00
5-901
      MS, m/z: 472.42
5-902
      MS, m/z: 472.42
5-903
      MS, m/z: 452.00
5-904
      MS, m/z: 543.86
5-905
      MS, m/z: 488.03
5-906
      MS, m/z: 466.03
5-907
      MS, m/z: 361.87
5-908
      MS, m/z: 417.98
5-909
      MS, m/z: 401.94
5-910
      MS, m/z: 387.91
5-911
      MS, m/z: 385.89
5-912
      MS, m/z: 452.00
5-913
      MS, m/z: 469.99
5-914
      MS, m/z: 508.11
5-915
      MS, m/z: 469.99
5-916
      MS, m/z: 466.03
5-917
      MS, m/z: 486.44
5-918
      MS, m/z: 486.44
5-919
      MS, m/z: 466.03
5-920
      MS, m/z: 548.88
5-921
      MS, m/z: 502.06
5-922
      MS, m/z: 587.99
5-923
      MS, m/z: 375.90
5-924
      MS, m/z: 432.01
5-925
      MS, m/z: 415.96
5-926
      MS, m/z: 401.94
5-927
      MS, m/z: 399.92
5-928
      MS, m/z: 466.03
5-929
      MS, m/z: 484.02
5-930
      MS, m/z: 522.13
5-931
      MS, m/z: 484.02
5-932
      MS, m/z: 480.05
5-933
      MS, m/z: 500.47
5-934
      MS, m/z: 500.47
5-935
      MS, m/z: 480.05
5-936
      MS, m/z: 562.91
5-937
      MS, m/z: 516.09
5-938
      MS, m/z: 602.02
5-939
      MS, m/z: 389.93
5-940
      MS, m/z: 446.03
5-941
      MS, m/z: 429.99
5-942
      MS, m/z: 415.96
5-943
      MS, m/z: 413.95
5-944
      MS, m/z: 480.05
5-945
      MS, m/z: 498.04
5-946
      MS, m/z: 536.16
5-947
      MS, m/z: 498.04
5-948
      MS, m/z: 494.08
5-949
      MS, m/z: 514.50
5-950
      MS, m/z: 494.08
5-949
      MS, m/z: 514.50
5-950
      MS, m/z: 514.50
5-951
      MS, m/z: 494.08
5-952
      MS, m/z: 576.94
5-953
      MS, m/z: 530.11
5-954
      MS, m/z: 616.05
5-955
      MS, m/z: 403.95
5-956
      MS, m/z: 460.06
5-957
      MS, m/z: 444.02
5-958
      MS, m/z: 429.99
5-959
      MS, m/z: 427.98
5-960
      MS, m/z: 514.07
5-961
      MS, m/z: 532.06
5-962
      MS, m/z: 570.18
5-963
      MS, m/z: 532.06
5-964
      MS, m/z: 528.10
5-965
      MS, m/z: 548.51
5-966
      MS, m/z: 548.51
5-967
      MS, m/z: 528.10
5-968
      MS, m/z: 610.96
5-969
      MS, m/z: 564.13
5-970
      MS, m/z: 542.12
5-971
      MS, m/z: 437.97
5-972
      MS, m/z: 494.08
5-973
      MS, m/z: 478.04
5-974
      MS, m/z: 464.01
5-975
      MS, m/z: 461.99
5-976
      MS, m/z: 528.10
5-977
      MS, m/z: 546.09
5-978
      MS, m/z: 584.21
5-979
      MS, m/z: 546.09
5-980
      MS, m/z: 542.12
5-981
      MS, m/z: 562.54
5-982
      MS, m/z: 562.54
5-983
      MS, m/z: 542.12
5-984
      MS, m/z: 624.98
5-985
      MS, m/z: 578.16
5-986
      MS, m/z: 664.09
5-987
      MS, m/z: 452.00
5-988
      MS, m/z: 508.11
5-989
      MS, m/z: 492.06
5-990
      MS, m/z: 478.04
5-991
      MS, m/z: 476.02
5-992
      MS, m/z: 534.14
5-993
      MS, m/z: 552.14
5-994
      MS, m/z: 590.25
5-995
      MS, m/z: 552.14
5-996
      MS, m/z: 548.17
5-997
      MS, m/z: 568.59
5-998
      MS, m/z: 568.59
5-999
      MS, m/z: 548.17
5-1000
      MS, m/z: 631.03
5-1001
      MS, m/z: 584.21
5-1002
      MS, m/z: 670.14
5-1003
      MS, m/z: 458.05
5-1004
      MS, m/z: 514.15
5-1005
      MS, m/z: 498.11
5-1006
      MS, m/z: 484.08
5-1007
      MS, m/z: 482.07
5-1008
      MS, m/z: 459.63
5-1009
      MS, m/z: 477.62
5-1010
      MS, m/z: 515.74
5-1011
      MS, m/z: 477.62
5-1012
      MS, m/z: 473.66
5-1013
      MS, m/z: 494.08
5-1014
      MS, m/z: 494.08
5-1015
      MS, m/z: 473.66
5-1016
      MS, m/z: 556.52
5-1017
      MS, m/z: 509.69
5-1018
      MS, m/z: 487.69
5-1019
      MS, m/z: 383.54
5-1020
      MS, m/z: 439.64
5-1021
      MS, m/z: 423.60
5-1022
      MS, m/z: 409.57
5-1023
      MS, m/z: 407.56
5-1024
      1H NMR(500 MHz, CDCl3) δ 7.39˜7.28(m, 9H), 6.67˜6.54(m, 3H), 4.89(d, 1H, J=11.4 Hz), 4.71 (d, 1H, J=11.4 Hz), 4.44(d, 1H, J=7.6 Hz), 4.23(s, 2H), 3.74˜3.66(m, 2H), 3.60(d, 1H, J=7.6 Hz), 1.40(s, 3H), 1.31(s, 9H), 1.22(s, 3H), 1.19(s, 3H); MS, m/z = 431.58; MS, m/z: 473.66
5-1025
      1H NMR(500 MHz, CDCl3) δ 7.37˜7.30(m, 6H), 7.05˜7.01(m, 2H), 6.66˜6.56(m, 3H), 4.86(d, 1H, J=11.4 Hz), 4.67(d, 1H, J=11.4 Hz), 4.43(d, 1H, J=7.6 Hz), 4.23(s, 2H), 3.70˜3.67(m, 2H), 3.58(d, 1H, J=7.6 Hz), 1.39(s, 3H), 1.31˜1.30(m, 9H), 1.21˜1.19(m, 6H); MS, m/z: 491.65
5-1026
      1H NMR(500 MHz, CDCl3) δ 7.39˜7.30(m, 8H), 6.69˜6.57(m, 3H), 4.86(d, 1H, J=11.2 Hz), 4.68(d, 1H, J=11.2 Hz), 4.42(d, 1H, J=7.6 Hz), 4.23(s, 2H), 3.74˜3.65(d, 2H), 3.59(d, 1H, J= 7.6 Hz), 1.41(s, 3H), 1,32˜1.29(m, 18H), 1.21˜1.19(m, 6H); MS, m/z: 529.77
5-1027
      1H NMR(500 MHz, CDCl3) δ 7.38˜7.28(m, 5H), 7.13˜7.07(m, 2H), 7.00(m, 1H), 6.69˜6.56(m, 3H), 4.91(d, 1H, J=11.8 Hz), 4.71 (d, 1H, J=11.8 Hz), 4.46(d, 1H, J=7.7 Hz), 4.23(s, 2H), 3.72˜3.67(m, 2H), 3.59(d, 1H, J=7.7 Hz), 1.42(s, 3H), 1.32(s, 9H), 1.24(s, 3H), 1.21(t, 3H, J=6.95 Hz); MS, m/z: 491.65
5-1028
      1H NMR(500 MHz, CDCl3) δ 7.39˜7.30(m, 5H), 7.21˜7.15(m, 3H), 6.66˜6.54(m, 3H), 4.93(d, 1H, J=11.7 Hz), 4.69(d, 1H, J=11.7 Hz), 4.45(d, 1H, J=7.7 Hz), 4.23(s, 2H), 3.71˜3.64(m, 2H), 3.62(d, 1H, J=7.7 Hz), 2.35(s, 3H), 1.38(s, 3H), 1.31(s, 9H), 1.22(s, 3H), 1.19(t, 3H, t=7.0 Hz); MS, m/z: 487.69
5-1029
      1H NMR(500 MHz, CDCl3) δ 7.54(m, 1H), 7.38˜7.22″(m, 8H), 6.70˜6.57(m, 3H), 5.04(d, 1H, J=12.7 Hz), 4.81(d, 1H, J= 12.7 Hz), 4.48(d, 1H, J=7.6 Hz), 4.24(s, 2H), 3.71(q, 2H, J=7.0 Hz), 3.67(d, 1H, J=7.7 Hz), 1.43(s, 3H), 1.33(s, 9H), 1.26(s, 3H), 1.21(t, 3H, J=7.0 Hz); MS, m/z: 508.11
5-1030
      1H NMR(500 MHz, CDCl3) δ 7.38˜7.24(m, 8H), 6.69˜6.65(m, 2H), 6.58(m, 1H), 4.89(d, 1H, J=11.8 Hz), 4.70(d, 1H, J= 11.8 Hz), 4.46(d, 1H, J=7.8 Hz), 4.24(s, 2H), 3.68(m, 2H), 3.59(d, 1H, J=7.8 Hz), 1.42(s, 3H), 1.31 (s, 9H), 1.24(s, 3H), 1.21 (t, 3H, J=6.95 Hz); MS, m/z: 508.11
5-1031
      MS, m/z = 487.69
5-1032
      1H NMR(500 MHz, CDCl3) δ 7.37˜7.20(m, 7H), 6.70˜6.55(m, 3H), 489(d, 1H, J=11.9 Hz), 4.71 (d, 1H, J=11.9 Hz), 4.42(d, 1H, J=7.7 Hz), 4.23(s, 2H), 3.72˜3.67(m, 2H), 3.59(d, 1H, J= 7.7 Hz)1.40(s, 3H), 1.30(s, 9H), 1.23˜1.19(m, 6H); MS, m/z: 570.55
5-1033
      MS, m/z = 523.72
5-1034
      MS, m/z = 609.66
5-1035
      1H NMR(500 MHz, CDCl3) δ 7.37˜7.30(m, 4H), 6.70˜6.54(m, 3H), 4.33(d, 1H, J=7.5 Hz), 4.23(s, 2H), 3.78˜3.70(m, 2H), 3.60(s, 3H), 3.31 (d, 1H, J=7.5 Hz), 1.41 (s, 3H), 1.31(s, 9H), 1.24(t, 3H, J=7.1 Hz), 1.19(s, 3H); MS, m/z: 398.56
5-1036
      1H NMR(500 MHz, CDCl3) δ 7.36(d, 2H, J=8.3 Hz), 7.31(d, 2H, J=8.3 Hz), 6.70˜6.57(m, 3H), 4.32(d, 1H, J=7.7 Hz), 4.22(s, 3H), 3.82˜3.819m, 1H), 3.76˜3.72(m, 2H), 3.60˜3.58(m, 1H), 3.38(d, 1H, J=7.7 Hz), 1.62˜1.59(m, 1H), 1.40(s, 3H), 1.37˜1.28(m, 13H), 1.23(t, 3H, J=7.0 Hz), 1.19(s, 3H), 0.91(m, 3H); MS, m/z: 453.67
5-1037
      1H NMR(500 MHz, CDCl3) δ 7.36(d, 2H, J=8.3 Hz), 7.31(d, 2H, J=8.3 Hz), 6.68˜6.56(m, 3H), 5.75˜5.61(m, 2H), 4.40˜4.34(m, 1H), 4.30˜4.23(m, 1H), 4.22(s, 2H), 4.13˜4.09(m, 1H), 3.79˜3.70(m, 2H), 3.47(d, 1H, J=7.7 Hz), 1.73˜1.68(m, 3H), 1.40(s, 3H), 1.31(s, 9H), 1.25˜1.20(m, 6H); MS, m/z = 437.63
5-1038
      1H NMR(500 MHz, CDCl3) δ 7.36(d, 2H, J=8.4 Hz), 7.31(d, 2H, J=8.4 Hz), 6.68˜6.56(m, 3H), 6.00˜5.92(m, 1H), 5.32˜5.28(m, 1H), 5.17˜5.16(m, 1H), 4.36(d, 1H, J=7.6 Hz), 4.35˜4.34(m, 1H), 4.23(s, 2H), 4.21˜4.16(m, 1H), 3.77˜3.70(m, 2H), 3.46(d, 1H, J=7.7 Hz), 1.41(s, 3H), 1.31(s, 9H), 1.24˜1.21 (m, 6H); MS, m/z: 423.60
5-1039
      1H NMR(500 MHz, CDCl3) δ 7.34(d, 2H, J=8.3 Hz), 7.30(d, 2H, J=8.3 Hz), 6.66˜6.56(m, 3H), 4.44(s, 2H), 4.44(d, 1H, J= 7.7 Hz), 4.22(s, 2H), 3.72˜3.67(m, 3H), 2.44(t, 1H, J=2.4 Hz), 1.43(s, 3H), 1.30(s, 9H), 1.22˜1.20(m, 6H); MS, m/z: 421.58
5-1040
      MS, m/z: 487.69
5-1041
      MS, m/z: 505.68
5-1042
      MS, m/z: 543.80
5-1043
      MS, m/z: 505.68
5-1044
      MS, m/z: 501.72
5-1045
      MS, m/z: 522.13
5-1046
      MS, m/z: 522.13
5-1047
      MS, m/z: 501.72
5-1048
      MS, m/z: 584.57
5-1049
      MS, m/z: 537.75
5-1050
      MS, m623.69/z:
5-1051
      MS, m/z: 411.59
5-1052
      MS, m/z: 467.70
5-1053
      MS, m/z: 451.66
5-1054
      MS, m/z: 437.63
5-1055
      MS, m/z: 435.61
5-1056
      MS, m/z: 501.72
5-1057
      MS, m/z: 519.71
5-1058
      MS, m/z: 557.82
5-1059
      MS, m/z: 519.71
5-1060
      MS, m/z: 515.74
5-1061
      MS, m/z: 536.16
5-1062
      MS, m/z: 536.16
5-1063
      MS, m/z: 515.74
5-1064
      MS, m/z: 598.60
5-1065
      MS, m/z: 551.78
5-1066
      MS, m/z: 637.71
5-1067
      MS, m/z: 425.62
5-1068
      MS, m/z: 481.73
5-1069
      MS, m/z: 465.68
5-1070
      MS, m/z: 451.66
5-1071
      MS, m/z: 449.64
5-1072
      MS, m/z: 535.73
5-1073
      MS, m/z: 553.72
5-1074
      MS, m/z: 591.84
5-1075
      MS, m/z: 553.72
5-1076
      MS, m/z: 549.76
5-1077
      MS, m/z: 570.18
5-1078
      MS, m/z: 570.18
5-1079
      MS, m/z: 549.76
5-1080
      MS, m/z: 632.62
5-1081
      MS, m/z: 585.79
5-1082
      MS, m/z: 563.79
5-1083
      MS, m/z: 459.63
5-1084
      MS, m/z: 515.74
5-1085
      MS, m/z: 499.70
5-1086
      MS, m/z: 485.67
5-1087
      MS, m/z: 483.66
5-1088
      MS, m/z: 493.65
5-1089
      MS, m/z: 511.64
5-1090
      MS, m/z: 549.76
5-1091
      MS, m/z: 511.64
5-1092
      MS, m/z: 507.68
5-1093
      MS, m/z: 528.10
5-1094
      MS, m/z: 528.10
5-1095
      MS, m/z: 507.68
5-1096
      MS, m/z: 590.54
5-1097
      MS, m/z: 543.71
5-1098
      MS, m/z: 629.65
5-1099
      MS, m/z: 417.55
5-1100
      MS, m/z: 473.66
5-1101
      MS, m/z: 457.62
5-1102
      MS, m/z: 443.59
5-1103
      MS, m/z: 441.58
5-1104
      MS, m/z: 555.81
5-1105
      MS, m/z: 573.80
5-1106
      MS, m/z: 611.92
5-1107
      MS, m/z: 573.80
5-1108
      MS, m/z: 569.84
5-1109
      MS, m/z: 590.25
5-1110
      MS, m/z: 590.25
5-1111
      MS, m/z: 569.84
5-1112
      MS, m/z: 652.69
5-1113
      MS, m/z: 605.87
5-1114
      MS, m/z: 691.80
5-1115
      MS, m/z: 479.71
5-1116
      MS, m/z: 535.82
5-1117
      MS, m/z: 519.77
5-1118
      MS, m/z: 505.75
5-1119
      MS, m/z: 503.73
5-1120

EXAMPLE II

Hydroxy Alkoxy Addition and Departure of N-methyl-substituted Olefin Resin (2a)

(II-1) Hydroxy Methoxy Addition and Departure of N-methylsubstituted Olefin Resin (2a)

N-methyl-substituted olefin resin (200.00 mg, 0.11 mmol) of the formula (2a) was added to the mixed solution of dichloromethane (3 ml) and methanol (3 ml) and agitated for 30 min, after which metachloroperbenzoic acid (m-CPBA, 81 mg, 0.55 mmol) was added at room temperature and agitated to proceed with a reaction for 15 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding the resin of the formula (3-1) as a light yellow solid (208.6 mg). Thus obtained resin (3-1) was added to a solution of dichloromethane (5 ml) and agitated, followed by addition of filtrate was washed repeatedly with CH₂Cl₂ and MeOH. The filtrates were combined and concentrated. To the concentrates, ethylacetate (3 ml) was added, filtered thorough strong anion exchange resin (SAX resin) and washed repeatedly with ethylacetate to remove residual trifluoroacetic acid. Following concentration of the filtrate under reduced pressure, the concentrate was purified with silica gel column chromatography in the presence of hexane/ethylacetate (4/1, v/v), thereby yielding the compound of the formula (5-1121) as a light-yellow oil (16.3 mg, resin 1; from loading capacity 0.55 mmol/g, yield=63%): ¹H NMR(300 MHz, CDCl₃) δ(PPM) 6.69 (d, 1H, J=5.2 Hz), 6.65 (d, 1H, J=1.7 Hz), 6.58 (dd, 1H, J=5.2 Hz, J=1.7 Hz), 4.34 (d, 1H, J=4.4 Hz), 3.84 (d, 1H, J=4.4 Hz), 3.49 (s, 3H), 2.82 (s, 3H), 1.43 (s, 3H), 1.26 (s, 3H); ¹³C (75 MHz) δ 145.49, 143.00, 121.33, 117.84, 115.50, 111.70, 78.16, 71.99, 55.70, 31.90, 25.68, 20.04; M/S 237.30(II-2) Hydroxy Ethoxy Addition and Departure of N-methyl-substituted Olefin Resin (2a)

N-methyl-substituted olefin resin (200.00 mg, 0.11 mmol) of the formula (2a) was added to the mixed solution of dichloromethane (3 ml) and ethanol (3 ml) and agitated for 30 min, after which metachloroperbenzoic acid (m-CPBA, 81 mg, 0.55 mmol) was added at room temperature and agitated to proceed with a reaction for 15 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding the resin of the formula (3-2) as a light yellow solid (207.4 mg). Thus obtained resin (3-2) was added to a solution of dichloromethane (5 ml) and agitated, followed by addition of trifluoroacetic acid (TFA, 1 ml) and agitation for 4 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and the filtrate was washed repeatedly with CH₂Cl₂ and MeOH. The filtrates were combined and concentrated. To the concentrates, ethylacetate (3 ml) was added, filtered thorough strong anion exchange resin (SAX resin) and washed repeatedly with ethylacetate to remove residual trifluoroacetic acid. Following concentration of the filtrate under reduced pressure, the concentrate was purified with silica gel column chromatography in the presence of hexane/ethylacetate (4/1, v/v), giving the compound of the formula (5-1121) as a light-yellow oil (16.7 mg, resin 1; from loading capacity 0.55 mmol/g, yield=60%): ¹H NMR (200 MHz, CDCl₃) δ (PPM) 6.70-6.50 (m, 3H), 4.36 (d, 1H, J=7.4 Hz), 3.82-3.67 (m, 3H), 2.81 (s, 3H), 1.43 (s, 3H), 1.32-1.25 (m, 61); M/S 251.33(II-3) Hydroxy 2-propoxy Addition and Departure of N-methyl-substituted Olefin Resin (2a)

N-methyl-substituted olefin resin (200.00 mg, 0.11 mmol) of the formula (2a) was added to the mixed solution of dichloromethane (3 ml) and 2-propanol (3 ml) and agitated for 30 min, after which metachloroperbenzoic acid (m-CPBA, 81 mg, 0.55 mmol) was added at room temperature and agitated to proceed with a reaction for 15 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding the resin of the formula (3-3) as a light yellow solid (206.8 mg). Thus obtained resin (3-3) was added to a solution of dichloromethane (5 ml) and agitated, followed by addition of trifluoroacetic acid (TFA, 1 ml) and agitation for 4 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and the filtrate was washed repeatedly with CH₂Cl₂ and MeOH. The filtrates were combined and concentrated. To the concentrates, ethylacetate (3 ml) was added, filtered thorough strong anion exchange resin (SAX resin) and washed repeatedly with ethylacetate to remove residual trifluoroacetic acid. Following concentration of the filtrate under reduced pressure, the concentrate was purified with silica gel column chromatography in the presence of hexane/ethylacetate (4/1, v/v), giving the compound of the formula (5-1123) as a light-yellow oil (14.8 mg, resin 1; from loading capacity 0.55 mmol/g, yield=56%): M/S 265.36(II-4) Hydroxy 2-butoxy Addition and Departure of N-methyl-substituted Olefin Resin (2a)

N-methyl-substituted olefin resin (200.00 mg, 0.11 mmol) of the formula (2a) was added to the mixed solution of dichloromethane (3 ml) and butanol (3 ml) and agitated for 30 min, after which metachloroperbenzoic acid (m-CPBA, 81 mg, 0.55 mmol) was added at room temperature and agitated to proceed with a reaction for 15 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding the resin of the formula (3-4) as a light yellow solid (208.3 mg). Thus obtained resin (3-4) was added to a solution of dichloromethane (5 ml) and agitated, followed by addition of trifluoroacetic acid (TFA, 1 ml) and agitation for 4 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and the filtrate was washed repeatedly with CH₂Cl₂ and MeOH. The filtrates were combined and concentrated. To the concentrates, ethylacetate (3 ml) was added, filtered thorough strong anion exchange resin (SAX resin) and washed repeatedly with ethylacetate to remove residual trifluoroacetic acid. Following concentration of the filtrate under reduced pressure, the concentrate was purified with silica gel column chromatography in the presence of hexane/ethylacetate (4/1, v/v), thereby yielding the compound of the formula (5-1124) as a light-yellow oil (19.1 mg, resin 1; from loading capacity 0.55 mmol/g, yield=62%): ¹H NMR (200 MHz, CDCl₃) δ (PPM) 6.70-6.50 (m, 3H), 4.35 (d, 1H, J=7.2 Hz), 3.80 (d, 1H, J=7.2 Hz) 3.67 (t, 2H, J=6.2 Hz), 2.81 (s, 3H), 1.67-1.53 (m, 2H), 1.49-1.30 (m, 2H), 1.42 (s, 3H), 1.25(s, 3H), 0.94 (t, 3H, J=7.2 Hz); M/S 279.38

The 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives synthesized according to the method of parallel synthesis on the solid-phase as Example II are summarized in Table 2.

In construction of the library in Table 2, the following precursors were employed to preparing combinations of each substituent: for example, R¹ precursor includes CH₃I, C₂H₅I, tBuI, 4-BuI, 4-F—C₄H₉I, 4-Me-C₄H₉I, 2-CH₃-C₄H₉I, 3-Cl—C₄H₉I, 4-tBu-C₄H₉I and 3-F—C₄H₉I; R² precursor includes CH₃OH, C₂H₅OH, iPrOH, tBuOH, C₄H₉OH, 2-Ph-EtOH and 2-cyclohexyl-EtOH.

TABLE 2
	(5)
Compound
No.	R1	R2	NMR/MS Data
5-1121
5-1122
5-1123
5-1124
5-1125			M/S 307.44
5-1126			1H NMR(200MHz, CDCl3) δ 6.70˜6.52(m, 3H), 4.34(d, 1H, J=7.0Hz), 3.80(d, 1H, J=7.0Hz), 3.70(t, 2H, J=6.6Hz), 2.81(s, 3H), 1.75˜0.94(m, 19H); M/S 333.47
5-1127			M/S 333.47
5-1128			M/S 279.38
5-1129			M/S 307.44
5-1130			M/S 293.41
5-1131			1H NMR(200MHz, CDCl3) δ 7.44˜7.28(m, 5H), 6.78˜6.69(m, 3H), 4.76(s, 2H), 4.48(d, 1H, J=7.0Hz), 3.85(d, 1H, J=7.0Hz), 2.78(s, 3H), 1.44(s, 3H), 1.27(s, 3H); M/S 313.40
5-1132			M/S 331.39
5-1133			M/S 343.43
5-1134			M/S 327.43
5-1135			M/S 327.43
5-1136			M/S 345.41
5-1137			M/S 369.51
5-1138			M/S 341.45
5-1139			M/S 349.38
5-1140			M/S 358.39
5-1141			M/S 251.33
5-1142			M/S 265.36
5-1143			M/S 279.38
5-1144			M/S 293.40
5-1145			M/S 321.46
5-1146			M/S 347.50
5-1147			M/S 347.50
5-1148			M/S 293.41
5-1149			M/S 321.46
5-1150			M/S 307.44
5-1151			M/S 327.43
5-1152			M/S 345.42
5-1153			M/S 357.45
5-1154			M/S 341.45
5-1155			M/S 341.45
5-1156			M/S 359.44
5-1157			M/S 383.54
5-1158			M/S 355.48
5-1159			M/S 363.41
5-1160			M/S 372.42
5-1161			M/S 265.36
5-1162			M/S 279.38
5-1163			M/S 293.41
5-1164			M/S 307.44
5-1165			M/S 335.49
5-1166			M/S 361.53
5-1167			M/S 361.53
5-1168			M/S 307.44
5-1169			M/S 335.49
5-1170			M/S 321.46
5-1171			M/S 341.45
5-1172			M/S 359.44
5-1173			M/S 371.48
5-1174			M/S 355.48
5-1175			M/S 355.48
5-1176			M/S 373.47
5-1177			M/S 397.56
5-1178			M/S 369.50
5-1179			M/S 377.44
5-1180			M/S 386.45
5-1181			M/S 279.38
5-1182			M/S 293.41
5-1183			M/S 307.44
5-1184			M/S 321.46
5-1185			M/S 349.52
5-1186			M/S 375.56
5-1187			M/S 375.56
5-1188			M/S 321.46
5-1189			M/S 349.52
5-1190			M/S 335.49
5-1191			M/S 335.48
5-1192			M/S 373.47
5-1193			M/S 385.51
5-1194			M/S 369.51
5-1195			M/S 369.51
5-1196			M/S 387.49
5-1197			M/S 411.59
5-1198			M/S 383.54
5-1199			M/S 391.46
5-1200			M/S 400.48
5-1201			M/S 293.41
5-1202			M/S 307.44
5-1203			M/S 321.46
5-1204			M/S 335.49
5-1205			M/S 363.55
5-1206			M/S 389.58
5-1207			M/S 389.58
5-1208			M/S 335.49
5-1209			M/S 363.55
5-1210			M/S 349.52
5-1211			M/S 369.51
5-1212			M/S 387.49
5-1213			M/S 399.53
5-1214			M/S 383.54
5-1215			M/S 383.54
5-1216			M/S 401.53
5-1217			M/S 425.62
5-1218			M/S 397.56
5-1219			M/S 405.49
5-1220			M/S 414.51
5-1221			1H NMR(300MHz, CDCl δ 7.36(m, 4H), 7.28(d, 1H, J=4.3Hz), 6.67(m, 2H), 6.57(dd, 1H, J=5.2Hz J=1.7Hz), 4.31(d, 1H, J=4.5Hz), 4.28(s, 2H), 3.82(d, 1H, J=4.5Hz), 3.82(d, 1H, J=4.4Hz), 3.41 (s, 3H), 1.43(s, 3H), 1.25(s, 3H); M/S 313.40
5-1222			M/S 327.43
5-1223			1H NMR(200MHz, CDCl3) δ 7.40˜7.24(m, 5H), 6.67˜6.50(m, 3H), 4.70(s, 2H), 6.27(d, 1H, J=6.6Hz), 4.01˜3.95(m, 1H), 3.67(d, 1H, J=6.6Hz), 1.40(s, 2H), 1.29˜1.22(m, 10H); M/S 341.45
5-1224			M/S 355.48
5-1225			M/S 383.54
5-1226			1H NMR(300MHz, CDCl3) δ 7.28(m, 5H), 7.00(d, 1H, J=2.5Hz), 6.87(dd, 1H, J=8.7Hz, J=2.5Hz), 6.68(d, 1H, J=8.7Hz), 4.23(d, 1H, J=7.0Hz), 4.23(s, 2H), 3.73(d, 1H, J=7.0Hz), 3.66(td, 2H, J=6.84Hz, J=3.36Hz), 1.72˜1.63(m, 5H), 1.50(td, 2H, J=6.84Hz, J=6.77Hz), 1.41 (s, 3H), 1.25(s, 3H), 1.21˜1.17(m, 4H), 0.92(m, 2H); M/S 409.57
5-1227			M/S 409.57
5-1228			M/S 355.48
5-1229			M/S 383.54
5-1230			M/S 369.51
5-1231			1H NMR(200MHz, CDCl3) δ 7.37˜7.25(m, 10H), 6.65˜6.56(m, 3H), 4.68(s, 2H), 4.48(d, 1H, J=7.4Hz), 4.23(s, 2H), 3.86(d, 1H, J=7.4 Hz), 1.43(s, 3H), 1.25(s, 3H); M/S 389.49
5-1232			M/S 407.49
5-1233			M/S 419.53
5-1234			M/S 403.53
5-1235			M/S 403.53
5-1236			M/S 421.52
5-1237			M/S 445.60
5-1238			M/S 417.55
5-1239			M/S 425.47
5-1240			M/S 434.49
5-1241			M/S 327.42
5-1242			M/S 341.45
5-1243			M/S 355.48
5-1244			M/S 369.50
5-1245			M/S 397.56
5-1246			M/S 423.60
5-1247			M/S 423.60
5-1248			M/S 369.50
5-1249			M/S 397.56
5-1250			M/S 383.53
5-1251			M/S 403.52
5-1252			M/S 421.51
5-1253			M/S 433.55
5-1254			M/S 431.58
5-1255			M/S 417.55
5-1256			M/S 435.54
5-1257			M/S 459.63
5-1258			M/S 431.58
5-1259			M/S 439.50
5-1260			M/S 448.52
5-1261			1H NMR(300MHz, CDCl3) δ 7.26(d, 2H, J=4.8Hz), 7.14(d, 2H, J=4.8Hz), 6.67(d, 1H, J=5.2Hz, J=1.7Hz), 6.65(d, 1H, J=1.7Hz), 6.56(dd, 1H, J=5.2Hz, J=1.7Hz), 4.31(d, 1H, J=4.4Hz), 4.23(s, 2H), 3.82(d, 1H, J=4.4Hz), 3.43(s, 3H), 2.34(s, 3H), 1.43(s, 9H), 1.25(s, 3H); 13C(75 MHz) δ 145.33, 142.20, 136.89, 136.27, 129.25, 127.71, 121.28, 117.81, 115.56,
# 111.94, 78.13, 72.00, 55.62, 49.16 25.74, 21.08, 20.00, M/S 327.42
5-1262			M/S 341.45
5-1263			M/S 355.48
5-1264			M/S 369.50
5-1265			M/S 397.56
5-1266			M/S 423.60
5-1267			M/S 423.60
5-1268			M/S 369.50
5-1269			M/S 397.56
5-1270			M/S 383.53
5-1271			M/S 403.52
5-1272			M/S 421.51
5-1273			M/S 433.55
5-1274			M/S 431.58
5-1275			M/S 417.55
5-1276			M/S 435.54
5-1277			M/S 459.63
5-1278			M/S 431.58
5-1279			M/S 439.50
5-1280			M/S 448.52
5-1281			1H NMR(300MHz, CDCl3) δ 7.37(d, 2H, J=5.0Hz), 7.31(d, 2H, J=5.0Hz), 6.67(d, 1H, J=5.2Hz, J=1.7Hz), 6.65(d, 1H, J=1.7Hz), 6.58(dd, 1H, J=5.2Hz, J=1.7Hz), 4.31(d, 1H, J=4.5Hz), 4.24(s, 2H), 3.82(d, 1H, J=4.5), 3.41 (s, 3H), 1.43(s, 3H), 1.32(s, 9H), 1.25(s, 3H); —C(75 MHz) δ 150.26, 145.39, 142.20, 136.21, 127.56, 125.49, 121.24, 117.83, 115.67, 111.98, 78.10, 71.96, 55.51, 49.13,
# 34.49, 31.35, 25.75, 19.98; M/S 369.50
5-1282			1H NMR(300MHz, CDCl3) δ 7.40(d, 1H, J=4.9 Hz), 7.37(d, 2H, J=4.9Hz), 7.31(d, 2H, J=4.9 Hz), 6.66(d, 1H, J=5.2Hz), 6.65(d, 1H, J=1.5 Hz), 6.57(dd, 1H, J=5.2Hz, J=1.5Hz), 4.33(d, 1H, J=4.5Hz), 4.23(s, 2H), 3.78(d, 1H, J=4.5 Hz), 3.65(qd, 2H, J=4.2Hz, J=1.8Hz), 1.43(s, 3H), 1.31 (s, 3H), 1.24(s, 3H), 1.20(t, 3H, J=4.2 Hz); M/S 383.53
5-1283			M/S 397.56
5-1284			M/S 411.58
5-1285			M/S 439.64
5-1286			M/S 465.68
5-1287			M/S 465.68
5-1288			M/S 411.58
5-1289			M/S 439.64
5-1290			M/S 425.61
5-1291			M/S 445.60
5-1292			M/S 463.59
5-1293			M/S 475.63
5-1294			M/S 473.66
5-1295			M/S 459.63
5-1296			M/S 477.62
5-1297			M/S 501.71
5-1298			M/S 473.66
5-1299			M/S 481.58
5-1300			M/S 490.60
5-1301			1H NMR(300MHz, CDCl3) δ 7.33(m, 2H), 7.01(m, 2H), 6.67(d, 1H, J=5.1Hz), 6.63(d, 1H, J=1.7Hz), 6.55(dd, 1H, J=5.1Hz, J=1.7Hz), 4.30(d, 1H, J=4.5Hz), 4.25(s, 2H), 3.81(d, 1H, J=4.5Hz), 3.42(s, 3H), 1.43(s, 3H), 1.24(s, 3H); M/S 331.39
5-1302			M/S 345.41
5-1303			1H NMR(300MHz, CDCl3) δ 7.34(dd, 2H, J=4.9 Hz, J=3.4Hz), 7.01(t, 2H, J=5.2Hz), 6.65(m, 2H), 6.60(d, 1H, J=5.3Hz), 4.26(d, 1H, J=4.1 Hz), 4.24(s, 2H), 3.97(m, 1H), 3.66(d, 1H, J=4.1Hz), 1.40(s, 3H), 1.28(s, 3H), 1.26(d, 3H, J=3.6Hz), 1.23(d, 3H, J=3.7Hz); M/S 359.44
5-1304			1H NMR(300MHz, CDCl3) δ 7.30˜7.28(m, 2H), 6.98˜6.94(m, 2H), 6.90(s, 1H), 6.81(d, 1H, J=5.4Hz), 6.69(d, 1H, J=5.4Hz), 4.25(d, 1H, J=4.3Hz), 4.23(s, 2H), 3.76(d, 1H, J=4.3Hz), 3.62(t, 2H, J=3.2Hz), 1.58(m, 2H), 1.44˜1.35(m, 5H), 1.26(s, 3H), 0.94(t, 3H, J=4.4Hz); M/S 373.47
5-1305			M/S 401.52
5-1306			1H NMR(300MHz, CDCl3) δ 7.33(ddd, 2H, J=8.6Hz, J=2.1Hz), 7.01(ddd, 2H, J=8.6Hz, J=2.1Hz), 6.66(d, 1H, J=8.7Hz), 6.64(d, 1H, J=2.8Hz), 6.56(dd, 1H, J=8.7Hz, J=2.8), 4.29(d, 1H, J=7.4Hz), 4.24(s, 2H), 3.84(d, 1H, J=7.4Hz), 3.63(t, 2H, J=6.7Hz), 1.71˜1.67(m, 4H), 1.52˜1.18(m, 8H), 1.42(s, 3H), 1.24(s, 3H), 0.92(m, 1H); M/S 427.56
5-1307			M/S 427.56
5-1308			M/S 373.47
5-1309			M/S 401.52
5-1310			M/S 387.49
5-1311			M/S 407.48
5-1312			M/S 425.47
5-1313			M/S 437.51
5-1314			M/S 435.54
5-1315			1H NMR(300MHz, CDCl3) δ 7.39˜7.17(m, 7H), 7.00(t, 2H, J=8.7Hz), 6.62(d, 1H, J=8.7Hz), 6.54(dd, 1H, J=8.7Hz, J=2.7Hz), 6.31(d, 1H, J=2.7Hz), 4.27(d, 1H, J=7.8Hz), 4.15(s, 2H), 3.89˜3.76(m, 2H), 3.65(d, 1H, J=7.8Hz), 2.88(dd, 2H, 6.6??), 1.35(s, 3H), 1.16(s, 3H); M/S 421.51
5-1316			M/S 439.50
5-1317			M/S 463.59
5-1318			M/S 435.54
5-1319			M/S 443.47
5-1320			M/S 452.48
5-1321			1H NMR(300MHz, CDCl3) δ 7.29(m, 1H), 7.15(d, 1H, J=4.6Hz), 7.09(m, 1H), 6.95(ddd, 1H, J=5.0Hz, J=1.5Hz), 6.67(d, 1H, J=5.2Hz), 6.65(d, 1H, J=1.7Hz), 6.57(dd, 1H, J=5.2Hz, J=1.7Hz), 4.30(d, 1H, J=4.5Hz), 4.29(s, 2H), 3.81 (d, 1H, J=4.5Hz), 3.41(s, 3H), 1.43(s, 3H), 1.25(s, 3H); M/S 345.41
5-1322			M/S 331.39
5-1323			1H NMR(300MHz, CDCl3) δ 7.34(dd, 2H, J=4.9, J=3.4Hz), 7.01(t, 2H, J=5.2Hz), 6.65(m, 2H), 6.60(d, 1H, J=5.3Hz), 4.26(d, 1H, J=4.1Hz), 4.24(s, 2H), 3.97(m, 1H), 3.66(d, 1H, J=4.1Hz), 1.40(s, 3H), 1.28(s, 3H), 1.26(d, 3H, J=3.6Hz), 1.23(d, 3H, J=3.7Hz), M/S 359.44
5-1324			M/S 373.47
5-1325			M/S 401.52
5-1326			M/S 427.56
5-1327			M/S 427.56
5-1328			M/S 373.47
5-1329			M/S 401.52
5-1330			M/S 387.49
5-1331			M/S 407.48
5-1332			M/S 425.47
5-1333			M/S 437.51
5-1334			M/S 435.54
5-1335			M/S 421.51
5-1336			M/S 439.50
5-1337			M/S 463.59
5-1338			M/S 435.54
5-1339			M/S 443.47
5-1340			M/S 452.48
5-1341			M/S 341.45
5-1342			M/S 355.48
5-1343			M/S 369.50
5-1344			M/S 383.53
5-1345			M/S 411.58
5-1346			M/S 437.62
5-1347			M/S 437.62
5-1348			M/S 383.53
5-1349			M/S 411.58
5-1350			M/S 397.56
5-1351			M/S 417.55
5-1352			M/S 435.54
5-1353			M/S 447.57
5-1354			M/S 445.60
5-1355			M/S 431.58
5-1356			M/S 449.57
5-1357			M/S 473.66
5-1358			M/S 445.60
5-1359			M/S 453.53
5-1360			M/S 462.55
5-1361			M/S 410.28
5-1362			M/S 424.31
5-1363			M/S 438.34
5-1364			M/S 452.36
5-1365			M/S 480.42
5-1366			M/S 506.46
5-1367			M/S 506.46
5-1368			M/S 452.36
5-1369			M/S 480.42
5-1370			M/S 466.39
5-1371			M/S 486.38
5-1372			M/S 504.37
5-1373			M/S 516.41
5-1374			M/S 514.43
5-1375			M/S 500.41
5-1376			M/S 518.40
5-1377			M/S 542.49
5-1378			M/S 514.43
5-1379			M/S 522.36
5-1380			M/S 531.38
5-1381			M/S 363.46
5-1382			M/S 377.48
5-1383			M/S 391.51
5-1384			M/S 405.54
5-1385			M/S 433.59
5-1386			M/S 459.63
5-1387			M/S 459.63
5-1388			M/S 405.54
5-1389			M/S 433.59
5-1390			M/S 419.56
5-1391			M/S 439.55
5-1392			M/S 457.54
5-1393			M/S 469.58
5-1394			M/S 453.58
5-1395			M/S 453.58
5-1396			M/S 471.57
5-1397			M/S 495.66
5-1398			M/S 467.61
5-1399			M/S 475.54
5-1400			M/S 484.55
5-1401			M/S 327.42
5-1402			M/S 341.45
5-1403			M/S 355.48
5-1404			M/S 369.50
5-1405			M/S 397.56
5-1406			M/S 423.60
5-1407			M/S 423.60
5-1408			M/S 369.50
5-1409			M/S 397.56
5-1410			M/S 383.53
5-1411			M/S 403.52
5-1412			M/S 421.51
5-1413			M/S 433.55
5-1414			M/S 417.55
5-1415			M/S 417.55
5-1416			M/S 435.54
5-1417			M/S 459.63
5-1418			M/S 431.58
5-1419			M/S 439.50
5-1420			M/S 448.52
5-1421			1H NMR(300MHz, CDCl3) δ 7.27(d, 2H, J=8.6Hz), 6.87(d, 2H, J=8.6Hz), 6.67(d, 1H, J=8.7Hz), 6.64(d, 1H, J=2.8Hz), 6.53(dd, 1H, J=8.7Hz, J=2.8Hz), 4.31(d, 1H, J=7.3Hz), 3.81(d, 1H, J=7.3Hz), 3.80(s, 3H), 3.43(s, 3H), 1.43(s, 3H), 1.24(s, 3H); M/S 343.42
5-1422			1H NMR(300MHz, CDCl3) δ 7.29(d, 2H, J=8.6Hz), 6.87(d, 2H, J=8.6Hz), 6.67(d, 1H, J=8.7Hz), 6.64(d, 1H, J=2.8Hz), 6.56(dd, 1H, J=8.7Hz, J=2.8Hz), 4.33(d, 1H, J=8.4Hz), 3.20(d, 1H, J=7.3Hz), 3.80(d, 3H), 3.78(d, 1H, J=8.4Hz), 3.66(m, 2H), 1.43(s, 3H), 1.24(s, 3H), 1.22(s, 3H); M/S 357.45
5-1423			1H NMR(300MHz, CDCl3) δ 7.28(d, 2H, J=8.6Hz), 6.85(d, 2H, J=8.6Hz), 6.65(br, 2H), 6.75(s, 1H), 4.26(d, 1H, J=6.6Hz), 4.19(s, 2H), 3.98(m, 1H), 3.78(s, 3H), 3.66(d, 1H, J=6.6Hz), 1.40˜1.23(m, 12H); M/S 371.48
5-1424			1H NMR(300MHz, CDCl3) δ 7.27(d, 2H, J=8.6Hz), 6.83(d, 2H, J=8.6Hz), 6.70(m, 3H), 4.28(d, 1H, J=7.1Hz), 4.20(s, 2H), 3.77(s, 3H), 3.76(d, 1H, J=7.1Hz), 3.61(t, 2H, J=6.6Hz), 1.58(m, 2H), 1.38(m, 2H), 1.42(s, 3H), 1.25(s, 3H), 0.93(d, 3H, J=7.3Hz); M/S 385.50
5-1425			M/S 413.56
5-1426			1H NMR(300MHz, CDCl3) δ 7.28(d, 2H, J=8.6Hz), 6.83(d, 2H, J=8.6Hz), 6.77(m, 3H), 4.28(d, 1H, J=7.1Hz), 4.19(s, 2H), 3.78(d, 1H, J=7.1Hz), 3.78(s, 3H), 3.66(t, 2H, J=6.7Hz), 1.48(s, 3H), 1.26(s, 3H), 1.72˜0.90(m, 13H); M/S 439.60
5-1427			M/S 439.60
5-1428			M/S 385.50
5-1429			M/S 413.56
5-1430			M/S 399.53
5-1431			1H NMR(300MHz, CDCl3) δ 7.38˜7.24(m, 7H), 6.83(d, 2H, J=8.7Hz), 6.72˜6.64(m, 3H), 4.68(s, 2H), 4.45(d, 1H, J=7.1Hz), 4.15(s, 2H), 3.85(d, 1H, J=7.1Hz), 3.76(s, 2H), 1.43(s, 3H), 1.25(s, 3H); M/S 419.52
5-1432			M/S 437.51
5-1433			M/S 449.55
5-1434			M/S 433.55
5-1435			1H NMR(300 MHZ, CDCl3) δ 7.27(m, 6H), 7.17(t, 1H, J=7.2Hz), 6.88(d, 2H, J=8.7Hz), 6.52(dd, 1H, J=8.7Hz, J=2.8Hz), 6.38(d, 1H, J=2.8Hz), 4.30(d, 1H, J=7.8Hz), 4.12(s, 2H), 3.83(m, 2H), 3.79(s, 3H), 3.67(d, 1H, J=7.8Hz), 2.89(t, 2H, J=6.5Hz), 1.36(s, 3H), 1.17(s, 3H); M/S 433.55
5-1436			M/S 451.54
5-1437			M/S 475.63
5-1438			M/S 447.57
5-1439			M/S 455.50
5-1440			M/S 464.52
5-1441			M/S 381.39
5-1442			M/S 395.42
5-1443			M/S 409.45
5-1444			M/S 423.47
5-1445			M/S 451.53
5-1446			M/S 477.57
5-1447			M/S 477.57
5-1448			M/S 423.47
5-1449			M/S 451.53
5-1450			M/S 437.50
5-1451			M/S 457.49
5-1452			M/S 475.48
5-1453			M/S 487.52
5-1454			M/S 471.52
5-1455			M/S 471.52
5-1456			M/S 489.51
5-1457			M/S 513.60
5-1458			M/S 485.55
5-1459			M/S 493.47
5-1460			M/S 502.49
5-1461			M/S 355.48
5-1462			M/S 369.50
5-1463			M/S 383.53
5-1464			M/S 397.56
5-1465			M/S 425.61
5-1466			M/S 451.65
5-1467			M/S 451.65
5-1468			M/S 397.56
5-1469			M/S 425.61
5-1470			M/S 411.58
5-1471			M/S 431.58
5-1472			M/S 449.57
5-1473			M/S 461.60
5-1474			M/S 445.60
5-1475			M/S 445.60
5-1476			M/S 449.57
5-1477			M/S 487.68
5-1478			M/S 459.63
5-1479			M/S 467.56
5-1480			M/S 476.57

EXAMPLE III

Synthesis of 2,2-dimethyl-3-acetylester-4-methoxy-6-methylamino Benzopyran

(III-1) N-methylation of Olefin Resin (Formula 1)

Carbamate resin having benzopyran structure of the formula (1) (200.00 mg, 0.11 mmol) was added to dimethylsulfoxide (DMSO; 3 ml) and agitated for 10 min at room temperature, followed by adding 1 M lithium t-butoxide solution (LiOtBu)(0.36 ml, 0.36 mmol) and agitating for 20 min at the same temperature. To the mixture, iodomethane (MeI; 0.051 ml, 0.36 mmol) was added and agitated to proceed with a reaction for 15 hr at 35° C. Upon completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding N-4-methyl substituted carbamate resin of the formula (2a) as light brown-colored solid (ATR-FTIR: N-methylation carbamate, 1700 cm⁻¹)(III-2) Addition of Hydroxy Methoxy to N-methyl-substituted Olefin Resin (Formula 2a)

N-methyl-substituted carbamate resin (200 mg, 0.12 mmol) of the formula (2a) was added to the mixed solution of dichloromethane (3 ml) and methanol (3 ml) and agitated for 30 min, after which metachloroperbenzoic acid (m-CPBA, 103 mg, 0.60 mmol) was added at room temperature and agitated to proceed with a reaction for 12 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding the resin of the formula (3a) as a light yellow solid.(111-3) Esterification of N-methyl-substituted Hydroxyl Methoxy Resin (Formula 3a)

2,2-dimethyl-3-hydroxy-4-methoxy-6-methyl amino benzopyran resin (200 mg, 0.12 mmol) linked to a carbamate linker represented by the formula (3a) was added to a solution of dichloromethane (3 ml) and agitated for 10 min at room temperature, followed by adding pyridine (0.136 ml, 1.68 mmol) and agitating for 30 min to proceed a reaction. To the mixture, acetyl chloride (0.119 ml, 1.68 mmol) and 4-dimethylaminopyridine (0.0137 g, 0.112 mmol) were added and allowed reaction for 12 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and washed repeatedly with DMF, MC, MC/MeOH and MeOH, thereby yielding the resin of the formula (4a) as a light brown solid.(III-4) Departure Reaction of N-methyl-substituted Ester Methoxy Resin (Formula 4a)

The resin (200 mg) of the formula (4a) was added to a solution of dichloromethane (4 ml) and agitated, followed by addition of trifluoroacetic acid (TFA, 1 ml) and agitation for 3 hr at room temperature. After completion of the reaction, the reactant mixture was filtered and the filtrate was washed repeatedly with dichloromethane and methyl alcohol. The filtrates were combined and concentrated. To the concentrates, ethylacetate (3 ml) was added, filtered thorough strong anion exchange resin (SAX) and washed repeatedly with ethylacetate to remove residual TFA. Following concentration of the filtrate under reduced pressure, the concentrate was purified with silica gel column chromatography in the presence of hexane/ethylacetate (4/1, v/v), giving the compound of the formula (5-1481) as light-yellow oil (17.42 mg, yield=51.97%; 4 step overall yield from resin 1; loading capacity of resin 1=0.55 mmol/g).

The 2,2-dimethyl-3-ester-4-alkoxy-6-alkyl amino benzopyran derivatives synthesized according to the method of parallel synthesis on the solid-phase as Example III are summarized in Table 3.

In construction of the library in Table 3, the following precursors were employed to preparing combinations of each substituent: for example, R¹ precursor includes MeI, EtI, BnBr, 4-MeO-BnCl, 4-Fe-BnBr and 4-Me-BnBr; R² precursor includes MeOH, EtOH, ⁱPrOH, ⁱBuOH, BnOH, PhEtOH and ^cHexEtOH; R³ precursor includes acetyl chloride, t-butylacetyl chloride, cyclohexanecarbonyl chloride, 3,3-dimethylacryloyl chloride, benzoyl chloride, p-toluyl chloride, 4-anisoyl chloride, 4-fluorobenzoyl chloride, 2-thiopencarbonyl chloride and 2-furoyl chloride.

TABLE 3
Compound No. NMR/MS Data
             1H NMR(200MHz, CDCl3) δ 7.26˜6.56(m, 3H), 5.23(d, 1H, J=5.3Hz), 4.30(d, 1H, J=5.3Hz), 3.45(s, 3H), 2.82(s, 3H), 2.12(s, 3H), 1.35(s, 3H), 1.29(s, 3H); MS, m/z: 279.3
             1H NMR(200MHz, CDCl3) δ 6.74˜6.55(m, 3H), 5.24(d, 1H, (J=6.0Hz), 4.35(d, 1H, J=6.0Hz), 3.41(s, 3H), 2.80(s, 3H), 2.27(s, 2H), 1.36(s, 3H), 1.29(s, 3H), 1.05(s, 9H); MS, m/z: 335.4
             1H NMR(200MHz, CDCl3) δ 6.74(m, 3H), 5.23(d, 1H, J=5.8 Hz), 4.29(d, 1H, J=5.8Hz), 3.44(s, 3H), 2.81(s, 3H), 2.35(m, 1H), 1.93˜1.26(m, 10H), 1.34(s, 3H), 1.29(s, 3H); MS, m/z: 347.4
             1H NMR(200MHz, CDCl3) δ 6.75˜6.58(m, 3H), 5.72(m, 1H), 5.26(d, 1H, J=5.3Hz), 4.31(d, 1H, J=5.3Hz), 3.48(s, 3H), 2.82(s, 3H), 2.18(s, 3H), 1.90(s, 3H), 1.36(s, 3H), 1.30(s, 3H); MS, m/z: 319.4
             1H NMR(200MHz, CDCl3) δ 8.05(d, 1H, J=7.1Hz), 7.58-7.40(m, 3H), 6.79˜6.61(m, 3H), 5.48(d, 1H, J=5.5Hz), 4.46(d, 1H, J=5.5Hz), 3.52(s, 3H), 2.82(s, 3H), 1.41 (s, 3H), 1.39(s, 3H); MS, m/z: 341.4
             1H NMR(200MHz, CDCl3) δ 8.07˜7.78(m, 2H), 7.27˜7.21(m, 2H), 6.87˜6.59(m, 3H), 5.46(d, 1H, J=5.6Hz), 4.44(d, 1H, J=5.6Hz), 3.52(s, 3H), 2.83(s, 3H), 2.41(s, 3H), 1.49-1.13(m, 6H); MS, m/z: 355.4
             MS, m/z: 371.4 MS, m/z:359.4
             1H NMR(200MHz, CDCl3) δ 7.83(m, 1H), 7.58(m, 1H), 7.14(m, 1H), 6.74(d, 1H, J=8.5Hz), 6.63˜6.51(m, 3H), 5.42(d, 1H, J=6.0Hz), 4.50(d, 1H, J=6.0Hz), 3.49(s, 3H), 2.81(s, 3H), 1.40(s, 3H), 1.36(s, 3H); MS, m/z: 347.4
             1H NMR(200MHz, CDCl3) δ 7.60(m, 1H), 7.22(m, 1H), 6.74(d, 1H, J=8.3Hz), 6.62˜6.46(m, 3H), 5.43(d, 1H, J=5.8Hz), 4.47(d, 1H, J=5.8Hz), 3.48(s, 3H), 2.81(s, 3H), 1.40(s, 3H), 1.35(s, 3H); MS, m/z: 331.3
             1H NMR(200MHz, CDCl3) δ 6.73˜6.53(m, 3H), 5.19(d, 1H, J=5.2Hz), 4.33(d, 1H, J=5.2Hz), 3.70(q, 2H, J=7.0Hz), 2.81 (s, 3H), 2.11 (s, 3H), 1.35(s, 3H), 1.29(s, 3H), 1.23(t, 3H, J=6.9Hz); MS, m/z: 293.3
             1H NMR(200MHz, CDCl3) δ 6.73˜6.52(m, 3H), 5.21(d, 1H, J=5.7Hz), 4.38(d, 1H, J=5.7Hz), 3.66(q, 2H, J=6.9Hz), 2.80(s, 3H), 2.26(s, 3H), 1.36(s, 3H), 1.29(s, 3H), 1.21(t, 3H, J=6.9Hz), 1.04(s, 9H); MS, m/z: 349.4
             1H NMR(200MHz, CDCl3) δ 6.73˜6.54(m, 3H), 5.19(d, 1H, J=5.6Hz), 4.33(d, 1H, J=5.6Hz), 3.67(q, 2H, J=6.9Hz), 2.80(s, 3H), 2.36(m, 1H), 1.90˜0.88(m, 10H), 1.34(s, 3H), 1.28(s, 3H), 1.22(t, 3H, J=6.9Hz); MS, m/z: 361.4
             1H NMR(200MHz, CDCl3) δ 6.73˜6.54(m, 3H), 5.71(d, 1H, J=1.4Hz), 5.21(d, 1H, J=5.1Hz), 4.33(d, 1H, J=5.1Hz), 3.72(m, 2H), 2.80(s, 3H), 2.17(s, 3H), 1.89(s, 3H), 1.36(s, 3H), 1.30(s, 3H), 1.28˜1.26(m, 3H); MS, m/z: 333.4
             1H NMR(200MHz, CDCl3) δ 8.07˜8.03(m, 2H), 7.90˜7.40(m, 3H), 6.85˜6.51(m, 3H), 5.44(d, 1H, J=5.2Hz), 4.59(d, 1H, J=5.2Hz), 3.77(m, 2H), 2.81 (s, 3H), 1.41 (s, 3H), 1.39(s, 3H), 1.23(t, 3H, J=6.9Hz); MS, m/z: 355.4
             1H NMR(200MHz, CDCl3) δ 7.93(d, 2H, J=8.1Hz), 7.21(m, 2H), 6.84˜6.51(m, 3H), 5.42(d, 1H, J=5.1Hz), 4.48(d, 1H, J=5.1Hz), 3.77(m, 2H), 2.81(s, 3H), 2.40(s, 3H), 1.40(s, 3H), 1.38(s, 3H), 1.22(t, 3H, J=6.9Hz); MS, m/z: 369.4
             1H NMR(200MHz, CDCl3) δ 7.99(d, 2H, J=9.1Hz), 6.90(d, 2H, J=9.1Hz), 6.74˜6.64(m, 3H), 5.40(d, 1H, J=5.0Hz), 4.42(d, 1H, J=5.0Hz), 3.85(s, 3H), 3.76(m, 2H), 2.82(s, 3H), 1.41(s, 3H), 1.38(s, 3H), 1.23(m, 3H); MS. m/z: 371.4
             1H NMR(200MHz, CDCl3) δ 8.09˜8.02(m, 2H), 7.17˜7.06(m, 2H), 6.78˜6.62(m, 3H), 5.41(d, 1H, J=5.2Hz), 4.46(d, 1H, J=5.2Hz), 3.75(m, 2H), 2.82(s, 3H), 1.41 (s, 3H), 1.38(s, 3H), 1.23(m, 3H); MS, m/z: 373.4
             MS, m/z: 361.4 MS, m/z: 345.4
             1H NMR(200MHz, CDCl3) δ 6.90˜6.79(m, 3H), 5.04(d, 1H, J=4.0Hz), 4.24(d, 1H, J=4.0Hz), 4.06(m, 1H, 2.86(s, 3H), 2.08(s, 3H), 1.50˜1.20(m, 6H); MS, m/z: 307.3
             1H NMR(200MHz, CDCl3) δ 6.75˜6.72(m, 3H), 5.02(d, 1H, J=3.6Hz), 4.21(d, 1H, J=3.6Hz), 4.10(m, 1H), 2.82(s, 3H), 2.22(s, 2H), 1.50˜1.12(m, 15H); MS, m/z: 363.5
             1H NMR(200MHz, CDCl3) δ 6.81˜6.68(m, 3H), 5.04(d, 1H, J=3.9Hz), 4.20(d, 1H, J=3.9Hz), 4.06(m, 1H), 2.81(s, 3H), 2.32(m, 1H), 1.88˜1.19(m, 22H); MS, m/z: 375.5
             MS, m/z: 347.4 MS, m/z: 369.4
             MS, m/z: 383.4
             1H NMR(200MHz, CDCl3) δ 7.97(d, 2H, J=9.0Hz), 6.92˜ 6.70(m, 5H), 5.27(d, 1H, J=4.1Hz), 4.38(1H, J=4.1Hz), 4.11(m, 1H), 4.38(s, 3H), 2.83(s, 3H), 1.42˜1.21(m, 12H); MS, m/z: 399.4
             MS, m/z: 387.4 MS, m/z: 375.4
             1H NMR(200MHz, CDCl3) δ 7.58(m, 1H), 7.17(m, 1H), 6.77˜ 6.62(m, 3H), 6.47(m, 1H), 5.24(d, 1H, J=4.4Hz), 4.39(d, 1H, J=4.4Hz), 4.10(m, 1H), 2.81(s, 3H), 1.41˜1.18(m, 12H); MS, m/z: 359.4
             1H NMR(200MHz, CDCl3) δ 6.75˜6.59(m, 3H), 5.19(d, 1H, J=5.1Hz), 4.30(d, 1H, J=5.1Hz), 3.66(m, 2H), 2.81(s, 3H), 2.10(s, 3H), 1.59(m, 2H), 1.56(m, 2H), 1.35(s, 3H), 1.30(s, 3H), 0.92(t, 3H, J=7.2Hz): MS, m/z: 321.4
             MS, m/z: 377.5 MS, m/z: 389.5
             1H NMR(200MHz, CDCl3) δ 7.16˜6.77(m, 3H), 5.70(m, 1H), 5.21(d, 1H, J=4.7Hz), 4.28(d, 1H, J=4.7Hz), 3.70(m, 2H), 2.88(s, 3H), 2.17(s, 3H), 1.89(s, 3H), 1.58(m, 2H), 1.44(m, 2H), 1.37(s, 3H), 1.32(s, 3H), 0.91(t, 3H, J=7.2Hz); MS, m/z: 361.4
             MS, m/z: 393.4 MS, m/z: 397.5
             1H NMR(200MHz, CDCl3) δ 7.99(d, 2H, J=9.0Hz), 6.90(d, 2H, J=9.0Hz), 6.79˜6.63(m, 3H), 5.40(d, 1H, J=4.9Hz), 4.44(d, 1H, J=4.9Hz), 3.86(s, 3H), 3.68(m, 2H), 2.82(s, 3H), 1.70(m, 2H), 1.50(m, 2H), 1.41(s, 3H), 1.38(s, 3H), 0.95(m, 3H); MS, m/z: 399.4
             MS, m/z; 401.4
             1H NMR(200MHz, CDCl3) δ 7.82(m, 1H), 7.57(m, 1H), 7.11(m, 1H), 6.77˜6.59(m, 3H), 5.37(d, 1H, J=5.7Hz), 4.49(d, 1H, J=5.7Hz), 3.72(t, 2H, J=6.4Hz), 2.82(s, 3H), 1.58(m, 2H), 1.43(m, 2H), 1.41 (s, 3H), 1.37(s, 3H), 0.88(t, 3H, J=7.2Hz); MS, m/z: 389.5
             1H NMR(200MHz, CDCl3) δ 7.60(m, 1H), 7.20(m, 1H), 6.74(d, 1H, J=8.5Hz), 6.64˜6.58(m, 2H), 6.50(m, 1H), 5.39(d, 1H, J=5.4Hz), 4.46(d, 1H, J=5.4Hz), 3.71(t, 2H, J=6.3Hz), 2.82(s, 3H), 1.66˜1.43(m, 4H), 1.40(s, 3H), 1.36(s, 3H), 0.89(t, 3H, J=7.2Hz); MS, m/z: 373.4
             1H NMR(200MHz, CDCl3) δ 7.39˜7.26(m, 5H), 6.92˜6.76(m, 3H), 5.27(d, 1H, J=4.3Hz), 4.75(s, 2H), 4.40(d, 1H, J=4.4Hz), 2.81 (s, 3H), 2.09(s, 3H), 1.40(s, 3H), 1.35(s, 3H); MS, m/z: 355.4
             1H NMR(200MHz, CDCl3) δ 7.38˜7.25(m, 5H), 7.10˜6.80(m, 3H), 5.28(d, 1H, J=4.0Hz), 4.75(s, 2H), 4.38(d, 1H, J=4.0 Hz), 2.84(s, 3H), 2.23(s, 2H), 1.44˜1.20(m, 6H), 1.00(s, 9H); MS, m/z: 411.5
             1H NMR(200MHz, CDCl3) δ 7.40˜7.26(m, 5H), 6.78˜6.73(m, 3H), 5.29(d, 1H, J=4.6Hz), 4.72(s, 2H), 4.39(d, 1H, J=4.6 Hz), 2.79(s, 3H), 2.34(m, 1H), 1.89˜1.25(m, 11H), 1.38(s, 3H), 1.33(s, 3H); MS, m/z: 423.5
             MS, m/z: 395.5 MS, m/z: 417.5
             MS, m/z: 431.5 MS, m/z: 447.5
             1H NMR(200MHz, CDCl3) δ 8.04(m, 2H), 7.41˜7.26(m, 5H), 7.10(m, 2H), 6.77˜6.56(m, 3H), 5.49(d, 1H, J=4.4Hz), 4.80(s, 2H), 4.56(d, 1H, J=4.4Hz), 2.77(s, 3H), 1.45(s, 3H), 1.41(s, 3H); MS, m/z: 435.5
             1H NMR(200MHz, CDCl3) δ 7.83(m, 1H), 7.58(m, 1H), 7.36(m, 5H), 7.27(m, 1H), 6.77˜6.25(m, 3H), 5.46(d, 1H, J=4.4Hz), 4.79(s, 2H), 4.61 (d, 1H, J=4.4Hz), 2.78(s, 3H), 1.44(s, 3H), 1.40(s, 3H); MS, m/z: 423.5
             1H NMR(200MHz, CDCl3) δ 7.60(m, 1H), 7.42˜7.26(m, 5H), 7.18(d, 1H, J=3.5Hz), 6.79˜6.63(m, 3H), 6.51˜6.48(m, 1H), 5.47(d, 1H, J=5.0Hz), 4.78(s, 2H), 4.58(d, 1H, J=4.0Hz), 2.76(s, 3H), 1.44(s, 3H), 1.39(s, 3H); MS, m/z: 407.4
             1H NMR(200MHz, CDCl3) δ 7.30˜7.20(m, 5H), 6.70(d, 1H, J=8.7Hz), 6.56(dd, 1H, J=8.7Hz, J=2.6Hz), 6.39(d, 1H, J=6.7Hz), 2.91 (t, 2H, J=6.7Hz), 2.76(s, 3H), 2.08(s, 3H), 1.27(s, 6H); MS, m/z: 369.4 J = 2.6 Hz), 5.16(d, 1H, J = 5.3 Hz), 4.32(d, 1H, J = 5.3 Hz), 3.89(t, 2H,
             1H NMR(200MHz, CDCl3) δ 7.89˜7.20(m, 5H), 6.72˜6.07(m, 3H), 5.17(d, 1H, J=5.5Hz), 4.36(d, 1H, J=5.5Hz), 3.85(t, 2H, J=6.7Hz), 2.89(t, 2H, J=6.7Hz), 2.75(s, 3H), 2.17(s, 2H), 1.29(s, 3H), 1.27(s, 3H), 1.04(s, 9H); MS, m/z: 425.5
             1H NMR(200MHz, CDCl3) δ 7.29˜7.19(m, 5H), 6.71˜6.37(m, 3H), 5.17(d, 1H, J=5.5Hz), 4.32(d, 1H, J=5.5Hz), 3.86(t, 2H, J=6.7Hz), 2.89(t, 2H, J=6.7Hz), 2.75(s, 3H), 2.33(m, 1H), 1.90˜1.26(m, 17H); MS, m/z: 437.5
             MS, m/z: 409.5 MS, m/z: 431.5
             MS, m/z: 445.5
             1H NMR(200MHz, CDCl3) δ 8.01˜7.96(m, 2H), 7.27˜7.20(m, 5H), 6.93˜6.51 (m, 5H), 5.37(d, 1H, J=5.0Hz), 4.43(d, 1H, J=5.0Hz), 3.96(m, 2H), 3.86(s, 3H), 2.90(m, 2H), 2.77(s, 3H), 1.37˜1.30(m, 6H); MS, m/z: 461.5
             1H NMR(200MHz, CDCl3) δ 8.15˜8.01(m, 2H), 7.28˜7.24(m, 5H), 7.24˜7.02(m, 2H), 6.79˜6.24(m, 3H), 5.37(d, 1H, J=5.1 HZ), 4.45(d, 1H, J=5.1Hz), 3.95(t, 2H, J=6.8Hz), 2.90(t, 2H, J=6.8Hz), 2.75(s, 3H), 1.34(s, 3H), 1.31(s, 3H); MS, m/z: 437.5
             1H NMR(200MHz, CDCl3) δ 7.82(m, 1H). 7.57(m, 1H), 7.27˜ 7.15(m, 5H), 7.09(m, 1H), 6.78˜6.34(m, 3H), 5.35(d, 1H, J=5.9Hz), 4.50(d, 1H, J=5.9Hz), 3.94(t, 2H, J=6.7Hz), 2.90(t, 2H, J=6.7Hz), 2.74(s, 3H), 1.33(s, 6H); MS, m/z: 437.5
             1H NMR(200MHz, CDCl3) δ 7.60(m, 1H), 7.26˜7.18(m, 6H), 6.73˜6.27(m, 4H), 5.36(d, 1H, J=5.7Hz), 4.48(d, 1H, J=5.7 Hz), 3.93(t, 2H, J=6.8Hz), 2.90(t, 2H, J=6.8Hz), 2.74(s, 3H), s, 6H); MS, m/z: 421 .5
             1H NMR(200MHz, CDCl3) δ 7.19˜6.75(m, 3H), 5.14(d, 1H, J=4.5Hz), 4.23(d, 1H, J=4.5Hz), 3.71(m, 2H), 2.86(s, 3H), 2.07(s, 3H), 1.64˜0.86(m, 13H), 1.33(s, 3H), 1.29(s, 3H); MS, m/z 375.5
             MS, m/z: 431.6
             1H NMR(200MHz, CDCl3) δ 7.07˜6.56(m, 3H), 5.15(d, 1H, J=4.9Hz), 4.22(d, 1H, J=4.9Hz), 3.69(m, 2H), 2.86(s, 3H), 2.30(m, 1H), 1.87˜0.86(m, 13H), 1.32(s, 3H), 1.28(s, 3H); MS, m/z: 443.6
             MS, m/z: 415.5 MS, m/z 437.5
             MS, m/z: 451.6 MS, m/z 467.6
             1H NMR(200MHz, CDCl3) δ 8.01(m, 2H), 7.27˜6.84(m, 5H), 5.73(d, 1H, J=4.1Hz), 4.38(d, 1H, J=4.1Hz), 3.75(m, 2H), 2.89(s, 3H), 1.79˜1.12(m, 19H); MS, m/z: 455.5
             MS, m/z: 443.6
             1H NMR(200MHz, CDCl3) δ 7.56(m, 1H), 7.13(m, 1H), 6.70(d, 1H, J=8.1Hz), 6.57˜6.46(m, 3H), 5.36(d, 1H, J=5.5Hz), 4.43(d, 1H, J=5.5Hz), 3.68(m, 2H), 2.78(s, 3H), 1.62˜ 0.86(m, 13H), 1.37(s, 3H), 1.33(s, 3H); MS, m/z: 427.5
             1H NMR(200MHz, CDCl3) δ 6.72˜6.54(m, 3H), 5.22(d, 1H, J=5.5Hz), 4.30(d, 1H, J=5.5Hz), 3.43(s, 3H), 3.10(q, 2H, J=7.1Hz), 2.11(s, 3H), 1.34(s, 3H), 1.28(s, 3H), 1.20(m, 3H); MS, m/z: 293.3
             1H NMR(200MHz, CDCl3) δ 6.76˜6.69(m, 3H), 5.24(d, 1H, J=5.7Hz), 4.33(d, 1H, J=5.9Hz), 3.41(s, 3H), 3.14(q, 2H, J=7.1Hz), 2.26(s, 2H), 1.36(s, 3H), 1.29(s, 3H), 1.24(m, 3H), 1.04(s, 9H); MS, m/z: 349.4
             1H NMR(200MHz, CDCl3) δ 6.74˜6.61(m, 3H), 5.22(d, 1H, J=5.6Hz), 4.28(d, 1H, J=5.6Hz), 3.43(s, 3H), 3.13(q, 2H, J=7.1Hz), 2.36(m, 1H), 2.00˜1.21(br, 10Hz), 1.33(s, 3H), 1.28(s, 3H), 1.24(m, 3H); MS, m/z: 361.4
             1H NMR(200MHz, CDCl3) δ 6.97˜6.74(m, 3H), 5.71(d, 1H, J=1.5Hz), 5.24(d, 1H, J=5.0Hz), 4.26(d, 1H, J=5.0Hz), 3.49(s, 3H), 3.18(q, 2H, J=7.1Hz), 2.18(s, 3H), 1.89(s, 3H), 1.35(s, 3H), 1.31(s, 3H), 1.25(m, 3H); MS, m/z: 333.4
             1H NMR(200MHz, CDCl3) δ 8.08˜8.03(m, 2H), 7.58˜7.53(m, 1H), 7.48˜7.26(m, 2H), 6.82˜6.75(m, 3H0, 5.47(d, 1H, J=5.5 Hz), 4.44(d, 1H, J=5.5Hz), 3.51(s, 3H), 3.15(q, 2H, J=7.2Hz), 1.41 (s, 3H), 1.39(s, 3H), 1.25(t, 3H, J=7.2Hz); MS, m/z: 355.4
             1H NMR(200MHz, CDCl3) δ 7.03(d, 2H, J=7.6Hz), 7.23(d, 2H, J=7.6Hz), 6.82˜6.75(m, 3H), 5.46(d, 1H, J=5.5Hz), 4.43(d, 1H, J=5.5Hz), 3.51(s, 3H), 3.15(q, 2H, J=7.2Hz), 2.41(s, 3H), 40(s, 3H), 1.38(s, 3H), 1.25(t, 3H, J=7.1Hz); MS, m/z: 369.4
             1H NMR(200MHz, CDCl3) δ 8.10˜8.03(m, 2H), 7.25˜7.06(m, 2H), 6.78˜6.64(m, 3H), 5.45(d, 1H, J=5.4Hz), 4.43(d, 1H, J=5.4Hz), 3.50(s, 3H), 3.13(q, 2H, J=7.1Hz), 1.40(s, 3H), 1.37(s, 3H), 1.24(t, 3H, J=7.1Hz); MS, m/z: 373.4
             1H NMR(200MHz, CDCl3) δ 7.85˜7.82(m, 1H), 7.60˜7.57(m, 1H), 7.13˜7.09(m, 1H), 6.73(d, 1H, J=10.5 6.54(m, 2H), 5.42(d, 1H, J=6.2Hz), 4.50(d, 1H, J=6.2Hz), 3.47(s, 3H), 3.12(q, 2H, J=7.1Hz), 1.40(s, 3H), 1.36(s, 3H), 1.24(t, 3H, J=7.0Hz), ; MS, m/z: 361.4
             1H NMR(200MHz, CDCl3) δ 7.60˜7.56(m, 1H), 7.26˜7.17(m, 1H), 6.75˜6.47(m, 4H), 5.43(d, 1H, J=5.9Hz), 4.47(d, 1H, J=5.9Hz), 3.46(s, 3H), 3.07(q, 2H, J=7.2Hz), 1 .39(s, 3H), 1.35(s, 3H). 1.23(t, 3H, J=7.1Hz); MS, m/z: 345.4
             MS, m/z: 307.3
             1H NMR(200MHz, CDCl3) δ 6.72˜6.62(m, 3H), 5.21(d, 1H, J=5.7Hz), 4.37(d, 1H, J=5.7Hz), 3.65(q, 2H, J=7.1Hz), 3.12(q, 2H, J=7.1Hz), 2.26(s, 2H), 1.36(s, 3H), 1.29(s, 3H), 1.21(m, 3H), 1.04(s, 9H); MS, m/z: 307.3
             1H NMR(200MHz, CDCl3) δ 6.69(d, 1H, J=8.5Hz), 6.62˜ 6.55(m, 2H), 5.19(d, 1H, J=5.7Hz), 4.32(d, 1H, J=5.7Hz), 3.65(q, 2H, J=7.1Hz), 3.10(q, 2H, J=7.1Hz), 2.35(m, 1H), 1.74˜1.17(m, 16H), 1.33(s, 3H), 1.28(s, 3H); MS, m/z: 375.5
             MS, m/z 347,4
             1H NMR(200MHz, CDCl3) δ 8.07˜8.03(m, 2H), 7.57˜7.39(m, 3H), 6.78˜6.61(m, 3H), 5.449d, 1H, J=5.4Hz), 4.48(d, 1H, J=5.4Hz), 3.76(q, 2H, J=7.1Hz), 3.13(q, 2H, J=7.1Hz), 1.41(s, 3H), 1.39(s, 3H), 1.28˜1.19(m, 6H); MS, m/z: 369.4
             1H NMR(200MHz, CDCl3) δ 7.93(d, 1H, J=8.1Hz), 7.23(d, 1H, J=8.0Hz), 6.78˜6.68(m, 3H), 5.42(d, 1H, J=5.4Hz), 4.47(d, 1H, J=5.4Hz), 3.76(q, 2H, J=6.9Hz), 3.12(q, 2H, J=7.1Hz), 2.40(s, 3H), 1.40(s, 3H), 1.38(s, 3H), 1.29˜1.18(m, 6H); MS, m/z: 383.4
             1H NMR(200MHz, CDCl3) δ 8.00(d, 2H, J=9.0Hz), 6.90(d, 2H, J=9.0Hz), 6.76˜6.71 (m, 3H), 5.41(d, 1H, J=5.4Hz), 4.46(d, 1H, J=5.4Hz), 3.85(s, 3H), 3.76(q, 2H, J=6.9Hz), 3.14(q, 2H, J=7.1Hz) 1.40(s, 3H), 1.38(s, 3H), 1.29˜1.18(m, 6H); MS, m/z: 399.4
             1H NMR(200MHz, CDCl3) δ 8.09˜8.02(m, 2H), 7.15˜7.069 m, 2H), 6.74(d, 1H, J=8.5Hz), 6.64˜6.58(m, 2H), 5.42(d, 1H, J=5.3Hz), 4.46(d, 1H, J=5.3Hz), 3.71(q, 2H, J=7.1Hz), 3.12(q, 2H, J=7.1Hz), 1.41(s, 3H), 1.37(s, 3H), 1.28˜1.19(m, 6H); MS, m/z: 387.4
             1H NMR(200MHz, CDCl3) δ 7.84˜7.81(m, 1H), 7.60˜7.56(m, 1H), 7.13˜7.08(m, 1H), 6.75˜6.57(m, 3H), 5.37(d, 1H, J=5.9 Hz), 4.51(d, 1H, J=5.9Hz), 3.74(q, 2H, J=6.9Hz), 3.12(q, 2H, J=7.1Hz), 1.40(s, 3H), 1.36(s, 3H), 1.28˜1.15(m, 6H); MS, m/z: 375.4
             1H NMR(200MHz, CDCl3) δ 7.60(m, 1H0, 7.20˜7.18(m, 1H), 6.72(d, 1H, J=8.5Hz), 6.66˜6.49(m, 2H), 5.39(d, 1H, J=5.7 Hz), 4.49(d, 1H, J=5.7Hz), 3.72(q, 2H, J=6.9Hz), 3.12(q, 2H, J=7.1Hz), 1.40(s, 3H), 1.35(s, 3H), 1.28˜1.18(m, 6H); MS, m/z: 359.4
             MS, m/z: 321.4 MS, m/z: 377.5
             MS, m/z: 389.5 MS, m/z: 361.4
             MS, m/z: 383.4 MS, m/z: 397.5
             MS, m/z: 413.5 MS, m/z: 401.3
             MS, m/z: 389.5 MS, m/z: 373.4
             1H NMR(200MHz, CDCl3) δ 6.69(d, 1H, J=8.3Hz), 6.57˜ 6.52(m, 2H), 5.19(d, 1H, J=5.1Hz), 4.30(d, 1H, J=5.1Hz), 3.64(m, 2H), 3.11(q, 2H, J=7.1Hz), 2.10(s, 3H), 1.55(m, 2H), 1.42(m, 2H), 1.35(s, 3H), 1.29(s, 3H); MS, m/z: 335.4
             MS, m/z: 391.5 MS, m/z: 403.5
             1H NMR(200MHz, CDCl3) δ 6.72˜6.52(m, 3H), 5.71(d, 1H, J=1.2Hz), 5.21(d, 1H, J=5.2Hz), 3.68(m, 2H), 2.17(s, 3H), 1.89(s, 3H), 1.54(m, 2H), 1.42(m, 2H), 1.35(s, 3H), 1.30(s, 3H), 1.24(t, 3H, J=7.1Hz), 0.91(t, 3H, J=7.2Hz); MS, m/z: 375.5
             1H NMR(200MHz, CDCl3) δ 8.07˜8.02(m, 2H), 7.57˜7.26(m, 3H), 6.77˜6.59(m, 3H), 5.43(d, 1H, J=5.3Hz), 4.45(d, 1H, J=5.3Hz), 3.72(m, 2H), 3.10(m, 2H), 1.54(m, 2H), 1.45(m, 2H), 1.41 (s, 3H), 1.39(s, 3H), 1.24(m, 3H), 0.88(t, 3H, J=7.2 Hz); MS, m/z: 397.5
             1H NMR(200MHz, CDCl3) δ 7.93(d, 2H, J=8.6Hz), 7.25˜ 7.20(m, 2H), 6.74(d, 1H, J=8.5Hz), 6.65˜6.63(m, 2H), 5.42(d, 1H, J=5.3Hz), 4.44(d, 1H, J=5.3Hz), 3.72(q, 2H, J=7.1Hz), 2.40(s, 3H), 1.55(m, 2H), 1.43˜1.28(m, 2H), 1.40(s, 3H), 1.37(s, 3H), 1.24(t, 3H, J=7.1Hz), 0.88(t, 3H, J=7.2Hz); MS, m/z: 411.5
             1H NMR(200MHz, CDCl3) δ 7.99(d, 2H, J=8.2Hz), 6.90(d, 2H, J=8.2Hz), 5.40(d, 1H, J=4.5Hz), 4.42(d, 1H, J=4.5Hz), 3.85(s, 3H-), 3.71(m, 2H), 3.11(m, 2H), 1.57˜1.35(m, 4H), 1.40(s, 3H), 1.37(s, 3H), 1.24(m, 3H), 0.88(t, 3H, J=7.1Hz); MS, m/z: 413.5
             MS, m/z: 415.5
             1H NMR(200MHz, CDCl3) δ 7.84˜7.81(m, 1H), 7.59˜7.56(m, 1H), 7.13˜7.08(m, 1H), 6.72(d, 1H, J=8.5Hz), 6.64˜6.54(m, 2H), 5.37(d, 1H, J=6.0Hz), 4.48(d, 1H, J=6.0Hz), 3.70(t, 2H, J=6.4Hz), 3.11(q, 2H, J=7.1Hz), 1.61˜1.46(m, 2H), 1.43˜ 1.32(m, 2H), 1.40(s, 3H), 1.36(s, 3H), 1.24(t, 3H, J=7.1Hz), 0.88(t, 3H, J=7.1Hz); MS, m/z: 403.5
             1H NMR(200MHz, CDCl3) δ 7.59(m, 1H), 7.20˜7.18(m, 2H), 6.72(d, 1H, J=8.5Hz), 6.62˜6.49(m, 3H), 5.39(d, 1H, J=5.6 Hz), 4.45(d, 1H, J=5.6Hz), 3.69(t, 2H, J=6.9Hz), 3.10(q, 2H, J=7.2Hz), 1.55(m,.2H), 1.51˜1.35(m, 2H), 1.39(s, 3H), 1.35(s, 3H), 1.24(t, 3H, J=7.1Hz), 0.88(t, 3H, J=7.2Hz); MS, m/z: 387.4
             1H NMR(200MHz, CDCl3) δ 7.42˜7.24(m, 5H), 6.73˜6.47(m, 3H), 5.27(d, 1H, J=4.7Hz), 4.72(s, 2H), 4.42(d, 1H, J=4.7 Hz), 3.05(q, 2H, J=7.1Hz), 2.10(s, 3H), 1.39(s, 3H), 1.33(s, 3H), 1.22(t, 3H, J=7.1Hz); MS, m/z: 369.4
             1H NMR(200MHz, CDCl3) δ 7.42˜7.28(m, 5H), 6.70(d, 1H, J=8.5Hz), 6.57˜6.43(m, 2H), 5.29(d, 1H, J=5.0Hz), 4.70(s, 2H), 4.44(d, 1H, J=5.0Hz), 3.04(q, 2H, J=7.1Hz), 2.25(s, 2H), 1.40(s, 3H), 1.33(s, 3H), 1.21(t ,3H, J=7.1Hz), 1.02(s, 9H); MS, m/z: 425.5
             1H NMR(200MHz, CDCl3) δ 7.41˜7.26(m, 5H), 6.70(d, 1H, J=8.5Hz), 6.57˜6.47(m, 2H), 5.29(d, 1H, J=5.1Hz), 4.70(s, 2H), 4.41(d, 1H, J=5.1Hz), 3.05(q, 2H, J=7.1Hz), 2.35(m, 1H), 2.00˜1.18(m, 10H), 1.38(s, 3H), 1.32(s, 3H), 1.21(m, 3H); MS, m/z: 437.5
             MS, m/z: 409.5 MS, m/z: 431.5
             MS, m/zL 445.5
             1H NMR(200MHz, CDCl3) δ 8.01(d, 2H, J=8.9Hz), 7.40˜ 7.27(m,SH), 6.90(d, 2H, J=8.9Hz), 6.75(d, 1H, J=8.6Hz), 6.64˜6.28(m, 2H), 5.49(d, 1H, J=4.9Hz), 4.79(s, 2H), 4.56(d, 1H, J=4.9Hz), 3.85(s, 3H), 3.05(q, 2H, J=7.0Hz), 1.44(s, 3H), 1.40(s, 3H), 1.21(m, 3H); MS, m/z: 461.5
             MS, m/z: 449.5
             1H NMR(200MHz, CDCl3) δ 7.84˜7.82(m, 1H), 7.60(m, 1H), 7.40˜7.26(m, 5H), 6.73(d ,1H, J=8.3Hz), 6.59˜6.51(m, 2H), 5.47(d, 1H, J=5.3Hz), 4.77(s, 2H), 4.62(d, 1H, J=5.3Hz), 3.03(q, 2H, J=7.1Hz), 1.44(s, 3H), 1.39(s, 3H), 1.21(t, 3H, J=7.1Hz); MS, m/z: 437.5
             1H NMR(200MHz, CDCl3) δ 7.60˜7.59(m, 1H), 7.41˜7.18(m, 6H), 6.73(d, 1H, J=8.5Hz), 6.59˜6.45(m, 3H), 5.47(d, 1H, J=5.1Hz), 4.77(s, 2H), 4.58(d, 1H, J=5.0Hz), 3.10˜3.02(m, 2H), 1.43(s, 3H), 1.39(s, 3H), 1.21(m, 3H); MS, m/z: 421.5
             MS, m/z: 383.4 MS, m/z: 439.6
             MS, m/z: 451.6 MS, m/z: 423.5
             MS, m/z: 445.4 MS, m/z: 459.5
             MS, m/z: 475.5 MS, m/z: 463.5
             MS, m/z: 451.5 MS, m/z: 435.5
             MS, m/z: 389.5 MS, m/z: 445.6
             MS, m/z: 457.6 MS, m/z: 429.6
             MS, m/z: 451.6 MS, m/z: 465.6
             MS, m/z: 481.6 MS, m/z: 469.6
             MS, m/z: 457.6 MS, m/z: 441.5
             1H NMR(200MHz, CDCl3) δ 7.25˜7.37(m, 5H), 6.59˜ 6.70(m, 3H), 5.18(d, 1H, J=5.09Hz), 4.28(d, 1H, J=5.09 Hz), 4.27(s, 2H), 3.56˜3.60(m, 2H), 2.10(s, 3H), 2.03˜ 2.09(m, 1H), 1.38˜1.50(m, 2H), 1.35(s, 3H), 1.29(s, 3H), 1.26˜1.35(m, 2H), 0.91(t, 3H, J=7.12Hz) MS, m/z: 355.4
             MS, m/z: 411.5
             1H NMR(200MHz, CDCl3) δ 7.23˜7.40(m, 5H), 6.54˜ 6.71(m, 3H), 5.18(d, 1H, J=5.49Hz), 4.28(d, 1H, J=5.49 Hz), 4.27(s, 2H), 3.52˜3.61(m, 2H), 2.29˜2.34(m, 1H), 1.30˜1.89(m, 14H), 1.33(s, 3H), 1.27(s, 3H), 0.90(t, 3H, J=7.12Hz); MS, m/z: 423.5
             MS, m/z: 395.5 MS, m/z: 417.5
             MS, m/z: 431.5 MS, m/z: 447.5
             MS, m/z: 435.5 MS, m/z: 423.5
             MS, m/z: 407.4 MS, m/z: 369.4
             MS, m/z: 425.5 MS, m/z: 437.5
             MS, m/z: 409.5 MS, m/z: 431.5
             MS, m/z: 445.5 MS, m/z: 461.5
             MS, m/z: 449.5 MS, m/z: 437.5
             MS, m/z: 421.5 MS, m/z: 383.4
             MS, m/z: 439.6 MS, m/z: 451.6
             MS, m/z: 423.5 MS, m/z: 445.5
             MS, m/z: 495.5 MS, m/z: 475.5
             MS, m/z: 463.5 MS, m/z: 451.5
             MS, m/z: 435.5 MS, m/z: 397.5
             MS, m/z: 453.6 MS, m/z: 465.5
             MS, m/z: 427.5 MS, m/z: 459.5
             MS, m/z: 473.6 MS, m/z: 489.6
             MS, m/z: 477.5 MS, m/z: 465.6
             MS, m/z: 449.5 MS, m/z: 431.5
             MS, m/z: 487.6 MS, m/z: 499.6
             MS, m/z: 471.6 MS, m/z: 493.6
             MS, m/z: 507.6 MS, m/z: 523.6
             MS, m/z: 511.6 MS, m/z: 499.6
             MS, m/z: 483.5 MS, m/z: 445.5
             MS, m/z: 501.6 MS, m/z: 513.68
             MS, m/z: 485.6 MS, m/z: 507.6
             MS, m/z: 521.6 MS, m/z: 537.6
             MS, m/z: 525.6 MS, m/z: 513.6
             MS, m/z: 497.6 MS, m/z: 451.6
             MS, m/z: 507.7 MS, m/z: 519.7
             MS, m/z: 491.6 MS, m/z: 513.6
             MS, m/z: 527.7 MS, m/z: 543.7
             MS, m/z: 531.6 MS, m/z: 519.7
             MS, m/z: 503.6
             1H NMR(200MHz, CDCl3) δ 7.28(d, 2H, J=8.5Hz), 6.86(d, 2H, J=8.5Hz), 6.72˜6.55(m, 3H), 5.22(d, 1H, J=5.7Hz), 4.29(d, 1H, J=5.7Hz), 4.19(s, 2H), 3.79(s, 3H), 3.40(s, 3H), 2.11(s, 3H), 1.34(s, 3H), 1.28(s, 3H); MS, m/z: 385.4
             1H NMR(200MHz, CDCl3) δ 7.27(m, 2H), 6.87(d, 2H, J=8.7Hz), 6.70(d, 1H, J=8.5Hz), 6.62˜6.50(m, 2H), 5.24(d, 1H, J=6.0Hz), 4.34(d, 1H, J=6.0Hz), 4.20(s, 2H), 3.80(s, 3H), 3.37(s, 3H), 2.27(s, 3H), 1.36(s, 3H), 1.29(s, 3H), 1.05(s, 9H); MS, m/z: 441.5
             1H NMR(200MHz, CDCl3) δ 7.28(d, 2H, J=9.0Hz), 6.86(d, 2H, J=9.0Hz), 6.84˜6.60(m, 3H), 5.22(d, 1H, J=5.7Hz), 4.30(d, 1H, J=5.7Hz), 4.19(s, 3H), 3.79(s, 3H), 3.38(s, 1.28(s, 3H); MS, m/z: 453.5
             1H NMR(200MHz, CDCl3) δ 7.28(d, 2H, J=9.0Hz), 6.86(d, 2H, J=9.0Hz), 6.72˜6.56(m, 3H), 5.71 (d, 1H, J=1.2Hz), 5.25(d, 1H, J=5.3Hz), 4.29(d, 1H, J=5.3Hz), 4.19(s, 2H), 3.79(s, 3H), 3.44(s, 3H), 2.18(s, 3H), 1.89(s, 3H), 1.35(s, 3H), 1.29(s, 3H); MS, m/z: 425.5
             1H NMR(200MHz, CDCl3) δ 8.05(d, 2H, J=8.3Hz), 7.61˜ 7.19(m, 5H), 6.89˜6.57(m, 5H), 5.48(d, 1H, J=5.7Hz), 4.45(d, H, J=5.7Hz), 4.20(s, 2H), 3.79(s, 3H), 3.47(s, 3H), 1.41(s, 3H), 1.38(s, 3H); MS, m/z: 447.5
             1H NMR(200MHz, CDCl3) δ 7.94(d, 2H, J=8.3Hz), 7.31˜ 7.21(m, 4H), 6.89˜6.62(m, 5H), 5.46(d, 1H, J=5.6Hz), 4.44(d, 1H, J=5.6Hz), 4.20(s, 2H), 3.80(s, 3H), 3.47(s, 3H), 2.41(s, 3H), 1.40(s, 3H), 1.38(s, 3H); MS, m/z: 461.5
             1H NMR(200MHz, CDCl3) δ 7.99(d, 2H, J=9.0Hz), 6.94˜ 6.64(m, 5H), 5.43(d, 1H, J=5.5Hz), 4.41 (d, 1H, J=5.5Hz), 4.19(s, 2H), 3.86(s, 3H), 3.78(s, 3H), 3.47(s, 3H), 1.39(s, 3H), 1.37(s, 3H); MS, m/z: 477.5
             1H NMR(200MHz, CDCl3) δ 8.10˜8.03(m, 2H), 7.31 7.25(m, 2H), 7.15˜7.07(m, 2H), 6.87(d, 2H, J=8.8Hz), 6.75(d, 1H, 8.5Hz), 5.45(d, 1H, J=5.4Hz), 4.44(d, 1H, J=5.4Hz), 4.20(s, 2H), 3.80(s, 3H), 3.46(s, 3H), 1.41(s, 3H), 1.38(s, 3H); MS, m/z: 465.5
             MS, m/z: 453.5 MS, m/z: 437.5
             1H NMR(200MHz, CDCl3) δ 7.31˜7.25(m, 2H), 6.91˜ 6.85(m, 2H), 6.72˜6.59(m, 3H), 5.18(d, 1H, J=5.4Hz), 4.31(d, 1H, J=5.4Hz), 4.20(s, 2H), 3.80(s, 3H), 3.70˜ 3.59(m, 2H), 2.10(s, 3H), 1.35(s, 3H), 1.29(s, 3H), 1.18(t, 3H, J=7.1Hz); MS, m/z: 399.4
             1H NMR(200MHz, CDCl3) δ 7.28(d, 2H, J=8.6Hz), 6.87(d, 2H, J 32  8.6Hz), 6.72˜6.58(m, 3H), 5.20(d, 1H, J=5.8Hz), 4.36(d, 1H, J=5.8Hz), 4.20(s, 2H), 3.80(s, 3H), 3.60(q, 2H, J=6.9Hz), 2.26(s, 2H), 1.36(s, 3H), 1.29(s, 3H), 1.17(t, 3H, J=6.9Hz), 1.04(s, 9H); MS, m/z: 455.6
             1H NMR(200MHz, CDCl3) δ 7.29(d, 2H, J=8.4Hz), 6.87(d, 2H, J=8.5Hz), 6.72˜6.55(m, 3H), 5.19(d, 1H, J=5.7Hz), 4.32(d, 1H, J=5.7Hz), 4.20(s, 2H), 3.80(s, 3H), 3.62(q, 2H, J=6.9Hz), 2.35(m, 1H), 1.90˜1.22(m, 13H), 1.34(s, 3H), 1.28(s, 3H), 1.17(t, 3H, J=6.9Hz); MS, m/z: 467.6
             1H NMR(200MHz, CDCl3) δ 7.29(d, 2H, J=8.5Hz), 6.87(d, 2H, J=8.5Hz), 6.72˜6.54(m, 3H), 5.72(d, 1H, J=1.2Hz), 5.21(d, 1H, J=5.2Hz), 4.32(d, 1H, J=5.2Hz), 4.19(s, 2H), 3.80(s, 3H), 3.67(m, 2H), 2.17(s, 3H), 1.89(s, 3H), 1.36(s, 3H), 1.30(s, 3H), 1.18(m, 3H): MS, m/z: 439.5
             1H NMR(200MHz, CDCl3) δ 8.08˜8.03(m, 2H), 7.58˜ 7.26(m, 5H), 6.87(d, 2H, J=8.5Hz), 6.74(d, 2H, J=8.5Hz), 6.64˜6.57(m, 3H), 5.43(d, 1H, J=5.4Hz), 4.47(d, 1H, J=5.4Hz), 4.20(s, 2H), 3.80(s, 3H), 3.77˜3.67(m, 2H), 1.41(s, 3H), 1.38(s, 3H), 1.18(t, 3H, J=6.9Hz); MS, m/z:461.5
             MS, m/z: 475.5
             1H NMR(200MHz, CDCl3) δ 7.99(d, 2H, J=9.0Hz), 7.29(d, 2H, J=9.0Hz), 6.93˜6.80(m, 4H), 6.77˜6.49(m, 3H), 5.49(d, 1H, J=5.2Hz), 4.45(d, 1H, J=5.2Hz), 4.20(s, 2H), 3.85(s, 3H), 3.79(s, 3H), 3.76(m, 2H), 1.40(s, 3H), 1.37(s, 3H), 1.18(t, 3H, J=7.0Hz); MS, m/z: 491.5
             MS, m/z: 479.5 MS, m/z: 467.5
             MS, m/z: 451.5 MS, m/z: 413.5
             MS, m/z: 469.6 MS, m/z: 481.6
             MS, m/z: 453.5 MS, m/z: 475.5
             MS, m/z: 489.6 MS, m/z: 505.6
             MS, m/z: 493.5 MS, m/z: 481.6
             MS, m/z: 465.5
             1H NMR(200MHz, CDCl3) δ 7.39(d, 2H, J=8.7Hz), 6.88(d, 2H, J=8.7Hz0, 6.83˜6.55(m, 3H), 5.18(d, 1H, J=5.2Hz), 4.28(d, 1H, J=5.2Hz), 4.19(s, 2H), 3.80(s, 3H), 3.75˜ 1.38(m, 2H), 1.35(s, 3H), 1.29(s, 3H), 0.91 (t, 3H); MS, m/z: 427.5
             1H NMR(200MHz, CDCl3) δ 7.28(d, 2H, J=9.0Hz), 6.86(d, 2H, J=8.6Hz), 6.72˜6.60(m, 3H), 5.19(d, 1H, J=5.4Hz), 2H, J=6.3Hz), 2.25(s, 3H), 1.53˜1.42(m, 4H), 1.36(s, 3H), 1.29(s, 3H), 1.04(s, 9H), 0.93(m, 3H); MS, m/z: 483.6
             1H NMR(200MHz, CDCl3) δ 7.29(d, 2H, J=8.7Hz), 6.87(d, 2H, J=8.7Hz), 6.72˜6.60(m, 3H), 5.18(d, 1H, J=5.5Hz), 4.28(d, 1H, J=5.5Hz), 4.19(s, 2H), 3.79(s, 3H), 3.58˜ 3.57(m, 2H), 2.30(m, 1H), 2.0˜1.20(m, 14H), 1.33(s, 3H), 1.28(s, 3H), 0.90(t, 3H, J=7.2Hz); MS, m/z: 495.6
             1H NMR(200MHz, CDCl3) δ 7.28(d, 2H, J=8.7Hz), 6.86(d, 2H, J=8.7Hz), 6.72˜6.60(m, 3H), 5.70(d, 1H, J=1.2Hz), 5.20(d, 1H, J=5.0Hz), 4.28(d, 1H, J=5.0Hz), 4.19(s, 2H), 3.79(s, 3H), 3.68˜3.55(m, 2H), 2.17(s, 3H), 1.89(s, 3H), 1.62˜1.45(m, 2H), 1.42˜1.26(m, 2H), 1.35(s, 3H), 1.29(s, 3H), 0.90(t, 3H, J=7.2Hz); MS, m/z: 467.6
             1H NMR(200MHz, CDCl3) δ 8.04(d, 2H, J=8.7Hz), 7.57˜ 7.25(m, 6H), 6.88˜6.61(m, 5H), 5.43(d, 1H, J=5.2Hz), 4.43(d, 1H, J=5.2Hz), 4.20(s, 2H), 3.79(s, 3H), 3.72˜ 3.65(m, 2H), 1.54˜1.26(m, 4H), 1.41(s, 3H), 1.39(s, 3H), 0.87(t, 3H, J=7.2Hz); MS, m/z: 489.6
             MS, m/z: 503.6 MS, m/z: 519.6
             1H NMR(200MHz, CDCl3) δ 8.08˜8.01 (m, 2H), 7.30˜ 7.14(m, 2H), 7.10˜7.05(m, 2H), 6.87˜6.73(m, 5H), 5.39(d, 1H, J=5.1Hz), 4.40(d, 1H, J=5.1Hz), 4.19(s, 2H), 3.78(s, 3H), 3.66(m, 2H), 1.57˜1.25(m, 4H), 1.40(s, 3H), 1.37(s, 3H), 0.87(t, 3H, J=7.2Hz); MS, m/z: 507.6
             1H NMR(200MHz, CDCl3) δ 7.38˜7.23(m, 7H), 6.88˜ 6.53(m, 5H), 5.28(d, 1H, J=4.7Hz), 4.69(s, 2H), 4.41(d, 1H, J=4.7Hz), 4.13(s, 2H), 3.79(s, 3H), 2.10(s, 3H), 1.39(s, 3H), 1.33(s, 3H); MS, m/z: 461.5
             1H NMR(200MHz, CDCl3) δ 7.38˜7.23(m, 7H), 6.85(d, 2H, J=8.5Hz), 6.79˜6.56(m, 3H), 5.29(d, 1H, J=4.9Hz), 4.67(s, 2H), 4.41(d, 1H, J=4.9Hz), 4.12(s, 2H), 3.78(s, 3H), 2.25(s, 2H), 1.40(s, 3H), 1.33(s, 3H), 1.02(s, 9H); MS, m/z: 517.6
             1H NMR(200MHz, CDCl3) δ 7.38˜7.18(m, 7H), 6.85(d, 2H, J=8.5Hz), 6.79˜6.58(m, 3H), 5.29(d, 1H, J=4.9Hz), 4.66(s, 2H), 4.40(d, 1H, J=4.9Hz), 4.13(s, 2H), 3.78(s, 3H), 2.34(m, 1H), 2.00˜1.20(m, 10H), 1.37(s, 3H), 1.32(s, 3H); MS, m/z: 529.6
             1H NMR(200MHz, CDCl3) δ 7.38˜7.18(m, 7H), 6.88˜ 6.52(m, 5H), 5.71(d, 1H, J=1.4Hz), 5.32(d, 1H, J=4.6Hz), 4.72(s, 2H), 4.42(d, 1H, J=4.6Hz), 4.12(s, 2H), 3.17(s, 3H), 2.19(s, 3H), 1.89(s, 3H), 1.40(s, 3H), 1.33(s, 3H); MS, m/z: 501.6
             1H NMR(200MHz, CDCl3) δ 8.08˜7.98(m, 2H), 7.58˜ 7.19(m, 10H), 6.87˜6.58(m, 5H), 5.52(d, 1H, J=4.7Hz), 4.76(s, 2H), 4.57(d, 1H, J=4.7Hz), 4.13(s, 2H), 3.77(s, 3H), 1.45(3, 3H), 1.42(3, 3H); MS, m/z: 523.6
             1H NMR(200MHz, CDCl3) δ 7.94(d, 2H, J=8.3Hz), 7.33˜ 7.19(m, 9H), 6.89˜6.73(m, 3H), 6.61˜6.52(m, 2H), 5.52(d, 1H, J=4.8Hz), 4.75(s, 2H), 4.47(d, 1H, J=4.8Hz), 4.13(s, 2H), 3.79(s, 3H), 2.41(s, 3H), 1.44(s, 3H), 1.41(s, 3H); MS, m/z: 537.6
             MS, m/z: 553.6 MS, m/z: 541.6
             MS, m/z: 529.6 MS, m/z: 513.6
             MS, m/z: 475.5 MS, m/z: 531.7
             MS, m/z: 543.7 MS, m/z: 515.6
             MS, m/z: 537.6 MS, m/z: 551.6
             MS, m/z: 567.6 MS, m/z: 555.6
             MS, m/z: 543.6 MS, m/z: 527.6
             MS, m/z: 481.6 MS, m/z: 537.7
             MS, m/z: 549.7 MS, m/z: 521.7
             MS, m/z: 543.7 MS, m/z: 557.7
             MS, m/z: 573.7 MS, m/z: 561.7
             MS, m/z: 549.7 MS, m/z: 533.6
             1H NMR(200MHz, CDCl3) δ 7.26˜7.37(m, 2H), 6.97˜ 7.06(m, 2H), 6.53˜6.68(m, 3H), 5.22(d, 1H, J=5.70Hz), 4.28(d, 1H, J=5.70Hz), 4.24(s, 2H), 3.40(s, 3H), 2.11(s, 3H), 1.34(s, 3h), 1.26(s, 3H); MS, m/z: 373.4
             1H NMR(200MHz, CDCl3) δ 7.26˜7.36(m, 2H), 6.97˜ 7.05(m, 2H), 6.55˜6.72(m, 3H), 5.23(d, 1H, J=6.10Hz), 5.32(d, 1H, J=6.10), 4.24(s, 2H), 3.35(3, 3H), 2.26(s, 2H), 1.36(s, 3H), 1.28(s, 3H), 1.04(s, 9H); MS, m/z: 429.5
             1H NMR(200MHz, CDCl3) δ 7.26˜7.37(m, 2H), 6.97˜ 7.06(m, 2H), 6.53˜6.72(m, 5.21(d, 1H J=5.90Hz), 4.27(d, 1H, J=5.90Hz), 4.24(s, 2H), 3.37(s, 3H), 2.31˜ 2.41(m, 1H), 1.37˜1.92(m, 10H), 1.33(s, 3H), 1.28(s, 3H); MS, m/z: 441.5
             MS, m/z: 413.4
             1H NMR(200MHz, CDCl3) δ 7.30˜7.58(m, 7H), 6.97˜ 7.05(m, 2H), 6.58˜6.77(m, 3H), 5.46(d, 1H, J=5.49Hz), 4.44(d, 1H, J=5.49), 4.25(s, 2H), 3.46(s, 3H), 1.40(s, 3H), 1.38(s, 3H) MS, m/z: 435.5
             1H NMR(200MHz, CDCl3) δ 7.93(d, 2H, J=8.34Hz), 7.21˜ 7.37(m, 4H), 6.96˜7.05(m, 2H), 6.59˜6.77(m, 3H), 5.44(d, 1H, J=5.49Hz), 4.42(d, 1H, J=5.49Hz), 4.25(s, 2H), 3.45(s, 3H), 2.41(s, 3H), 1.39(s, 3H), 1.37(s, 3H); MS, m/z: 449.5
             1H NMR(200MHz, CDCl3) δ 7.98˜8.02(m, 2H), 7.30˜ 7.37(m, 2H), 6.88˜7.05(m, 4H), 6.59˜6.77(m, 3H), 5.44(d, 1H, J=5.49Hz), 4.41(d, 1H, J=5.49Hz), 4.25(s, 2H), 3.86(s, 3H), 3.46(s, 3H), 1.39(s, 3H), 1.37(s, 3H); MS, m/z: 465.5
             1H NMR(200MHz, CDCl3) δ 8.03˜8.10(m, 2H), 7.26˜ 7.37(m, 2H), 6.97˜7.25(m, 4H), 6.58˜6.77(m, 3H), 5.45(d, 1H, J=5.49Hz), 4.42(d, 1H, J=5.49Hz), 4.25(s, 2H), 3.45(s, 3H), 1.40(s, 3H), 1.37(s, 3H); MS, m/z: 453.4
             1H NMR(200MHz, CDCl3) δ 7.82˜7.85(m, 1H), 7.57˜ 7.60(m, 1H), 7.26˜7.37(m, 2H), 6.97˜7.13(m, 3H), 6.55˜ 6.75(m, 3H), 5.40(d, 1H, J=6.10Hz), 4.48(d, 1H, J=6.30 Hz), 4.25(s, 2H), 3.44(s, 3H), 1.40(s, 3H), 1.36(s, 3H); MS, m/z: 441.5
             1H NMR(200MHz, CDCl3) δ 7.59˜7.60(m, 1H), 7.19˜ 7.37(m, 3H), 6.97˜7.05(m, 2H), 6.49˜6.75(m, 4H), 5.42(d, 1H, J=5.90Hz), 4.45(d, 1H, J=5.90Hz), 4.24(s, 2H), 3.42(s, 3H), 1.39(s, 3H), 1.35(s, 3H) MS, m/z: 425.4
             1H NMR(200MHz, CDCl3) δ 7.26˜7.36(m, 2H), 6.96˜ 7.17(m, 2H), 6.59˜6.73(m, 3H), 5.17(d, 1H, J=5.29Hz), 4.29(d, 1H, J=5.29Hz), 4.24(s, 2H), 3.63(q, 2H, 6.92Hz), 2.10(s, 3H), 1.34(s, 3H), 1.29(s, 3H), 1.17(t, 3H, J=7.12 Hz) MS, m/z: 387.4
             -1H NMR(200MHz, CDCl3) δ 7.11˜7.36(m, 4H), 6.80˜ 1H, J=4.88Hz), 3.64(q, 2H, 6.92Hz), 1.36(s, 3H), 1.32(s, 3H), 1.18(t, 3H, J=6.92Hz), 1.01(s, 9H) MS, m/z: 443.5
             MS, m/z: 455.5 MS, m/z: 427.5
             MS, m/z: 449.5 MS, m/z: 463.5
             MS, m/z: 479.5 MS, m/z: 467.5
             MS, m/z: 455.5
             1H NMR(200MHz, CDCl3) δ 7.59˜7.60(m, 1H), 7.18˜ 7.56(m, 3H), 6.92˜7.16(m, 2H), 6.63˜6.88(m, 3H), 6.45˜ 6.52(m, 1H), 5.37(d, 1H, J=5.70Hz), 4.45(d, 1H, J=5.70 Hz), 4.24(s, 2H), 3.68(q, 2H, J=6.92Hz), 1.39(s, 3H), 1.35(s, 3H), 1.16˜1.26(m, 3H); MS, m/z: 439.4
             MS, m/z: 401.4 MS, m/z: 457.5
             MS, m/z: 469.6 MS, m/z: 441.5
             MS, m/z: 463.5 MS, m/z: 477.5
             MS, m/z: 493.5 MS, m/z: 481.5
             MS, m/z: 469.5 MS, m/z: 453.5
             MS, m/z: 415.5
             1H NMR(200MHz, CDCl3) δ 7.30˜7.37(m, 2H), 6.96˜ 7.05(m, 2H), 6.59˜6.67(m, 3H), 5.18(d, 1H, J=5.29Hz), 4.30(d, 1H, J=5.29Hz), 4.24(s, 2H), 3.55(t, 2H, J=6.31 Hz), 2.24(s, 2H), 1.40˜1.54(m, 4H), 1.35(s, 3H), 1.28(s, 3H), 1.03(s, 9H), 0.90˜0.93(m, 3H); MS, m/z: 471.6
             MS, m/z: 483.6
             1H NMR(200MHz, CDCl3) δ 7.30˜7.37(m, 2H), 6.96˜ 7.05(m, 2H), 6.63˜6.68(m, 3H), 5.70(d, 1H, J=1.20Hz), 5.20(d, 1H, J=5.09Hz), 4.26(d, 1H, J=5.09Hz), 4.24(s, 2H), 3.61˜3.64(m, 2H), 2.16(d, 3H, J=1.02Hz), 1.88(d, 3H, J=1.42Hz), 1.35(s, 3H), 1.29(s, 3H), 0.90(t, 3H, J=6.90Hz); MS, m/z: 455.5
             1H NMR(200MHz, CDCl3) δ 8.04(d, 2H, J=8.34Hz), 7.30˜ 7.57(m, 5H), 6.96˜7.04(m, 3H), 6.59˜6.76(m, 3H), 5.41(d, 1H, J=5.09Hz), 4.41(d, 1H, J=5.09Hz), 4.24(s, 2H), 3.63˜3.70(m, 2H), 1.31˜1.59(m, 4H), 1.40(s, 3H), 1.38(s, 3H), 0.86(t, 3H, J=7.12Hz); MS, m/z: 477.5
             1H NMR(200MHz, CDCl3) δ 7.93(d, 2H, J=8.14Hz), 7.20˜ 7.37(m, 4H), 6.96˜7.05(m, 2H), 6.58˜6.76(m, 3H), 5.40(d, 1H, 5.09Hz), 4.41 (d, 1H, J=5.09Hz), 4.24(s, 2H), 3.62˜3.68(m, 2H), 2.40(s, 3H), 1.22˜1.55(m, 4H), 1.39(s, 3H), 1.37(s, 3H), 0.86(t, 3H, J=7.33Hz); MS, m/z: 491.6
             1H NMR(200MHz, CDCl3) δ 7.98(d, 2H, J=8.95Hz), 7.26˜ 7.92(m, 2H), 6.86˜7.05(m, 4H), 6.57˜6.76(m, 3H), 5.39(d, 1H, J=5.09Hz), 4.40(d, 1H, J=5.09Hz), 4.24(s, 2H), 3.85(s 3H), 3.62˜3.83(m, 2H), 1.22˜1.56(m, 4H), 1.39(s, 3H), 1.37(s, 3H), 0.90(t, 3H, J=4.27Hz); MS, m/z: 507.6
             MS, m/z: 495.5
             1H NMR(200MHz, CDCl3) δ 7.82(dd, 1H, J=1.02Hz, J=3.87Hz), 7.57(dd, 1H, J=1.02Hz, J=3.87Hz), 7.26˜ 7.37(m, 2H), 6.97˜7.13(m, 3H), 6.55˜6.74(m, 3H), 5.36(d, 1H, J=5.70Hz), 4.45(d, 1H, J=5.70Hz), 4.24(s, 2H), 3.65(t, 2H, J=6.10Hz), 1.22˜1.55(m, 4H), 1.40(s, 3H), 1.36(s, 3H), 0.86(t, 3H, J=7.12Hz); MS, m/z: 483.6
             1H NMR(200MHz, CDCl3) δ 7.59(d, 1H, J=1.02Hz), 7.30˜ 7.37(m, 2H), 7.18(d, 1H, J=3.46Hz), 6.97˜7.05(m, 2H), 6.54˜6.74(m, 3H), 6.49˜6.51(m, 1H), 5.37(d, 1H, J=5.49 Hz), 4.42(d, 1H, J=5.49Hz), 4.24(s, 2H), 3.64(t, 2H, J=6.31Hz), 1.22˜1.55(m, 4H), 1.39(s, 3H), 1.35(s, 3H), 0.87(t, 3H, J=7.32Hz); MS, m/z: 467.5
             MS, m/z: 449.5
             1H NMR(200MHz, CDCl3) δ 7.26˜7.32(m, 7H), 6.95˜ 7.04(m, 2H), 6.47˜6.72(m, 3H), 5.28(d, 1H, J=4.68Hz), 4.17(s, 2H), 4.40(d, 1H, J=4.68Hz), 4.17(s, 2H), 2.24(s, 2H), 1.39(s, 3H), 1.33(s, 3H), 1.01 (s, 9H); MS, m/z: 505.6
             MS, m/z: 517.6 MS, m/z: 489.5
             MS, m/z: 511.6
             1H NMR(200MHz, CDCl3) δ 7.93(d, 2H, J=7.94Hz), 7.21˜ 7.86(m, 9H), 6.96˜7.04(m, 2H), 6.49˜6.76(m, 3H), 5.51(d, 1H, J=4.88Hz), 4.75(s, 2H), 4.56(d, 1H, J=4.88 Hz), 4.17(s, 2H), 2.41(s, 2H), 2.41(s, 3H), 1.43(s, 3H), 1.40(s, 3H); MS, m/z: 525.6
             1H NMR(200MHz, CDCl3) δ 8.00(d, 2H, J=8.75Hz), 7.26˜ 7.29(m, 7H), 6.88˜7.04(m, 4H), 6.51˜6.76(m, 3H), J=4.88Hz), 4.75(s, 2H), 4.50(d, 1H, J=4.88 Hz), 4.17(s, 2H), 3.85(s, 3H), 1.43(s, 3H), 1.40(s, 3H); MS, m/z: 541.6
             1H NMR(200MHz, CDCl3) δ , 8.02˜8.09(m, 2H), 7.27˜ 7.35(m, 7H), 7.00˜7.15(m, 4H), 6.49˜6.77(m, 3H), 5.50(d, 1H, J=4.68Hz), 4.75(s, 2H), 4.55(d, 1H, J=4.68 Hz), 4.17(s, 2H), 1.44(s, 3H), 1.41(s, 3H); MS, m/z: 529.5
             1H NMR(200MHz, CDCl3) δ 7.82˜7.84(m, 1H), 7.57˜ 7.60(m, 1H), 7.26˜7.33(m, 7H), 6.96˜7.13(m, 3H), 5.46(d, 1H, J=5.29Hz), 4.73(s, 2H), 4.60(d, 1H, J=5.29 Hz), 4.17(s, 2H), 1.43(s, 3H), 1.39(s, 3H); MS, m/z: 517.6
             1H NMR(200MHz, CDCl3) δ 7.59˜7.60(m, 1H), 7.20˜ 7.35(m, 7H), 7.18˜7.20(m, 1H), 6.96˜7.05(m, 2H), 6.49˜ 6.75(m, 4H), 5.47(d, 1H, J=5.09Hz), 4.73(s, 2H), 4.56(d, 1H, J=5.09Hz), 4.17(s, 2H), 1.43(s, 3H), 1.38(s, 3H); MS, m/z: 501.5
             MS, m/z: 463.5 MS, m/z: 519.6
             MS, m/z: 531.6 MS, m/z: 503.6
             MS, m/z: 525.6 MS, m/z: 539.6
             MS, m/z: 555.6 MS, m/z: 543.6
             MS, m/z: 531.6 MS, m/z: 515.5
             MS, m/z: 469.9 MS, m/z: 525.7
             MS, m/z: 537.7 MS, m/z: 509.6
             MS, m/z: 531.6 MS, m/z: 545.7
             MS, m/z: 561.7 MS, m/z: 549.6
             MS, m/z: 537.7 MS, m/z: 521.6
             1H NMR(200MHz, CDCl3) δ 7.12˜7.26(m, 4H), 6.59˜ 6.73(m, 3H), 5.22(d, 1H, J=5.49Hz), 4.28(d, 1H, J=5.49 Hz), 4.22(s, 2H), 3.40(s, 3H), 2.33(s, 3H), 2.11(s, 3H), 1.35(s, 3H), 1.29(s, 3H); MS, m/z: 369.4
             1H NMR(200MHz, CDCl3) δ 7.12˜7.27(m, 4H), 6.57˜ 6.73(m, 3H), 5.24(d, 1H, J=10Hz), 4.33(d, 1H, J=6.10 Hz), 4.22(s, 2H), 3.36(s, 3H), 2.33(s, 3H), 2.27(s, 2H), 1.36(s, 3H), 1.29(s, 3H), 1.05(s, 9H); MS, m/z: 425.5
             1H NMR(200MHz, CDCl3) δ 7.12˜7.28(m, 4H), 6.56˜ 6.73(m, 3H), 5.22(d, 1H, J=5.9Hz), 4.29(d, 1H, J=5.9Hz), 4.22(s, 2H), 3.39(s, 3H), 2.98˜2.37(m, 1H), 1.28˜ 1.93(m, 10H), 1.34(s, 3H), 1.28(s, 3H); MS, m/z: 437.5
             1H NMR(200MHz, CDCl3) δ 7.12˜7.27(m, 4H), 6.58˜ 216.73(m, 3H), 5.72˜5.73(m, 1H), 5.25(d, 1H, J=5.49Hz), 4.29(d, 1H, J=5.49Hz), 4.22(s, 2H), 3.43(s, 3H), 2.33(s, 3H), 2.18(d, 3H, J=1.20Hz), 1.90(d, 3H, J=1.20Hz), 1.36(s, 3H), 1.30(s, 3H); MS, m/z: 409.5
             1H NMR(200MHz, CDCl3) δ 8.04˜8.09(m, 2H), 7.41˜ 7.58(m, 3H), 7.07˜7.37(m, 4H), 6.61˜6.78(m, 3H), 5.48(d, 1H, J=5.70), 4.45(d, 1H, J=5.70Hz), 4.23(s, 2H), 3.47(s, 3H), 2.33(s, 3H), 1.42(s, 3H), 1.39(s, 3H); MS, m/z: 431.5
             1H NMR(200MHz, CDCl3) δ 7.94(d, 2H, J=8.34Hz), 7.12˜ 7.28(m, 6H), 6.60˜6.77(m, 3H), 5.46(d, 1H, J=5.70Hz), 4.44(d, 1H, J=5.70Hz), 4.23(s, 2H), 3.46(s, 3H), 2.41(s, 3H), 2.33(s, 3H), 1.40(s, 3H), 1.38(s, 3H); MS, m/z: 445.5
             1H NMR(200MHz, CDCl3) δ 8.00(dd, 2H, J=2.04Hz, J=6.92Hz), 7.11˜7.26(m, 4H), 6.89˜6.85(m, 2H), 6.65˜ 6.77(m, 3H), 5.43(d, 1H, J=5.49Hz), 4.41(d, 1H, J=5.49 Hz), 4.22(s, 2H), 3.86(s, 3H), 3.46(s, 3H), 2.32(s, 3H), 1.40(s, 3H), 1.37(s, 3H); MS, m/z: 461.5
             1H NMR(200MHz, CDCl3) δ 8.03˜8.10(m, 2H), 7.07˜ 7.28(m, 6H), 6.59˜6.77(m, 3H), 5.45(d, 1H, J=5.48Hz), 4.43(d, 1H, J=5.49Hz), 4.23(s, 2H), 3.46(s, 3H), 2.33(s, 3H), 1.41(s, 3H), 1.38(s, 3H); MS, m/z: 449.5
             1H NMR(200MHz, CDCl3) δ 7.84(dd, 1H, J=1.22Hz, J=3.87Hz), 7.58(dd, 1H, J=1.22Hz, J=3.87Hz), 7.09˜ 7.28(m, 5H), 6.58˜6.76(m, 3H), 5.41(d, 1H, J=6.31Hz), 4.49(d, 1H, J=6.31Hz), 4.23(s, 2H), 3.44(s, 3H), 2.33(s, 3H), 1.41(s, 3H), 1.36(s, 3H); MS, m/z: 437.5
             1H NMR(200MHz, CDCl3) δ 7.60(dd, 1H, J=0.81Hz, J=1.83Hz), 7.12˜7.27(m, 5H), 6.58˜6.75(m, 3H), 6.51 (dd, 1H, J=1.83Hz, J=3.46Hz), 5.42(d, 1H, J=6.10 Hz), 4.46(d, 1H, J=6.10Hz), 4.22(s, 2H), 3.43(s, 3H), 2.33(s, 3H), 1.40(s, 3H), 1.35(s, 3H); MS, m/z: 421.5
             MS, m/z: 383.4 MS, m/z: 439.6
             MS, m/z: 351.6 MS, m/z: 423.5
             MS, m/z: 445.4 MS, m/z: 459.5
             MS, m/z: 451.5 MS, m/z: 463.5
             MS, m/z: 451.5 MS, m/z: 435.5
             MS, m/z: 397.5 MS, m/z: 453.6
             MS, m/z: 465.6 MS, m/z: 437.5
             MS, m/z: 459.5 MS, m/z: 473.6
             MS, m/z: 489.6 MS, m/z: 477.5
             MS, m/z: 465.6 MS, m/z: 449.5
             MS, m/z: 411.5 MS, m/z: 467.6
             MS, m/z: 479.6
             1H NMR(200MHz, CDCl3) δ 7.16˜7.26(m, 4H), 7.06˜ 7.09(m, 2H), 6.71˜6.98(m, 3H), 5.68(d, 1H, J=1.42Hz), 5.19(d, 1H, J=4.68Hz), 4.22(d, 1H, J=4.68Hz), 4.17(s, 2H), 3.59˜3.68(m, 2H), 2.26(s, 3H), 2.17(s, 3H), 1.89(s, 3H), 1.35(s, 3H), 1.30(s, 3H), 1.19˜1.59(m, 4H), 0.90(t, 3H, J=7.32Hz); MS, m/z: 451.6
             1H NMR(200MHz, CDCl3) δ 8.01˜8.05(m, 2H), 7.26˜ 7.57(m, 3H), 7.07˜7.23(m, 4H), 6.77˜6.83(m, 3H), 5.41(d, 1H, J=4.55Hz), 4.40(d, 1H, J=4.55Hz), 4.20(s, 2H), 3.21˜3.70(s, 2H), 2.28(s, 3H), 1.40(s, 3H), 1.38(s, 3H), 1.19˜1.57(m, 4H), 0.86(t, 3H, J=7.32Hz); MS, m/z: 473.6
             MS, m/z: 487.6
             1H NMR(200MHz, CDCl3) δ 7.93˜7.98(m, 2H), 6.98˜ 7.26(m, 6H), 6.79˜6.97(m, 3H), 5.35(d, 1H, J=4.68Hz), 4.30(d, 1H, J=4.68Hz), 4.16(s, 2H), 3.84(s, 3H), 3.65˜ 3.76(m, 2H), 2.17(s, 3H), 1.39(s, 3H), 1.37(s, 3H), 1.19˜ 1.52(m, 4H), 0.86(t, 3H, J=7.12Hz); MS, m/z: 503.6
             1H NMR(200MHz, CDCl3) δ 8.00˜8.07(m, 2H), 7.06˜ 7.25(m, 6H), 6.78˜6.87(m, 3H), 5.38(d, 1H, J=4.88Hz), 4.37(d, 1H, J=4.88Hz), 4.18(s, 2H), 3.62˜3.70(m, 2H), 2.27(s, 3H), 1.40(s, 3H), 1.37(s, 3H), 1.19˜1.56(m, 4H), 0.87(t, 3H, J=7.12Hz); MS, m/z: 491.6
             1H NMR(200MHz, CDCl3) δ 7.81 (dd, 1H, J=1.42Hz, J=3.87Hz), 7.57(dd, 1H, J=1.42Hz, J=3.87Hz), 7.08˜ 7.26(m, 5H), 6.72˜7.06(m, 3H), 5.33(d, 1H, J=5.49Hz), 4.40(d, 1H, J=5.49Hz), 4.18(s, 2H), 3.66(t, 2H, J=6.31 Hz), 2.26(s, 3H), 1.39)s, 3H), 1.36(s, 3H), 1.19˜1.56(m, 4H), 0.82(t, 3H, J=7.12Hz); MS, m/z: 479.6
             1H NMR(200MHz, CDCl3) δ 7.58(s, 1H), 7.01˜7.18(m, 7H), 6.75˜6.80(m, 1H), 6.49˜6.51(m, 1H), 5.33(d, 1H, J=5.09Hz), 4.33(d, 1H, J=5.09Hz), 4.16(s, 2H), 3.65(t, 2H, J=6.71Hz), 2.21(s, 3H), 1.38(s, 3H), 1.35(s, 3H), 1.18˜ 1.56(m, 4H), 0.87(t, 3H, J=7.12Hz); MS, m/z: 463.5
             MS, m/z: 445.5 MS, m/z: 501.6
             MS, m/z: 513.6 MS, m/z: 485.6
             MS, m/z: 507.6 MS, m/z: 521.6
             MS, m/z: 537.6 MS, m/z: 525.6
             MS, m/z: 513.6 MS, m/z: 497.6
             MS, m/z: 459.5 MS, m/z: 515.7
             MS, m/z: 527.7 MS, m/z: 499.6
             MS, m/z: 521.6 MS, m/z: 535.6
             MS, m/z: 551.6 MS, m/z: 539.6
             MS, m/z: 527.6 MS, m/z: 511.6
             MS, m/z: 465.6 MS, m/z: 521.7
             MS, m/z: 533.7 MS, m/z: 505.7
             MS, m/z: 527.7 MS, m/z: 541.7
             MS, m/z: 557.7 MS, m/z: 545.7
             MS, m/z: 533.7 MS, m/z: 517.6

The following specific formulations comprising the compound of this invention as an active ingredient are intended to be illustrative of the invention and should not be construed as limiting the scope of the invention.

FORMULATION EXAMPLE 1

Tablet (Direct Pressure)

5.0 mg of active ingredient were sieved, and 14.1 mg of lactose, 0.8 mg of crosspovidone USNF and 0.1 mg of magnesium stearate were mixed and then pressured to prepare tablets.

FORMULATION EXAMPLE 2

Tablet (Wet Granulation)

5.0 mg of active ingredient was sieved, and 16.0 mg of lactose and 4.0 mg of starch were mixed. 0.3 mg of polysorbate 80 in purified water was added to the mixture and the resultant was treated to form fine granules. After drying, the fine granules were sieved and 2.7 mg of colloidal silicone dioxide and 2.0 mg of magnesium stearate were mixed. The fine granules were pressured to prepare tablets.

FORMULATION EXAMPLE 3

Powder and Capsule

5.0 mg of active ingredient was sieved, and 14.8 mg of lactose, 10.0 mg of polyvinyl pyrrolidone and 0.2 mg of magnesium stearate were mixed. The mixture was introduced into No. 5 gelatin capsule by use of a suitable device.

FORMULATION EXAMPLE 4

Injections

100 mg of active ingredient, 180 mg of mannitol, 26 mg of Na₂HPO₄·12H₂O and 2974 mg of distilled water were employed to produce injections.

The inhibitory effect of the present compounds on lipid peroxidation induced by iron was evaluated as follows:

EXPERIMENTAL EXAMPLE

Inhibitory Effect on Lipid Peroxiation

Rat brain was homogenized in Krebs buffer (15 mM HEPES, 10 mM glucose, 140 mM NaCl, 3.6 mM KCl, 1.5 mM CaCl₂, 1.4 mM KH₂PO₄ and 0.7 mM MgCl, pH 7.4) and centrifuged at 12,000 rpm to obtain the supernatant serving as a raw material of lipid. To the brain homogenates, FeCl² was added to give a final concentration of 400 μM and allowed to stand for 30 min at 37° C. for promoting oxidation. Each of the compounds to be tested was added to give a concentration of 12.5 μM and a control group was solely added with dimethylsulfoxide (DMSO).

When iron is added to brain homogenates, oxidation is promoted to increase the amount of malondialdehyde (MDA) as lipid peroxidation product. Therefore, in this Example, the level of lipid peroxidation was evaluated according to MDA measurement method. In general MDA measurement, the test sample is reacted with TBA (2-thiobarbituric acid) and the absorbance at 530 nm was measured. However, since such process includes a boiling step, it is unsuitable for dealing with test samples in large quantity. Therefore, in this Example, N-methyl-2-phenylindole was used as a color developing reagent in place of TBA so as to avoid boiling step. Two molecules of N-methyl-2-phenylindole are reacted with one molecule of MDA to form chromophore that shows its maximum absorption at 586 nm (absorption measurement with Bioxytech LPO-586 Kit). The inhibitory effect on lipid peroxidation of test compounds was evaluated by calculating the decreased level of MDA in percentage based on the amount of MDA in the control group. For the test compounds showing more than 80% inhibitory effect, the concentration-lipid peroxidation inhibition curves were plotted with reference to the decrease rate of MDA amount based on the amount of MDA in the control group and their IC₅₀ values was calculated through least linear regression analysis. The results are summarized in Table 4.

In addition, the representative antioxidants commercialized such as Promethazine, Trolox, Probucol and N-propyl gallate were examined in terms of 50% inhibition concentration (IC₅₀) according to the above procedure and the results are shown in Table 4.

	TABLE 4
	Compound No.	IC50 (μM)	Compound No.	IC50 (μM)
	5-49	2.85	5-50	4.90
	5-51	5.20	5-52	0.98
	5-53	1.80	5-55	2.61
	5-57	4.37	5-63	2.46
	5-64	2.57	5-65	1.13
	5-67	6.06	5-68	1.39
	5-69	1.42	5-70	1.15
	5-71	1.70	5-72	7.39
	5-73	2.85	5-74	3.60
	5-77	2.50	5-78	1.14
	5-79	0.79	5-80	1.08
	5-97	5.34	5-98	5.30
	5-100	3.89	5-101	6.03
	5-103	5.10	5-104	4.01
	5-106	5.51	5-289	1.32
	5-290	3.02	5-292	3.25
	5-293	3.68	5-295	1.29
	5-296	5.85	5-298	6.07
	5-300	1.36	5-306	4.12
	5-307	3.55	5-308	4.75
	5-309	2.90	5-310	1.10
	5-311	1.19	5-312	4.13
	5-313	1.44	5-315	3.43
	5-318	5.27	5-464	3.81
	5-465	6.41	5-466	1.20
	5-467	3.60	5-468	4.27
	5-469	4.38	5-470	4.15
	5-471	4.85	5-472	3.90
	5-473	2.72	5-474	3.45
	5-476	1.35	5-477	3.63
	5-478	6.21	5-480	5.55
	5-485	2.66	5-486	0.91
	5-490	2.24	5-495	2.04
	5-510	9.45	5-511	0.12
	5-512	3.60	5-514	2.39
	5-519	4.60	5-562	6.47
	5-564	4.33	5-566	5.73
	5-1126	2.56	5-1131	9.38
	5-1223	4.29	5-1231	1.00
	5-1235	1.00	5-1261	4.7
	5-1482	5.27	5-1483	2.39
	5-1489	3.33	5-1490	3.04
	5-1515	2.23	5-1516	6.34
	5-1520	3.10	5-1552	5.43
	5-1558	3.37	5-1560	2.31
	5-1561	2.89	5-1562	3.03
	5-1563	2.05	5-1568	4.09
	5-1569	3.41	5-1570	3.03
	5-1762	1.80	5-1765	5.13
	5-1767	2.63	5-1768	2.73
	5-1769	5.97	5-1770	3.11
	5-1797	3.56	5-1799	6.01
	5-1800	3.90	5-1802	4.12
	5-1806	5.85	5-1808	3.97
	5-1809	6.36	5-1810	4.34
	5-1831	2.71	5-1832	1.09
	5-1834	1.29	5-1835	1.14
	5-1836	1.16	5-1837	4.25
	5-1838	1.31	5-1839	1.07
	5-1840	1.03
	Promethazine	10.2	Trolox	24.6
	Probucol	18.2	N-propyl gallate	25.0

As shown in Table 4, the present compounds exhibit inhibitory effect on iron-induced lipid peroxidation. Of them, several compounds showed inhibition rate of at below 2.0 μM, thus showing high inhibition potency.

As described previously, although the conventional processes perform multi-step reactions in a solution and require several treatment and purification steps after several reactions, the process of the present invention for preparing 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivative according to parallel synthesis on solid-phase makes it possible to significantly reduce the number of treatments and purification steps to a single step, thereby enabling to construct a large amount of benzopyran library in a short period of time. In particular, the present process comprises: the first step for producing N-substituted carbamate resin of the formula (2); the second step for producing 2,2-dimethyl-3-hydroxy-4-alkoxy-6-alkylamino benzopyran resin of the formula (3); the third step for producing 2,2-dimethyl-3-substituted-4-alkoxy-6-alkylamino benzopyran resin of the formula (4); and the fourth step for producing, the compound of interest of the formula (5) by use of dichloromethane solution containing TFA or an organic solvent containing an organic acid. The present process is very useful in mass production of 6-amino-2,2-dimethyl-3,4,6° trisubstituted benzopyran derivatives.

Therefore, the present invention establishes the technology for construction of 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran library according to parallel synthesis on solid-phase, which highlights the applicability of combinatorial chemical synthesis technology. Furthermore, the present invention permits to easily screen and optimize structure and function of the lead compound with novel structure useful in developing drugs for preventing and treating diseases of nervus craniales induced by accumulation of oxidized molecules through lipid peroxidation in nerve cells such as apoplexy and dementia, as well as inflammatory diseases such as arthritis, cardiac infarction and acute or chronic tissue injury.

Claims

1. A compound chosen from the following formula (5) and optical isomers thereof: wherein R1 represents a C1-C10 alkyl, allyl, benzyl or substituted benzyl, or phenethyl group; R2 represents a C1-C10 alkyl, benzyl or substituted benzyl, or phenethyl group; R3 represents a C1-C10 alkyl group, a C2-C10 alkenyl group, a C2-C10 alkynyl, benzyl or substituted benzyl, naphthylmethyl groups, or —C(O)R4; R4 represents phenyl or substituted phenyl groups or five-or seven-membered heterocyclic ring containing a heteroatom selected from the group consisting of oxygen and sulfur; and said substituted phenyl or said substituted benzyl group may be substituted with 1-4 substituents selected from the group consisting of a halogen atom, a nitro group, a C1-C10 alkyl group, a C1-C10 alkoxy group and a C1-C10 haloalkyl group.

2. A process for preparing a compound chosen from the following formula (5) and optical isomers thereof, comprising the following steps of: (a) synthesizing an N-alkyl substituted carbamate resin of the following formula (2) by introducing an alkyl substituent selectively to a nitrogen atom of benzopyran linked to a carbamate linker represented by the following formula (1); (b) synthesizing a 2,2-dimethyl-3-hydroxy-6-alkyl amino benzopyran resin of the following formula (3) or its optical isomers by performing epoxidation and alkoxy addition simultaneously by adding metachloroperbenzoic acid (m-CPBA) and alcohol to the compound of the following formula (2); (c) synthesizing a 2,2-dimethyl-3-substituted-4-alkoxy-6-alkyl amino benzopyran resin of the following formula (4) or its optical isomers by introducing a substituent R3 to 3-hydroxyl group of the compound of the following formula (3) or its optical isomers; and (d) synthesizing said compound by releasing said compound from the resin of the following formula (4) or its optical isomers with dichloromethane solution containing trifluoroacetic acid (TFA) or an organic solvent containing an organic acid;

3. A pharmaceutical composition, which comprises (a) at least one pharmaceutically acceptable component chosen from carriers, additives, vehicles, and diluents, and (b) a pharmaceutically effective amount of a compound chosen from the following formula (5) and optical isomers thereof: wherein the pharmaceutical composition is pharmaceutically acceptable; the said compound is an active ingredient of the pharmaceutical composition; R1 represents a C1-C10 alkyl, allyl, benzyl or substituted benzyl, or phenethyl group; R2 represents a C1-C10 alkyl, benzyl or substituted benzyl, or phenethyl group; R3 represents a C1-C10 alkyl group, a C2-C10 alkenyl group, a C2-C10 alkynyl, benzyl or substituted benzyl, naphthylmethyl groups, or —C(O)R4; R4 represents phenyl or substituted phenyl groups or five-or seven-membered heterocyclic ring containing a heteroatom selected from the group consisting of oxygen and sulfur; and said substituted phenyl or said substituted benzyl group may be substituted with 1-4 substituents selected from the group consisting of a halogen atom, a nitro group, a C1-C10 alkyl group, a C1-C10 alkoxy group and a C1-C10 haloalkyl group.

4. A pharmaceutical composition for inhibiting lipid peroxidation, which comprises (a) at least one pharmaceutically acceptable component chosen from carriers, additives, vehicles, and diluents, and (b) a pharmaceutically effective amount of a compound chosen from the following formula (5) and optical isomers thereof: wherein the pharmaceutical composition is pharmaceutically acceptable; said compound is an active ingredient of the pharmaceutical composition; R1 represents a C1-C10 alkyl, allyl, benzyl or substituted benzyl, or phenethyl group; R2 represents a C1-C10 alkyl, benzyl or substituted benzyl, or phenethyl group; R3 represents a C1-C10 alkyl group, a C2-C10 alkenyl group, a C2-C10 alkynyl, benzyl or substituted benzyl, naphthylmethyl groups, or —C(O)R4; R4 represents phenyl or substituted phenyl groups or five-or seven-membered heterocyclic ring containing a heteroatom selected from the group consisting of oxygen and sulfur; and said substituted phenyl or said substituted benzyl group may be substituted with 1-4 substituents selected from the group consisting of a halogen atom, a nitro group, a C1-C10 alkyl group, a C1-C10 alkoxy group and a C1-C10 haloalkyl group.