Claims
- 1. A compound of formula I, ##STR7## wherein R.sub.1 is a branched chain alkyl of 3 to 5 carbon atoms, branched at the .alpha.-position to the nitrogen to which it is bound, and
- R.sub.2 is methyl or ethyl,
- or a pharmaceutically acceptable acid addition salt thereof.
- 2. A compound of claim 1, wherein R.sub.1 is isopropyl.
- 3. A compound of claim 1, wherein R.sub.2 is methyl.
- 4. The compound of claim 1, which is 5-nor-6-isopropyl-9,10-dihydro-2'.beta.-methyl-5'.alpha.-isopropylergopeptine.
- 5. The compound of claim 1, which is 6-nor-6-isopropyl-9,10-dihydro-2'.beta.-ethyl-5'.alpha.-isopropylergopeptine.
- 6. A pharmaceutical composition useful in treating migraine comprising 0.1 to 3 milligrams of a compound of claim 1 in association with a pharmaceutical carrier or diluent.
- 7. The pharmaceutical composition of claim 6 in unit dosage form comprising from 0.02 to 1.5 milligrams of the said compound per unit dosage.
- 8. The pharmaceutical composition of claim 6 wherein, in the said compound, R.sub.1 is isopropyl.
- 9. The pharmaceutical composition of claim 6 wherein, in the said compound, R.sub.2 is methyl.
- 10. The pharmaceutical composition of claim 6 wherein the said compound is 5-nor-6-isopropyl-9,10-dihydro-2'.beta.-methyl-5'.alpha.-isopropyl-ergopeptine.
- 11. The pharmaceutical composition of claim 6 wherein the said compound is 6-nor-6-isopropyl-9,10-dihydro-2'.beta.-ethyl-5'.alpha.-isopropyl-ergopeptine.
- 12. A method of treating migraine in animals which comprises administrating to an animal in need of such treatment a therapeutically effective amount of a compound of claim 1.
- 13. The method of claim 12, wherein 0.1 to 3.0 milligrams of the said compound are administered daily.
- 14. The method of claim 13, wherein the dosage is administered in unit dosage form comprising 0.02 to 1.5 milligrams of the said compound.
- 15. The method of claim 12 wherein, in said compound, R.sub.1 is isopropyl.
- 16. The method of claim 12 wherein, in said compound, R.sub.2 is methyl.
- 17. The method of claim 12 wherein the said compound is 5-nor-6-isopropyl-9,10-dihydro-2'.beta.-methyl-5'.alpha.-isopropyl-ergopeptine.
- 18. The method of claim 12 wherein the said compound is 6-nor-6-isopropyl-9,10-dihydro-2'.beta.-ethyl-5'.alpha.-isopropyl-ergopeptine.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8533/74 |
Jun 1974 |
CHX |
|
Parent Case Info
This is a continuation, of application Ser. No. 762,647 filed Jan. 26, 1977, now abandoned, which in turn is a continuation-in-part of our application Ser. No. 587,289 of June 16, 1975 now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3336311 |
Hofmann et al. |
Aug 1967 |
|
3652569 |
Stadler et al. |
Mar 1972 |
|
3920664 |
Clemens et al. |
Nov 1975 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
769260 |
Mar 1957 |
GBX |
Non-Patent Literature Citations (2)
Entry |
Fehr et al., Helo. Chem. Acta. vol. 53, pp. 2197-2201, (1970). |
Hofmann Die Nurtterkorn Alhodocill pp. 66-67, (1964). |
Continuations (1)
|
Number |
Date |
Country |
Parent |
762647 |
Jan 1977 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
587289 |
Jun 1975 |
|