Claims
- 1. A 6-thioxanthine of formula I or a pharmaceutically acceptable salt thereof ##STR3## wherein R.sub.3 is selected from a group consisting of ethyl, n-propyl, isopropyl, isobutyl, secondary butyl, cyclopropylmethyl, n-pentyl, 2-methylbutyl, 3-methylbutyl and 2,2-dimethylpropyl, and R.sub.8 is selected from a group consisting of ethyl, isopropyl, cyclopropyl, n-butyl, isobutyl, t-butyl, cyclobutyl and n-pentyl, provided that
- when R.sub.3 is ethyl, R.sub.8 is selected from isopropyl, cyclopropyl, isobutyl, t-butyl, cyclobutyl and n-pentyl.
- when R.sub.3 is n-propyl, R.sub.8 is selected from isopropyl, isobutyl and t-butyl
- when R.sub.3 is isobutyl, R.sub.8 is selected from ethyl, isopropyl, cyclopropyl, isobutyl, t-butyl, cyclobutyl and n-pentyl,
- when R.sub.3 is n-pentyl, 2-methylbutyl, 3-methylbutyl, or 2,2-dimethylpropyl R.sub.8 is selected from isopropyl, cyclopropyl, n-butyl, isobutyl, t-butyl, cyclobutyl and n-pentyl.
- 2. A 6-thioxanthine according to claim 1 wherein R.sub.3 is selected from ethyl, n-propyl and isopropyl.
- 3. A 6-thioxanthine according to claim 1 wherein R.sub.8 is selected from isopropyl, cyclopropyl and cyclobutyl.
- 4. A 6-thioxanthine according to claim 1 wherein R.sub.3 and R.sub.8, when combined, contain from 5 to 8 carbon atoms.
- 5. Compound according to claim 1 wherein said compound is selected from the group consisting of 3-Ethyl-8-cyclopropyl-6-thioxanthine and pharmaceutically acceptable salts thereof.
- 6. Compound according to claim 1 wherein said compound is selected from the group consisting of 3-Cyclopropylmethyl-8-cyclopropyl-6-thioxanthines and pharmaceutically acceptable salts thereof.
- 7. Compound according to claim 1 wherein said compound is selected from the group consisting of 3-Ethyl-8-isopropyl-6-thioxanthines and pharmaceutically acceptable salts thereof.
- 8. Compound according to claim 1 wherein said compound is selected from the group consisting of 3,8-Di-isopropyl-6-thioxanthines and pharmaceutically acceptable salts thereof.
- 9. Compound according to claim 1 wherein said compound is selected from the group consisting of 3-Cyclopropylmethyl-8-ethyl-6-thioxanthines and pharmaceutically acceptable salts thereof.
- 10. Compound according to claim 1 wherein said compound is selected from the group consisting of 3-sec.Butyl-8-isopropyl-6-thioxanthines and pharmaceutically acceptable salts thereof.
- 11. Compound according to claim 1 wherein said compound is selected from the group consisting of 3-(2,2-Dimethylpropyl)-8-cyclopropyl-6-thioxanthines and pharmaceutically acceptable salts thereof.
- 12. Compound according to claim 1 wherein said compound is selected from the group consisting of 3-Ethyl-8-t-butyl-6-thiooxanthine and pharmaceutically acceptable salts thereof.
- 13. A pharmaceutical composition for use in the treatment of chronic obstructive airway disease comprising a 6-thioxanthine or a pharmaceutically acceptable salt thereof according to claim 1 in conjunction with a pharmaceutically acceptable diluent or carrier.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8618931 |
Aug 1986 |
GBX |
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation in part of abandoned U.S. patent application Ser. No. 322,364, filed Mar. 13, 1989, which is itself a continuation of U.S. patent application Ser. No. 78,545, filed July 7, 1987 now U.S. Pat. No. 4,925,879, which is itself a continuation in part of U.S. patent application Ser. No. 699,254, filed Feb. 7, 1985, now U.S. Pat. No. 4,710,503.
US Referenced Citations (3)
Non-Patent Literature Citations (1)
Entry |
Armitage et al, Brit. J. Pharmacol. vol. 17 pp. 196-207. |
Continuations (1)
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Number |
Date |
Country |
Parent |
78545 |
Jul 1987 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
322364 |
Mar 1989 |
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Parent |
699254 |
Feb 1985 |
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