Claims
- 1. A compound represented by the formula
- 2. A compound according to claim 1, which is represented by formula II:
- 3. A compound according to claim 1, which is represented by formula III:
- 4. A compound according to claim 1, which is represented by formula IV:
- 5. A compound according to claim 1, which is represented by formula V:
- 6. A compound according to claim 1, which is represented by formula VI:
- 7. A compound according to claim 1, which is represented by formula VII:
- 8. A compound according to claim 1, which is represented by formula VIII:
- 9. A compound according to claim l, which is represented by formula IX:
- 10. A compound according to claim 1, which is represented by formula X:
- 11. A compound according to claim 1 which is selected from:
Compound of formula IV: A and B taken together with the carbon atom to which they are attached=C═CH2, Q=OH, R2′ is H, and R4″=Ac; Compound of formula IV: A and B taken together with the carbon atom to which are attached=C═CH2, Q=H, R2′=H, and R4″=Ac; Compound of formula V: A and B taken together with the carbon atom to which they are attached=C═CH2, Q=H, and R2′=H; Compound of formula V: A and B taken together with the carbon atom to which they are attached=C═CH2, Q=Ac, and R2′=H; Compound of formula IV: A and B taken together with the carbon atom to which they are attached=C═CH2, Q=O—CH2OCH3, R2′=H, and R4″=Ac; Compound of formula V: A and B taken together with the carbon atom to which they are attached=C═CH2, Q=O—CH2OCH3, and R2′=H; Compound of formula I: A and B taken together with the carbon atom to which they are attached=C═CH2, X and Y taken together with the carbon atom to which they are attached=C═NAc, L=CH2CH3, W is N(CH3)2, Z=H and R2′=H; Compound of formula I: A and B taken together with the carbon atom to which they are attached=C═CH2, X and Y taken together with the carbon atom to which they are attached=C═NAc, L=CH2CH3, Z=OC(O)(p-nitrophenyl) and R2′=H; Compound of formula I: A and B taken together with the carbon atom to which they are attached=C═CH2, X and Y taken together with the carbon atom to which they are attached=C═NAc, L=CH2CH3, W is N(CH3)2, Z=OC(O)[2-(NO2), 4-(CF3)Phenyl] and R2′=H; Compound of formula I: A and B taken together with the carbon atom to which they are attached=C═CH2, X and Y taken together with the carbon atom to which they are attached=C═NAc, L=CH2CH3, W is N(CH3)2, Z=OC(O)CH2(p-methoxyphenyl) and R2′=H; Compound of formula IV: A and B taken together with the carbon atom to which they are attached=C═CH2, Q=Ac, R2′=H, and R4″=Ac; Compound of formula I: Compound of formula IV: A and B taken together with the carbon atom to which they are attached=C═O, Q=Ac, R2′=H, and R4″=Ac; Compound of formula IV: A and B taken together with the carbon atom to which they are attached=C═OBz, Q=Ac, R2′=H, and R4″=Ac; Compound of formula IV: A and B taken together with the carbon atom to which they are attached=C═(3-quinolyl), Q=Ac, R2′=H, and R4″=Ac; Compound of formula I: A and B taken together with the carbon atom to which they are attached=C═CH2, X and Y taken together with the carbon atom to which they are attached=C═O, L=CH2CH3, W is N(CH3)2, Z=4-acetoxycladinose and R2′=H; Compound of formula I: A and B taken together with the carbon atom to which they are attached=C═CH-quinolin-3-yl, X and Y taken together with the carbon atom to which they are attached=C═O, L=CH2CH3, W is N(CH3)2, Z=4-acetoxycladinose and R2′=H; Compound of formula I: A and B taken together with the carbon atom to which they are attached=C═CH-quinolin-3-yl, X and Y taken together with the carbon atom to which they are attached=C═O, L=CH2CH3, W is N(CH3)2, Z=OH, and R2′=H; Compound of formula I: A and B taken together with the carbon atom to which they are attached=C═CH2, X and Y taken together with the carbon atom to which they are attached=C═O, L=CH2CH3, W is N(CH3)2, Z=OH and R2′=H; Compound of formula IV: A and B taken together with the carbon atom to which they are attached=C═CH2-phenyl, Q=OH, R2′=H, and R4″=Ac; Compound of formula V: A and B taken together with the carbon atom to which they are attached are C═CH-phenyl, Q=Ac, and R2′=H; Compound of formula I: A and B taken together with the carbon atom to which they are attached=C═O, X and Y taken together with the carbon atom to which they are attached=C═NAc, L=CH2CH3, W is N(CH3)2, Z=OCH2CH=CH(quinolin-3-yl), and R2′=H; Compound of formula I: A and B taken together with the carbon atom to which they are attached=C═CHCHCH-phenyl, X and Y taken together with the carbon atom to which they are attached=C═NAc, L=CH2CH3, W is N(CH3)2, Z=OC(O)-benzyl and R2=H; Compound of formula I: A and B taken together with the carbon atom to which they are attached=C═CHCHCH-phenyl, X and Y taken together with the carbon atom to which they are attached=C═NAc, L=CH2CH3, W is N(CH3)2, Z=OC(O)CH2(2-pyridyl) and R2=H; Compound of formula I: A and B taken together with the carbon atom to which they are attached=C═CH2, X and Y taken together with the carbon atom to which they are attached=C═NOH, L=CH2CH3, W is N(CH3)2, Z=4-oxocladinose and R2=H; Compound of formula I: A and B taken together with the carbon atom to which they are attached=C═CH2, X and Y taken together with the carbon atom to which they are attached=C═NOH, L=CH2CH3, W is N(CH3)2, Z=4-oximecladinose and R2=H; Compound of formula IV: A and B taken together with the carbon atom to which they are attached are C═CH2, Q=OH, and R2=R4″=H; or Compound of formula I: Compound of formula IV: A and B taken together with the carbon atom to which they are attached=C═CH2, Q=OH, R2′=H, and R4″=Ac.
- 12. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1, or its pharmaceutically-acceptable salt, ester or prodrug, in combination with a pharmaceutically acceptable carrier.
- 13. A method for controlling a bacterial infection in a subject in need of such treatment, comprising administering to said subject a therapeutically effective amount of a pharmaceutical composition according to claim 12.
- 14. A process for preparing a compound according to the formula
- 15. A process for preparing a compound represented by the formula:
- 16. A process for the preparation of a compound represented by the formula (IX):
REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation in part of prior copending U.S. patent application Ser. No. 10/144,396, filed May 13, 2002.
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
10144396 |
May 2002 |
US |
Child |
10436622 |
May 2003 |
US |