Claims
- 1. A compound of the formula ##STR42## wherein: R.sub.1 is hydrogen, C.sub.1 to C.sub.4 alkyl, a carboxy-substituted alkyl or carboxy-substituted cycloalkyl group represented by the formula ##STR43## wherein m is 0 to 3; a and b when taken separately are independently hydrogen or C.sub.1 to C.sub.3 alkyl, or when taken together with the carbon to which they are attached form a C.sub.3 to C.sub.7 carboxylic ring; R' is hydroxy, amino, C.sub.1 to C.sub.4 alkoxy, or --OR" where R" is a carboxy-protecting group; or R.sub.1 is a secondary amido group of the formula ##STR44## wherein R'" is C.sub.1 to C.sub.4 alkyl, phenyl or C.sub.1 to C.sub.3 alkyl substituted by phenyl; R.sub.8 is hydrogen or an amino protecting group; G is chloro, bromo, hydroxy, C.sub.1 to C.sub.4 alkoxy, phenoxy, or a group of the formula
- --O--J
- wherein J is the residue of a group forming an activated ester; or a group of the formula
- --O.sup..crclbar. M.sup..sym.
- wherein M.sup..sym. is a monovalent cation.
- 2. The compound of claim 1, wherein R.sub.1 is C.sub.1 to C.sub.4 alkyl.
- 3. The compound of claim 2, wherein R.sub.1 is methyl.
- 4. The compound of claim 1, wherein R.sub.8 is hydrogen.
- 5. The compound of claim 1, wherein R.sub.8 is an amino protecting group.
- 6. The compound of claim 5, wherein R.sub.8 is chloroacetyl.
- 7. The compound of claim 1, wherein G is hydroxy.
- 8. The compound of claim 7, wherein R.sub.1 is C.sub.1 to C.sub.4 alkyl.
- 9. The compound of claim 8, wherein R.sub.1 is methyl.
- 10. The compound of claim 9, wherein R.sub.8 is hydrogen.
- 11. The compound of claim 1, wherein G is a group of the formula
- --O--J
- wherein J is the residue of a group forming an activated ester.
- 12. The compound of claim 11, wherein J is ##STR45##
- 13. The compound of claim 11, wherein R.sub.1 is C.sub.1 to C.sub.4 alkyl.
- 14. The compound of claim 13, wherein R.sub.1 is methyl.
- 15. The compound of claim 14, wherein J is ##STR46##
- 16. The compound of claim 15, wherein J is ##STR47##
- 17. The compound of claim 16, wherein R.sub.8 is hydrogen.
- 18. The compound of claim 1, wherein G is C.sub.1 to C.sub.4 alkoxy.
- 19. The compound of claim 18, wherein G is ethoxy.
- 20. The compound of claim 18, wherein R.sub.1 is C.sub.1 to C.sub.4 alkyl.
- 21. The compound of claim 20, wherein R.sub.1 is methyl.
- 22. The compound of claim 21, wherein G is ethoxy.
- 23. The compound of claim 22, wherein R.sub.8 is an amino protecting group.
- 24. The compound of claim 23, wherein R.sub.8 is chloroacetoxy.
- 25. The compound of claim 22, wherein R.sub.8 is hydrogen.
Parent Case Info
This application is a division of application Ser. No. 300,140, filed Sept. 8, 1981.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4152432 |
Iteymes et al. |
May 1979 |
|
4258041 |
O'Callaghan et al. |
Mar 1981 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
300140 |
Sep 1981 |
|