Claims
- 1. An acid having the D configuration in the 7-sidechain and the formula ##STR38## wherein n is one or two, R.sup.1 is hydrogen or formyl and R is ##STR39## and Y is hydrogen, chlorine, bromine, fluorine, trifluoromethyl, amino, nitro, hydroxy, lower alkyl of 1-4 carbon atoms or lower alkoxy of 1-4 carbon atoms or a nontoxic, pharmaceutically acceptable salt thereof.
- 2. The sodium salt of an acid of claim 1.
- 3. The potassium salt of an acid of claim 1.
- 4. A nontoxic, pharmaceutically acceptable salt of an acid of claim 1.
- 5. A pivaloyloxymethyl ester of an acid having the D configuration in the 7-sidechain and the formula ##STR40## wherein n is one or two, R.sup.1 is hydrogen or formyl and R is ##STR41## and Y is hydrogen, chlorine, bromine, fluorine, trifluoromethyl, amino, nitro, hydroxy, lower alkyl of 1-4 carbon atoms or lower alkoxy of 1-4 carbon atoms.
- 6. An acetoxymethyl ester of an acid having the D configuration in the 7-sidechain and the formula ##STR42## wherein n is one or two, R.sup.1 is hydrogen or formyl and R is ##STR43## and Y is hydrogen, chlorine, bromine, fluorine, trifluoromethyl, amino, nitro, hydroxy, lower alkyl of 1-4 carbon atoms or lower alkoxy of 1-4 carbon atoms.
- 7. An acetonyl ester of an acid having the D configuration in the 7-sidechain and the formula ##STR44## wherein n is one or two, R.sup.1 is hydrogen or formyl and R is ##STR45## and Y is hydrogen, chlorine, bromine, fluorine, trifluoromethyl, amino, nitro, hydroxy, lower alkyl of 1-4 carbon atoms or lower alkoxy of 1-4 carbon atoms.
- 8. A phenacyl ester of an acid having the D configuration in the 7-sidechain and the formula ##STR46## wherein n is one or two, R.sup.1 is hydrogen or formyl and R is ##STR47## and Y is hydrogen, chlorine, bromine, fluorine, trifluoromethyl, amino, nitro, hydroxy, lower alkyl of 1-4 carbon atoms or lower alkoxy of 1-4 carbon atoms.
- 9. A methoxymethyl ester of an acid having the D configuration in the 7-sidechain and the formula ##STR48## wherein n is one or two, R.sup.1 is hydrogen or formyl and R is ##STR49## and Y is hydrogen, chlorine, bromine, fluorine, trifluoromethyl, amino, nitro, hydroxy, lower alkyl of 1-4 carbon atoms or lower alkoxy of 1-4 carbon atoms.
- 10. An acid having the D configuration in the 7-sidechain and the formula ##STR50## wherein Y is hydrogen, chlorine, bromine, fluorine, trifluoromethyl, amino, nitro, hydroxy, lower alkyl of 1-4 carbon atoms or lower alkoxy of 1-4 carbon atoms or a nontoxic, pharmaceutically acceptable salt thereof.
- 11. The sodium salt of an acid of claim 10.
- 12. The potassium salt of an acid of claim 10.
- 13. The acid of claim 1 having the D configuration in the 7-sidechain and the formula ##STR51## or a nontoxic, pharmaceutically acceptable salt thereof.
- 14. The sodium salt of the acid of claim 13.
- 15. The potassium salt of the acid of claim 13.
- 16. The acid of claim 1 having the D configuration in the 7-sidechain and the formula ##STR52## or a nontoxic, pharmaceutically acceptable salt thereof.
- 17. The sodium salt of the acid of claim 16.
- 18. The potassium salt of the acid of claim 16.
- 19. An acid of claim 10 having the D configuration in the 7-sidechain and the formula ##STR53## wherein R is chlorophenyl, bromophenyl, trifluoromethylphenyl, tolyl or methoxyphenyl, or a nontoxic, pharmaceutically acceptable salt thereof.
- 20. The sodium salt of an acid of claim 19.
- 21. The potassium salt of an acid of claim 19.
- 22. The acid having the D configuration in the 7-sidechain and the formula ##STR54## or a nontoxic, pharmaceutically acceptable salt thereof.
- 23. The sodium salt of the acid of claim 22.
- 24. The potassium salt of the acid of claim 22.
- 25. The acid having the D configuration in the 7-sidechain and the formula ##STR55## or a nontoxic, pharmaceutically acceptable salt thereof.
- 26. The sodium salt of the acid of claim 25.
- 27. The potassium salt of the acid of claim 25.
- 28. An acid having the D configuration in the 7-sidechain and the formula ##STR56## wherein Y is hydrogen, chlorine, bromine, fluorine, trifluoromethyl, amino, nitro, hydroxy, lower alkyl of 1-4 carbon atoms or lower alkoxy of 1-4 carbon atoms or a nontoxic, pharmaceutically acceptable salt thereof.
- 29. The sodium salt of an acid of claim 28.
- 30. The potassium salt of an acid of claim 28.
- 31. The acid of claim 1 having the D configuration in the 7-sidechain and the formula ##STR57## or a nontoxic, pharmaceutically acceptable salt thereof.
- 32. The sodium salt of the acid of claim 31.
- 33. The potassium salt of the acid of claim 31.
- 34. The acid of claim 1 having the D configuration in the 7-sidechain and the formula ##STR58## or a nontoxic, pharmaceutically acceptable salt thereof.
- 35. The sodium salt of the acid of claim 34.
- 36. The potassium salt of the acid of claim 34.
- 37. An acid of claim 1 having the D configuration in the 7-sidechain and the formula ##STR59## wherein R is chlorophenyl, bromophenyl, trifluoromethylphenyl, tolyl or methoxyphenyl, or a nontoxic, pharmaceutically acceptable salt thereof.
- 38. The sodium salt of an acid of claim 37.
- 39. The potassium salt of an acid of claim 37.
- 40. The acid having the D configuration in the 7-sidechain and the formula ##STR60## or a nontoxic, pharmaceutically acceptable salt thereof.
- 41. The sodium salt of the acid of claim 40.
- 42. The potassium salt of the acid of claim 40.
- 43. The acid having the D configuration in the 7-sidechain and the formula ##STR61## or a nontoxic, pharmaceutically acceptable salt thereof.
- 44. The sodium salt of the acid of claim 43.
- 45. The potassium salt of the acid of claim 43.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of our prior, copending application Ser. No. 705,226 filed July 13, 1976, now abandoned.
US Referenced Citations (11)
Non-Patent Literature Citations (2)
Entry |
Farmdoc Abstract 22850w. |
Farmdoc Abstract 18330x. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
705226 |
Jul 1976 |
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