Claims
- 1. A 7-oxoprostacyclin compound of formula I ##STR8## wherein R.sub.1 is OR.sub.3 or NHR.sub.4 ;
- W is a hydroxymethylene or a ##STR9## group, wherein the OH-group can be respectively esterified with a benzoyl or an alkanoic acid residue of 1-4 carbon atoms or etherified with a tetrahydropyranyl, tetrahydrofuranyl, (C.sub.1 -C.sub.4 -alkoxy)-C.sub.1 -C.sub.4 -alkyl or tri-(C.sub.1 -C.sub.4 -alkyl)-silyl residue, wherein the free or modified OH-group can be in the .alpha.- or .beta.-position;
- D is 2,3-propylene
- R.sub.2 is ethyl;
- R.sub.3 is hydrogen or C.sub.1 -C.sub.10 -alkyl optionally substituted by halogen, phenyl, C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.4 -dialkylamino;
- R.sub.4 is C.sub.1 -C.sub.10 -alkanoyl or C.sub.1 -C.sub.10 -alkanesulfonyl;
- R.sub.5 is a hydroxy group which can be esterified with an alkanoic acid residue of 1-4 carbon atoms or etherified with a tetrahydropyranyl, tetrahydrofuranyl, (C.sub.1 -C.sub.4 -alkoxy)-C.sub.1 -C.sub.4 -alkyl or tri-(C.sub.1 -C.sub.4 -alkyl)silyl residue;
- X is an oxygen atom or the residue --CH.sub.2--;
- and, if R.sub.3 is hydrogen, the salts thereof with physiologically compatible bases.
- 2. A compound of claim 1, wherein X is oxygen.
- 3. A compound of claim 1, wherein X is --CH.sub.2 --.
- 4. (16S)-13,14,18,18,19,19-Hexadehydro-16,20-dimethyl-7-oxo-PGI.sub.2 a compound of claim 1.
- 5. (16S)-13,14,18,18,19,19-Hexadehydro-16,20-dimethyl-3-oxa-7-oxo-PGI.sub.2 a compound of claim 1.
- 6. A pharmaceutical composition comprising an effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
- 7. A method of inhibiting thrombocyte aggregation, comprising administering a compound of claim 1.
- 8. A method of achieving an antihypertensive effect, comprising administering a compound of claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3610556 |
Mar 1986 |
DEX |
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Parent Case Info
This application is a continuation of application Ser. No. 07/146,780, filed Feb. 2, 1988 now abandoned.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/DE87/00132 |
3/25/1987 |
|
|
2/2/1988 |
2/2/1988 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO87/05900 |
10/8/1987 |
|
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Number |
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Date |
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3923861 |
Nelson |
Dec 1975 |
|
4330553 |
Simonidesz et al. |
May 1982 |
|
4466969 |
Nickolson et al. |
Aug 1984 |
|
4499293 |
Johnson et al. |
Feb 1985 |
|
4687864 |
Djuric et al. |
Aug 1987 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
0119949 |
Sep 1984 |
EPX |
8502187 |
May 1985 |
WOX |
Non-Patent Literature Citations (2)
Entry |
Bindra et al., Prostaglandin Synthesis, Academic Press, N.Y., pp. 453, 460, 461, 471 (1977). |
Skerballa et al. I, Adv. in Prostaglandin Thromboxane, Leukotriene Research, vol. 15 (Raven Press), pp. 271-273 (1985). |
Continuations (1)
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Number |
Date |
Country |
Parent |
146780 |
Feb 1988 |
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