Claims
- 1. A 7-substituted fused ring tetracycline compound of the formula:
- 2. The compound of claim 1, wherein R5, R6 and R6′ are each hydrogen and R4 and R4′ are each methyl.
- 3. The compound of claim 1, wherein Y and Y′ are each oxygen.
- 4. The compound of claim 1, wherein m is 1.
- 5. The compound of claim 1, wherein said compound is 7-(3′,4′-methylene dioxyphenyl)sancycline.
- 6. A method for treating a tetracycline responsive state in a mammal, comprising administering to said mammal a 7-substituted fused ring tetracycline compound of formula (I):
- 7. The method of claim 6 wherein R5, R6 and R6′ are each hydrogen and R4 and R4′ are each methyl.
- 8. The method of claim 6, wherein Y and Y′ are each oxygen.
- 9. The method of claim 6, wherein m is 1.
- 10. The method of claim 7, wherein said compound is 7-(3′,4′-methylene dioxyphenyl)sancycline.
- 11. The method of claim 7, wherein said tetracycline responsive state is a bacterial infection.
- 12. The method of claim 11, wherein said bacterial infection is associated with E. coli.
- 13. The method of claim 11, wherein said bacterial infection is associated with S. aureus.
- 14. The method of claim 11, wherein said bacterial infection is associated with E. faecalis.
- 15. The method of claim 11, wherein said bacterial infection is resistant to other tetracycline antibiotics.
- 16. The method of claim 11, wherein said compound is administered with a pharmaceutically acceptable carrier.
- 17. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
- 18. The pharmaceutical composition of claim 16, wherein said compound is 7-(3′,4′-methylene dioxyphenyl)sancycline.
RELATED APPLICATIONS
[0001] This application is a continuation of U.S. patent application Ser. No. 09/852,908, filed May 10, 2001, Issuing, which claims priority to U.S. Provisional Patent Application Serial No.: 60/204,158, filed on May 15, 2000. The entire contents each of the aforementioned applications are hereby incorporated herein by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60204158 |
May 2000 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09852908 |
May 2001 |
US |
Child |
10652712 |
Aug 2003 |
US |