Claims
- 1. A compound of the formula ##STR2## wherein R is CF.sub.3 or CF.sub.3 CH.sub.2 ;
- n is 0, 1, or 2;
- X is SHet; and
- Het is tetrazolyl, triazolyl, thiadiazolyl, or oxadiazolyl, each unsubstituted or substituted with 1 or 2 alkyl groups of 1-4 carbon atoms,
- or a pharmaceutically acceptable salt thereof.
- 2. A compound as claimed in claim 1 where Het is tetrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, 1,3,4-thiadiazolyl, or 1,3,4-oxadiazolyl, each unsubstituted or substituted with 1 or 2 methyl groups.
- 3. A compound as claimed in claim 2 being the compound 7.alpha.-methoxy-7.beta.-trifluoromethylmercaptoacetamido-3-(1-methyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid.
- 4. A compound as claimed in claim 2 being the compound 7.alpha.-methoxy-7.beta.-trifluoromethylmercaptoacetamido-3-(1,2,3-triazol-4-ylthiomethyl)-3-cephem-4-carboxylic acid.
- 5. A compound as calimed in claim 2 being the compound 7.alpha.-methoxy-7.beta.-trifluoromethylmercaptoacetamido-3-(4-methyl-1,2,4-triazol-3-ylthiomethyl)-3-cephem-4-carboxylic acid.
- 6. A compound as claimed in claim 2 being the compound 7.alpha.-methoxy-7.beta.-trifluoromethylmercaptoacetamido-3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid.
- 7. A compound as claimed in claim 2 being the compound 7.alpha.-methoxy-7.beta.-trifluoromethylmercaptoacetamido-3-(5-methyl-1,3,4-oxadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid.
- 8. A compound as claimed in claim 2 being the compound 7.alpha.-methoxy-7.beta.-trifluoromethylsulfinylacetamido-3-(1-methyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid.
- 9. A compound as claimed in claim 2 being the compound 7.alpha.-methoxy-7.beta.-trifluoroethylmercaptoacetamido-3-(1-methyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid.
- 10. A compound as claimed in claim 2 being the compound 7.alpha.-methoxy-7.beta.-trifluoroethylsulfinylacetamido-3-(1-methyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid.
Parent Case Info
This is a continuation-in-part of copending application Ser. No. 504,619, filed Sept. 9, 1974, now abandoned.
US Referenced Citations (7)
Foreign Referenced Citations (2)
Number |
Date |
Country |
2,455,884 |
May 1975 |
DT |
1,023,285 |
Feb 1976 |
JA |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
504619 |
Sep 1974 |
|