Claims
- 1. A compound having the formula: ##STR11## wherein R.sub.1 is selected from the group consisting of hydrogen, alkyl(C.sub.1 -C.sub.6), phenyl and substituted phenyl wherein the substituents are alkyl(C.sub.1 -C.sub.6); R.sub.2 is selected from the group consisting of hydrogen, diphenylmethyl, .alpha.-acyloxyalkyl, t-butyl, benzyl, 4-nitrobenzyl and 4-methoxybenzyl and pharmaceutically acceptable salts selected from the group consisting of sodium and potassium; and R.sub.3 is selected from the group consisting of ##STR12## and 2-thienylacetyl; and R.sub.4 is selected from the group consisting of hydrogen, --O--alkyl, --S--alkyl and formamido.
- 2. The compound according to claim 1, (Z)-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(5-phenyl-1,2,3-thiadiazol-4-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.
- 3. The compound according to claim 1, (Z)-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[5-[4-(1,1-dimethylethyl)phenyl]-1,2,3-thiadiazol-4-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.
- 4. The compound according to claim 1, (Z)-3-[[[5-(1,1-dimethylethyl)-1,2,3-thiadiazol-4-yl]thio]methyl]-7-[[(methoxyimino)[2-[(triphenylmethyl)amino]-4-thiazolyl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]-oct-2-ene-2-carboxylic acid, diphenylmethyl ester.
- 5. The compound according to claim 1, (Z)-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[5-(1,1-dimethylethyl)-1,2,3-thiadiazol-4-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]-oct-2-ene-2-carboxylic acid.
- 6. The compound according to claim 1, (6R-trans)-3-[[(5-methyl-1,2,3-thiadiazol-4-yl)thio]methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 1,1-dimethylethyl ester.
- 7. The compound according to claim 1, (6R-trans)-3-[[(5-methyl-1,2,3-thiadiazol-4-yl]thio]methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.
- 8. The compound according to claim 1, (6R-trans)-3-[[(5-ethyl-1,2,3-thiadiazol-4-yl)thio]methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid, 1,1-dimethylethyl ester.
- 9. The compound according to claim 1, (6R-trans)-3-[[(5-ethyl-1,2,3-thiadiazol-4-yl)thio]methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.
- 10. The compound according to claim 1, (6R-trans)-7-[[[(2-triphenylmethylamino)-4-thiazolyl](methoxyimino)acetyl]amino]-3-[[(5-methyl-1,2,3-thiadiazol-4-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 1,1-dimethylethyl ester.
- 11. The compound according to claim 1, [6R-[6.alpha.,7.beta.(Z)]]-7-[[(2-amino-4-thiazolyl(methoxyimino)acetyl]amino]-3-[[(5-methyl-1,2,3-thiadiazol-4-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.
- 12. The compound according to claim 1, (6R-trans)-7-[[[(2-triphenylmethylamino)-4-thiazolyl](methoxyimino)acetyl]amino]-3-[[[5-ethyl-1,2,3-thiadiazol-4-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 1,1-dimethylethyl ester.
- 13. The compound according to claim 1, [6R-[6.alpha.,7.beta.(Z)]]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(5-ethyl-1,2,3-thiadiazol-4-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.
- 14. The compound according to claim 1, (Z)-7-[[(2-amino-4-thiazolyl)methoxyimino)acetyl]amino]-3-[[[5-ethyl-1,2,3-thiadiazol-4-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, acetoxymethyl ester.
- 15. The compound according to claim 1, (Z)-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[5-ethyl-1,2,3-thiadiazol-4-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, ethoxycarbonylethoxy ester.
- 16. The compound of claim 1, wherein R.sub.1 is hydrogen.
- 17. The compound of claim 1, wherein R.sub.1 is methyl.
- 18. The compound of claim 1, wherein R.sub.1 is ethyl.
- 19. The compound of claim 1, wherein R.sub.1 is n-propyl.
- 20. The compound of claim 1, wherein R.sub.1 is isopropyl.
- 21. The compound of claim 1, wherein R.sub.1 is n-butyl.
Parent Case Info
This application is a continuation-in-part of Ser. No. 882,996, filed July 8, 1986, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4399132 |
Curran et al. |
Aug 1983 |
|
4692519 |
Naitor et al. |
Sep 1987 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
882996 |
Jul 1986 |
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