Claims
- 1. 8.alpha.-(N,N-diethylsulfamoylamino)-6-n-propylergoline in free base form or in pharmaceutically acceptable acid addition salt form.
- 2. A pharmaceutical composition which comprises a compound of claim 1 in free base form or in pharmaceutically acceptable acid addition salt form in association with a pharmaceutically carrier or diluent.
- 3. A method of inhibiting prolactin secretion in a subject in need of said treatment which comprises administering a therapeutically effective amount of a compound of claim 1 to a subject in need of such treatment.
- 4. A method of treating Morbus Parkinson in a subject in need of said treatment which comprises administering a therapeutically effective amount of a compound of claim 1 to a subject in need of such treatment.
- 5. A method of treating depression in a subject in need of said treatment which comprises administering a therapeutically effective amount of a compound of claim 1 to a subject in need of such treatment.
- 6. The compound of claim 1 which is the hydrochloride salt of 8-(N,N-diethylsulfamoylamino)-6-n-propylergoline.
Priority Claims (5)
Number |
Date |
Country |
Kind |
5723/80 |
Jul 1980 |
CHX |
|
5724/80 |
Jul 1980 |
CHX |
|
7359/80 |
Oct 1980 |
CHX |
|
7358/80 |
Oct 1980 |
CHX |
|
7360/80 |
Oct 1980 |
CHX |
|
Parent Case Info
This is a continuation of application Ser. No. 856,602, filed Apr. 25, 1986, now abandoned, which in turn is a continuation of application Ser. No. 787,220, filed Oct. 15, 1985, now abandoned, which in turn is a continuation of application Ser. No. 604,992, filed Apr. 27, 1984, now abandoned, which in turn is a continuation-in-part of application Ser. No. 349,503, filed Feb. 17, 1982, now abandoned, which in turn is a continuation-in-part of application Ser. No. 286,417, filed July 24, 1981, now abandoned.
US Referenced Citations (5)
Number |
Name |
Date |
Kind |
4180582 |
Kornfeld et al. |
Dec 1979 |
|
4202279 |
Kornfeld et al. |
May 1980 |
|
4348391 |
Stutz et al. |
Sep 1982 |
|
4348392 |
Fehr et al. |
Sep 1982 |
|
4379790 |
Horowski et al. |
Apr 1983 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
605938 |
Oct 1978 |
CHX |
1517971 |
Jul 1978 |
GBX |
1567484 |
Mar 1980 |
GBX |
Non-Patent Literature Citations (6)
Entry |
Clemens et al., Chemical Regulation of Biological Mechanisms, pp. 167-180. |
Fuller et al., Neuroendocrinology 36, 285-290, 1983. |
Fuller et al., Endocrinolgy, vol. 109, No. 4, pp. 1026-1032, (1981). |
Lemberger et al., Science, vol. 205, (1979), p. 1151. |
Clemens et al., IRCS Medical Science: Biochemistry; Nervous System; Pharmacology; Psychology and Psychiatry 6, 427. |
Nakamura et al., Communication in Psychopharmacology, vol. 3, pp. 179-183, (1979). |
Continuations (3)
|
Number |
Date |
Country |
Parent |
856602 |
Apr 1986 |
|
Parent |
787220 |
Oct 1985 |
|
Parent |
604992 |
Apr 1984 |
|
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
349503 |
Feb 1982 |
|
Parent |
286417 |
Jul 1981 |
|