Claims
- 1. A compound of the formula ##STR12## wherein: R.sup.1 is hydroxy, cyano, or CONR.sup.4 R.sup.5 in which R.sup.4 and R.sup.5 independently are hydrogen or C.sub.1 -C.sub.6 alkyl;
- R.sup.2 and R.sup.3 independently are hydrogen, C.sub.1 -C.sub.6 alkyl, CH.sub.2 C.sub.2 -C.sub.5 alkenyl, phenyl-C.sub.1 -C.sub.3 alkyl, or taken together with the nitrogen to which they are attached are a cyclic group of the formula ##STR13## in which R.sup.8 is hydrogen or C.sub.1 -C.sub.4 alkyl; A is CH.sub.2, O or NH; and y is zero or one; provided that R.sup.2 is hydrogen when R.sup.1 is hydroxy;
- n is 3, 4 or 5;
- R.sup.6 and R.sup.7 independently are hydrogen, C.sub.1 -C.sub.4 alkyl or halogen,
- and the pharmaceutically acceptable salts thereof.
- 2. The compound of claim 1 wherein:
- R.sup.1 is hydroxy, cyano, or CONR.sup.4 R.sup.5 in which R.sup.4 and R.sup.5 independently are hydrogen or C.sub.1 -C.sub.6 alkyl;
- n is 3 or 4;
- R.sup.2 and R.sup.3 independently are hydrogen, C.sub.1 -C.sub.6 alkyl, CH.sub.2 C.sub.2 -C.sub.5 alkenyl, phenyl-C.sub.1 -C.sub.3 alkyl, or taken together are C.sub.4 -C.sub.5 alkylene or --CH.sub.2 CH.sub.2 --O--CH.sub.2 CH.sub.2 --;
- R.sup.6 and R.sup.7 are hydrogen;
- and the pharmaceutically acceptable acid addition salts and lower alkyl quaternary ammonium salts thereof.
- 3. The compound of claim 2 wherein R.sup.1 is hydroxy, R.sup.2 is hydrogen and R.sup.3 is C.sub.1 -C.sub.6 alkyl.
- 4. The compound of claim 3 wherein R.sup.3 is C.sub.1 -C.sub.3 alkyl.
- 5. The compound of claim 4 wherein R.sup.3 is methyl.
- 6. The compound of claim 4 wherein R.sup.3 is ethyl.
- 7. The compound of claim 4 wherein R.sup.3 is n-propyl.
- 8. The compound of claim 4 wherein R.sup.3 is iso-propyl.
- 9. The compound of claim 1 wherein R.sup.1 is cyano.
- 10. The compound of claim 9 wherein R.sup.3 is C.sub.1 -C.sub.6 alkyl.
- 11. The compound of claim 10 wherein R.sup.3 is C.sub.1 -C.sub.3 alkyl.
- 12. The compound of claim 11 wherein R.sup.3 is iso-propyl.
- 13. The compound of claim 1 wherein R.sup.1 is CONR.sup.4 R.sup.5.
- 14. The compound of claim 13 wherein R.sup.4 and R.sup.5 both are hydrogen.
- 15. The compound of claim 14 wherein R.sup.6 and R.sup.7 both are hydrogen.
- 16. The compound of claim 15 wherein R.sup.3 is C.sub.1 -C.sub.6 alkyl.
- 17. The compound of claim 16 wherein R.sup.2 is hydrogen.
- 18. The compound of claim 17 wherein R.sup.3 is C.sub.1 -C.sub.3 alkyl.
- 19. The compound of claim 18 wherein n is 3.
- 20. The compound of claim 19 wherein R.sup.3 is methyl or ethyl.
- 21. The compound of claim 19 wherein R.sup.3 is n-propyl.
- 22. The compound of claim 18 wherein R.sup.3 is iso-propyl.
- 23. The compound of claim 22, said compound being 9-(3-isopropylaminopropyl)-9-aminocarbonylfluorene.
- 24. The compound of claim 1 as a pharmaceutically acceptable acid addition salt.
- 25. The compound of claim 24, said compound being 9-(3-isopropylaminopropyl)-9-aminocarbonylfluorene hydrochloride.
- 26. The compound of claim 24, said compound being 9-(3-isopropylaminopropyl)-9-aminocarbonylfluorene hydrobromide.
- 27. The compound of claim 1 as a C.sub.1 -C.sub.6 alkyl quaternary ammonium salt.
- 28. The compound of claim 1 wheren n is 4.
- 29. The compound of claim 1 wheren n is 5.
Parent Case Info
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a division of application Ser. No. 232,281, filed Feb. 6, 1981, now U.S. Pat. No. 4,382,093, which is a division of Ser. No. 141,228, filed Apr. 17, 1980, now U.S. Pat. No. 4,227,495, which is a continuation-in-part of Ser. No. B 019,533, filed Mar. 12, 1979, now abandoned.
US Referenced Citations (7)
Foreign Referenced Citations (1)
Number |
Date |
Country |
960758 |
Jun 1964 |
GBX |
Non-Patent Literature Citations (9)
Entry |
Wheatley et al., J. Org. Chem. 19, 794-801 (1954). |
Libman et al., Chem. Abs. 59, 561 (1963). |
Miocque et al., Chem. Abs. 61, 8267 (1964). |
Boehringer et al., Chem. Abs. 59, 13906-13907 (1963). |
Boehringer et al., Chem. Abs. 70, 37664 (1969). |
Bonvicino et al., Chem. Abs. 55, 27340-27343 (1961). |
Boehringer, Chem. Abs. 64, 14199 (1966). |
Gautier et al., Bull Soc. Chim. Fr., 11, 3162 (1965). |
Boehringer, Chem. Abs. 70, 3442 (1969). |
Divisions (2)
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Number |
Date |
Country |
Parent |
232281 |
Feb 1981 |
|
Parent |
141228 |
Apr 1980 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
19533 |
Mar 1979 |
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