Claims
- 1. A pharmaceutical formulation useful in the treatment of cardiac arrhythmias which comprises a carrier or diluent admixed with an antiarrhythmic amount of a 9-aminoalkylfluorene antiarrhythmic agent of the formula ##STR12## wherein: R.sup.o is hydroxy, cyano, CONR.sup.4 R.sup.5 or COOR.sup.9 in which R.sup.4 and R.sup.5 independently are hydrogen or C.sub.1 -C.sub.6 alkyl and R.sup.9 is hydrogen or C.sub.1 -C.sub.4 alkyl;
- R.sup.2 and R.sup.3 independently are hydrogen, C.sub.1 -C.sub.6 alkyl, CH.sub.2 C.sub.2 -C.sub.5 alkenyl, phenyl-C.sub.1 -C.sub.3 alkyl; or taken together with the nitrogen to which they are attached are a cyclic group of the formula ##STR13## in which R.sup.8 is hydrogen or C.sub.1 -C.sub.4 alkyl; A is CH.sub.2, O or NH; and y is zero or one; provided that R.sup.2 is hydrogen when R.sup.1 is hydroxy;
- n is 3, 4 or 5;
- R.sup.6 and R.sup.7 independently are hydrogen, C.sub.1 -C.sub.4 alkyl or halogen; and the pharmaceutically acceptable salts thereof.
- 2. The formulation of claim 1 wherein R.sup.o is hydroxy, cyano or CONR.sup.4 R.sup.5.
- 3. The formulation of claim 2 wherein n is 3.
- 4. The formulation of claim 3 wherein R.sup.2 is hydrogen.
- 5. The formulation of claim 4 wherein R.sup.3 is C.sub.1 -C.sub.6 alkyl.
- 6. The formulation of claim 5 wherein R.sup.6 and R.sup.7 both are hydrogen.
- 7. The formulation of claim 6 wherein R.sup.3 is C.sub.1 -C.sub.3 alkyl.
- 8. The formulation of claim 7 wherein R.sup.3 is isopropyl.
- 9. The formulation of claim 8 wherein the active ingredient is 9-(3-isopropylaminopropyl)-9-aminocarbonylfluorene.
- 10. The formulation of claim 6 wherein the active ingredient is a pharmaceutically acceptable salt.
- 11. The formulation of claim 10 wherein the active ingredient is 9-(3-isopropylaminopropyl)-9-aminocarbonylfluorene hydrochloride.
- 12. The formulation of claim 1 wherein R.sup.o is COOR.sup.9.
- 13. The formulation of claim 12 wherein R.sup.9 is C.sub.1 -C.sub.4 alkyl.
- 14. The formulation of claim 1 wherein n is 4.
- 15. The formulation of claim 1 wherein n is 5.
CROSS-REFERENCE TO RELATED APPLICATIONS
This is a division of Ser. No. 141,228, filed Apr. 17, 1980, now U.S. Pat. No. 4,277,495, which is a continuation-in-part of application Ser. No. 19,533, filed Mar. 12, 1979, now abandoned.
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3660485 |
Cusic et al. |
May 1972 |
|
3843657 |
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|
4197313 |
Lacefield et al. |
Apr 1980 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
960758 |
Jun 1964 |
GBX |
Non-Patent Literature Citations (6)
Entry |
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Libman et al., Chem. Abs., 59, 561 (1963). |
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Divisions (1)
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Number |
Date |
Country |
Parent |
141228 |
Apr 1980 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
19533 |
Mar 1979 |
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