Claims
- 1. A compound of the formula
- wherein Y is CHOH; R.sup.1 is hydrogen or loweralkyl; R.sup.2 is hydrogen, loweralkyl, or phenylloweralkyl; R.sup.3 is OR.sup.4 wherein R.sup.4 is hydrogen, COR.sup.5 wherein R.sup.5 is loweralkyl, X is hydrogen, loweralkyl, halogen, loweralkoxy, hydroxy, or trifluoromethyl, the geometric or optical isomers thereof, N-oxides thereof, or the pharmaceutically acceptable acid addition salts thereof.
- 2. A compound according to claim 1 wherein Y is CHOH and R.sup.3 is OR.sup.4 wherein R.sup.4 is hydrogen.
- 3. The compound according to claim 2 which is 9-amino-1,2,3,4-tetrahydro-1,4-acridinediol, having a melting point of 200.degree. C. (dec).
- 4. The compound according to claim 2 which is 9-amino-1,2,3,4-tetrahydro-1,4-acridinediol, having a melting point of 183.degree. C. (dec).
- 5. The compound according to claim 2 which is 9-amino-1,2,3,4-tetrahydro-1,3-acridinediol, having a melting point of 158.degree.-162.degree. C.
- 6. The compound according to claim 2 which is 9-amino-1,2,3,4-tetrahydro-1,3-acridinediol, having a melting point of 139.degree.-141.degree. C.
- 7. A method of relieving memory dysfunction in mammals comprising administering to a mammal requiring memory dysfunction relief, a memory dysfunction relieving effective amount of a compound of claim 1.
- 8. A memory of dysfunction relieving composition comprising and adjuvant and as the active ingredient, a memory dysfunction relieving effective amount of a compound of claim 1.
Parent Case Info
This is a division, of application Ser. No. 07/654,691 filed Feb. 13, 1991, U.S. Pat. No. 5,210,087.
US Referenced Citations (3)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0179383 |
Apr 1986 |
EPX |
Non-Patent Literature Citations (3)
Entry |
A. A. Akhrem, et al., Synthesis, p. 43 (Jan. 1978), entitled "A Convenient One-Step Synthesis of Tetrahydrobenzisoxazoles via 1,3-Cycloaddition of Nitrile Oxides to Cyclohexane-1,3-dione Derivatives" and published in Russia. |
G. M. Shutske, Journal of Heterocyclic Chemistry, vol. 27, pp. 1617 to 1621 (Sep. 1990) entitled "A Novel Synthesis of the Isoxazolo[5,4,3-kl]acridine Ring System"& published in the U.S. |
Shutske et al., Journal of Medicinal Chemistry, vol. 32, No. 8, pp. 1805-1813 Aug. 1989. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
654691 |
Feb 1991 |
|