Claims
- 1. A prostaglandin analog of formula VI ##STR2## wherein Y.sub.1 is trans--CH.dbd.CH--, --C.tbd.C--, --CH.sub.2 CH.sub.2 --, or cis--CH.dbd.CH--;
- wherein M.sub.1 is .alpha.-R.sub.5 :.beta.-OH or .alpha.-OH:.beta.-R.sub.5, wherein R.sub.5 is hydrogen or methyl;
- wherein L.sub.1 is .alpha.-R.sub.3 :.beta.-R.sub.4, .alpha.-R.sub.4 :.beta.-R.sub.3, or a mixture of .alpha.-R.sub.3 :.beta.-R.sub.4 and .alpha.-R.sub.4 :.beta.-R.sub.3 wherein R.sub.3 and R.sub.4 are hydrogen, methyl, or fluoro, being the same or different, with the proviso that one of R.sub.3 and R.sub.4 is fluoro only when the other is hydrogen or fluoro;
- wherein g is 3, 4, or 5;
- wherein m is one to 5, inclusive, and
- wherein L.sub.4 is
- (a) amino of the formula --NR.sub.21 R.sub.22, wherein R.sub.21 and R.sub.22 are
- (i) hydrogen;
- (ii) alkyl or one to 12 carbon atoms, inclusive;
- (iii) cycloalkyl of 3 to 10 carbon atoms, inclusive;
- (iv) aralkyl of 7 to 12 carbon atoms, inclusive;
- (v) phenyl;
- (vi) phenyl substituted with one, 2 or 3 chloro, alkyl of one to 3 carbon atoms, inclusive, hydroxy, carboxy, alkoxycarbonyl of one to 4 carbon atoms, inclusive, or nitro;
- (vii) carboxyalkyl of 2 to 5 carbon atoms, inclusive;
- (viii) carbamoylalkyl of 2 to 5 carbon atoms, inclusive;
- (ix) cyanoalkyl of 2 to 5 carbon atoms, inclusive;
- (x) acetylalkyl of 3 to 6 carbon atoms, inclusive;
- (xi) benzoylalkyl of 7 to 11 carbon atoms, inclusive;
- (xii) benzoylalkyl substituted by one, 2 or 3 carbon atoms, inclusive, hydroxy, alkoxy of one to 3 carbon atoms, inclusive, carboxy, alkoxycarbonyl of one to 4 carbon atoms, inclusive, or nitro;
- (xiii) pyridyl;
- (xiv) pyridyl substituted by one, 2 or 3 chloro, alkyl of one to 3 carbon atoms, inclusive, or alkoxy of one to 3 carbon atoms, inclusive;
- (xv) pyridylalkyl of 6 to 9 carbon atoms, inclusive;
- (xvi) pyridylalkyl substituted by one, 2 or 3 carbon atoms, inclusive, hydroxy or alkoxy of one to 3 carbon atoms, inclusive;
- (xvii) hydroxyalkyl of one to 4 carbon atoms, inclusive;
- (xviii) dihydroxyalkyl of one to 4 carbon atoms; or
- (xix) trihydroxyalkyl of one to 4 carbon atoms;
- with the further proviso that not more than one of R.sub.21 and R.sub.22 is other than hydrogen or alkyl;
- (b) cycloamino selected from the group consisting of
- (i) pyrrolidino,
- (ii) piperidino,
- (iii) morpholino,
- (iv) piperazino,
- (v) hexamethyleneimino,
- (vi) pyrrolino,
- (vii) 3,4-didehydropiperidinyl, or
- (viii) pyrrolidino, piperidino, morpholino, piperazino, hexamethyleneimino, pyrrolino, or 3,4-didehydropiperidinyl substituted by one or two alkyl of one to 12 carbon atoms, inclusive;
- (c) carbonylamino of the formula--NR.sub.23 COR.sub.21, wherein R.sub.23 is hydrogen or alkyl of one to 4 carbon atoms and R.sub.21 is other than hydrogen, but otherwise as defined above; or
- (d) sulfonylamino of the formula --NR.sub.23 SO.sub.2 R.sub.21, wherein R.sub.21 and R.sub.23 are as defined in (c).
CROSS REFERENCE TO RELATED APPLICATIONS
The present application is a divisional application of U.S. Ser. No. 035,144, filed May 1, 1979, now pending.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4123441 |
Johnson |
Oct 1978 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
35144 |
May 1979 |
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