TREA

9-Deoxy-9-methylene-PGE compounds

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Information

  • Patent Grant
  • 4461917
  • Patent Number
    4,461,917
  • Date Filed
    Monday, September 12, 1977
    46 years ago
  • Date Issued
    Tuesday, July 24, 1984
    39 years ago
Information
Abstract
This invention comprises certain analogs PGE or 11-deoxy-PGE compounds in which the carbonyl at C-9 is replaced by methylene. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
Description
Claims
  • 1. A prostaglandin analog of the formula ##STR1## wherein Y.sub.1 is trans--CH.dbd.CH--, --C.tbd.C--, or --CH.sub.2 CH.sub.2 --;
  • wherein M.sub.1 is ##STR2## wherein R.sub.5 is hydrogen or methyl; wherein L.sub.1 is ##STR3## or a mixture of ##STR4## wherein R.sub.3 and R.sub.4 are hydrogen, methyl, or fluoro, being the same or different, with the proviso that one of R.sub.3 and R.sub.4 is fluoro only when the other is hydrogen or fluoro;
  • wherein g is one, 2 or 3; and
  • wherein m is one to 5, inclusive.
CROSS REFERENCE TO RELATED APPLICATIONS

The present application is a divisional application of Ser. No. 682,848, filed May 4, 1976, now issued as U.S. Pat. No. 4,060,534 on Nov. 29, 1977; which is a continuation-in-part of Ser. No. 651,622 filed Jan. 23, 1976, issued as U.S. Pat. No. 4,021,467 on May 3, 1977; which is a division of Ser. No. 556,768, filed Mar. 10, 1975, issued as U.S. Pat. No. 3,950,363 on Apr. 13, 1976.

US Referenced Citations (1)
Number Name Date Kind
4060534 Bundy Nov 1977
Non-Patent Literature Citations (1)
Entry
Samuelsson et al, Advances in Prostaglandin and Thromboxane Research, vol. 1 (1976) 488-491.
Divisions (2)
Number Date Country
Parent 682848 May 1976
Parent 556768 Mar 1975
Continuation in Parts (1)
Number Date Country
Parent 651622 Jan 1976