Claims
- 1. A compound having the formula ##STR32## wherein R.sub.1 is selected from the group consisting of hydrogen, alkanoyl having from one to five carbon atoms and --CO--(CH.sub.2).sub.p --NR.sub.2 R.sub.3 wherein p is 0 or an integer from 1 to 4; each of R.sub.2 and R.sub.3 when taken individually is selected from the group consisting of hydrogen and alkyl having from one to four carbon atoms; R.sub.2 and R.sub.3 when taken together with the nitrogen to which they are attached form a 5- or 6-membered heterocyclic ring selected from the group consisting of piperidino, pyrrolo, pyrrolidino, morpholino and N-alkylpiperazino having from one to four carbon atoms in the alkyl group;
- each of R.sub.4 and R.sub.5 is selected from the group consisting of hydrogen, methyl and ethyl;
- R.sub.0 is selected from the group consisting of oxo and alkylenedioxy having from two to four carbon atoms;
- Z is --(alk.sub.1).sub.m --X--(alk.sub.2).sub.n -- wherein each of (alk.sub.1) and (alk.sub.2) has from 1 to 9 carbon atoms, with the proviso that the summation of carbon atoms in (alk.sub.1) plus (alk.sub.2) is not greater than 9;
- each of m and n is 0 or 1;
- X is selected from the group consisting of O, S, SO and SO.sub.2 ; and
- W is selected from the group consisting of methyl, pyridyl, piperidyl, ##STR33## wherein W.sub.1 is selected from the group consisting of hydrogen, fluoro and chloro; and ##STR34## wherein W is selected from the grup consisting of hydrogen and ##STR35## and a is an integer from 1 to 5 and b is 0 or an integer from 1 to 5; with the proviso that the sum of a and b is not greater than 5.
- 2. A compound according to claim 1 wherein R.sub.0 is oxo.
- 3. A compound according to claim 2 wherein each of R.sub.4 and R.sub.5 is methyl and W is ##STR36## wherein W.sub.1 is hydrogen.
- 4. A compound according to claim 3 wherein Z is --(alk.sub.1).sub.m --O--(alk.sub.2).sub.n --.
- 5. A compound according to claim 4 wherein m is 0 and n is 1.
- 6. A compound according to claim 4 wherein m is 1 and n is 0.
- 7. The compound according to claim 4 wherein each of m and n is 0.
- 8. The compound according to claim 5 wherein --(alk.sub.2)-- is --CH(CH.sub.3)--(CH.sub.2).sub.3 --.
- 9. The compound according to claim 5 wherein --(alk.sub.2)-- is --CH(CH.sub.3)--(CH.sub.2).sub.2 --.
- 10. The compound according to claim 6 wherein --(alk.sub.1)-- is --CH(CH.sub.3)--(CH.sub.2).sub.3 --.
- 11. The compound according to claim 6 wherein --(alk.sub.1)-- is --CH(CH.sub.3)--(CH.sub.2).sub.2 --.
- 12. A compound according to claim 2 wherein each of R.sub.4 and R.sub.5 is methyl and W is methyl.
- 13. A compound according to claim 12 wherein Z is --(alk.sub.1).sub.m --O--(alk.sub.2).sub.n --.
- 14. A compound according to claim 13 wherein m is 0 and n is 1.
- 15. The compound according to claim 14 wherein (alk.sub.2) is --CH(CH.sub.3)--(CH.sub.2).sub.4 --.
- 16. A process for producing an anti-hypertensive effectn in a mammal which comprises administering to the mammal an antihypertensive producing quantity of a compound of claim 1.
- 17. The process of claim 16 wherein R.sub.0 is oxo.
- 18. The process of claim 17 wherein each of R.sub.4 and R.sub.5 is methyl and W is ##STR37## wherein W.sub.1 is hydrogen.
- 19. The process of claim 18 wherein Z is --(alk.sub.1).sub.m --O--(alk.sub.2).sub.n --.
- 20. The process of claim 19 wherein m is 0 and n is 1.
- 21. The process of claim 20 wherein --(alk.sub.2)-- is --CH(CH.sub.3)--(CH.sub.2).sub.3 --.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation of application Ser. No. 730,672 filed Oct. 7, 1976 and now abandoned which in turn is a continuation-in-part of application Ser. No. 628,210, filed Nov. 3, 1975 and now abandoned.
US Referenced Citations (3)
Continuations (1)
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Date |
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Parent |
730672 |
Oct 1976 |
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Continuation in Parts (1)
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Number |
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628210 |
Nov 1975 |
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