A Fiber Optic Fluorence Detector for the Lithium Ion

Information

• NSF Award
• 8960187

Owner

• COVALENT ASSOCIATES, INC.

• Award Id

  8960187

• Award Effective Date

  1/1/1990 - 34 years ago

• Award Expiration Date

  9/30/1990 - 33 years ago

• Award Amount

  $ 50,000.00

• Award Instrument

  Standard Grant

It is proposed to develop a fiber optic probe for lithium ion based on new fluorescent lithium ion carriers immobilized on fiber optic bundles by Langmuir-Blodgett film techniques. In Phase I the new fluorescent ionophore will be synthesized and tested for Li/Na specificity. Optical properties will also be investigated to determine suitability for use in a fiber optic probe. Following, some additional analog of the flourophores prepared in Phase I will be synthesized. Those having the best specificities and optical properties for lithium will be used to prepare fiber optic probes. The probes will be used to develop a method for determination of Li+ ion in the blood serum of patients being treated with lithium for manic/depressive psychosis. Immediate application of the lithium ion sensor is in an inexpensive instrument for determination of Li+ in the blood of manic/depressive patients using Li therapy. The use of L-B films as a means of immobilizing specific fluorescent chelator will have much broader application in the preparation of ion sensors for other metal ions.

• Program Officer

  Ritchie B. Coryell

• Min Amd Letter Date

  12/27/1989 - 34 years ago

• Max Amd Letter Date

  12/27/1989 - 34 years ago

• ARRA Amount

• Name

  Covalent Associates Incorporated

• City

  WOBURN

• State

  MA

• Country

  United States

• Address

  10 STATE ST

• Postal Code

  018011682

• Phone Number

  6179381140

• First Name

  Margaret

• Last Name

  Langmuir

• Email Address

  langmuir@covalent.usa1.com

• Start Date

  1/1/1990 12:00:00 AM