Research Project
10156640
Abstract The alarming scope of the rapidly growing opioid epidemic has commanded the nation?s attention. The White House?s Council of Economic Advisers estimates that in 2015, the economic cost of the opioid crisis was over $504.0 billion (2.8% of GDP); and it is only expected to continue rising. Today, 1 in 5 fatalities amongst young adults is opioid related; with half a million fatal overdoses projected over the next decade. Due to the high cost in lives, dollars associated with non-fatal overdosing, and expenditures for treating addiction, there is broad acknowledgement of an urgent societal need for resources to help mitigate the dangers of the opioid epidemic. At the epicenter of the most lethal drug crisis in American history is the synthetic opioid fentanyl. The recent spike in opioid deaths is largely attributed to the illicit use of fentanyl as an inexpensive method to augment the strength of heroin. As fentanyl is 100x more potent than morphine with a lethal dose of 3 mg, its unregulated use has proven extremely dangerous. Underscoring the risks posed by use and/or handling of fentanyl is the fact that it is readily absorbed into the human body via inhalation, injection, ingestion, contact with mucous membranes, and transdermal transmission. The dangers of fentanyl extend well beyond drug users, however. First responders, in particular, face unique occupational hazards when called to situations where they may be exposed to synthetic opioids. Given its facile absorption into the body, even incidental exposures to extremely small quantities of fentanyl can cause serious health effects. Therefore, the ability for first responders to quickly and accurately determine the identity of an unknown powder could mean the difference between life and death. Seacoast Science, Inc. (Seacoast) in collaboration with Professors Nathaniel Lynd and Feng Zhang (UT Austin) and Professor Erik Berda (UNH), jointly propose the development of a low-cost, handheld, biomimetic narcotics detector that is comparable in accuracy and resolution to high-end portable Raman spectrometers. The proposed technology is based on the use of smart, bioinspired nanomaterials as chemical transducers in the proprietary, low-power, micro-electro-mechanical systems (MEMS) sensor platforms engineered at Seacoast. The integration of these nanotechnologies provides an innovative roadmap toward the advent of an accurate handheld narcotics detector with a price that justifies rapid, broadscale emplacement amongst first responders. This proposal describes the development of a suite of modular, biomimetic polymers rationally programmed to detect a panel of synthetic opioids with high fidelity. The polymers will be deposited onto MEMS sensors and evaluated in a controlled environmental chamber for responsiveness to a selected suite of fentanyl derivatives and cutting agents. A range of opioid concentrations will be screened, mapped against MEMS resistance and capacitance measurements, and analyzed to develop proprietary chemometric pattern recognition algorithms for each molecular target. This sensing platform will provide an accurate and affordable handheld narcotics detector for rapid diagnostics of fentanyl and other synthetic opioids.
