A novel pre-defined CDR library for selection of affinity reagents

Information

• Research Project
• 8452855

• ApplicationId

  8452855

• Core Project Number

  R43GM105080

• Full Project Number

  1R43GM105080-01

• Serial Number

  105080

• FOA Number

  PA-12-088

• Sub Project Id

• Project Start Date

  7/15/2013 - 11 years ago

• Project End Date

  1/14/2015 - 10 years ago

• Program Officer Name

  GERRATANA, BARBARA

• Budget Start Date

  7/15/2013 - 11 years ago

• Budget End Date

  1/14/2015 - 10 years ago

• Fiscal Year

  2013

• Support Year

  01

• Suffix

• Award Notice Date

  7/15/2013 - 11 years ago

Organizations

• AXIOMX, INC.

DESCRIPTION: We intend to refine the affinity-reagent discovery process so that it is not only cheaper and faster than currently possible, but also so that we produce reagents that are more versatile and useful than current monoclonal antibodies. We propose to use in vitro combinatorial recombination of pre-defined synthetic complementarity determining regions (CDRs) of single chain variable fragment (scFv) antibodies to synthesize a novel type of highly diverse synthetic display library. We have termed this new library-type as a 'pre-defined CDR' (PDC) library. This novel library system will have properties that will also enable it to greatly facilitate both the downstream affinity-reagent selection and the maturation processes. Methods for testing this library using microfluidics and emulsion screening are discussed.

IC Name

• Activity

  R43

• Administering IC

  GM

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

  334656

• Sub Project Total Cost

• ARRA Funded

  False

• CFDA Code

  859

• Ed Inst. Type

• Funding ICs

  NIGMS:334656\

• Funding Mechanism

  SBIR-STTR RPGs

• Study Section

  ZRG1

• Study Section Name

  Special Emphasis Panel

• Organization Name

  AXIOMX, INC.

• Organization Department

• Organization DUNS

  078402317

• Organization City

  BRANFORD

• Organization State

  CT

• Organization Country

  UNITED STATES

• Organization Zip Code

  064052971

• Organization District

  UNITED STATES