Claims
- 1. A method of inhibiting PLA.sub.2 activity in animals which comprises administering a PLA.sub.2 -inhibiting amount of a compound selected from A87689, which in its calcium salt form has the following characteristics:
- Molecular weight=1222.418
- Empirical formula=C.sub.66 H.sub.70 O.sub.20 Ca
- FAB-MS (M+1): Found: 1223.4175,
- Calculated: 1223.4254; and
- IR: as shown in FIG. 1 of the drawings, a C.sub.1 -C.sub.6 alkyl ether or a C.sub.1 -C.sub.6 alkanoyl ester of A87689, or a pharmaceutically acceptable salt thereof, to said animal.
- 2. A method of treating arthritic disease in animals which comprises administering to said animal a compound selected from A87689, which in its calcium salt form has the following characteristics:
- Molecular weight=1222.418
- Empirical formula=C.sub.66 H.sub.70 O.sub.20 Ca
- FAB-MS (M+1): Found: 1223.4175,
- Calculated: 1223.4254; and
- IR: as shown in FIG. 1 of the drawings, a C.sub.1 -C.sub.6 alkyl ether or a C.sub.1 -C.sub.6 alkanoyl ester of A87689, or a pharmaceutically acceptable salt thereof.
- 3. A method of treating asthma in animals which comprises administering to said animal an amount of a compound selected from A87689, which in its calcium salt form has the following characteristics:
- Molecular weight=1222.418
- Empirical formula=C.sub.66 H.sub.70 O.sub.20 Ca
- FAB-MS (M+1): Found: 1223.4175,
- Calculated: 1223.4254; and
- IR: as shown in FIG. 1 of the drawings, a C.sub.1 -C.sub.6 alkyl ether or a C.sub.1 -C.sub.6 alkanoyl ester of A87689, or a pharmaceutically acceptable salt thereof, sufficient to reduce the inflammation of an asthmatic animal's respiratory system.
- 4. A method of inhibiting PLA.sub.2 activity in animals which comprises administering a PLA.sub.2 -inhibiting amount of at least one compound selected from the group consisting of BU-3889V A.sub.1, BU-3889V A.sub.2, BU-3889V A.sub.3, BU-3889V D.sub.1, BU-3889V D.sub.2, BU-3889V D.sub.3, or a pharmaceutically acceptable salt thereof, to said animal.
- 5. A method of reducing inflammation in animals which comprises administering to said animal an inflammation-inhibiting amount of at least one compound selected from the group consisting of BU-3889V A.sub.1, BU-3889V A.sub.2, BU-3889V A.sub.3, BU-3889V D.sub.1, BU-3889V D.sub.2, BU-3889V D.sub.3, or a pharmaceutically acceptable salt thereof.
- 6. A method of treating arthritic disease in animals which comprises administering to said animal an effective amount of at least one compound selected from the group consisting of BU-3889V A.sub.1, BU-3889V A.sub.2, BU-3889V A.sub.3, BU-3889V D.sub.1, BU-3889V D.sub.2, BU-3889V D.sub.3, or a pharmaceutically acceptable salt thereof.
- 7. A method of treating asthma in animals which comprises administering to said animal an amount of at least one compound selected from the group consisting of BU-3889V A.sub.1, BU-3889V A.sub.2, BU-3889V A.sub.3, BU-3889V D.sub.1, BU-3889V D.sub.2, BU-3889V D.sub.3, or a pharmaceutically acceptable salt thereof, sufficient to reduce the inflammation of an asthmatic animal's respiratory system.
- 8. A method of reducing inflammation in an animal which comprises administering to said animal an inflammation inhibiting amount of a compound selected from the group consisting of
- (a) A87689, which in its calcium salt form has the following characteristics:
- Molecular weight=1222.418
- Empirical formula=C.sub.66 H.sub.70 O.sub.20 Ca
- FAB-MS (M+1): Found: 1223.4175,
- Calculated: 1223.4254; and
- IR: as shown in FIG. 1 of the drawings;
- (b) A C.sub.1-6 -alkyl ether of C.sub.1-6 -alkanoyl ester derivative of A87689; or
- (c) a salt of A87689 or of said ether or ester derivative.
- 9. A method according to claim 8 wherein said compound is C.sub.1-6 alkyl ether of A87689, or a pharmaceutically acceptable salt thereof.
CROSS REFERENCE TO RELATED APPLICATION
This application is a division of application Ser. No. 07/878,254, filed May 4, 1992, now U.S. Pat. No. 5,278,064 which is a continuation-in- part of application Ser. No. 07/738,969, filed Aug. 1, 1991, now abandoned
Foreign Referenced Citations (1)
Number |
Date |
Country |
0405864AZ |
Jan 1991 |
EPX |
Divisions (1)
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Number |
Date |
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Parent |
878254 |
May 1992 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
738969 |
Aug 1991 |
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