Claims
- 1. A compound represented by formula I″: whereinR1 is a hydrogen, chlorine or bromine atom or a methyl, methylthio, hydroxy, cyano, nitro or carboxamido group; R2 is C1-C3 alkyl or an allyl group; R3 and R4 are independently a hydrogen atom, a linear or branched C1-C5 alkyl group, a linear or branched C3-C5 alkenyl group, a C5-C6 cycloalkyl C1-C3 alkyl group, a phenyl-C1-C3 alkyl, a phenyl-C3-C5 alkenyl or phenyl group: which groups are optionally substituted by C1-C3 alkyl, C1-C3 alkoxy, trifluoromethyl, hydroxy or amino group; or a group of the formula whereinR6 is a hydrogen atom or a C1-C3 alkyl group and R7 is a phenyl group or a substituted phenyl group as described above; between positions 9-10 represents a single or a double bond; R5 is a hydrogen, bromine, fluorine or iodine atom or a methoxy, cyano, carboxamido, nitro, methylthio or trifluoromethyl or a group of the formula NR8R9 wherein R8 and R9 are independently a hydrogen atom, or a C1-3 alkyl, acetyl, methanesulphonyl or trifluoroacetyl group; and R represents a hydrogen atom or a C1-5 linear or branched alkyl, methanesulphonyl or acetyl group or a group of the formula CONR8R9 wherein R8 and R9 are as defined above; or a pharmaceutically acceptable salt thereof.
- 2. The compound of claim 1, or a pharmaceutically acceptable salt thereof, whereinR1 represents a hydrogen atom, a cyano group, or a carboxamido group, R2 represents a methyl group, R3 represents a hydrogen atom, R4 represents a group of the formula —CH(OH)Ph, R5 represents hydrogen, fluorine, iodo, methoxy, methylthio, trifluoromethyl, nitro, a carboxamido group, or a group of the formula NR8R9, wherein R8 and R9 are, independently, a hydrogen atom or a C1-3 alkyl, acetyl, methanesulphonyl or trifluoroacetyl group, and the hydrogen atom at position 5 and the residue at position 8 are both β.
- 3. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the 9-10 positions are bonded by a double bond.
- 4. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the 9-10 positions are bonded by a single bond.
- 5. The compound of claim 1, or a pharmaceutically acceptable salt thereof, which is 5β-(10→9)abeo-2,3β-dihydro-9,10-didehydro-6-methyl-8β-methyl-ergoline.
- 6. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein R5 is a bromine, fluorine or iodine atom or a methoxy, cyano, carboxamido, nitro, methylthio, trifluoromethyl or a group of the formula NR8R9, wherein R8 and R9 are as defined above.
- 7. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein R3 is a phenyl-C1-C3 alkyl, a phenyl-C3-C5 alkenyl or a phenyl group, wherein these groups are optionally substituted by a C1-C3 alkyl, C1-C3 alkoxy, trifluoromethyl, hydroxy or an amino group,or R3 is a group of the formula -C(OH)R6R7, wherein R6 is a hydrogen atom or a C1-C3 alkyl group and R7 is a phenyl group, or a phenyl group substituted with a C1-C3 alkyl, C1-C3 alkoxy, trifluoromethyl, hydroxy or an amino group.
- 8. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein R1 is a chlorine or bromine atom or a methyl, methylthio, hydroxy, cyano, nitro or carboxamido group.
- 9. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein R is a C1-5 linear or branched alkyl, methanesulphonyl, acetyl or a group of the formula CONR8R9, wherein R8 and R9 are as defined above.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9407637 |
Apr 1994 |
GB |
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Parent Case Info
This application is a Continuation of application Ser. No. 08/553,545, filed on Dec. 14, 1995, now abandoned, which was filed as International Application No. PCT/EP95/01398, filed on Apr. 13, 1995.
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1 482 871 |
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GB |
Non-Patent Literature Citations (1)
Entry |
Bernardi et al., “5(10 9) ABEO-Ergolines form 9-Hydroxyergolines”, J.C.S. Chem. Comm., 1976, p. 570. |
Continuations (1)
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Number |
Date |
Country |
Parent |
08/553545 |
|
US |
Child |
08/998867 |
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US |