Ablation catheter

Description

INCORPORATION BY REFERENCE

All publications and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference.

FIELD OF THE INVENTION

The present invention relates generally to catheters and methods for performing targeted tissue ablation in a subject. In particular, the present invention provides devices comprising catheters having distal ends configured to treat two dimensional regions of target tissue, including deployable distal ends, and methods for treating conditions (e.g., cardiac arrhythmias) with these and similar devices.

BACKGROUND OF THE INVENTION

Tissue ablation is used in numerous medical procedures to treat a patient. Ablation can be performed to remove undesired tissue such as cancer cells. Ablation procedures may also involve the modification of the tissue without removal, such as to stop electrical propagation through the tissue in patients with an arrhythmia. Often the ablation is performed by passing energy, such as electrical energy, through one or more electrodes causing the tissue in contact with the electrodes to heats up to an ablative temperature. Ablation procedures can be performed on patients with atrial fibrillation by ablating tissue in the heart.

Mammalian organ function typically occurs through the transmission of electrical impulses from one tissue to another. A disturbance of such electrical transmission may lead to organ malfunction. One particular area where electrical impulse transmission is critical for proper organ function is in the heart. Normal sinus rhythm of the heart begins with the sinus node generating an electrical impulse that is propagated uniformly across the right and left atria to the atrioventricular node. Atrial contraction leads to the pumping of blood into the ventricles in a manner synchronous with the pulse.

Atrial fibrillation refers to a type of cardiac arrhythmia where there is disorganized electrical conduction in the atria causing rapid uncoordinated contractions that result in ineffective pumping of blood into the ventricle and a lack of synchrony. During atrial fibrillation, the atrioventricular node receives electrical impulses from numerous locations throughout the atria instead of only from the sinus node. This overwhelms the atrioventricular node into producing an irregular and rapid heartbeat. As a result, blood pools in the atria that increases a risk for blood clot formation. The major risk factors for atrial fibrillation include age, coronary artery disease, rheumatic heart disease, hypertension, diabetes, and thyrotoxicosis. Atrial fibrillation affects 7% of the population over age 65.

Atrial fibrillation treatment options are limited. Lifestyle change only assists individuals with lifestyle related atrial fibrillation. Medication therapy assists only in the management of atrial fibrillation symptoms, may present side effects more dangerous than atrial fibrillation, and fail to cure atrial fibrillation. Electrical cardioversion attempts to restore sinus rhythm but has a high recurrence rate. In addition, if there is a blood clot in the atria, cardioversion may cause the clot to leave the heart and travel to the brain or to some other part of the body, which may lead to stroke. What are needed are new methods for treating atrial fibrillation and other conditions involving disorganized electrical conduction.

Various ablation techniques have been proposed to treat atrial fibrillation, including the Cox-Maze procedure, linear ablation of various regions of the atrium, and circumferential ablation of pulmonary vein ostia. The Cox-Maze procedure and linear ablation procedures are tedious and time-consuming, taking several hours to accomplish. Pulmonary vein ostial ablation is proving to be difficult to do, and has lead to rapid stenosis and potential occlusion of the pulmonary veins. There is therefore a need for improved atrial ablation products and techniques.

BRIEF DESCRIPTION OF THE DRAWINGS

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate various embodiments of the present invention, and, together with the description, serve to explain the principles of the invention. In the drawings:

FIG. 1 illustrates the treatment to be accomplished with the devices and methods described below;

FIG. 2 illustrates a side view of an ablation catheter consistent with the present invention;

FIG. 3 illustrates an end view of the distal portion of the ablation catheter of FIG. 2;

FIG. 4 illustrates an enlarged sectional view of the distal portion of the ablation catheter of FIG. 2;

FIGS. 5a, 5c, and 5d illustrate a sectional views of a distal portion of an ablation catheter consistent with the present invention demonstrating a series of deployments of the carrier assembly in a fully deployed, partially constrained and fully constrained condition, respectively;

FIG. 5b illustrates an end view of the distal portion of the ablation catheter of FIGS. 5a, 5c, and 5d;

FIG. 6 illustrates a perspective, partial cutaway view of an ablation catheter consistent with the present invention in which the carrier element has three carrier arms, the ablation catheter further including a handle for performing multiple functions;

FIG. 6a illustrates a sectional view of the distal end of the ablation catheter of FIG. 6;

FIG. 7 illustrates a perspective view of an ablation catheter consistent with the present invention in which the carrier element is in a spiral configuration;

FIGS. 8a and 8b are sectional views of the distal end of an ablation catheter consistent with the present invention in which the carrier assembly and control shaft are a continuous conduit. FIG. 8a illustrating the carrier assembly in a fully deployed condition and FIG. 8b illustrating the carrier assembly in a fully constrained condition;

FIG. 9 illustrates an ablation element of an ablation catheter consistent with the present invention in which the ablation element includes an ultrasound crystal and a thermocouple;

FIG. 10 illustrates an ablation element assembly of an ablation catheter consistent with the present invention in which the assembly is a semiconductor with integrated electronics;

FIG. 11 is an end view of a carrier assembly of an ablation catheter consistent with the present invention;

FIG. 11a is a side sectional view of the distal portion of the ablation catheter of FIG. 11 in which the carrier assembly lies in multiple planes when fully expanded;

FIG. 11b is a side sectional view of the distal portion of the ablation catheter of FIG. 11 in which the carrier assembly lies in a single plane when fully expanded; and

FIG. 12 is an end view of the carrier assembly of an ablation catheter consistent with the present invention in which the carrier assembly consists of multiple wire segments each attached to a coupler.

DETAILED DESCRIPTION OF THE INVENTION

Reference will now be made in detail to the present embodiments of the invention, examples of which are illustrated in the accompanying drawings. Wherever possible, the same reference numbers will be used throughout the drawings to refer to the same or like parts.

The present invention provides catheters for performing targeted tissue ablation in a subject. In preferred embodiments, the catheters comprise a tubular body member having a proximal end and distal end and preferably a lumen extending therebetween. The catheter is preferably of the type used for performing intracardiac procedures, typically being introduced from the femoral vein in a patient's leg. The catheter is preferably introducible through a sheath and also preferably has a steerable tip that allows positioning of the distal portion such as when the distal end of the catheter is within a heart chamber. The catheters include ablation elements mounted on a carrier assembly. The carrier assembly is attached to a coupler, which in turn is connected to a control shaft that is coaxially disposed and slidingly received within the lumen of the tubular body member. The carrier assembly is deployable from the distal end of the tubular body member by advancing the control shaft, such as to engage one or more ablation elements against cardiac tissue, typically atrial wall tissue or other endocardial tissue. Retraction of the control shaft causes the carrier assembly to be constrained within the lumen of the tubular body member.

Arrays of ablation elements, preferably electrode arrays, may be configured in a wide variety of ways and patterns. In particular, the present invention provides devices with electrode arrays that provide electrical energy, such as radiofrequency (RF) energy, in monopolar (unipolar), bipolar or combined monopolar-bipolar fashion, as well as methods for treating conditions (e.g., atrial fibrillation, supra ventricular tachycardia, atrial tachycardia, ventricular tachycardia, ventricular fibrillation, and the like) with these devices. Alternative to or in combination with ablation elements that deliver electrical energy to tissue, other forms and types of energy can be delivered including but not limited to: sound energy such as acoustic energy and ultrasound energy; electromagnetic energy such as electrical, magnetic, microwave and radiofrequency energies; thermal energy such as heat and cryogenic energies; chemical energy such as energy generated by delivery of a drug; light energy such as infrared and visible light energies; mechanical and physical energy; radiation; and combinations thereof.

As described above, the normal functioning of the heart relies on proper electrical impulse generation and transmission. In certain heart diseases (e.g., atrial fibrillation) proper electrical generation and transmission are disrupted or are otherwise abnormal. In order to prevent improper impulse generation and transmission from causing an undesired condition, the ablation catheters of the present invention may be employed.

One current method of treating cardiac arrhythmias is with catheter ablation therapy. Physicians make use of catheters to gain access into interior regions of the body. Catheters with attached electrode arrays or other ablating devices are used to create lesions that disrupt electrical pathways in cardiac tissue. In the treatment of cardiac arrhythmias, a specific area of cardiac tissue having aberrant conductive pathways, such as atrial rotors, emitting or conducting erratic electrical impulses, is initially localized. A user (e.g., a physician) directs a catheter through a main vein or artery into the interior region of the heart that is to be treated. The ablating element is next placed near the targeted cardiac tissue that is to be ablated. The physician directs energy, provided by a source external to the patient, from one or more ablation elements to ablate the neighboring tissue and form a lesion. In general, the goal of catheter ablation therapy is to disrupt the electrical pathways in cardiac tissue to stop the emission of and/or prevent the propagation of erratic electric impulses, thereby curing the heart of the disorder. For treatment of atrial fibrillation, currently available methods and devices have shown only limited success and/or employ devices that are extremely difficult to use or otherwise impractical.

The ablation catheters of the present invention allow the generation of lesions of appropriate size and shape to treat conditions involving disorganized electrical conduction (e.g., atrial fibrillation). The ablation catheters of the present invention are also practical in terms of ease-of-use and limiting risk to the patient, as well as significantly reducing procedure times. The present invention addresses this need with, for example, spiral shaped and radial arm shaped (also called umbrella shaped) carrier assemblies whose ablation elements create spiral, radial, or other simple or complex shaped patterns of lesions in the endocardial surface of the atria by delivery of energy to tissue or other means. The lesions created by the ablation catheters are suitable for inhibiting the propagation of inappropriate electrical impulses in the heart for prevention of reentrant arrhythmias.

Definitions. To facilitate an understanding of the invention, a number of terms are defined below.

As used herein, the terms “subject” and “patient” refer to any animal, such as a mammal like livestock, pets, and preferably a human. Specific examples of “subjects” and “patients” include, but are not limited, to individuals requiring medical assistance, and in particular, requiring atrial fibrillation catheter ablation treatment.

As used herein, the terms “catheter ablation” or “ablation procedures” or “ablation therapy,” and like terms, refer to what is generally known as tissue destruction procedures. Ablation is often used in treating several medical conditions, including abnormal heart rhythms. It can be performed both surgically and non-surgically. Non-surgical ablation is typically performed in a special lab called the electrophysiology (EP) laboratory. During this non-surgical procedure a catheter is inserted into the heart using fluoroscopy for visualization, and then an energy delivery apparatus is used to direct energy to the heart muscle. This energy either “disconnects” or “isolates” the pathway of the abnormal rhythm (depending on the type of ablation). It can also be used to disconnect the conductive pathway between the upper chambers (atria) and the lower chambers (ventricles) of the heart. For individuals requiring heart surgery, ablation can be performed during coronary artery bypass or valve surgery.

As used herein, the term “ablation element” refers to an energy delivery element, such as an electrode for delivering electrical energy. Ablation elements can be configured to deliver multiple types of energy, such as ultrasound energy and cryogenic energy, either simultaneously or serially. Electrodes can be constructed of a conductive plate, wire coil, or other means of conducting electrical energy through contacting tissue. In monopolar energy delivery, the energy is conducted from the electrode, through the tissue to a ground pad, such as a conductive pad attached to the back of the patient. The high concentration of energy at the electrode site causes localized tissue ablation. In bipolar energy delivery, the energy is conducted from a first electrode to one or more separate electrodes, relatively local to the first electrode, through the tissue between the associated electrodes. Bipolar energy delivery results in more precise, shallow lesions while monopolar delivery results in deeper lesions. Both monopolar and bipolar delivery provide advantages, and the combination of their use is a preferred embodiment of this application. Energy can also be delivered using pulse width modulated drive signals, well known to those of skill in the art. Energy can also be delivered in a closed loop fashion, such as a system with temperature feedback wherein the temperature modifies the type, frequency and or magnitude of the energy delivered.

As used herein, the term “carrier assembly” refers to a flexible carrier, on which one or more ablation elements are disposed. Carrier assemblies are not limited to any particular size, or shape, and can be configured to be constrained within an appropriately sized lumen.

As used herein, the term “spiral tip” refers to a carrier assembly configured in its fully expanded state into the shape of a spiral. The spiral tip is not limited in the number of spirals it may contain. Examples include, but are not limited to, a wire tip body with one spiral, two spirals, ten spirals, and a half of a spiral. The spirals can lie in a relatively single plane, or in multiple planes. A spiral tip may be configured for energy delivery during an ablation procedure.

As used herein the term “umbrella tip” refers to a carrier assembly with a geometric center which lies at a point along the axis of the distal portion of the tubular body member, with one or more bendable or hinged carrier arms extending from the geometric center, in an umbrella configuration. Each carrier arm may include one or more ablation elements. Each carrier arm of an umbrella tip includes a proximal arm segment and a distal arm segment, the distal arm segment more distal than the proximal arm segment when the carrier assembly is in a fully expanded condition. One or more additional carrier arms can be included which include no ablation elements, such as carrier arms used to provide support or cause a particular deflection. An umbrella tip body is not limited to any particular size. An umbrella tip may be configured for energy delivery during an ablation procedure.

As used herein, the term “lesion,” or “ablation lesion,” and like terms, refers to tissue that has received ablation therapy. Examples include, but are not limited to, scars, scabs, dead tissue, burned tissue and tissue with conductive pathways that have been made highly resistive or disconnected.

As used herein, the term “spiral lesion” refers to an ablation lesion delivered through a spiral tip ablation catheter. Examples include, but are not limited to, lesions in the shape of a wide spiral, and a narrow spiral, a continuous spiral and a discontinuous spiral.

As used herein, the term “umbrella lesion” or “radial lesion,” and like terms, refers to an ablation lesion delivered through an umbrella tip ablation catheter. Examples include, but are not limited to, lesions with five equilateral prongs extending from center point, lesions with four equilateral prongs extending from center point, lesions with three equilateral prongs extending from center point, and lesions with three to five non-equilateral prongs extending from center point.

As used herein, the term “coupler” refers to an element that connects the carrier assembly to the control shaft. Multiple shafts, or ends of the carrier assembly may connect to the coupler. Multiple carrier arms can have one or more of their ends attached to the coupler. The coupler may include anti-rotation means that work in combination with mating means in the tubular body member. Couplers may be constructed of one or more materials such as polyurethane, steel, titanium, and polyethylene.

As used herein, the term “carrier arm” refers to a wire-like shaft capable of interfacing with electrodes and the coupler. A carrier arm is not limited to any size or measurement. Examples include, but are not limited to: stainless steel shafts; Nitinol shafts; titanium shafts; polyurethane shafts; nylon shafts; and steel shafts. Carrier arms can be entirely flexible, or may include flexible and rigid segments.

As used herein, the term “carrier arm bend point” refers to a joint (e.g., junction, flexion point) located on a carrier arm. The degree of flexion for a carrier arm bend point may range from 0 to 360 degrees. The bend portion can be manufactured such what when the carrier assembly is fully expanded the bend point is positioned in a relatively straight portion, a curved portion, or in a discrete transition from a first direction to a second transition, such as a 45 degree bend transition. The bend portion can include one or more flexing means such as a spring, a reduced diameter segment, or a segment of increased flexibility.

The present invention provides structures that embody aspects of the ablation catheter. The present invention also provides tissue ablation systems and methods for using such ablation systems. The illustrated and preferred embodiments discuss these structures and techniques in the context of catheter-based cardiac ablation. These structures, systems, and techniques are well suited for use in the field of cardiac ablation.

However, it should be appreciated that the invention is applicable for use in other tissue ablation applications such as tumor ablation procedures. For example, the various aspects of the invention have application in procedures for ablating tissue in the prostrate, brain, gall bladder, uterus, and other regions of the body, preferably regions with an accessible wall or flat tissue surface, using systems that are not necessarily catheter-based.

The multifunctional catheters of the present invention have advantages over previous prior art devices. FIGS. 1-12 show various preferred embodiments of the multifunctional catheters of the present invention. The present invention is not limited to these particular configurations.

FIG. 1 illustrates the treatment to be accomplished with the devices and methods described herebelow. FIG. 1 shows a cutaway view of the human heart 1 showing the major structures of the heart including the right atrium 2, the left atrium 3, the right ventricle 4, and the left ventricle 5. The atrial septum 6 separates the left and right atria. The fossa ovalis 7 is a small depression in the atrial septum that may be used as an access pathway to the left atrium from the right atrium. The fossa ovalis 7 can be punctured, and easily reseals and heals after procedure completion. In a patient suffering from atrial fibrillation, aberrant electrically conducive tissue may be found in the atrial walls 8 and 9, as well as in the pulmonary veins 10 and the pulmonary arteries 11. Ablation of these areas, referred to arrhythmogenic foci (also referred to as drivers or rotors), is an effective treatment for atrial fibrillation. Though circumferential ablation of the pulmonary vein usually cures the arrhythmia that originates in the pulmonary veins, it may result in eventual stenosis of these pulmonary veins, a very undesirable condition. The catheters of the present invention provide means of creating lesions remote from these pulmonary veins and their ostia while easily being deployed to ablate the driver and rotor tissue.

To accomplish this, catheter 100 is inserted into the right atrium 2, preferably through the inferior vena cava 20, as shown in the illustration, or through the superior vena cava 21. Catheter 100 may include an integral sheath, such as a tip deflecting sheath, or may work in combination with a separate sheath. When passing into the left atrium, the catheter passes through or penetrates the fossa ovalis 7, such as over a guide wire placed by a trans-septal puncture device. The catheter 100 carries a structure carrying multiple ablation elements such as RF electrodes, carrier assembly 120, into the left atrium. Carrier assembly 120 is adapted to be deformable such that pressing carrier assembly into left atrial wall 9 will cause one or more, and preferably all of electrodes 130 to make contact with tissue to be analyzed and/or ablated. Each of the electrodes 130 is attached via connecting wires to an energy delivery apparatus, RF delivery unit 200 which is also attached to patch electrode 25, preferably a conductive pad attached to the back of the patient.

RF delivery unit 200 is configured to delivery RF energy in monopolar, bipolar or combination monopolar-bipolar energy delivery modes. In a preferred embodiment, monopolar energy delivery is followed by bipolar energy delivery, which is then followed a period without energy delivery, such as a sequence in which the three steps are have equal durations. In another preferred embodiment, RF delivery unit 200 is configured to also provide electrical mapping of the tissue that is contacted by one or more electrodes integral to carrier assembly 120. Electrodes 130 can also be configured to be mapping electrodes and/or additional electrodes can be integral to carrier assembly 120 to provide a mapping function. Carrier assembly 120 is configured to be engaged over an endocardial surface to map and/or ablate tissue on the surface. RF energy is delivered after a proper location of the electrodes 130 is confirmed with a mapping procedure. If the position is determined to be inadequate, carrier assembly 120 is repositioned through various manipulations at the proximal end of the ablation catheter 100. In another preferred embodiment, RF delivery unit 200 is configured to delivery both RF energy and ultrasound energy the identical or different electrodes 130. In another preferred embodiment, RF delivery unit 200 is configured to accept a signal from one or more sensors integral to ablation catheter 100, not shown, such that the energy delivered can be modified via an algorithm which processes the information received from the one or more sensors.

Referring now to FIG. 2, a preferred embodiment of ablation catheter 100 is illustrated. Ablation catheter 100 includes a tubular body member which is an elongated, flexible, hollow tube, catheter shaft 101, that connects at its proximal end to handle 110. The material used for the construction of the catheter shaft 101 and each component which resides or is configured to be inserted through a lumen integral to catheter shaft 101, are selected to provide the suitable flexibility, column strength and steerability to allow percutaneous introduction of ablation catheter 100 to various body locations including the left or right atrium of the heart. Catheter shaft 101 and other tubular conduits of ablation catheter 100 are constructed of materials such as Pebax™; polyimide; polyurethane; silicone; nylon; polyvinyl chloride (PVC); polyester; and combinations thereof. These types of conduits may be constructed of an outer layer, an inner layer and a braid residing therebetween. The braid may be constructed of various materials including stainless steel; Nitinol; monofilament fiber; a polymer; and combinations thereof.

Control shaft 150 extends from the proximal end to distal end 102 of catheter shaft 101 and resides in a lumen therebetween. Control shaft 150 is also constructed of material to provide suitable flexibility and column strength to be percutaneously introduced into the patient as well as perform other functions such as the advancement and contraction of carrier assembly 120. Applicable materials for control shaft 150 are Nitinol™; stainless steel; titanium; gold; platinum; copper; a polymer; a polymer embedded with conductive material; an elastomer; a plastic; and combinations thereof. In a preferred embodiment, control shaft 150 is constructed of both stainless steel and Nitinol. In another preferred embodiment, control shaft 150 is selected-from the group consisting of: a monofilament fiber; a spring coil; a wire; and combinations thereof. In another preferred embodiment, control shaft 150 has a guidewire construction such as a core with a tightly coiled wire sheath, the sheath surrounding a substantial length of the core. In another preferred embodiment, the control shaft 150 includes a lumen from its proximal end and its distal end 102 such as to permit over-the-wire introduction via that lumen.

Coupler 140, located at the distal end 102 of control shaft 150 connects control shaft 150 to carrier assembly 120. Carrier assembly 120 is a flexible filamentous assembly that includes at least one ablation element, such as electrode 130, to deliver energy to tissue. Carrier assembly 120 includes one or more carrier arms 123, each of which has a proximal arm segment 125 and a distal arm segment 127, which are connected by a resiliently flexible segment, carrier arm bend portion 121. Bend portion 121 may include various elements to assist in bending such as a spring; a hinge; a reduced diameter segment; a bend created during a heat treatment of a wire such as the “training” of a Nitinol wire; and combinations thereof. Bend point 121 provides means for rotatably joining the distal arm segment 127 to the proximal arm segment 125. Carrier arms 123 are preferably constructed of a wire, such as a ribbon wire, and may have segments with different levels of flexibility. Bend point 121 may comprises two or more wires bonded together with a joint. Carrier arms 123 may include no ablation elements, such as a carrier arm 123 to provide support only. Carrier arms 123 may also include mapping electrodes, thermal sensors or other sensors, with or without the inclusion of ablation elements. In a preferred embodiment, each carrier arm 123 includes at least one ablation element.

Carrier assembly 120 can be configured to assume various geometries when in its expanded condition, such as the umbrella configuration of FIG. 2 through 4. Carrier assembly 120, coupler 140 and control shaft 150 are configured such that control shaft 150 can be retracted to constrain carrier assembly 120 within a lumen of catheter shaft 101 and advancement of control shaft 150 causes carrier assembly 120 to advance beyond distal end 102 of control shaft 101 thus allowing carrier assembly 120 to deploy to its fully expanded condition. Coupler 140 is preferably more rigid than control shaft 150. Control shaft 150 extends proximally to a location inside handle 110 where it is operably connected to knob 111 that slides in slot 112. Alternative to sliding knob 111 is a rotating knob or a mechanical or electromechanical linear actuator, not shown. Sliding knob 111 is configured such that an operator of the system can with minimal effort advance and deploy carrier assembly 120 to its distal position where it is fully deployed for engagement with tissue, as well as retract and constrain carrier assembly within a lumen at the distal end 102 of catheter shaft 101. One or more knobs can work in conjunction with a cam assembly, or a series of gears, both not shown, such that motion or force can be multiplied with the resultant mechanical advantage.

Each electrode 130 of carrier assembly 120 of ablation catheter 100 is connected to one or more wires, not shown but preferably extending from each electrode 130 of the distal arm segment 127, running parallel with the segment toward the axis of distal end 102 of the catheter shaft 101, then traveling proximally toward coupler 140 and then through catheter shaft 101 to handle 110. The wires may pass through coupler 140, along side coupler 140, or may be electrically connected to coupler 140 such that these wires connect to wires on the proximal end of coupler 140. The wires may be within a lumen internal to control shaft 150, a space between control shaft 150 and catheter shaft 101, and a separate lumen of catheter shaft 101. The wires are looped within handle 110 to provide the distension necessary for the resilient deployment of carrier assembly 120 as illustrated in FIG. 2.

The electrode 130 wires provide a drive signal and a ground signal, or two or more alternating drive signals to each electrode 130. Electrodes 130 can be wired independently, such that each electrode 130 can deliver energy independent of any other electrode, or two or more electrodes can be connected in parallel or serial fashion. In a preferred embodiment, ablation catheter 100 and an energy delivery apparatus can be configured to drive two ablation elements, such as electrodes 130, independently or simultaneously. Handle 110 includes RF attachment port 181 which can be connected to a separate energy delivery apparatus such as an RF delivery apparatus. Mapping port 182 is also included, which can be used to connect to a mapping device to assist in determining and/or confirming the proper ablation location. Handle 110 further includes button 116, which is connected to switch means, not shown, for starting and/or stopping the delivery of energy to one or more of electrodes 130. In an alternative embodiment, an energy delivery apparatus is integrated into handle 110 such that a separate apparatus and port 181 are not needed. In this configuration, handle 110 may include a plug, not shown, for attachment to a power supply or wall outlet. In another alternative embodiment, handle 110 includes an audible transducer, such as an audible transducer that is activated when energy is being delivered to tissue, or an alarm condition has been entered. In another alternative embodiment, handle 110 includes a power supply, such as a battery or rechargeable battery, both not shown. In another alternative embodiment, ablation catheter 100 includes one or more elements requiring power such as from an integrated battery, these elements selected from the group consisting of: an integral a light such as an LED; a display such as a liquid crystal display or touch screen display; an audible transducer; a tactile transducer such as a vibration transducer which readily alerts anyone holding the device; a relay such as a relay which disconnects power to one or more ablation elements; mapping circuitry embedded in one or more components of ablation catheter 100, or electrode 130; and combinations thereof.

Referring now to FIG. 3, an end view of the distal end of the catheter of FIG. 2 is illustrated, showing the umbrella tip configuration. Four carrier arms 123 extend radially out from the central axis of catheter shaft 101, the arms positioned in a symmetric configuration with equal angles (ninety degrees in a four arm configuration) between each arm. In alternative embodiments, three or more arms can be separated by different angles. The four carrier arms 123 are connected to coupler 140 which is concentric with the axis of catheter shaft 101 and connected to control shaft 150, not shown. Each arm is shown with two electrodes 130 mounted to distal arm segment 127, preferably 1-4 mm in length and distributed in a radial pattern covering a range from 1 cm³to 12 cm³. In a preferred embodiment, a first electrode is a different length than a second electrode.

Referring now to FIG. 4, an enlarged portion of the catheter of FIG. 2 at circle “A” is illustrated. Control shaft 150, which exits the distal end of catheter shaft 101, is connected to coupler 140. Carrier assembly 120 includes carrier arms 123, each of which includes proximal arm segment 125 and distal arm segment 127. One end of distal arm segment 127 is attached to coupler 140 with glue 141, near to the central axis of catheter shaft 101. In an alternative embodiment, the connection is made with a press fit or crimp. The other end of distal arm segment 127 transitions to proximal arm segment 125 through bend point 121. The other end of proximal arm segment 125 attaches to the distal end of control shaft 140 such as with glue, a circumferential band, or other attachment means at arm fixation portion 126.

Electrodes 130 are mounted to distal arm segment 127 of carrier arms 123. These electrodes can consist of wire coils; conductive plates; semiconductor plates; and combinations thereof. Each electrode is connected to one or more wires, each wire traveling from the electrode inward toward the axis of catheter shaft axis, and then proximal toward the end of control shaft 150. The wires are joined in a bundle, wire bundle 151 which travels along side control shaft 150. Wire bundle 151 may be glued or banded to control shaft 150 to avoid binding. In an alternative embodiment, wire bundle 151 travels internal to control shaft 150.

Carrier arm 123 includes proximal arm segment 125 and distal arm segment 127, carrier arm bend point 121. In the configuration of FIGS. 2 through 4, each proximal arm segment 125 resiliently bends radially outwardly from coupler 140, while each distal arm segment 127 bends radially inwardly from the bend point 121 toward the longitudinally axis of catheter shaft 101. The distal arm segments 127 are shown to also tend proximally, and to establish an acute angle with the proximal arm segment 125 from which it extends, and the angle is small such that the distal end of the distal arm segment 127 is proximal to the carrier arm bend point 121. In an alternative embodiment, the distal arm segments 127 are configured to tend distally, and to establish an obtuse angle with proximal arm segment 125. Proximal arm segment 125 and distal arm segment 127 are preferably Nitinol wires, such as a continuous flat wire that also includes bend point 121. The Nitinol wires can be trained to be flexible, but resiliently biases in a pre-determined shape. Wires are preferably of a non-circular cross-section such as an ova, rectangle, trapezoid or parallelepiped. The cross-section may vary along its length, and may be configured to cause preferential bending at a specific location and/or in a specific direction. In an alternative embodiment, proximal arm segment 125, distal arm segment 127 and/or bend point 121 are comprised of a non-metallic material such as a plastic, a monofilament flexible fiber or other non-metallic material. In a preferred embodiment, carrier assembly 120 is constructed such that it is more flexible than control shaft 150. In another preferred embodiment, carrier assembly 120 includes one or more wire segments, such as ribbon wire. In another preferred embodiment, carrier assembly 120 includes flat Nitinol wires.

Referring now to FIGS. 5a through 5d, which illustrate the distal end of an ablation catheter of the current invention in various deployment conditions, specifically where carrier assembly 120 is in a fully deployed, partially constrained and fully constrained condition. Referring to FIG. 5a, carrier assembly 120 is shown with two carrier arms 123 with integral electrodes 130 aligned to form a linear lesion. The distal arm segments 127 are also aligned such as when the control shaft 150 is advanced pressing carrier assembly 120 against tissue. Carrier assembly 120, when deployed and flattened against a surface such as an endocardial surface, is preferably about 15 to 30 mm in diameter (to the outer extent of the carrier arm), with each distal arm segment 127 being about 7 to 15 mm long. The wire width of carrier assembly 120 shafts are preferably about 0.26 mm, and the distal face of the electrodes is preferably about 1 to 2 mm wide, and 2 to 3 mm long. Carrier assembly 120 is shown with two carrier arms 123, however any number can be used, and each arm can carry one or more electrodes, or be void of electrodes. Bipolar RF energy may be applied pairs of the electrodes, including an electrode near the distal portion of the ablation catheter but not integral to the carrier assembly, or monopolar energy may be applied to any of the electrodes 130, the energy grounded to a surface electrode or a return electrode located proximally on the catheter body. FIG. 5b shows an end view of the catheter of FIG. 5a in the same deployment condition. FIG. 5b depicts the two carrier arms 123 and the linear arrangement of electrodes 130. FIG. 5c shows a condition in which carrier assembly 120 is partially constrained, such as when control shaft 140 is retracted and/or catheter shaft 101 is advanced. Coupler 140 is shown completely within the lumen of catheter shaft 101, and an end of proximal arm segment 125 and an end of distal arm segment 127 is also within the lumen such that the other ends of proximal arm segment 125 and distal arm segment 127 are rotated inward toward the central axis of catheter shaft 101. FIG. 5d shows the carrier assembly in a completely constrained condition, such as when control shaft 140 is further retracted and/or catheter shaft 101 is further advanced. Now both ends of proximal arm segments 125 and distal arm segments 127 are constrained within the lumen of catheter shaft 101. The lumen of catheter shaft 101 and electrodes 130 are sized and shaped to allow carrier assembly 120 to be constrained within the lumen but permit easy advancement and retraction. In a preferred embodiment, control shaft 150, coupler 140 and carrier assembly 120 can be fully removed from catheter shaft 101, allowing reinsertion of an assembly with a different configuration of control shaft 150, coupler 140 and/or carrier assembly 120.

Referring now to FIGS. 6 and 6a, another preferred embodiment of ablation catheter 100 and ablation system of the present invention is illustrated. Catheter 100 includes carrier assembly 120 configured in another umbrella tip configuration. Carrier assembly 120 includes three carrier arms 123, each of which includes two electrodes 130. In an alternative embodiment, different patterns of electrodes are employed, and one or more arms may be void of electrodes. Referring back to FIG. 6, carrier arms 123 extend radially out from the central axis of the distal end of catheter shaft 101. Each carrier arm 123 includes proximal arm segment 125 and distal arm segment 127, these segments connected at a bendable joint, bend point 121. In a preferred embodiment, proximal arm segment 125 and distal arm segment 127 and bend point 121 are a continuous resiliently flexible wire, such as a “trained” Nitinol wire which creates the umbrella tip. Each electrode 130 is mounted to an insulator, insulating band 131 such that the electrode is electrically isolated from the wire segments of carrier assembly 120. Each electrode 130 is connected to wires which extend along shafts of carrier assembly 120, toward a lumen of catheter shaft 101, and proximally to handle 110. These wires, not shown but described in detail hereabove, include insulation to electrically isolate one wire from another. One end of each distal arm segment 127 is attached to a cylinder, coupler 140, which is sized to be slidably received within a lumen of catheter shaft 101.

Referring again to FIGS. 6 and 6a, coupler 140 can be flexible or rigid, and may contain both rigid and flexible portions along its length. Coupler 140 may provide electrical connection means to connect wires extending from the handle to wires from carrier assembly 120 electrodes. The ends of the distal arm segments 127 and the ends of the proximal arm segments 125 can be attached to the outside of coupler 140, the inside of coupler 140 or both. Coupler 140 includes along its outer surface, a projection, projection 142, which has a cross section profile which mates with a recess, groove 106 of catheter shaft 101 which prevents undesired rotation of carrier assembly 120. In an alternative embodiment, catheter shaft 101 includes a projection, and coupler 140 includes a groove to accomplish a similar prevention of rotation. In another alternative embodiment, control shaft 150 additionally or alternatively includes a projection or other means to mate with catheter shaft 101 to prevent undesired rotation of carrier assembly 120. As depicted in FIG. 6a, control shaft 140 includes a thru lumen, lumen 152, such that ablation catheter 101 can be inserted over a guidewire (guidewire exit on handle 110 not shown). Additionally or alternatively, lumen 150 may include one or more wires or other filamentous conduits extending from proximal handle 110 a point more distal.

Control shaft 150 is mechanically attached to coupler 140. Control shaft 150 extends proximally to handle 110 and is operably connected to knob 115 such that rotation of knob 115 from a deployed position to a withdrawn position causes carrier assembly 120 to be constrained within a lumen of catheter shaft 101, and rotation of knob 115 from a withdrawn position to a deployed position causes carrier assembly 120 to extend beyond the distal end of catheter shaft 101 to be in an expanded condition. In a preferred embodiment, knob 115 is operably connected to control shaft 150 via a cam, or set of gears, not shown, to provide a mechanical advantage in the distance traveled by control shaft 150.

Catheter shaft 101 is preferably part of a steerable sheath, steering mechanism not shown, and includes flush port 170, which is configured to be attachable to a flushing syringe, used to flush blood and other debris or contaminants from the lumen of an empty catheter shaft 101 (wherein control shaft 150, coupler 140 and carrier assembly 120 have been removed) or for flushing the space between control shaft 150 and the inner wall of catheter shaft 101. Catheter shaft 101 is not connected to handle 110, such that handle 110 can be withdrawn, removing control shaft 150, coupler 140 and carrier assembly 120 from catheter shaft 101. This configuration is useful when these components are provided in a kit form, including combinations of different versions of these components, the different combinations made available to treat multiple patients, or a single patient requiring multiple electrode patterns. A preferred example of a kit would include the catheter shaft 101 and flush port 170 of FIG. 6 acting as a sheath; kitted with handle 110, control shaft 150, coupler 140 and umbrella tipped carrier assembly 120 of FIG. 6 as well as handle 110, control shaft 150, coupler 140 and spiral tipped carrier assembly 120 of FIG. 7.

Also depicted in FIG. 6 is a system of the present invention, including in addition to ablation catheter 100, RF delivery unit 200, an energy delivery apparatus of the present invention which connects to handle 110 with a multi-conductor cable 202 attached to RF attachment port 181. RF delivery unit 200 includes user interface 201, such as a user interface including data input devices like touch screens, buttons, switches, keypads, magnetic readers and other input devices; and also including data output devices like screens, lights, audible transducers, tactile transducers and other output devices. User interface 201 is used to select electrodes to receive energy (electrodes 130 of carrier assembly 120), set power levels, durations, threshold levels and other ablation and other parameters, initiate power delivery, deactivate an alarm condition and other functions common to electronic medical devices. In a preferred embodiment, RF delivery unit 200 also includes cardiac mapping means, such that mapping attachment port 182 can be attached to RF delivery unit 200 avoiding the need for a separate piece of equipment in the system. In another preferred embodiment, RF delivery unit 200 can also deliver ultrasound and/or another form of energy, such energy delivered by one or more additional ablation elements integral to carrier assembly 120, additional ablation elements not shown. Applicable types of energy include but are not limited to: sound energy such as acoustic energy and ultrasound energy; electromagnetic energy such as electrical, magnetic, microwave and radio frequency energies; thermal energy such as heat and cryogenic energies; chemical energy; light energy such as infrared and visible light energies; mechanical energy; radiation; and combinations thereof.

In a preferred embodiment, ablation catheter 100 includes an embedded identifier (ID), an uploadable electronic or other code, which can be used by RF delivery unit 200 to confirm compatibility and other acceptability of the specific catheter 100 with the specific RF delivery unit 200. The electronic code can be a bar code, not shown, on handle 110 which is read by RF delivery unit 200, an electronic code which is transferred to RF delivery unit 200 via a wired or wireless connection, not shown, or other identifying means, such as an RF tag embedded in handle 110. In another preferred embodiment, RF delivery unit 200 also includes an embedded ID, such as an ID which can be downloaded to catheter 100 for a second or alternative acceptability check. The embedded ID can also be used to automatically set certain parameters or certain parameter ranges, and can be used to increase safety by preventing inadvertent settings outside of an acceptable range for the specific catheter 100.

Handle 110 includes two push buttons, first button 116 and second button 117. These buttons can be used to perform one or more functions, and can work in cooperation with user input components of user interface 201 such that commands entered into user interface 201 set the action taken when either or both button 116 and button 117 are pressed. In a preferred embodiment, both button 116 and button 117 must be pressed simultaneously to deliver energy to one or more ablation elements of catheter 100. At the distal end of catheter shaft 101 is a circumferential band, band 104. Band 104 is preferably a visualization marker, such as a radiographic marker, ultrasound marker, electromagnetic marker, magnetic marker and combinations thereof. In an alternative embodiment, band 104 transmits or receives energy, such as when the marker is used as a ground or other electrode during an ablation. In another alternative embodiment, band 104 is an antenna used to determine the position of the distal end of catheter shaft 101 or the location of another component in relation to band 104. In another preferred embodiment, band 104 is used to store energy, such as capacitively stored energy that can be used to generate a magnetic field or to deliver ablation energy.

Referring now to FIG. 7, another preferred embodiment of ablation catheter 100 and ablation system of the present invention is illustrated comprising a catheter with a deflecting tip and a spiral tip carrier assembly. Catheter 100 includes carrier assembly 120 configured in a spiral tip configuration. Carrier assembly 120 includes a continuous wire construction such as a Nitinol wire that has been trained to be resiliently biased, at body temperature, in the spiral shape shown. Carrier assembly 120 includes multiple electrodes, mounted at equal distances from each other and electrically isolated to the wire of carrier assembly 120. Wires, attached to each electrode but not shown, are also electrically insulated from each other and travel along the spiral to the coupler 140, and then proximally to attachment means incorporated into handle 110. In an alternative embodiment, different patterns of electrodes are employed, such as a pattern of electrodes placed along a set of radial projections from the center of the spiral. Electrodes 130 may be conductive plates, coils, or other applicable structures for deploying energy, such as RF energy to tissue, and carrier assembly 130 can consist of electrodes with different construction materials and/or geometries.

Referring back to FIG. 7, each end of the spiral carrier assembly 120 is attached to coupler 140 which is sized to be slidably received within a lumen of distal end 102 of catheter shaft 101. Coupler 140 can be flexible or rigid, and may contain both rigid and flexible portions along its length. Coupler 140 may provide electrical connection means to connect wires extending from the handle to wires from carrier assembly 120 electrodes. The ends of spiral carrier assembly 120 can be attached to the outside of coupler 140, the inside of coupler 140 or both. Coupler 140 may include anti-rotation means, not shown but described in detail in reference to FIGS. 6 and 6a. Control shaft 140 may include a thru lumen, also not shown, such that ablation catheter 101 can be inserted over a guidewire (guidewire exit on handle 110 not shown).

Coupler 140 is mechanically attached to control shaft 150 which is mechanically attached to coupler 140. Control shaft 150 extends proximally to handle 110 and is operably connected to sliding knob 111, wherein sliding knob 111 can be distally advanced or proximally retracted in slot 112. Retraction of knob 111 from a distal position to a proximal position causes carrier assembly 120 to be constrained within a lumen at distal end 102 of catheter shaft 101, and advancement of knob 111 from a proximal position to a distal position causes carrier assembly 120 to extend beyond distal end 102 of catheter shaft 101, carrier assembly 120 resiliently expanding to its spiral shaped tip. In a preferred embodiment, knob 111 is operably connected to control shaft 150 via a cam, or set of gears, not shown, to provide a mechanical advantage in the distance traveled by control shaft 150, or the force exerted on control shaft 150.

Catheter shaft 101 is part of a steerable sheath, including pull wire 105 which is secured at one end to the distal end of control shaft 150 and at the other end is operably attached to knob 113, wherein sliding knob 113 can be distally advanced or proximally retracted in slot 114. The pull wire is operably connected to the control knob 113 so that sliding of the control knob pulls pull wire 105 to effectuate steering of the distal end 102 of control shaft 150. Retraction of knob 113 proximally causes distal end of control shaft 150 to deflect and advancement of knob 113 distally causes the distal end of control shaft 150 to straighten. Using knob 113, the operator can steer the carrier assembly 120 as needed to contact different areas of the atrium wall or other tissue surface. The pull wire 105 may be unsecured to the control shaft 150 along much of its length, or it may be embedded in the control shaft 150 wall or otherwise restrained to the control shaft 150. The entire distal end of the ablation catheter 100 may also be steered with pull wire 105, as the catheter shaft 101 is sufficiently flexible that it will deform along with the control shaft 150. In an additional or alternative embodiment, a second pull wire, not shown, is attached to the distal end of catheter shaft 101, this pull wire similarly attached to control means included in handle 101. In a preferred embodiment, knob 112 is operably connected to pull wire 105 via a cam, or set of gears, not shown, to provide a mechanical advantage in the distance traveled by pull wire 105, or the force exerted on pull wire 105. In an alternative or additional embodiment, a pull wire and handle control means can be connected to either catheter shaft 101 and/or control shaft 150 and/or coupler 140 and/or carrier assembly 120 at any location along their length, to cause a specific deflection pattern. In another preferred embodiment, the shaft to which the pull wire is attached includes multiple discrete levels of stiffness and/or variable levels of stiffness, near the attachment point, such that non-continuous bending occurs, i.e. bending with multiple radii or continuously variable radii.

Catheter shaft 101 includes flush port 170, which is configured to be attachable to a flushing syringe, used to flush blood and other contaminants from the lumen of an empty catheter shaft 101 (wherein control shaft 150, coupler 140 and carrier assembly 120 have been removed) or for flushing the space between control shaft 150 and the inner wall of catheter shaft 101. In a preferred embodiment, catheter shaft 101 is not connected to handle 110, such that handle 110 can be withdrawn, removing control shaft 150, coupler 140 and carrier assembly 120 from catheter shaft 101. This configuration is useful when these components are provided in a kit form, including combinations of different versions of these components, these different combinations made available to treat multiple patients, or a single patient.

Also depicted in FIG. 7 is a system of the present invention, including in addition to ablation catheter 100, RF delivery unit 200, a energy delivery apparatus of the present invention which connects to handle 110 with a multi-conductor cable 202 attached to RF attachment port 181. RF delivery unit 200 includes user interface 201, such as a user interface including data input devices like touch screens, buttons, switches, keypads, magnetic readers and other input devices; and also including data output devices like screens, lights, audible transducers, tactile transducers and other output devices. User interface 201 is used to select electrodes to receive energy (electrodes 130 of carrier assembly 120) and perform other functions as has been described in detail in reference to FIG. 6. In a preferred embodiment, RF delivery unit 200 can also deliver ultrasound and/or another form of energy, such energy delivered by one or more additional ablation elements integral to carrier assembly 120, additional ablation elements not shown. Applicable types of energy include but are not limited to: sound energy such as acoustic energy and ultrasound energy; electromagnetic energy such as electrical, magnetic, microwave and radiofrequency energies; thermal energy such as heat and cryogenic energies; chemical energy; light energy such as infrared and visible light energies; mechanical energy; radiation; and combinations thereof.

In a preferred embodiment, ablation catheter 100 and/or RF delivery unit 200 include an embedded identifier (ID), an uploadable or downloadable electronic or other code, which can be used by the system to confirm component compatibility and/or other acceptability of the specific catheter 100 with the specific RF delivery unit 200. The electronic code and some omits uses have been described in detail in reference to FIG. 6.

Referring now to FIGS. 8a and 8b, another preferred embodiment of the ablation catheter of the present invention is illustrated comprising a carrier assembly and control shaft that collectively consist of a continuous wire with one or more electrodes secured to a mid-portion of the wire. Depicted in FIGS. 8a and 8b is the distal end 102 of catheter shaft 101 which includes lumen 107, which extends from distal end 102 to a handle mounted on the proximal end of catheter shaft 101, handle not shown but similar in construction and function to the handles of previous figures. Included within lumen 107 is a wire assembly which comprises the control shaft and carrier assembly of the present invention. The wire assembly includes wire 129′ with a first end and a second end, and wire 129″ with a first end and a second end (both first ends not shown), such that both the first end of wire 129′ and the first end of wire 129″ exit the proximal end of catheter shaft 101, the mid-portion of the wire assembly comprising carrier assembly 120 which resides near the distal end 102 of the catheter shaft 101. The wire assembly has a length such that a when the mid-portion, carrier assembly 120, fully resides distal to the distal end 102 of catheter shaft 101 and wire 129′ and wire 129″ travel proximally within lumen 107 of catheter shaft 101, both the second end of wire 129′ and the second end of wire 129″ are proximal to the proximal end of the catheter shaft 101 (proximal end not shown).

Included in the carrier assembly 120 are four electrodes 130, noting that one or more electrodes should be considered within the scope of this application. Carrier assembly 120 includes a carrier wire 128, to which the electrodes 130 are mounted. Carrier wire 128 is preferably a non-conductive wire, such as a Teflon™ coated Nitinol wire, or a braided nylon line such that the electrodes can be electrically isolated from carrier wire 128. Alternatively, each electrode 130 can include an insulator. At each end of carrier assembly 120, carrier wire 128 transitions to wire 129′ and wire 129″ through transition point 122′ and transition point 122″ respectively. Depicted in FIGS. 8a and 8b carrier wire 128 has a smaller diameter than wire 129′ and wire 129″, such that wire 129′ and wire 129″ provides support of carrier assembly 120, in the configuration illustrated, such that carrier assembly 120 can be “pushed” into tissue while carrier wire 128 flexes in response to the tissue interaction. In alternative embodiments, various diameters, including continuous diameters and varied diameters can be used for each of the three components including a different diameter for each as well as a single diameter for the three, for example a single diameter Nitinol wire making up wire 129′, transition point 122′, carrier wire 128, transition point 122″ and carrier wire 129″. In an alternative embodiment, carrier wire 128 is a different material, with the same diameter or a different diameter, than one or more of wire 129′ and wire 129″. The carrier assembly 120 of FIGS. 8a and 8b is resiliently biased in a linear shape such that when carrier assembly 120 is fully exterior to lumen 107 of catheter shaft 101, as depicted in FIG. 8a, carrier wire 128 is relatively perpendicular to the axis of catheter shaft 101 and electrodes 130 are in a linear pattern. In an alternative embodiment, carrier wire 128 has a resiliently biased bowed shape, such as a bowed in shape or a bowed out shape. In another alternative embodiment, the electrodes 130 lie in multiple planes.

Carrier assembly 120 can be constrained within lumen 107 catheter shaft 101 by retracting wire 129′, wire 129″ or both. Utilizing control means incorporated into a handle, both not shown but described in detail in reference to previous figures, these advancements can be accomplished by an operator. Referring specifically to FIG. 8b, wire 129″ has been retracted such that transition point 122′ first enters lumen 107. Continued retraction of wire 129″ causes carrier wire 128 and its electrodes 130 to enter lumen 107, followed by transition point 122′ and a small segment of wire 129′. Alternatively or additionally, wire 129″ can be retracted with a similar, symmetrical result, or both wires can be retracted in similar or dissimilar amounts wherein all described retractions cause carrier assembly 120 to be constrained with lumen 107 of catheter shaft. Performing the opposite step of advancing wire 129′, wire 129″ or both wires, such as with the same control that retracted the one or more wires, will cause carrier assembly 120 to advance past distal end 102 of catheter shaft 101, carrier assembly 120 then expanding to its resiliently biased condition. The ablation catheter of FIGS. 8a and 8b does not include the coupler of FIGS. 1 through 7, although in an alternative embodiment, two couplers can be incorporated onto the ends of carrier wire 128 and on to wire 129′ and wire 129″. In another alternative embodiment, the ablation catheter of FIGS. 8 and 8b can includes two wire assemblies, each including a separate carrier assembly each having ends attached to wires extending proximally. The multiple wire assemblies can have carrier assemblies with different or similar components and resiliently biased patterns of electrodes.

Referring now to FIG. 9, an ablation element of the present invention is illustrated. Electrode 130, shown mounted to distal arm segment 127, such as a distal arm segment 127 of FIGS. 2 through 4. Included in electrode 130, is ultrasound crystal 132 and thermocouple 133. Wires, now shown, are attached to electrode 130, ultrasound crystal 132 and thermocouple 133, and travel along distal arm segment 127, to the lumen of the ablation catheter and proximally to the handle of the ablation catheter, all not shown. These wires interface with electronics within the handle and/or connected to a energy delivery apparatus, such as the RF delivery apparatus of FIGS. 6 and 7. The ultrasound crystal can be used to deliver ultrasound energy, simultaneous with or at a different time from RF energy being delivered to the tissue. Thermocouple 133 can be used to measure the temperature local to thermocouple 133 such as prior to, during or after the delivery of ablation energy. When an ablation is performed in the left atrium, such as the posterior wall of the left atrium, maintaining the tissue at a temperature below a threshold is needed. This wall is fairly thin, and the patient's esophagus lies immediately behind this wall. Ablation in this area entails a risk of perforating the atrial wall and the esophagus. In a preferred embodiment, information recorded from the thermocouple 133 is used to adjust energy delivery such as to start or stop one or more energy deliveries, or to increase, decrease, modify the frequency of, modify the bipolar or monopolar delivery means, or otherwise adjust the energy delivery based on a determined temperature or temperature information analysis. In another preferred embodiment, energy delivery is ceased when information from the thermocouple is one or more of: higher than a threshold, lower than a threshold such as lower than expected body temperature; or when the information is unavailable such as when the thermocouple is nonfunctional. In another preferred embodiment, in addition or alternative to the ultrasound energy, another form of energy is delivered by electrode 130. In another alternative embodiment, ultrasound crystal 133 and electrode 130 are two discrete components, located in proximity to one another on distal arm segment 127.

Referring now to FIG. 10, an electrode assembly of the present invention is illustrated with electrode assembly 230 connected to power, signal and ground wires. Electrode assembly 230 includes a semiconductor substrate, such as a silicon substrate, in which is embedded numerous components fabricated using one or more of: integrated circuit fabrication machinery; Micro Electro-Mechanical Systems (MEMS) fabrication machinery; nano-system fabrication machines; other semi-conductor fabrication machinery; and combinations thereof. Electrode assembly 230 includes relay 236, which is configured to connect and disconnect ablation electrode 231 from an energy delivery apparatus connected to the ablation catheter to which electrode assembly 230 is a component. Other forms of relays can be integrated with multiple poles and multiple throws. Relays can connect and disconnect sources of signals and/or power. Multiple electrode assemblies 230 can be attached to a single, continuous ablation power wire and return ground greatly reducing the number of wires needed to travel from the proximal handle to the carrier assembly. Individual, or combination control of each ablation electrode 231 can be provided however, through opening or closing of relay 236 which is accomplished via timing circuitry 235. Control signals are sent to the embedded electronics of timing circuitry 235 such that digital or analog information can be transferred into logic that open and closed each relay 236, at precise times, and utilizing specific electronic identifiers embedded in each electrode assembly 230, can independently control all of the components of electrode assembly 230. Timing circuitry 235 can interpret signals that it receives from another electrode assembly 230, or a device external to the patient. Timing circuitry 235 can produce pulse-width modulated opening and closing of relay 236, or other sophisticated timing patterns which may be specific to the construction or makeup of electrode assembly 230.

Electrode assembly 230 further includes sensor 233, which can be an individual sensor or bank of multiple sensors such as a sensor to sense one or more of: chemical activity, light characteristic such as intensity or wavelength, electrical activity, pH, temperature, pressure, fluid flow or other physiologic parameter. Electrode assembly 230 further includes sensor interface 234 which includes various electronic components and circuitry such as circuitry created in various doping and other integrated circuit building processes used in a semiconductor substrate such as silicon. The information provided by sensor 233 can be processed by sensor interface 234 and/or by circuitry included in a proximal handle or energy delivery apparatus. This information can be used to start, stop, increase, decrease or otherwise modify energy delivery or control another function of electrode assembly 230 or another function of the ablation catheter of the present invention.

Electrode assembly 230 further includes mapping electrode 232 which provides recording of electrical signals of the heart, such as signals used to identify rotors to be ablated during the procedure. In an alternative embodiment, ablation electrode 231 is used to record the electrical signals of the heat. Electrode assembly 230 further includes functional element 237, which may include integrated circuit components described above, as well as MEMS or nanomachine components that are well known to being integrated into semiconductor substrates using the appropriate machinery. A preferred embodiment of FIG. 10 is the incorporation of a MEMS valve which is used to control fluid flow, such as fluid flow to cool electrode assembly 230 and/or ablation electrode 231 or a valve used to control the flow of or release cryogenic fluid used to ablate tissue. In another preferred embodiment, a MEMS pump can be used to pump fluid, such as a drug or other chemical used to chemically create a lesion in tissue. In another preferred embodiment a MEMS linear actuator is incorporated to deploy one or more microneedles used to deliver a fluid such as the described drug. In another preferred embodiment, micro controller or microprocessor circuitry is embedded in a semiconductor portion of electrode assembly 230 such that sophisticated signal processing and/or controlled loop delivery of energy can be configured such that complicated energy delivery can be used with one or more less sophisticated energy delivery apparatus.

Multiple semiconductor portions can be integrated into electrode assembly 230, such as portions which are connected with an insulating material and/or a flexible material providing a flexible joint between rigid portions of electrode assembly 230. Utilizing semiconductor technology and/or MEMS or other semiconductor fabrication means, numerous functions can be incorporated into electrode assembly 230 to improve therapeutic benefit of the procedure, provide enhanced safety to the procedure, or provide other therapeutic or non-therapeutic benefit to the patient or the operator of the system. In an alternative embodiment, the electrode assembly further comprises a cooling element, such as a heat sink, not shown.

Referring now to FIG. 11, an end view of another preferred embodiment of the carrier assembly of the present invention is illustrated comprising a carrier assembly in a spiral tip configuration. Carrier assembly 120, shown in its resiliently expanded condition, includes a single wire, carrier wire 128 which has a first end 143 and a second end 144. First end 143 in attached to coupler 140, travels radially out from the center axis of catheter shaft 101 and carrier wire 128 begins to travel along a continuously increasing radius creating a multiple loop spiral. After the creation of six spirals, carrier wire 128 travels radially in toward the central axis of catheter shaft 101, such that second end 144 also attached to coupler 140. Referring to FIG. 11a, a side view of the carrier assembly 120 of FIG. 11 is depicted in its fully expanded condition wherein the spirals lie in multiple planes. FIG. 11b illustrates a side view of an alternative embodiment of the carrier assembly of FIG. 11, in which the spirals of the carrier assembly 120, depicted in its fully expanded condition, lie in a relatively single plane. The spirals of both FIGS. 11a and 11b include one or more electrodes 130. The length and diameter of the carrier wire 128, as well as the size of the electrodes, are chosen such that the control shaft 150, which is connected to carrier assembly 120 by coupler 140, can be retracted such that the entire carrier assembly 120 appropriately folds and is constrained within a lumen of catheter shaft 101.

Another alternative embodiment of the ablation catheter of the present invention is also depicted in FIG. 11b wherein means of anchoring the carrier assembly 120 to the tissue to be ablated is provided. In the center portion of the spiral, suction port 153 is provided. Suction port 153 is fluidly attached to control shaft lumen 152 which is also fluidly attached to a port on the proximal handle, not shown. A vacuum apparatus, such as a locking syringe, also not shown, when attached to the proximal handle, and the carrier assembly 120 is brought in contact with tissue; and the vacuum is generated such as drawing back the plunger of the syringe and locking the plunger, will cause the carrier assembly to be anchored to the tissue. This anchoring embodiment is of particular value when first performing an assessment such as a mapping procedure or other analysis from electrodes or other sensors; after which an ablation is to be performed in the same location. In an alternative embodiment, suction port 153 is replaced with a deployable tissue penetrating anchor, such as a corkscrew wire or barbed wire.

Referring now to FIG. 12, an end view of another preferred embodiment of the carrier assembly of the present invention is illustrated comprising a carrier assembly with multiple wires, each with a proximal end and a distal end, wherein each proximal end and each distal end is secured to coupler 140. Carrier assembly 120 includes multiple carrier wires 128, each with a flower petal or petaloid shape when fully expanded. Each end of carrier wire 128 is secured to coupler 140, which is attached to a control shaft, not shown. The control shaft is sized to be slidingly received by catheter shaft 101. Carrier wires 128 include one or more electrodes, and one or more carrier wires 128 may include no electrodes, all electrodes not shown. The carrier wire length and diameter, as well as the size of the electrodes, are chosen such that the control shaft can be retracted such that the entire carrier assembly 120 appropriately folds and is constrained within a lumen of catheter shaft 101. In an alternative embodiment, each proximal end of carrier wire assembly is attached to coupler 140, and each distal end is attached near the distal end of catheter shaft 101, such as within the lumen of catheter shaft 101, such that retraction of the control shaft causes coupler 140 and carrier assembly 120 to reside within a lumen of catheter shaft 101.

It should be understood that numerous other configurations of the systems, devices and methods described herein can be employed without departing from the spirit or scope of this application. It should be understood that the system includes multiple functional components, such as the ablation catheter and the energy delivery apparatus. The ablation catheter consists of a catheter shaft, a carrier assembly for providing electrodes in a resiliently biased configuration, a control shaft for deploying and withdrawing the carrier assembly, and a coupler for attaching the control shaft to the carrier assembly. The carrier assembly is a support structure which is shiftable from a storage or confined configuration, such as a radially constrained configuration, to a deployed or expanded configuration. The carrier assembly can includes wires, ribbons, cables and struts, made of either metals, non-metals or combinations of both. The carrier assembly can be constructed of one or more materials, including both metals and non-metals. Typical metals chosen for carrier assembly construction include but are not limited to: stainless steel, Nitinol, Elgiloy™, other alloys and combinations thereof.

The ablation catheter of the present invention may include a steerable outer sheath, or may work in conjunction as a system with a separate steerable outer sheath. One or more tubular components of the ablation catheter may be steerable such as with the inclusion of a controllable pull wire at or near the distal end. The ablation catheter of the present invention may be inserted over the wire, such as via a lumen within one of the tubular conduits such as within a lumen of the tubular body member or control shaft, or alternatively the catheter may include a rapid exchange sidecar at or near its distal end, consisting of a small projection with a guidewire lumen therethrough. A guidewire lumen may be included solely for the guidewire, or may provide other functions such as a vacuum lumen for an integral suction port integrated at the distal portion of the carrier assembly.

The ablation catheter of the present invention further includes ablation elements. In preferred embodiments, one or more ablation elements are electrodes configured to deliver RF energy. Other forms of energy, alternative or in addition to RF, may be delivered, including but not limited to: acoustic energy and ultrasound energy; electromagnetic energy such as electrical, magnetic, microwave and radiofrequency energies; thermal energy such as heat and cryogenic energies; chemical energy; light energy such as infrared and visible light energies; mechanical energy; radiation; and combinations thereof. One or more ablation elements may comprise a drug delivery pump or a device to cause mechanical tissue damage such as a forwardly advanceable spike or needle. The ablation elements can deliver energy individually, in combination with or in serial fashion with other ablation elements. The ablation elements can be electrically connected in parallel, in series, individually, or combinations thereof. The ablation catheter may include cooling means to prevent undesired tissue damage and/or blood clotting. The ablation elements may be constructed of various materials, such as plates of metal and coils of wire for RF energy delivery. The electrodes can take on various shapes including shapes used to focus energy such as a horn shape to focus sound energy, and shapes to assist in cooling such as a geometry providing large surface area. Electrodes can vary within a single carrier assembly, such as a spiral array of electrodes or a umbrella tip configuration wherein electrodes farthest from the central axis of the catheter have the largest major axis. Wires and other flexible conduits are attached to the ablation elements, such as electrical energy carrying wires for RF electrodes or ultrasound crystals, and tubes for cryogenic delivery.

The ablation elements requiring electrical energy to ablate require wired connections to an electrical energy power source such as an RF power source. In configurations with large numbers of electrodes, individual pairs of wires for each electrode may be bulky and compromise the cross-sectional profile of the ablation catheter. In an alternative embodiment, one or more electrodes, connected in serial fashion such that a reduced number of wires, such as two wires, can be attached to two or more electrodes, include switching means such that while a first electrode is powered, the remaining electrodes do not transmit ablative energy. Switching means may be a thermal switch, such that as a first electrodes heats up, a single pole double throw switch change state disconnecting power from that electrode and attaching power to the next electrode in the serial connection. This integral temperature switch may have a first temperature to disconnect the electrode, and a second temperature to reconnect the electrode wherein the second temperature is lower than the first temperature, such as a second temperature below body temperature. In an alternative embodiment, each electrode is constructed of materials in their conductive path such that as when the temperature increased and reached a predetermined threshold, the resistance abruptly decreased to near zero, such that power dissipation, or heat, generated by the electrode was also near zero, and more power could be delivered to the next electrode incorporating the above switching means.

The ablation catheter of the present invention preferably includes a handle activating or otherwise controlling one or more functions of the ablation catheter. The handle may include various knobs, such as rotating or sliding knobs which are operably connected to advanceable conduits, or are operably connected to gear trains or cams which are connected to advanceable conduits. These knobs, such as knobs use to deflect a distal portion of a conduit, or to advance or retract the carrier assembly, preferably include a reversible locking mechanism such that a particular tip deflection or deployment amount can be maintained through various manipulations of the system.

The ablation catheter may include one or more sensors, such as sensors used to detect chemical activity; light; electrical activity; pH; temperature; pressure; fluid flow or another physiologic parameter. These sensors can be used to map electrical activity, measure temperature, or gather other information that may be used to modify the ablation procedure. In a preferred embodiment, one or more sensors, such as a mapping electrode, can also be used to ablate tissue.

Numerous components internal to the patient, such as the carrier assembly or electrodes, may include one or more visual markers such as radiopaque markers visible under fluoroscopy, or ultrasound markers.

Selection of the tissue to be ablated may be based on a diagnosis of aberrant conduit or conduits, or based on anatomical location. RF energy may be delivered first, followed by another energy type in the same location, such as when a single electrode can deliver more than one type of energy, such as RF and ultrasound energy. Alternatively or additionally, a first procedure may be performed utilizing one type of energy, followed by a second procedure utilizing a different form of energy. The second procedure may be performed shortly after the first procedure, such as within four hours, or at a later date such as greater than twenty-four hours after the first procedure. Numerous types of tissue can be ablated utilizing the devices, systems and methods of the present invention. For example, the various aspects of the invention have application in procedures for ablating tissue in the prostrate, brain, gall bladder, uterus, other organs and regions of the body, and a tumor, preferably regions with an accessible wall or flat tissue surface. In the preferred embodiment, heart tissue is ablated, such as left atrial tissue.

In another preferred embodiment of the system of the present invention, an ablation catheter and a heat sensing technology are included. The heat sensing technology, includes sensor means that may be placed on the chest of the patient, the esophagus or another area in close enough proximity to the tissue being ablated to directly measure temperature effects of the ablation, such as via a temperature sensor, or indirectly such as through the use of an infrared camera. In the described system, when a temperature or a surrogate temperature reaches a threshold, such as an adjustable threshold, the ablation energy is reduced or stopped, to one or more ablation elements. The threshold will depend on the location of the sensor means, as well as where the ablation energy is being delivered. The threshold may be adjustable, and may be automatically configured.

Numerous kit configurations are also to be considered within the scope of this application. An ablation catheter is provided with multiple carrier assemblies. These carrier assemblies can be removed for the tubular body member of the catheter, or may include multiple tubular body members in the kit. The multiple carrier assemblies can have different patterns, different types or amounts of electrodes, and have numerous other configurations including compatibility with different forms of energy.

Though the ablation device has been described in terms of its preferred endocardial and transcutaneous method of use, the array may be used on the heart during open heart surgery, open chest surgery, or minimally invasive thoracic surgery. Thus, during open chest surgery, a short catheter or cannula carrying the carrier assembly and its electrodes may be inserted into the heart, such as through the left atrial appendage or an incision in the atrium wall, to apply the electrodes to the tissue to be ablated. Also, the carrier assembly and its electrodes may be applied to the epicardial surface of the atrium or other areas of the heart to detect and/or ablate arrhythmogenic foci from outside the heart.

Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the invention being indicated by the following claims. In addition, where this application has listed the steps of a method or procedure in a specific order, it may be possible, or even expedient in certain circumstances, to change the order in which some steps are performed, and it is intended that the particular steps of the method or procedure claim set forth herebelow not be construed as being order-specific unless such order specificity is expressly stated in the claims.

Claims

1. A method of ablating target tissue of a patient comprising: placing an array of electrodes of a medical device defining a major longitudinal axis on or near the targeted tissue, the array of electrodes including a flexible carrier assembly on which the array of electrodes is disposed, the flexible carrier assembly including a plurality of resilient arms, each arm having a proximal arm segment and a distal arm segment joined to each other at a bend point, and when the flexible carrier assembly is in a fully deployed configuration, the array of electrodes defines a substantially planar surface substantially orthogonal to the major longitudinal axis, the medical device having an elongate body, a control shaft within the elongate body, and a coupler coupling the control shaft to the flexible carrier assembly, the coupler including at least one projection to prevent rotation of the flexible carrier assembly;placing a conductive pad in contact with a part of the patient's body other than the targeted tissue;conducting electrical energy from a first electrode of the array through the target tissue to at least a second electrode of the array in a bipolar manner without conducting electrical energy to the conductive pad; andconducting electrical energy from at least one of the electrodes of the array through the target tissue to the conductive pad in a monopolar manner without conducting electrical energy from the first electrode to the second electrode.
2. The method of claim 1, wherein energy is conducted from the first electrode of the array through the target tissue to the second electrode of the array in the bipolar manner after energy is conducted from the first electrode of the array through the target tissue to the conductive pad in the monopolar manner.
3. The method of claim 2 further comprising ceasing conduction of electrical energy from the array of electrodes after conducting energy in the bipolar manner and after conducting energy in the monopolar manner, then conducting electrical energy from the first electrode of the array to at least the second electrode of the array.
4. The method of claim 3 further comprising measuring a temperature of at least one electrode of the electrode array after conducting the energy in the bipolar manner and before conducting energy in the monopolar manner.
5. The method of claim 1 wherein the target tissue is cardiac tissue.
6. The method of claim 1, further comprising assessing a condition of the targeted tissue.
7. The method of claim 1, further comprising assessing a condition of the targeted tissue before conducting electrical energy from at least one of the electrodes of the array through the target tissue to the conductive pad in a monopolar manner without conducting electrical energy from the first electrode to the second electrode.
8. The method of claim 7, wherein assessing the condition of the targeted tissue includes placing one or more sensors in contact with the targeted tissue.
9. The method of claim 8, wherein the one or more sensors are mapping electrodes, assessing the condition of the targeted tissue further including mapping electrical activity within the targeted tissue.
10. The method of claim 8, wherein the one or more sensors are at least one of chemical sensors, light sensors, electrical sensors, pH sensors, temperature sensors, and pressure sensors.

CROSS-REFERENCE TO RELATED APPLICATION

This application is a divisional of and claims priority to U.S. patent application Ser. No. 12/245,625, filed Oct. 3, 2008, entitled “Ablation Catheter”, which is a continuation of and claims priority to U.S. patent application Ser. No. 11/179,333, filed Jul. 12, 2005 entitled “Ablation Catheter” which claims the benefit under 35 U.S.C. 119 of U.S. Patent Application No. 60/618,753 filed Oct. 14, 2004, entitled “Ablation Catheter”, the entirety of which is incorporated herein by reference.

US Referenced Citations (465)

Number	Name	Date	Kind
3516412	Ackerman	Jun 1970	A
3951136	Wall	Apr 1976	A
4017903	Chu	Apr 1977	A
4112952	Thomas et al.	Sep 1978	A
4411266	Cosman	Oct 1983	A
4432377	Dickhudt	Feb 1984	A
4660571	Hess et al.	Apr 1987	A
4699147	Chilson et al.	Oct 1987	A
4785815	Cohen	Nov 1988	A
4860769	Fogarty et al.	Aug 1989	A
4869248	Narula	Sep 1989	A
4882777	Narula	Nov 1989	A
4896671	Cunningham et al.	Jan 1990	A
4907589	Cosman	Mar 1990	A
4920980	Jackowski	May 1990	A
4940064	Desai	Jul 1990	A
4966597	Cosman	Oct 1990	A
5010894	Edhag	Apr 1991	A
5016808	Heil, Jr. et al.	May 1991	A
5083565	Parins	Jan 1992	A
5100423	Fearnot	Mar 1992	A
5156151	Imran	Oct 1992	A
5184621	Vogel et al.	Feb 1993	A
5215103	Desai	Jun 1993	A
5228442	Imran	Jul 1993	A
5230349	Langberg	Jul 1993	A
5231995	Desai	Aug 1993	A
5234004	Hascoet et al.	Aug 1993	A
5239999	Imran	Aug 1993	A
5255679	Imran	Oct 1993	A
5279299	Imran	Jan 1994	A
5281213	Milder et al.	Jan 1994	A
5281218	Imran	Jan 1994	A
5309910	Edwards et al.	May 1994	A
5313943	Houser et al.	May 1994	A
5318525	West et al.	Jun 1994	A
5324284	Imran	Jun 1994	A
5327889	Imran	Jul 1994	A
5330466	Imran	Jul 1994	A
5334193	Nardella	Aug 1994	A
5342295	Imran	Aug 1994	A
5342357	Nardella	Aug 1994	A
5345936	Pomeranz et al.	Sep 1994	A
5348554	Imran et al.	Sep 1994	A
D351652	Thompson et al.	Oct 1994	S
5364352	Cimino et al.	Nov 1994	A
5365926	Desai	Nov 1994	A
5370644	Langberg	Dec 1994	A
5383852	Stevens-Wright	Jan 1995	A
5383917	Desai et al.	Jan 1995	A
5391147	Imran et al.	Feb 1995	A
5397304	Truckai	Mar 1995	A
5397339	Desai	Mar 1995	A
5400783	Pomeranz et al.	Mar 1995	A
5404638	Imran	Apr 1995	A
5406946	Imran	Apr 1995	A
5411025	Webster, Jr.	May 1995	A
5423808	Edwards et al.	Jun 1995	A
5423811	Imran et al.	Jun 1995	A
5433198	Desai	Jul 1995	A
5433739	Sluijter et al.	Jul 1995	A
5445148	Jaraczewski et al.	Aug 1995	A
5462521	Brucker et al.	Oct 1995	A
5462545	Wang et al.	Oct 1995	A
5465717	Imran et al.	Nov 1995	A
5471982	Edwards et al.	Dec 1995	A
5487757	Truckai et al.	Jan 1996	A
5492119	Abrams	Feb 1996	A
5500011	Desai	Mar 1996	A
5507802	Imran	Apr 1996	A
5509411	Littmann et al.	Apr 1996	A
5527279	Imran	Jun 1996	A
5533967	Imran	Jul 1996	A
5536267	Edwards et al.	Jul 1996	A
5540681	Strul et al.	Jul 1996	A
5545161	Imran	Aug 1996	A
5545193	Fleischman et al.	Aug 1996	A
5545200	West et al.	Aug 1996	A
5558073	Pomeranz et al.	Sep 1996	A
5562720	Stern et al.	Oct 1996	A
5573533	Strul	Nov 1996	A
5575766	Swartz et al.	Nov 1996	A
5575810	Swanson et al.	Nov 1996	A
5578007	Imran	Nov 1996	A
5582609	Swanson et al.	Dec 1996	A
5584830	Ladd et al.	Dec 1996	A
5588432	Crowley	Dec 1996	A
5588964	Imran et al.	Dec 1996	A
5595183	Swanson et al.	Jan 1997	A
5596995	Sherman et al.	Jan 1997	A
5598848	Swanson et al.	Feb 1997	A
5601088	Swanson et al.	Feb 1997	A
5606974	Castellano et al.	Mar 1997	A
5607462	Imran	Mar 1997	A
5620481	Desai et al.	Apr 1997	A
5626136	Webster, Jr.	May 1997	A
5630425	Panescu et al.	May 1997	A
5630837	Crowley	May 1997	A
5637090	McGee et al.	Jun 1997	A
D381076	Thornton et al.	Jul 1997	S
5645064	Littmann et al.	Jul 1997	A
5645082	Sung et al.	Jul 1997	A
5651780	Jackson	Jul 1997	A
5656029	Imran et al.	Aug 1997	A
5657755	Desai	Aug 1997	A
5658278	Imran et al.	Aug 1997	A
5662606	Cimino et al.	Sep 1997	A
5666970	Smith	Sep 1997	A
5673695	McGee et al.	Oct 1997	A
5680860	Imran	Oct 1997	A
5681280	Rusk et al.	Oct 1997	A
5682885	Littmann et al.	Nov 1997	A
5685322	Sung et al.	Nov 1997	A
5687723	Avitall	Nov 1997	A
5693078	Desai et al.	Dec 1997	A
5697927	Imran et al.	Dec 1997	A
5697928	Walcott et al.	Dec 1997	A
5699796	Littmann et al.	Dec 1997	A
5702438	Avitall	Dec 1997	A
5704791	Gillio	Jan 1998	A
5706809	Littmann et al.	Jan 1998	A
5711298	Littmann et al.	Jan 1998	A
5716389	Walinsky et al.	Feb 1998	A
5722401	Pietroski et al.	Mar 1998	A
5722975	Edwards et al.	Mar 1998	A
5724985	Snell et al.	Mar 1998	A
5733323	Buck et al.	Mar 1998	A
5735280	Sherman et al.	Apr 1998	A
5741320	Thornton et al.	Apr 1998	A
5766152	Morley et al.	Jun 1998	A
5769791	Benaron et al.	Jun 1998	A
5769847	Panescu et al.	Jun 1998	A
5772590	Webster, Jr.	Jun 1998	A
5775327	Randolph et al.	Jul 1998	A
5782239	Webster, Jr.	Jul 1998	A
5782760	Schaer	Jul 1998	A
5782828	Chen et al.	Jul 1998	A
5782899	Imran	Jul 1998	A
5792140	Tu et al.	Aug 1998	A
5800482	Pomeranz et al.	Sep 1998	A
5810740	Paisner	Sep 1998	A
5820568	Willis	Oct 1998	A
5827272	Breining et al.	Oct 1998	A
5837001	Mackey	Nov 1998	A
5849028	Chen	Dec 1998	A
5857464	Desai	Jan 1999	A
5857997	Cimino et al.	Jan 1999	A
5860920	McGee et al.	Jan 1999	A
5863291	Schaer	Jan 1999	A
5871523	Fleischman et al.	Feb 1999	A
5873865	Horzewski et al.	Feb 1999	A
5876399	Chia et al.	Mar 1999	A
5881732	Sung et al.	Mar 1999	A
5882333	Schaer et al.	Mar 1999	A
5885278	Fleischman	Mar 1999	A
5891027	Tu et al.	Apr 1999	A
5891135	Jackson et al.	Apr 1999	A
5891137	Chia et al.	Apr 1999	A
5891138	Tu et al.	Apr 1999	A
5893847	Kordis	Apr 1999	A
5893884	Tu	Apr 1999	A
5893885	Webster, Jr.	Apr 1999	A
5895355	Schaer	Apr 1999	A
5895417	Pomeranz et al.	Apr 1999	A
5897554	Chia et al.	Apr 1999	A
5904680	Kordis et al.	May 1999	A
5906605	Coxum	May 1999	A
5910129	Koblish et al.	Jun 1999	A
5911720	Bourne et al.	Jun 1999	A
5913854	Maguire et al.	Jun 1999	A
5916214	Cosio et al.	Jun 1999	A
5928191	Houser et al.	Jul 1999	A
5931835	Mackey	Aug 1999	A
5935063	Nguyen	Aug 1999	A
5938694	Jaraczewski et al.	Aug 1999	A
5941845	Tu et al.	Aug 1999	A
5951471	de la Rama et al.	Sep 1999	A
5954719	Chen et al.	Sep 1999	A
5957842	Littmann et al.	Sep 1999	A
5960796	Sung et al.	Oct 1999	A
5967978	Littmann et al.	Oct 1999	A
5968040	Swanson et al.	Oct 1999	A
5971980	Sherman	Oct 1999	A
5989245	Prescott	Nov 1999	A
5992418	de la Rama et al.	Nov 1999	A
5997532	McLaughlin et al.	Dec 1999	A
6001093	Swanson et al.	Dec 1999	A
6001095	de la Rama et al.	Dec 1999	A
6002956	Schaer	Dec 1999	A
6004269	Crowley et al.	Dec 1999	A
6014581	Whayne et al.	Jan 2000	A
6021340	Randolph et al.	Feb 2000	A
6023638	Swanson	Feb 2000	A
6029091	de la Rama et al.	Feb 2000	A
6032674	Eggers et al.	Mar 2000	A
6033403	Tu et al.	Mar 2000	A
6042580	Simpson	Mar 2000	A
6045550	Simpson et al.	Apr 2000	A
6048329	Thompson et al.	Apr 2000	A
6049737	Simpson et al.	Apr 2000	A
6050994	Sherman	Apr 2000	A
6052612	Desai	Apr 2000	A
6053937	Edwards et al.	Apr 2000	A
6056744	Edwards	May 2000	A
6059778	Sherman	May 2000	A
6063077	Schaer	May 2000	A
6063082	DeVore et al.	May 2000	A
6064902	Haissaguerre et al.	May 2000	A
6068629	Haissaguerre et al.	May 2000	A
6070094	Swanson et al.	May 2000	A
6071274	Thompson et al.	Jun 2000	A
6071279	Whayne et al.	Jun 2000	A
6071281	Burnside et al.	Jun 2000	A
6071282	Fleischman	Jun 2000	A
6074351	Houser	Jun 2000	A
6086581	Reynolds et al.	Jul 2000	A
6088610	Littmann et al.	Jul 2000	A
6096036	Bowe et al.	Aug 2000	A
6099524	Lipson et al.	Aug 2000	A
6106522	Fleischman et al.	Aug 2000	A
6107699	Swanson	Aug 2000	A
6115626	Whayne et al.	Sep 2000	A
6119041	Pomeranz et al.	Sep 2000	A
6120476	Fung et al.	Sep 2000	A
6129724	Fleischman et al.	Oct 2000	A
6141576	Littmann et al.	Oct 2000	A
6146379	Fleischman et al.	Nov 2000	A
6146381	Bowe et al.	Nov 2000	A
6165169	Panescu et al.	Dec 2000	A
6167291	Barajas et al.	Dec 2000	A
6171305	Sherman	Jan 2001	B1
6171306	Swanson et al.	Jan 2001	B1
6179833	Taylor	Jan 2001	B1
6200314	Sherman	Mar 2001	B1
6212426	Swanson	Apr 2001	B1
6214002	Fleischman et al.	Apr 2001	B1
6216043	Swanson et al.	Apr 2001	B1
6216044	Kordis	Apr 2001	B1
6217573	Webster	Apr 2001	B1
6217576	Tu et al.	Apr 2001	B1
6226542	Reisfeld	May 2001	B1
6231570	Tu et al.	May 2001	B1
6238390	Tu et al.	May 2001	B1
6241666	Pomeranz et al.	Jun 2001	B1
6241724	Fleischman et al.	Jun 2001	B1
6241725	Cosman	Jun 2001	B1
6241726	Raymond Chia et al.	Jun 2001	B1
6241727	Tu et al.	Jun 2001	B1
6241728	Gaiser et al.	Jun 2001	B1
6241754	Swanson et al.	Jun 2001	B1
6245067	Tu et al.	Jun 2001	B1
6245089	Daniel et al.	Jun 2001	B1
6251107	Schaer	Jun 2001	B1
6256540	Panescu et al.	Jul 2001	B1
6264653	Falwell	Jul 2001	B1
6264664	Avellanet	Jul 2001	B1
6267746	Bumbalough	Jul 2001	B1
6290697	Tu et al.	Sep 2001	B1
6293943	Panescu et al.	Sep 2001	B1
6302880	Schaer	Oct 2001	B1
6309385	Simpson	Oct 2001	B1
6312425	Simpson et al.	Nov 2001	B1
6319249	Tollner	Nov 2001	B1
6319251	Tu et al.	Nov 2001	B1
6325797	Stewart et al.	Dec 2001	B1
6332880	Yang et al.	Dec 2001	B1
6332881	Carner et al.	Dec 2001	B1
6346104	Daly et al.	Feb 2002	B2
6353751	Swanson et al.	Mar 2002	B1
6360128	Kordis et al.	Mar 2002	B2
6370435	Panescu et al.	Apr 2002	B2
6371955	Fuimaono et al.	Apr 2002	B1
6379352	Reynolds et al.	Apr 2002	B1
6389311	Whayne et al.	May 2002	B1
6391024	Sun et al.	May 2002	B1
6425894	Brucker et al.	Jul 2002	B1
6428536	Panescu et al.	Aug 2002	B2
6428537	Swanson et al.	Aug 2002	B1
6440129	Simpson	Aug 2002	B1
6447506	Swanson et al.	Sep 2002	B1
6451015	Rittman, III et al.	Sep 2002	B1
6454758	Thompson et al.	Sep 2002	B1
6456864	Swanson et al.	Sep 2002	B1
6460545	Kordis	Oct 2002	B2
6471693	Carroll et al.	Oct 2002	B1
6471699	Fleischman et al.	Oct 2002	B1
6475213	Whayne et al.	Nov 2002	B1
6475214	Moaddeb	Nov 2002	B1
6477396	Mest et al.	Nov 2002	B1
6478793	Cosman et al.	Nov 2002	B1
6485487	Sherman	Nov 2002	B1
6487441	Swanson et al.	Nov 2002	B1
6488678	Sherman	Dec 2002	B2
6490468	Panescu et al.	Dec 2002	B2
6493586	Stahmann et al.	Dec 2002	B1
6500167	Webster, Jr.	Dec 2002	B1
6500172	Panescu et al.	Dec 2002	B1
6514246	Swanson et al.	Feb 2003	B1
6517536	Hooven et al.	Feb 2003	B2
6522905	Desai	Feb 2003	B2
6529756	Phan et al.	Mar 2003	B1
6530922	Cosman et al.	Mar 2003	B2
6540744	Hassett et al.	Apr 2003	B2
6542773	Dupree et al.	Apr 2003	B2
6544262	Fleischman	Apr 2003	B2
6551271	Nguyen	Apr 2003	B2
6554794	Mueller et al.	Apr 2003	B1
6558378	Sherman et al.	May 2003	B2
6565511	Panescu et al.	May 2003	B2
6569114	Ponzi et al.	May 2003	B2
6569162	He	May 2003	B2
6569163	Hata et al.	May 2003	B2
6572612	Stewart et al.	Jun 2003	B2
6574492	Ben-Haim et al.	Jun 2003	B1
6575997	Palmer et al.	Jun 2003	B1
6583796	Jamar et al.	Jun 2003	B2
6597955	Panescu et al.	Jul 2003	B2
6602242	Fung et al.	Aug 2003	B1
6605087	Swartz et al.	Aug 2003	B2
6607505	Thompson et al.	Aug 2003	B1
6607520	Keane	Aug 2003	B2
6616657	Simpson et al.	Sep 2003	B2
6625482	Panescu et al.	Sep 2003	B1
6628976	Fuimaono et al.	Sep 2003	B1
6632223	Keane	Oct 2003	B1
6635056	Kadhiresan et al.	Oct 2003	B2
6638223	Lifshitz et al.	Oct 2003	B2
6638275	McGaffigan et al.	Oct 2003	B1
6640120	Swanson et al.	Oct 2003	B1
6652513	Panescu et al.	Nov 2003	B2
6652517	Hall et al.	Nov 2003	B1
6658279	Swanson et al.	Dec 2003	B2
6669692	Nelson et al.	Dec 2003	B1
6669693	Friedman	Dec 2003	B2
6671533	Chen et al.	Dec 2003	B2
6673290	Whayne et al.	Jan 2004	B1
6690972	Conley et al.	Feb 2004	B2
6701180	Desai	Mar 2004	B1
6702811	Stewart et al.	Mar 2004	B2
6711428	Fuimaono et al.	Mar 2004	B2
6730078	Simpson et al.	May 2004	B2
6738673	Desai	May 2004	B2
6740080	Jain et al.	May 2004	B2
6743225	Sanchez et al.	Jun 2004	B2
6746446	Hill, III et al.	Jun 2004	B1
6752804	Simpson et al.	Jun 2004	B2
6761716	Kadhiresan et al.	Jul 2004	B2
6805131	Kordis	Oct 2004	B2
6813520	Sampson et al.	Nov 2004	B2
6814732	Schaer	Nov 2004	B2
6830576	Fleischman et al.	Dec 2004	B2
6866662	Fuimaono et al.	Mar 2005	B2
6893438	Hall et al.	May 2005	B2
6893439	Fleischman	May 2005	B2
6893442	Whayne	May 2005	B2
6916306	Jenkins et al.	Jul 2005	B1
6936047	Nasab et al.	Aug 2005	B2
6939349	Fleischman et al.	Sep 2005	B2
6952615	Satake	Oct 2005	B2
6955173	Lesh	Oct 2005	B2
6960206	Keane	Nov 2005	B2
6961602	Fuimaono et al.	Nov 2005	B2
6964660	Maguire et al.	Nov 2005	B2
6966908	Maguire et al.	Nov 2005	B2
6972016	Hill, III et al.	Dec 2005	B2
6973339	Govari	Dec 2005	B2
6987995	Drysen	Jan 2006	B2
7001336	Mandrusov et al.	Feb 2006	B2
7025766	Whayne et al.	Apr 2006	B2
7029470	Francischelli et al.	Apr 2006	B2
7029471	Thompson et al.	Apr 2006	B2
7044135	Lesh	May 2006	B2
7047068	Haissaguerre	May 2006	B2
7048734	Fleischman et al.	May 2006	B1
7048756	Eggers et al.	May 2006	B2
7077823	McDaniel	Jul 2006	B2
7094235	Francischelli	Aug 2006	B2
7099711	Fuimaono et al.	Aug 2006	B2
7099712	Fuimaono et al.	Aug 2006	B2
7113831	Hooven	Sep 2006	B2
7115122	Swanson et al.	Oct 2006	B1
7118568	Hassett et al.	Oct 2006	B2
7122031	Edwards et al.	Oct 2006	B2
7151964	Desai et al.	Dec 2006	B2
7155270	Solis et al.	Dec 2006	B2
7156843	Skarda	Jan 2007	B2
7163537	Lee et al.	Jan 2007	B2
8808161	Gregg et al.	Aug 2014	B2
20010008967	Sherman	Jul 2001	A1
20010029366	Swanson et al.	Oct 2001	A1
20010039415	Francischelli et al.	Nov 2001	A1
20010044625	Hata et al.	Nov 2001	A1
20010051803	Desai et al.	Dec 2001	A1
20020065465	Panescu et al.	May 2002	A1
20020120263	Brown et al.	Aug 2002	A1
20020126036	Flaherty et al.	Sep 2002	A1
20020148476	Farley et al.	Oct 2002	A1
20020161422	Swanson et al.	Oct 2002	A1
20030018330	Swanson et al.	Jan 2003	A1
20030093069	Panescu et al.	May 2003	A1
20030125730	Berube et al.	Jul 2003	A1
20030181819	Desai	Sep 2003	A1
20030195407	Fuimaono et al.	Oct 2003	A1
20030195501	Sherman et al.	Oct 2003	A1
20030199746	Fuimaono et al.	Oct 2003	A1
20030204185	Sherman et al.	Oct 2003	A1
20030204186	Geistert	Oct 2003	A1
20030216727	Long	Nov 2003	A1
20040015164	Fuimaono et al.	Jan 2004	A1
20040044270	Barry	Mar 2004	A1
20040082947	Oral	Apr 2004	A1
20040116921	Sherman et al.	Jun 2004	A1
20040133154	Flaherty et al.	Jul 2004	A1
20040138545	Chen et al.	Jul 2004	A1
20040143256	Bednarek	Jul 2004	A1
20040147827	Bowe	Jul 2004	A1
20040152980	Desai	Aug 2004	A1
20040158141	Scheib	Aug 2004	A1
20040162556	Swanson	Aug 2004	A1
20040181139	Falwell et al.	Sep 2004	A1
20040181249	Torrance et al.	Sep 2004	A1
20040182384	Alfery	Sep 2004	A1
20040220625	Silvestri et al.	Nov 2004	A1
20040230227	Avrahami et al.	Nov 2004	A1
20040236324	Muller et al.	Nov 2004	A1
20040247164	Furnish	Dec 2004	A1
20040260279	Goble et al.	Dec 2004	A1
20050010095	Stewart et al.	Jan 2005	A1
20050010206	Nasab et al.	Jan 2005	A1
20050015084	Hill et al.	Jan 2005	A1
20050033137	Oral et al.	Feb 2005	A1
20050033315	Hankins	Feb 2005	A1
20050065512	Schaer	Mar 2005	A1
20050096644	Hall et al.	May 2005	A1
20050101946	Govari et al.	May 2005	A1
20050119651	Fuimaono et al.	Jun 2005	A1
20050148892	Desai	Jul 2005	A1
20050177146	Sherman	Aug 2005	A1
20050187545	Hooven et al.	Aug 2005	A1
20050234439	Underwood	Oct 2005	A1
20050234444	Hooven	Oct 2005	A1
20050240176	Oral et al.	Oct 2005	A1
20050251132	Oral et al.	Nov 2005	A1
20050256521	Kozel	Nov 2005	A1
20060030844	Knight et al.	Feb 2006	A1
20060084966	Maguire et al.	Apr 2006	A1
20060089637	Werneth et al.	Apr 2006	A1
20060106375	Werneth et al.	May 2006	A1
20060111700	Kunis et al.	May 2006	A1
20060111701	Oral et al.	May 2006	A1
20060111702	Oral et al.	May 2006	A1
20060111703	Kunis et al.	May 2006	A1
20060111708	Vanney et al.	May 2006	A1
20060142753	Francischelli et al.	Jun 2006	A1
20060167448	Kozel	Jul 2006	A1
20060189975	Whayne et al.	Aug 2006	A1
20060195082	Francischelli	Aug 2006	A1
20060206109	Swanson	Sep 2006	A1
20060241366	Falwell et al.	Oct 2006	A1
20070027448	Paul et al.	Feb 2007	A1
20070083193	Werneth et al.	Apr 2007	A1
20070083194	Kunis et al.	Apr 2007	A1
20070083195	Werneth et al.	Apr 2007	A1
20070106293	Oral et al.	May 2007	A1
20090030411	Werneth et al.	Jan 2009	A1

Foreign Referenced Citations (89)

Number	Date	Country
5200671	Oct 2005	AU
2327322	Nov 1999	CA
2327518	Nov 1999	CA
2328064	Nov 1999	CA
2328070	Nov 1999	CA
2371935	Dec 2000	CA
2222617	Jul 2002	CA
2437140	Jun 2004	CA
2492283	Jul 2005	CA
2194061	Apr 2006	CA
2276755	May 2006	CA
2251041	Jun 2006	CA
428812	Mar 1995	EP
779059	Jun 1997	EP
598742	Aug 1999	EP
879016	Oct 2003	EP
1360938	Nov 2003	EP
1364677	Nov 2003	EP
1554986	Jul 2005	EP
823843	Oct 2005	EP
1384445	Feb 2006	EP
1169976	Apr 2006	EP
1415680	Apr 2006	EP
1011437	May 2006	EP
1210021	May 2006	EP
1125549	Jun 2006	EP
1182980	Jun 2006	EP
1207798	Jun 2006	EP
1321166	Jul 2006	EP
1343427	Jul 2006	EP
828451	Sep 2006	EP
1070480	Sep 2006	EP
1014874	Dec 2006	EP
1383437	Dec 2006	EP
1455667	Jan 2007	EP
957794	Jul 2007	EP
2004188179	Jul 2004	JP
1512622	Oct 1989	SU
1544396	Feb 1990	SU
1690786	Nov 1991	SU
WO9006079	Jun 1990	WO
9300958	Jan 1993	WO
WO9308756	May 1993	WO
WO9325273	Dec 1993	WO
WO9412098	Jun 1994	WO
WO9610961	Apr 1996	WO
WO9632885	Oct 1996	WO
WO9632897	Oct 1996	WO
WO9634558	Nov 1996	WO
WO9634559	Nov 1996	WO
WO9634560	Nov 1996	WO
WO9634567	Nov 1996	WO
WO9634569	Nov 1996	WO
WO9634570	Nov 1996	WO
WO9634650	Nov 1996	WO
WO9634652	Nov 1996	WO
WO9634653	Nov 1996	WO
WO9636860	Nov 1996	WO
WO9639967	Dec 1996	WO
WO9715919	May 1997	WO
WO9717893	May 1997	WO
WO9717904	May 1997	WO
WO9725917	Jul 1997	WO
WO9725919	Jul 1997	WO
WO9732525	Sep 1997	WO
WO9736541	Oct 1997	WO
WO9740760	Nov 1997	WO
WO9742996	Nov 1997	WO
WO9818520	May 1998	WO
WO9819611	May 1998	WO
WO9826724	Jun 1998	WO
WO9828039	Jul 1998	WO
WO9838913	Sep 1998	WO
WO9902096	Jan 1999	WO
WO9956644	Nov 1999	WO
WO9956647	Nov 1999	WO
WO9956648	Nov 1999	WO
WO9956649	Nov 1999	WO
WO0078239	Dec 2000	WO
WO02060523	Aug 2002	WO
WO03041602	May 2003	WO
WO03089997	Oct 2003	WO
WO2005027765	Mar 2005	WO
WO2005027766	Mar 2005	WO
WO2005065562	Jul 2005	WO
WO2005065563	Jul 2005	WO
WO2005104972	Nov 2005	WO
WO2006017517	Feb 2006	WO
WO2006044794	Apr 2006	WO

Non-Patent Literature Citations (8)

Entry
Oral et al.; U.S. Appl. No. 11/932,378 entitled “Ablation catheters and methods for their use,” filed Oct. 31, 2007.
“Werneth et al.; U.S. Appl. No. 12/116,753 entitled ““Ablation therapy system and method for treating continuous atrial fibrillation,”” filed May 7, 2008”.
Sherman et. al.; U.S. Appl. No. 12/117,596 entitled “RF energy delivery system and method,” filed May 8, 2008.
Oral et al.; U.S. Appl. No. 12/176,115 entitled “Atrial ablation catheter adapted for treatment of septal wall arrhythmogenic foci and method of use,” filed Jul. 18, 2008.
Kunis et al.; U.S. Appl. No. 12/197,425 entitled “Atrial ablation catheter and method of use,” filed Aug. 25, 2008.
Wittkampf et al., “Radiofrequency ablation with a cooled porous electrode catheter,” (abstract) JACC, vol. 11, No. 2, pp. 17a, Feb. 1988.
Oral et al., Catheter Ablation for Paroxysmal Atrial Fibrillation: Segmental Pulmonary Vein Ostial Ablation Versus Left Atrial Ablation, Circulation 2003; vol. 108, pp. 2355-2360, originally published on line Oct. 13, 2003.
Oral et al., Segmental Ostial Ablation to Isolate the Pulmonary Veins During Atrial Fibrillation: Feasibility and Mechanistic Insights, Circulation 2002; vol. 106, pp. 1256-1262, originally published online Aug. 12, 2002.

Related Publications (1)

	Number	Date	Country
	20130331831 A1	Dec 2013	US

Provisional Applications (1)

	Number	Date	Country
	60618753	Oct 2004	US

Divisions (1)

	Number	Date	Country
Parent	12245625	Oct 2008	US
Child	13905307		US

Continuations (1)

	Number	Date	Country
Parent	11179333	Jul 2005	US
Child	12245625		US

Ablation catheter

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